Tolerance Characteristics Research Articles

Lead Tolerance and Enrichment Characteristics of Three Hydroponically Grown Ornamental Plants

Phytoremediation of lead (Pb) in contaminated soils using hyper-enriched plants is an important task. It is a green and sustainable measure. Studies have revealed that three ornamental plants, Tagetes patula (T. patula), Solanum nigrum (S. nigrum), and Mirabilis jalapa (M. jalapa), have the ability to enrich for Pb; however, studies on difference between them and root morphology and the relationship between tolerance and capacity are lacking. The ability of three lead-enriching plants, T. patula, S. nigrum, and M. jalapa, to cope with Pb stress was assessed in hydroponic experiments using five Pb stress concentrations (0–1000 mg/L). Under different Pb stress conditions, the growth of the shoots and roots of three tested ornamental plants was inhibited to varying degrees. In the three tested ornamental plants, Pb mainly accumulated in the roots, and the highest levels of Pb observed in the shoots of T. patula, S. nigrum, and M. jalapa were 1074.1 mg/kg, 958.7 mg/kg, and 975.3 mg/kg, respectively. All plants reached a critical level of Pb hyperaccumulation. Redundancy analysis showed that changes in the root architecture of the three tested ornamental plants were significantly and positively correlated with tolerance as well as the enrichment and transfer ability of the heavy metal Pb. Therefore, these three ornamental plants have the potential to remediate Pb-contaminated water and soil and can increase the tolerance and enrichment characteristics of Pb by regulating the root biomass and root length of the three test ornamental plants via various agronomic measures. In addition, more research should be conducted to assess their effectiveness as phytoextractants under field conditions.

Enhanced Higher Harmonic Generation in Modified MAPbBr3-xClx Single Crystal by Additive Engineering.

Mixed-halide perovskite materials (MHSCs) hold significant interest in photonics applications owing to their inherent advantages, including tunable bandgap properties, remarkable defect tolerance characteristics, and facile processability. These attributes position MHSCs as up-and-coming materials for various applications. However, the commercialization of these materials is severely affected by external factors, such as humidity and oxygen. The current work studies change in higher harmonics generation (HHG) in MAPbBr3-xClx single crystals (MHSC) with changing nitrogen-based additives. These additives act as a passivating layer and improve the nanolevel crystallinity. The additive engineering strategy impacts morphological and optical properties, depending on the additive's interaction.

Guest Editorial: Special Section on Advanced WPT Systems With High Efficiency and Misalignment Tolerance Characteristics

Guest Editorial: Special Section on Advanced WPT Systems With High Efficiency and Misalignment Tolerance Characteristics

Rhizospheric Lactobacillus spp. contribute to the high Cd-accumulating characteristics of Phytolacca spp. in acidic Cd-contaminated soil

Screening high Cd-accumulating plants and understanding the interactions between plants, rhizospheric microbes and Cd are important in developing microbe-assisted phytoremediation techniques for Cd-contaminated soils. In this study, the Cd tolerance and accumulation characteristics of Phytolacca americana L., P. icosandra L. and P. polyandra Batalin growing in acidic Cd-contaminated soil were compared to evaluate their phytoremediation potential. According to Cd concentrations (root: 8.26–37.09 mg kg−1, shoot: 2.80–9.26 mg kg−1), bioconcentration factors (BCFs) and translocation factors (TFs), the three Phytolacca species exhibited high Cd-accumulation capacities, ranked in the following order: P. icosandra (root BCF: 1.25, shoot BCF: 0.31, TF: 0.25) > P. polyandra (root BCF: 0.68, shoot BCF: 0.26, TF: 0.44) > P. americana (root BCF: 0.28, shoot BCF: 0.09, TF: 0.38). Phytolacca icosandra and P. polyandra can thus be considered as two new Cd accumulators for phytoremediation. Soil pH, available Cd (ACd) concentration and certain bacterial taxa (e.g. Lactobacillus, Helicobacter, Alistipes, Desulfovibrio and Mucispirillum) were differentially altered in the rhizospheres of the three Phytolacca species in comparison to unplanted soil. Correlation analysis showed that there were significant interactions between rhizospheric ACd concentration, pH and Lactobacillus bacteria (L. murinus, L. gasseri and L. reuteri), which affected Cd uptake by Phytolacca plants. The mono- and co-inoculation of L. murinus strain D51883, L. gasseri strain D51533 and L. reuteri strain D24591 in the rhizosphere of P. icosandra altered the rhizospheric pH and ACd concentrations, in addition to increasing the shoot Cd contents by 31.9%–44.6%. These results suggest that recruitment of rhizospheric Lactobacillus spp. by Phytolacca plants contributes to their high Cd-accumulating characteristics. This study provides novel insights into understanding the interactions between plants, rhizobacteria and heavy metals.

