Pain Tolerance Research Articles

Pain sensitivity after Roux-en-Y gastric bypass- associations with chronic abdominal pain and psychosocial aspects.

The aims of this study were to investigate modifications in pain sensitivity after RYGB and to explore associations between pain sensitivity and weight loss, chronic abdominal pain, total body pain, anxiety, depression, and pain catastrophizing. In total, 163 patients with obesity were examined with a cold pressor test for pain sensitivity before and two years after RYGB. Two aspects of pain sensitivity were registered: Pain intensity (numeric rating scale, range 0-10) and pain tolerance (seconds). Associations between pain sensitivity and the explanatory variables were assessed with linear regression. Two years after RYGB the pain intensity increased (mean±SD 0.64±1.9 score units, p<0.001). Pain tolerance decreased (7.2±32.4 s, p=0.005). A larger reduction in body mass index was associated with increased pain intensity, β=-0.090 (95 % CI-0.15 to-0.031, p=0.003), and decreased pain tolerance β=1.1 (95 % CI 0.95 to 2.2, p=0.03). Before surgery, participants with chronic abdominal pain reported 1.2±0.5 higher pain intensity (p=0.02) and had 19.2±9.3 s lower pain tolerance (p=0.04) than those without abdominal pain. No differences in pain sensitivity were observed between participants who did or did not develop chronic abdominal pain after RYGB. Pain sensitivity was associated with symptoms of anxiety but not with pain catastrophizing, depression or bodily pain. The pain sensitivity increased after RYGB and was associated with larger weight loss and anxiety symptoms. Changes in pain sensitivity were not associated with development of chronic abdominal pain after RYGB in our study.

Is This Going to Hurt, Doc? Predicting Pain with Corticosteroid Injections for Upper Extremity Conditions.

One-hundred patients indicated for a CSI for an upper extremity condition were recruited for the study. Patients completed a Brief Resilience Scale, Patient-Reported Outcomes Measurement Information System pain interference form, and assessment of pain tolerance before injection. Physicians predicted pain tolerance and resilience for each patient. Immediately after the procedure, patients completed a second survey, assessing pain during and 1 minute after injection. Physician-predicted patient resilience and pain tolerance was lower than that self-reported by patients. Pain with injection was inversely correlated with physician-predicted pain tolerance and resilience but not with patient-reported pain tolerance. Injection pain ratings did not correspond with patients' willingness to undergo subsequent injections. Procedural pain is an important consideration for many patients, especially in awake procedures. Appropriate counseling is crucial to support informed consent and enhance patient outcomes. This study demonstrated that a physician's clinical experience can be used to predict a patient's pain with CSI and should be considered when counseling patients.

Ischemic pressure vs. post-isometric relaxation for treatment of rhomboid latent myofascial trigger point: a systemic review.

This systematic review was carried out to review ischemic pressure and post-isometric relaxation for treatment of rhomboid latent myofascial trigger point. This systematic review was organized using PRISMA and Cochrane standards. This meta-analysis compares ischemic pressure to post-isometric relaxation for rhomboid latent myofascial trigger point. Search terms included: myofascial pain, trigger point, ischemia pressure, post-isometric relaxation, and electric stimulation. We first searched MEDLINE (including ePub, Ahead of Print, InProgress, and Other Non-Indexed Citations) and then EMBASE and the Cochrane CENTRAL Register of Controlled Trials. Searches were conducted from the databases' inception through August 2022. The RCT review followed PRISMA criteria. PubMed, Embase, PSYCHInfo, and the Cochrane Library were searched from their origin without language constraints to locate all RCTs linked to ischemic pressure vs. post-isometric relaxation for therapy of rhomboid latent myofascial trigger point. 463 duplicates were removed. 140 of 174 citations were removed. Seven high-quality full-text papers out of 34 were included. Conservative and noninvasive treatments can only raise pain tolerance. Compared to standard treatment, ischemia pressure and post-isometric relaxation reduced shoulder and neck pain and PPT discomfort. This study suggests that ischemia compression may be more effective than post-isometric relaxation for treating rhomboid latent myofascial trigger points (MTP). Future progress in the field will depend on multi-subject RCTs.