Enhancing Drought Tolerance and Fruit Characteristics in Tomato through Exogenous Melatonin Application

Drought stress not only affects the growth and development of tomato seedlings but also leads to a significant decrease in tomato fruit yield. Previous studies have shown that melatonin plays a crucial role in regulating plant tolerance to drought stress. The present study was conducted to investigate the impact of exogenous melatonin on the growth and development of tomato seedlings under drought stress, as well as its potential in improving fruit yield and quality. Our findings demonstrate that drought stress strongly suppressed growth and biomass accumulation, reduced photosynthetic pigments, and inhibited photosynthesis. Conversely, melatonin treatment led to a notable increase in plant height, stem diameter, aboveground biomass, and relative water content of tomato seedlings by 16.67%, 7.39%, 10.58%, and 13.31%, respectively, compared to the drought treatment. Moreover, the chlorophyll content increased by 40.51%, and the net photosynthetic rate increased by 1.2 times. Furthermore, the application of melatonin under drought stress resulted in a decrease in osmoregulation substances, reduced accumulation of reactive oxygen species, and enhanced activity of antioxidant enzymes in tomato seedlings. Exogenous melatonin was also found to inhibit the expression of abscisic-acid-synthesis-related genes, resulting in a reduction in the abscisic acid content in tomato seedlings. Additionally, it significantly increased the root length, root surface area, and root vitality of the plants. When compared to drought treatment, tomato plants treated with melatonin exhibited a 61.92% increase in average yield and a 37.79% increase in fruit weight per plant. Furthermore, the organic acid content decreased by 23.77%, while soluble solids and sugars increased by 15.07% and 35.49%, respectively. These findings suggest that exogenous melatonin effectively alleviates the inhibition of photosynthesis and growth in tomato seedlings under drought stress. It achieves this by regulating the content of osmotic stress substances and the activity of antioxidant enzymes, thus enhancing the resistance of tomato seedlings to drought stress. Moreover, melatonin regulates root growth by mediating the biosynthesis of endogenous ABA, thereby improving the absorption and utilization efficiency of water and nutrients in plants. Consequently, it enhances tomato fruit yield and quality under drought stress.

Deep neural network-enabled bifunctional terahertz metasurface design for absorption and polarization conversion

With the assistance of deep neural networks, a bifunctional metasurface (MS) was designed and optimized, i.e., a broadband absorber and a broadband polarization converter. The MS acts as a wide absorber when the vanadium dioxide (VO2) is in the metallic state and has an absorption bandwidth of 5.21 THz with an absorption rate ≥ 90%. In contrast, the MS acts as a linear–linear polarization converter when the top VO2 is in the insulating state and has a bandwidth of 3.7 THz with a conversion efficiency ≥ 90%. The bandwidth in both states is maximum compared to other bifunctional counterparts, while this bifunctional MS has good parametric and angular tolerance characteristics and low material cost. The proposed structure and design method of the bifunctional MS can provide a useful reference for the research of new multifunctional terahertz devices.

Colchicine-Induced Polyploidy in Leguminous Crops Enhances Morpho-Physiological Characteristics for Drought Stress Tolerance.

Legumes play a significant role in the alleviation of food insecurity, maintaining soil fertility, and achieving sustainable crop production under adverse environmental conditions. The increased demand in legume production contemplates that attention on the genetic improvement of these crops through various means such as genetic engineering and mutation breeding should take a centre stage in global agriculture. Therefore, this paper provides a succinct analysis of the currently available literature on morphological and physiological traits in polyploidised leguminous plants to counter the adverse effects of drought stress. The effects of colchicine on various morphological and physiological traits of polyploidised legumes compared to their diploid counterparts were examined. Numerous reports revealed variations in these traits, such as improved root and shoot growth, plant biomass, chloroplastidic content, protein, RNA, and DNA. The differences observed were also associated with the strong relationship between plant ploidy induction and colchicine application. Furthermore, the analysis indicated that polyploidisation remains dose-dependent and may be achievable within a shorter space of time as this antimitotic chemical interferes with chromosome separations in somatic plant cells. The efficiency of this process also depends on the advancement of treatment conditions (in vitro, in vivo, or ex vitro) and the successful regeneration of polyploidised plants for adaptation under drought stress conditions. As such, the improvement in metabolite profile and other essential growth characteristics serves as a clear indication that induced polyploidy needs to be further explored to confer resilience to environmental stress and improve crop yield under drought stress conditions in leguminous plants.

The Effect of Demographic Characteristics and Personality Traits on Financial Risk Tolerance. A Case Study of Lower Dir

This research investigates the intricate relationships between financial risk tolerance, personality traits, and demographic characteristics among investors in Lower Dir. By acknowledging the crucial role of these factors in shaping investment decisions, our analysis of 284 participants' data reveals that age, education, conscientiousness, and neuroticism significantly impact financial risk tolerance. On the other hand, gender, monthly income, openness to experience, and agreeableness show weaker or insignificant associations. These findings provide essential insights for devising effective financial planning and investment strategies. To further explore these relationships, future research should consider longitudinal or experimental approaches and larger sample sizes.

Improved error tolerance of programmable photonic integrated circuits for MNIST handwritten digit classification

Programmable photonic integrated circuits (PPICs) can realize linear optical unitary transformation between arbitrary multi-port input and multi-port output for optical computing and signal processing. With the scale increase of PPICs, the accumulation of manufacturing errors will lead to overall performance deviations. A symmetrical Mach-Zehnder interferometer (MZI) circuit with a shorter optical path and lower propagation loss has been proposed recently to replace the traditional asymmetrical MZI circuit. However, no systematic research on the error compensation of symmetrical MZI circuits has been reported yet. In this paper, the error tolerance characteristics of symmetrical MZI circuits and asymmetrical MZI circuits are analyzed and compared in detail. An effective strategy to compensate the 3 dB beam splitter error of a symmetrical MZI circuit is proposed. A deep learning task of the Modified National Institute of Standards and Technology (MNIST) handwritten digit dataset classification was carried out with two hidden layers, which are implemented by rectangular symmetrical MZI circuit structures. The recognition accuracy can be significantly improved with this error compensation method.

Specific features of impaired tolerance to antihypertensive treatment in patients with primary open-angle glaucoma and a hereditary history of the disease

This review considers possible reasons for the decrease in the effectiveness of antihypertensive treatment in primary open-angle glaucoma (POAG) patients with a family history of the disease, presents clinical practice examples of the effectiveness and duration of antiglaucoma topical therapy and the mechanisms and manifestations of tachyphylaxis and tolerance disorders in such patients. Clinical features and the nature of POAG progression in patients with a hereditary predisposition may be reflected in the early decrease in the effectiveness of antihypertensive treatment. In some recent publications the authors proved a more aggressive course of POAG in patients with a family history of the disease, but despite that, such works at the moment are very limited in number and unsystematized. This, in turn, prevents drawing unambiguous conclusions regarding the features of the prescribed antihypertensive therapy. The article also discusses modern aspects of pharmacogenetics in patients with POAG, its further development will help minimize unwanted side effects as well as increase the effectiveness of antihypertensive drug treatment. The results of the work presented in this review allow systematization of the available data on impaired tolerance to antihypertensive therapy and maintain the need of further clinical research in this area.