The use of virtual reality hypnosis for prostate cancer patients during transperineal biopsy/gold seed implantation: A needs assessment study

BackgroundPatients having radiation therapy treatment to the prostate may require invasive preparation procedures under local anesthesia (LA), such as the insertion of gold seeds into the prostate or targeted biopsies. These procedures can induce pain and anxiety for some patients. Virtual Reality Hypnosis (VRH) is the combination of a 360-degree video display with audio and mental guides for relaxation and distraction during medical procedures. The objective of this research was to assess the level of patient interest in the use of VRH during gold seed insertion and biopsy, and to identify a subset of patients that would be most likely to benefit from the use of VRH. MethodsThis single arm, prospective pilot study included patients who were receiving biopsy and/or gold seed insertion using a 2-step LA procedure. Participants were asked to complete a questionnaire about their level of knowledge and interest in VRH before and after their procedure. At the same time, pain and anxiety levels were collected before and after the procedure, as well as during each LA step and at the mid-seed drop/biopsy core extraction. A visual analogue scale for pain and the National Comprehensive Cancer Network's Distress Thermometer were used to verbally rate pain and distress respectively. Descriptive statistics and Pearson's correlation coefficient were calculated for all variables of interest. Results24 patients were recruited and 1 had their procedure cancelled, so a total of 23 patients completed this study. 74% of patients (n=23) agreed to try VRH before their procedures, whereas 65% of patients (n=23) were willing to try VRH after the procedure. Pain scores were highest at deep LA injection (mean= 5.48, SD= 2.56) and distress scores were also highest at deep LA injection (mean= 4.28, SD= 2.92). After the procedure, 83% of participants with pain scores above the mean at deep LA injection and 80% with anxiety scores above the mean at deep LA injection agreed that they would be willing to try VRH. ConclusionsPatients with higher pain and distress scores had more interest in trying VRH with the standard LA for gold seed insertion/biopsy procedures. Patients with a history of lower pain tolerance or who express having experienced high levels of pain during previous biopsies will be the target population for using VRH in future trials to determine feasibility and effectiveness.

The Effect of Kinesio Taping Tension on the Pressure-Pain Threshold and Pain Tolerance: A Randomized, Controlled, Doubled-blinded Trial

Purpose: To our knowledge, no study has demonstrated the effects of Kinesio Taping (KT) tension on pressure-pain threshold and tolerance. The aim of the study was to investigate the effect of KT tension tensions on pressure pain threshold and tolerance.&#x0D; Methods: A double-blind, randomized controlled study was conducted with 90 healthy male subjects with an average age of 21.04 ± 2.0 years. The subjects were randomized into four groups: 0% tension placebo (n=23), 50% tension (n= 24), 75% tension (n=22) and 100% tension groups (n=21). The KT was applied from distal to proximal, exposing the lateral epicondyle region on the dominant side. Pressure pain threshold and pain tolerance were measured using digital algometer over the lateral epicondyle. Measurements were carried out, before, immediate after and 30 minutes after KT.&#x0D; Results: There was no statistically significant difference between the groups in terms of PP threshold, pain tolerance and intensity (p&gt;0.05). There was a significant in-group difference only in the 100% Tension Group in terms of PP threshold (p

Longitudinal relationships between habitual physical activity and pain tolerance in the general population.

Physical activity (PA) might influence the risk or progression of chronic pain through pain tolerance. Hence, we aimed to assess whether habitual leisure-time PA level and PA change affects pain tolerance longitudinally in the population. Our sample (n = 10,732; 51% women) was gathered from the sixth (Tromsø6, 2007-08) and seventh (Tromsø7, 2015-16) waves of the prospective population-based Tromsø Study, Norway. Level of leisure-time PA (sedentary, light, moderate, or vigorous) was derived from questionnaires; experimental pain tolerance was measured by the cold-pressor test (CPT). We used ordinary, and multiple-adjusted mixed, Tobit regression to assess 1) the effect of longitudinal PA change on CPT tolerance at follow-up, and 2) whether a change in pain tolerance over time varied with level of LTPA. We found that participants with high consistent PA levels over the two surveys (Tromsø6 and Tromsø7) had significantly higher tolerance than those staying sedentary (20.4 s. (95% CI: 13.7, 27.1)). Repeated measurements show that light (6.7 s. (CI 3.4, 10.0)), moderate (CI 14.1 s. (9.9, 18.3)), and vigorous (16.3 s. (CI 6.0, 26.5)) PA groups had higher pain tolerance than sedentary, with non-significant interaction showed slightly falling effects of PA over time. In conclusion, being physically active at either of two time points measured 7-8 years apart was associated with higher pain tolerance compared to being sedentary at both time-points. Pain tolerance increased with higher total activity levels, and more for those who increased their activity level during follow-up. This indicates that not only total PA amount matters but also the direction of change. PA did not significantly moderate pain tolerance change over time, though estimates suggested a slightly falling effect possibly due to ageing. These results support increased PA levels as a possible non-pharmacological pathway towards reducing or preventing chronic pain.

Sensitivity to ostracism is blunted in suicide attempters only when they report suicidal ideation

BackgroundModified pain perception is at the core of many theories on suicide; however, studies on the relationship between pain perception and suicidal behavior (attempt) have produced contradictory results. In this experimental study, we investigated whether physical pain and social pain are concomitantly influenced by suicidal ideation (SI) and past suicidal behavior. Methods155 inpatients with depression (90 with and 65 without past history of suicide attempt) were included. They underwent thermal stimulation of the skin to assess physical pain tolerance and played the Cyberball game to assess their sensitivity to ostracism (social pain). Participants self-assessed current SI through the specific item in the Beck Depression Inventory. ResultsPain tolerance was not associated with history of suicide attempt, current SI, and their interaction. Social pain was associated with the interaction between history of suicide attempt and current SI. Social pain was decreased in suicide attempters, compared with non-attempters, only when they reported current SI. LimitationsCyberball game may not be representative of everyday stress and ecological social context. ConclusionsUnlike what suggested by many theories, pain tolerance does not seem to be necessary to attempt suicide. Suicide attempters with current SI displayed blunted sensitivity to ostracism and could be less willing to restore social affiliation compared with non-attempters.

Morphine Withdrawal-Induced Hyperalgesia in Models of Acute and Extended Withdrawal Is Attenuated by l-Tetrahydropalmatine.

Effective pain control is an underappreciated aspect of managing opioid withdrawal, and its absence presents a significant barrier to successful opioid detoxification. Accordingly, there is an urgent need for effective non-opioid treatments to facilitate opioid detoxification. l-Tetrahydropalmatine (l-THP) possesses powerful analgesic properties and is an active ingredient in botanical formulations used in Vietnam for the treatment of opioid withdrawal syndrome. In this study, rats receiving morphine (15 mg/kg, i.p.) for 5 days per week displayed a progressive increase in pain thresholds during acute 23 h withdrawal as assessed by an automated Von Frey test. A single dose of l-THP (5 or 7.5 mg/kg, p.o.) administered during the 4th and 5th weeks of morphine treatment significantly improves pain tolerance scores. A 7-day course of l-THP treatment in animals experiencing extended withdrawal significantly attenuates hyperalgesia and reduces the number of days to recovery to baseline pain thresholds by 61% when compared to vehicle-treated controls. This indicates that the efficacy of l-THP on pain perception extends beyond its half-life. As a non-opioid treatment for reversing a significant hyperalgesic state during withdrawal, l-THP may be a valuable addition to the currently limited arsenal of opioid detoxification treatments.

Distress tolerance and emotional regulation in individuals with alcohol use disorder.

Previous research suggests that low distress tolerance may be associated with poor emotion regulation, contribute to drinking to cope motives, and predict alcohol-related problems in non-clinical populations. However, little is known about the ability to tolerate distress among individuals with alcohol use disorder (AUD) and its association with emotional dysregulation. The aim of this study was to examine the link between emotional dysregulation and a behavioral measure of distress tolerance among individuals with AUD. The sample consisted of 227 individuals with AUD enrolled in an 8-week abstinence-based inpatient treatment program. Behavioral distress tolerance was assessed using a test of ischemic pain tolerance and the Difficulties in Emotion Regulation Scale (DERS) was used to assess emotion dysregulation. Distress tolerance was significantly associated with emotional dysregulation even when accounting for alexithymia, depressive symptomatology, age, and biological sex. The current study provides preliminary support for an association between low distress tolerance and emotion dysregulation in a clinical group of patients with AUD.