Effects of Weevil (Rhynchophorus palmarum), Teosinte (Dioon mejiae) and Caesar’s Mushroom (Amanita caesarea) on the Properties of Lactobacillus acidophilus LA-K

Weevil (Rhynchophorus palmarum) powder, teosinte (Dioon mejiae) and Caesar’s mushroom (Amanita caesarea) flour have bioactive compounds with significant nutritional applications. This paper aimed to examine the influence of weevil, teosinte, and mushroom powders on the protease activity, acid tolerance, bile tolerance, lysozyme tolerance, and gastric juice resistance ability of Lactobacillus acidophilus LA-K. Acid tolerance was determined by adjusting the pH of MRS broth to 2.0 for L. acidophilus incubated under aerobic conditions at 37 °C. Bile tolerance was determined by incorporating 0.3% of oxgall. Protease activity was determined spectrophotometrically at 340 nm. Resistance to 100 mg/L of lysozyme in an electrolyte solution was also determined. All ingredients were incorporated at 2% (w/v), while the control had no added ingredients. Acid and lysozyme tolerance were examined at 0, 30, 60, 90, and 120 min of incubation, whereas bile tolerance was analyzed at 0, 4, and 8 h. Gastric juice tolerance was determined at pH 2, 3, 4, 5, and 7 during 0 and 30 min of incubation, while protease activity was evaluated at 0, 12, and 24 h. Use of weevil flour, and Caesar’s mushroom powder resulted in significantly (p < 0.05) lower counts for bile tolerance, acid tolerance, lysozyme resistance and simulated gastric juice tolerance characteristics. Protease activity increased with the use of teosinte flour. As such, this probiotic bacterium can be used alongside certain novel food sources at 2% concentration in the manufacture of fermented products such as yogurt.

Assessment of Bangladeshi rice landraces for drought tolerance under controlled environment

Drought is one of the major challenging abiotic stresses for rice production in Bangladesh. This study investigated 48 rice landraces obtained from different Eco-zones of Bangladesh for their drought tolerance characteristics. Significant variation was observed in morpho-physiological traits such as length of root and shoot, dry weight of root and shoot, leaf stomatal resistance and stomata number. Stomatal conductance, root length, root dry weight showed significant correlation with visual drought score. A cluster analysis based on morpho-physiological characteristics identified six cluster groups and most of the promising drought tolerance landraces were found in cluster VI. Five landraces - Dhapa, Dud Kalam, Dular, Hogla Pata and Keora showed key desired characteristics for dry weight, stomatal conductance, evapotranspiration, water use efficiency and root parameters for drought tolerance. These landraces could be potential sources in breeding program for the development of drought tolerant rice varieties. Bangladesh Rice J. 26 (1): 1-16, 2022

On the performance and scalability of consensus mechanisms in privacy-enabled decentralized renewable energy marketplace

Renewable energy sources were introduced as an alternative to fossil fuel sources to make electricity generation cleaner. However, today’s renewable energy markets face a number of limitations, such as inflexible pricing models and inaccurate consumption information. These limitations can be addressed with a decentralized marketplace architecture. Such architecture requires a mechanism to guarantee that all marketplace operations are executed according to predefined rules and regulations. One of the ways to establish such a mechanism is blockchain technology. This work defines a decentralized blockchain-based peer-to-peer (P2P) energy marketplace which addresses actors’ privacy and the performance of consensus mechanisms. The defined marketplace utilizes private permissioned Ethereum-based blockchain client Hyperledger Besu (HB) and its smart contracts to automate the P2P trade settlement process. Also, to make the marketplace compliant with energy trade regulations, it includes the regulator actor, which manages the issue and consumption of guarantees of origin and certifies the renewable energy sources used to generate traded electricity. Finally, the proposed marketplace incorporates privacy-preserving features, allowing it to generate private transactions and store them within a designated group of actors. Performance evaluation results of HB-based marketplace with three main consensus mechanisms for private networks, i.e., Clique, IBFT 2.0, and QBFT, demonstrate a lower throughput than another popular private permissioned blockchain platform Hyperledger Fabric (HF). However, the lower throughput is a side effect of the Byzantine Fault Tolerant characteristics of HB’s consensus mechanisms, i.e., IBFT 2.0 and QBFT, which provide increased security compared to HF’s Crash Fault Tolerant consensus RAFT.