Pain tolerance after stroke: The Tromsø study.

Stroke lesions might alter pain processing and modulation by affecting the widely distributed network of brain regions involved. We aimed to compare pain tolerance in stroke survivors and stroke-free persons in the general population, with and without chronic pain. We included all participants of the sixth and seventh wave of the population-based Tromsø Study who had been tested with the cold pressor test (hand in cold water bath, 3°C, maximum time 106 s in the sixth wave and 120 s in the seventh) and who had information on previous stroke status and covariates. Data on stroke status were obtained from the Tromsø Study Cardiovascular Disease Register and the Norwegian Stroke Register. Cox regression models were fitted using stroke prior to study attendance as the independent variable, cold pressor endurance time as time variable and hand withdrawal from cold water as event. Statistical adjustments were made for age, sex, diabetes, hypertension, hyperlipidaemia, body mass index and smoking. In total 21,837 participants were included, 311 of them with previous stroke. Stroke was associated with decreased cold pain tolerance time, with 28% increased hazard of hand withdrawal (hazard ratio [HR] 1.28, 95% CI 1.10-1.50). The effect was similar in participants with (HR 1.28, 95% CI 0.99-1.66) and without chronic pain (HR 1.29, 95% CI 1.04-1.59). Stroke survivors, with and without chronic pain, had lower cold pressor pain tolerance, with possible clinical implications for pain in this group. We found lower pain tolerance in participants with previous stroke compared to stroke-free participants of a large, population-based study. The association was present both in those with and without chronic pain. The results may warrant increased awareness by health professionals towards pain experienced by stroke patients in response to injuries, diseases and procedures.

Mind-over-body beliefs in sport and exercise: A driving force for training volume and performance, but with risks for exercise addiction

We assume that athletic success is associated with certain beliefs that on the one hand promote performance-enhancing behavior (training volume), but on the other hand can also be detrimental to health (sports addiction). These beliefs are succinctly characterized by the title of the 9-item “Mind-over-Body” scale presented here. They are the three beliefs that 1) athletic performance requires a high level of effort, 2) that willpower plays an important role in athletic success, and 3) that athletic success requires pain tolerance. A total of six web-survey-based studies with a total of 1121 participants (approximately gender parity), including individuals with different levels of athletic performance (no competition; amateur sport; regional, national, or international competition), examined the psychometric network and construct and criterion validity of the MoB scale. Exploratory graph analyses, which included the studies with the largest sample sizes, showed that the three belief components (effort, willpower, pain) form separable communities within the MoB network and that the MoB items form communities distinct from self-control and self-efficacy. Meta-analyzed correlations across all six studies showed low positive correlations with self-control and self-efficacy. In terms of criterion validity, MoB beliefs were positively correlated with training volume and exercise addiction. We discuss MoBs as “on the edge of unhealthy” and place MOBs within a framework of related but distinct concepts.

EFFECTIVENESS OF LOCALANAESTHESIA SPRAY VS SUPRA PERIOSTEAL INFILTRATION IN MOBILE ANTERIOR / POSTERIOR TEETH – A COMPARATIVE STUDY.