Response of Photosynthesis in Wheat (Triticum aestivum L.) Cultivars to Moderate Heat Stress at Meiosis and Anthesis Stages

High temperature has seriously impacted the production of wheat in many countries. We examined four wheat cultivars (PBW343, Berkurt, Janz, and Attila) under heat stress (35/25 °C) and control treatments (23/15 °C) for 3 days at the meiosis and anthesis stages to evaluate the response and recovery of the four cultivars to heat stress and the relationship between photosynthetic parameters related to heat tolerance. Photosynthetic activity in all cultivars declined in plants that were treated at 35 °C, even for only 1 d compared with control plants. However, the differences among the four cultivars were obvious in net photosynthetic rate (Pn). At meiosis, the reduction of Pn in Berkut and PBW343 was lower and could nearly fully recover after 3 d of recovery and showed higher heat tolerance characteristics. The highest reduction in Pn occurred in Janz, which did not recover completely after 3 d of recovery. The same trend was observed at the anthesis stage, but Pn in all cultivars could not fully recover. Taking transpiration rate (Tr), stomatal conductance (gs), intercellular CO2 concentration (Ci), and limitation of stomatal conductance (Ls) into account, results suggested the decline in Pn under heat stress was mainly caused by non-stomatal restriction. In parallel with the decline in Pn, the maximum photochemical efficiency (Fv/Fm) decreased. In addition, both the maximum rate of net photosynthesis (Pmax) and the light saturation point declined after heat stress in all cultivars. However, the relevant photosynthetic parameters of PBW343 and Berkut recovered more quickly at both the meiotic and flowering stages. In summary, there were significant differences in the adaptability of different cultivars to high temperatures, with Berkut and PBW343 being more adaptable to heat stress than Janz and Attila. These may be used as valuable resources for further studies in breeding to understand the physiological mechanisms of heat sensitivity. This paper provides detailed information on the ecophysiological responses of wheat under heat stress.

Genetic analysis of heat tolerance in hot pepper: insights from comprehensive phenotyping and QTL mapping.

High temperatures present a formidable challenge to the cultivation of hot pepper, profoundly impacting not only vegetative growth but also leading to flower and fruit abscission, thereby causing a significant reduction in yield. To unravel the intricate genetic mechanisms governing heat tolerance in hot pepper, an F2 population was developed through the crossing of two distinct genotypes exhibiting contrasting heat tolerance characteristics: DLS-161-1 (heat tolerant) and DChBL-240 (heat susceptible). The F2 population, along with the parental lines, was subjected to comprehensive phenotyping encompassing diverse morphological, physiological, and biochemical heat-related traits under high temperature conditions (with maximum temperature ranging from 31 to 46.5°C and minimum temperature from 15.4 to 30.5°C). Leveraging the Illumina Nova Seq-6000 platform, Double digest restriction-site associated DNA sequencing (ddRAD-seq) was employed to generate 67.215 Gb data, with subsequent alignment of 218.93 million processed reads against the reference genome of Capsicum annuum. Subsequent variant calling and ordering resulted in 5806 polymorphic SNP markers grouped into 12 LGs. Further QTL analysis identified 64 QTLs with LOD values ranging from 2.517 to 11.170 and explained phenotypic variance ranging from 4.05 to 19.39%. Among them, 21 QTLs, explaining more than 10% phenotypic variance, were identified as major QTLs controlling 9 morphological, 3 physiological, and 2 biochemical traits. Interestingly, several QTLs governing distinct parameters were found to be colocalized, suggesting either a profound correlation between the QTLs regulating these traits or their significant genomic proximity. In addition to the QTLs, we also identified 368380 SSR loci within the identified QTL regions, dinucleotides being the most abundant type (211,381). These findings provide valuable insights into the genetics of heat tolerance in hot peppers. The identified QTLs and SSR markers offer opportunities to develop heat-tolerant varieties, ensuring better crop performance under high-temperature conditions.

What is the tolerance age of patients with cow's milk protein allergy? What are the parameters that can predict its persistence?

Objective: Cow’s milk allergy (CMA) is one of the most common food allergies in infants. The natural history of CMA indicates that resolution is common. Some studies suggest that food allergies are now being resolved at an older age. The aim of this study was to investigate the tolerance and persistence characteristics, as well as the timing of tolerance, in our own CMA patients. Material and Methods: Patients who were diagnosed with CMA and followed up in our pediatric immunology and allergy outpatient clinic between 2016-2021 years were evaluated retrospectively. Patients’ demographic characteristics, laboratory results, and tolerance time were recorded. Results: The 632 patients’ files were reviewed. 192 (30%) of the patients were followed for more than two years. The tolerance to baked products was observed with a median of 14 months, while the tolerance to fermented products was observed with a median of 17 months. Full tolerance was observed with a median of 25 months. The number of patients older than 2 years of age who could not consume any milk protein-containing product was 72 (11.4%) and 56 (77.7%) of them were IgE mediated CMA. The rate of girls with tolerance (43.5%) was found to be significantly higher than nontolerant girls (25%) (p=0.001). The mean skin test diameter of the tolerant group was significantly higher than the mean of the non-tolerant group (p=0.022). The percentage of eosinophils (p=0.003) and total IgE level (p=0.004) in the tolerant group were significantly lower compared to the intolerant group. There was no significant difference between the presence of tolerance in terms of allergy number, eosinophil count and specific IgE count (p>0.05). Conclusion: Identifying the factors influencing tolerance can lead to changes in the management of the disease. We observed that 88.6% of patients older than 2 years were tolerant to milk proteins, and all patients with non-IgE mediated CMA achieved tolerance by 2 years of age. The ratio of total IgE to specific IgE, age, total IgE and specific IgE levels, presence of non-IgE or IgE mediated allergy, and gender were factors that influenced the development of tolerance in our study. Age at diagnosis and having a single or multiple food allergies did not impact the tolerance status. The prognosis for CMA remains favorable. The use of the milk ladder in managing CMA is an important approach for promoting early tolerance.

Growth and drought reaction of European hornbeam, European white elm, field maple and wild service tree

Key messageConsidering their drought tolerance and growth characteristics, rare native tree species are well-suited admixed species for the development of climate-stable forests in Central Europe.In our study, we assessed the growth and drought reaction of the four rare native tree species European hornbeam (Carpinus betulus L.), European white elm (Ulmus laevis Pall.), field maple (Acer campestre L.), and wild service tree (Sorbus torminalis (L.) Crantz). Based on tree-ring data, we (I) evaluated their species-specific growth characteristics and variability and examined the influencing site and tree characteristics on annual growth. (II) We quantified their reaction to single drought events, also depending on site and tree variables. (III) We compared our results to oak (Quercus robur L., Quercus petraea (Matt.) Liebl.) and European beech (Fagus sylvatica L.). As they are well-known Central European tree species, there is a broad knowledge about their growth and drought response across wide geographical ranges available. Bringing the results of European beech and oak in relation with the rare native species, it allows to categorise their growth and drought reaction and to contextualise their performance. Our results show, that besides European white elm, the rare species showed an overall lower annual growth with a higher variability than European beech and oak. However, especially field maple and wild service tree were better adapted to drought than European beech and partially even recovered better than oak. Combining the aspects of growth stability and drought tolerance, we conclude that rare native tree species are well suited as admixed species in future forest stands. European hornbeam is a suitable match for European beech on wetter sites, while field maple and wild service tree are a sensible complement for the climate stable oak on drier sites.

A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects.