Objectives – To compare the Effectiveness of local Anesthesia spray vs supraperiosteal Inltration in mobile anterior or posterior teeth – a comparative study Methods– The study is an observational study and is being carried out in outpatient section of Department of Oral and Maxillofacial Surgery of a tertiary care hospital in Kelambakkam. 20 individuals diagnosed with periodontal pathologies in opposing quadrants that presents as Grade III mobility are advised for extraction as treatment plan. One Group will receive 10% lidocaine spray around the periapical and periodontal areas. Second Group will receive supraperiosteal Inltration. Pain tolerance will be recorded while performing the dental extraction at 3, and 5 minutes and at end of the procedure. The pain tolerance between the teeth that was extracted by administration of local anaesthetic spray and with those receiving supraperiosteal inltrations will be compared. Readings of the two groups will be recorded and subjected to statistical analysis. The extraction procedure will be performed by a single operator. The study is single blinded. Results – There is a signicant difference in the efcacy of 10% lignocaine spray and Supraperiosteal Inltration as in controlling pain during extraction of tooth, in adults Conclusion: The efcacy of supraperiosteal Inltration was superior compared to 10% lignocaine spray respectively. The patients who received supraperiosteal inltration perceived less pain during extraction of tooth when compared to patients who received 10% lignocaine spray. There is a signicant difference in the efcacy of 10% lignocaine spray and Supraperiosteal Inltration as in controlling pain during extraction of tooth, in adults. Hence, we advocate the use only of an inltration prior to any dental extraction.

A Prospectiv ospective-Randomiz e-Randomized Study: The Impact of F ed Study: The Impact of Four Diff our Different Caries Remo Caries Removal Method on P al Method on Pain and Clinical E ain and Clinical Evaluations aluations

Objective: There are many different methods for removing caries. In this study, to evaluate four caries removal methods in terms of patient comfort and to evaluate the clinical success of restorations according to modified-USPHS criteria. Methods: In 31 patients with at least 4 Class II caries in their posterior teeth, 4 teeth were randomly divided into four groups and 4 different methods (conventional method, Carisolv, Papacarie, Er-Cr:YSGG Laser) were used for caries removal. Pain formation during caries removal was determined by FACE Pain Scale questionnaire. The restorations were controlled with Modified-USPHS criteria in 3-6-12 months period. Mann-Whitney U test for two-group comparisons, Kruskal Wallis H test for comparison of three or more groups, Wilcoxon Sign test was used to examine the changes according to time (p &lt; 0.05). Results: A significant difference was found between conventional methods and alternative methods in terms of pain tolerance. In the 1-year clinical evaluation of the restorations, there was a significant decrease in the postoperative sensitivity in all groups. A significant difference was detected in Carisolv and laser groups between 6-months and 12-months for marginal coloration. A significant difference was found between the conventional and laser groups between 6-months and 12-months in terms of color match. Conclusion: The success of restorations, efficacy and efficiency of the methods used in the evaluation of all groups were found to be successful. In terms of patient comfort, all alternative methods gave positive results.

A comparative evaluation of placebo effect on pain perception parameters in open-label versus double-blind groups: a prospective randomized pilot study in healthy volunteers

Background: Considerable placebo response rate is commonly observed in placebo-controlled trials involving analgesics. However, there is paucity of evidence with regard to comparison of effect of open-label placebo versus double-blind placebo on pain perception. Methods: In this study, cold water maintained at 4±1°C was used to induce experimental pain. Enrolled subjects were randomized to receive either 2% lignocaine gel as active drug or K-Y jelly as placebo as per the groups in open-label (two groups) and double-blind (two groups) study. Pain perception was evaluated using pain threshold time and pain tolerance time after immersion of subject’s hand in the cold water. Pain intensity was assessed using visual analogue scale (VAS). Results: Sixty-nine subjects were randomized into 4 study groups namely open-label lignocaine (OLL; N=17), open-label placebo (OLP; N=18), double-blind lignocaine (DBL; N=17) and double-blind placebo (DBP; N=17). OLP application increased pain intensity on VAS from 67 (47, 84) to 72 (39, 88) mm (p=0.018). OLL application reduced pain perception pain threshold time from 20.4 (4.0, 45.1) to 24.1 (6.3, 124.2) seconds (p=0.049) and pain tolerance time from 32.7 (6.8, 110.2) to 40.0 (7.7, 156.7) seconds (p=0.019). The change in pain parameters (before and after application of study intervention) was comparable without any significant difference among the four study groups (p=0.257 for pain threshold time, p=0.165 for pain tolerance time and p=0.563 for pain intensity score). Conclusions: Lignocaine and placebo gel application showed comparable change in pain perception irrespective of blinding.