Background and objective: As a partial positive allosteric modulator of the gamma-aminobutyric acid A (GABAA) receptor, dimdazenil was used for the treatment of insomnia with the potential to alleviate associated side effects compared to full agonists. The objective of this trial is to assess the safety, tolerability, food effect and pharmacokinetics following single and multiple doses of dimdazenil in Chinese healthy subjects. Methods: In this phase 1 trial, 36 healthy subjects aged ≥18years were assigned to receive a single dose of 1.5, 2.5, or 5mg dimdazenil, with each dose cohort consisting of 12 subjects, and 14 subjects were assigned to receive a multiple 2.5mg daily dose of dimdazenil for 5days. Safety, tolerability, and pharmacokinetic characteristics were evaluated. Results: Of the 50 subjects enrolled and 49 completed the trial, the incidences of treatment-emergent adverse events (AEs) in the single-dose groups of 1.5, 2.5, and 5mg were 16.7%, 58.3% and 66.7% respectively, while 61.5% in the multiple-dose group. There were no serious AEs, deaths, AEs leading to discontinuation or AEs of requiring clinical intervention in any treatment groups. The most treatment-emergent AEs were dizziness (n = 4, 8.2%), hyperuricemia (n = 2, 6.1%), upper respiratory tract infection (n = 2, 6.1%), diastolic blood pressure decreased (n = 2, 6.1%), blood TG increased (n = 2, 6.1%) and RBC urine positive (n = 2, 6.1%). All AEs were mild-to-moderate and transient, and no severe AEs were documented in any study phase. The PK profile of dimdazenil and its active metabolite Ro46-1927 was linear across 1.5-5mg oral doses in humans. The median Tmax for dimdazenil was in the range of 0.5-1.5h, and the apparent terminal t1/2z ranged from 3.50 to 4.32h. Taking Dimdazenil with food may delay Tmax and decrease Cmax, without affecting the total exposure (AUC). No relevant accumulations of dimdazenil and Ro 46-1927 were observed in multiple-dose group. Conclusion: Dimdazenil was generally well tolerated in healthy Chinese subjects after single and 5days-multiple dosing. The pharmacokinetic properties of dimdazenil are compatible with a drug for the treatment of insomnia. Clinical Trial Registration: chinadrugtrials.org.cn, identifier CTR20201978.

The Effect of Using Electronic Assessment Based on Mobile-Installed Programs to Measure Students' Tolerance and Discipline Characteristics on Jordanian Teachers

The study aimed to explore the response of teachers in Jordan to the Electronic assessment based on software installed on cellular devices, mobiles, laptops and computers based on software installed on cellular devices, mobiles, laptops and computers based on software installed on cellular devices, mobiles, laptops and computers of students' personality (discipline and tolerance) in Three schools that were selected to apply the electronic assessment to them in the city of Amman for the first semester of the academic year 2022/2023. This study relied on quantitative data in addition to qualitative data. As for the research sample, it was taken intentionally and consisted of (110) students. Data was collected through a Tukey HSD questionnaire and test. Quantitative data were analyzed using one-way ANOVA, while qualitative data were processed using the Miles and Huberman technique. The The The results of the study reached through the research process of the study reached through the research process of the study showed that the response to the use of electronic assessment based on software installed on cellular devices, mobiles, laptops and computers based on software installed on cellular devices, mobiles, laptops and computers based on software installed on cellular devices, mobiles, laptops and computers among teachers was very good. And now the use of Electronic assessment based on software installed on cellular devices, mobiles, laptops and computers based on software installed on cellular devices, mobiles, laptops and computers based on software installed on cellular devices, mobiles, laptops and computers developed the educational process.

An NPC‐type fault‐tolerant MLI with symmetrical and asymmetrical voltage modes

SummaryCurrent studies have been challenging in reducing the number of devices and ensuring fault tolerance features of the multilevel inverters (MLIs). This article proposes a new fault‐tolerant neutral point clamped (NPC)‐type MLI using two three‐level NPC legs, which can work in symmetric and asymmetric modes to generate nine and 17‐level output voltage, respectively. The proposed converter has less device count and low total blocking voltage (TBV); further, the converter has different redundant switching states for tolerating different categories of faults. This article also implements a modified pulse width modulation (PWM) control strategy to ensure the zero‐dc offset at the output when asymmetrical voltage levels appear with the occurrence of switch faults. A detailed operation of the proposed converter under symmetric and asymmetric modes is presented for healthy and different categories of faults. The converter's feasibility is verified by its current and voltage characteristics obtained from the MATLAB‐SIMULINK software and the experimental prototype. Further, the efficiency of the converter is verified with the PLECS software. Finally, a comparison with recently proposed topologies is performed to emphasize converter performance.