Pengaruh Kombinasi Genggam Jari dan Aromaterapi Jasmine Terhadap Nyeri Pasien Post Operasi Sectio Caesarea

Mothers with sectio caesarea will experience several problems such as pain, impaired mobility and anxiety. The pain felt by the mother of Sectio Caesarea can come from the incision scar under the abdomen. However, the severity of pain experienced by the mother will differ depending on the psychological and physiological as well as the pain tolerance experienced by the mother. Non-pharmacological therapies that can be given to reduce pain are a combination of finger grips and Jasmine aromatherapy. The method used in this study is a descriptive case study design with a case study approach based on the application of evidence-based practice of giving a combination of finger grip with jasmine aromatherapy. The sample of 2 people in this study was mothers after sectio caesarea surgery. This case study was conducted in June 2022. The measuring instrument uses a numerical pain intensity scale. The results obtained from both pain subjects can decrease from moderate pain decreased to mild pain. There was a reduction in pain after a combination of finger grips and Jasmine aromatherapy in post-sectio caesarea mothers. Suggestions for the public are expected to be able to independently apply finger gripping techniques with a combination of jasmine aromatherapy in reducing pain.

Assessment of pain, scapulothoracic muscle strength, endurance and scapular dyskinesis in individuals with and without nonspecific chronic neck pain: A cross-sectional study

IntroductionThis study is aimed to evaluate pain, muscle strength, scapular muscular endurance and scapular kinesis in individuals with Nonspecific Chronic Neck Pain and to compare them with asymptomatic individuals. In addition, to investigate the effect of mechanical changes in the scapular region on neck pain. Method40 individuals who applied to Kırıkkale University Faculty of Medicine Hospital Physical Therapy and Rehabilitation Center and diagnosed with NSCNP and 40 asymptomatic individuals for the control group were included the study. Pain was evaluated with Visual Analogue Scale, pain threshold and pain tolerance with algometer, cervical deep flexor group muscle strength with Stabilizer Pressure Biofeedback device, and neck and scapulothoracic muscle strength with Hand Held Dynamometer. Scapular Dyskinesia Test, Scapular Depression Test and Lateral Scapular Slide Test were used to evaluate scapular kinesis. A timer was used to evaluate scapular muscular endurance. ResultPain threshold and pain tolerance values of the NSCNP group were lower (p < 0.05). Muscle strength around neck and scapulothoracic region of the NSCNP group were lower than the asymptomatic individuals (p < 0.05). NSCNP group had more scapular dyskinesia (p < 0.05). Scapular muscular endurance values of the NSCNP group were lower (p < 0.05). ConclusionAs a result, pain threshold and pain tolerance decreased, muscle strength of the neck region and the scapular region decreased, scapular endurance values decreased and the incidence of scapular dyskinesia increased in the individuals with NSCNP compared to the asymptomatic individuals. It is thought that our study will provide a different perspective in the evaluation of neck pain and including the scapular region to the evaluations.

Influence of Cannabinoid Treatment on Trajectories of Patient-Related Outcomes in Chronic Pain: Pain Intensity, Emotional Distress, Tolerability and Physical Disability

The treatment of chronic pain with cannabinoids is becoming more widespread and popular among patients. However, studies show that only a few patients experience any benefit from this treatment. It also remains unclear which domains are affected by cannabinoid treatment. Therefore, the present study is novel in that it explores the effects of cannabinoid treatment on four patient-related outcome measures (PROMs), and includes patients with chronic refractory pain conditions who have been given the option of cannabinoid treatment. A retrospective design was used to evaluate the impact of cannabinoid treatment on patients with refractory pain in two German outpatient pain clinics. The present study shows that pain intensity (mean relative reduction (-14.9 ± 22.6%), emotional distress (-9.2 ± 43.5%), pain-associated disability (-7.0 ± 46.5%) and tolerability of pain (-11 ± 23.4%)) improved with cannabinoid treatment. Interestingly, the trajectories of the PROMs seemed to differ between patients, with only 30% of patients responding with respect to pain intensity, but showing improvements in other PROMs. Although the mean treatment effects remained limited, the cumulative magnitude of change in all dimensions may affect patients' quality of life. In summary, a singular evaluation with pain intensity as the sole outcome does not cover the multidimensional effects of cannabinoids. Therefore, the treatment effects of cannabinoids should be evaluated with different PROMs.

The Mediating Role of Tolerance for Psychological Pain in the Relationship Between Different Types of Childhood Traumatic Experiences and Suicidal Ideation.

The aim of the present research was to evaluate the mediating effects of facets of the tolerance for psychological pain on the relationship between childhood trauma and suicidal ideation. A sample of 437 community individuals and a sample of 316 college students participated. For the community sample, managing the pain mediated the relationship between childhood trauma, the different types of traumatic experiences and suicidal ideation. In the college sample, managing the pain and enduring the pain mediated the relationship between childhood trauma, the different types of traumatic experiences and suicidal ideation, except for the case of sexual abuse. The present results have potential clinical implications. Mental health professionals should be aware of the long-term consequences of exposure to childhood trauma and need to assess the ability to tolerate psychological pain so as to implement appropriate psychological interventions that help individuals cope with their pain.

Myocardial Infarction Signs and Symptoms: Females vs. Males.

Cardiovascular disease is the number one killer of females in the United States today, and myocardial infarction (MI) plays a role in many of these deaths. Females also present with more "atypical" symptoms than males and appear to have differences in pathophysiology underlying their MIs. Despite both differences in symptomology and pathophysiology being present in females versus males, a possible link between the two has not been studied extensively. In this systematic review, we analyzed studies examining differences in symptoms and pathophysiology of MI in females and males and evaluated possible links between the two. A search was performed for sex differences in MI in the databases PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature) Complete, Biomedical Reference Collection: Comprehensive, Jisc Library Hub Discover, and Web of Science. Seventy-four articles were ultimately included in this systematic review. Typical symptoms for both ST-elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) such as chest, arm, or jaw pain were more common in both sexes, but females presented on average with more atypical symptoms such as nausea, vomiting, and shortness of breath. Females with MI also presented with more prodromal symptoms such as fatigue in days leading up to MI, had longer delays in presentation to the hospital after symptom onset, and were older with more comorbidities than males. Males on the other hand were more likely to have a silent or unrecognized MI, which concurs with their overall higher rate of MI. As they age, females have a decrease in antioxidative metabolites and worsened cardiac autonomic function than male. In addition, at all ages, females have less atherosclerotic burden than mles, have higher rates of MI not related to plaque rupture or erosion, and have increased microvasculature resistance when they have an MI. It has been proposed that this physiological difference is etiologic for the male-female difference in symptoms, but this has not been studied directly and is a promising area of future research. It is also possible that differences in pain tolerance between males and females may play a role in differing symptom recognition, but this has only been studied one time where females with higher pain thresholds were more likely to have unrecognized MI. Again, this is a promising area for future study for the early detection of MI. Finally, differences in symptoms for patients with different atherosclerotic burden and for patients with MI due to a cause other than plaque rupture or erosion has not been studied and are both promising avenues to improve detection and patient care in the future.

Effects on general pain perception and dental pulp sensibility in probable sleep bruxism subjects by experimentally induced pain in a pilot study

In this pilot study, the general pain perception and the dental pulp sensibility of probable sleep bruxism (SB) subjects were compared with that of non-SB subjects. The cold pressor test (CPT), electric pulp test (EPT), and thermal pulp test with CO2 snow were executed by one trained dentist (blind to SB diagnosis). A one-factorial multivariate analysis of variance (MANOVA) with SB diagnosis as independent variable and standardized measures regarding pain perception and evaluation was performed. One-hundred-and-five participants (53 SB and 52 non-SB subjects) were included. The one-factorial MANOVA revealed a significant difference between SB and non-SB subjects (p = 0.01) concerning pain perception variables. Post-hoc univariate analyses of variance (ANOVA) showed statistically significant lower general pain tolerance (p = 0.02), higher general subjective sensibility of the teeth (p < 0.01), and a statistical trend for higher subjective dental pain intensity (p = 0.07) in SB subjects. In most of the standardized variables, probable SB subjects seem to react and feel similar to non-SB subjects. However, as probable SB subjects subjectively perceive their teeth to be more sensitive and tend to rate their subjective dental pain intensity more intensely after CO2 testing, data might point to a somatosensory amplification.