You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy VIII1 Apr 2017MP97-20 PREDICTION OF NON-BIOCHEMICAL RECURRENCE RATE AFTER ROBOT ASSISTED RADICAL PROSTATECTOMY (RARP) IN A JAPANESE COHORT: DEVELOPMENT OF A POSTOPERATIVE NOMOGRAM Kazuki Hasama, Makoto Ohori, Yosuke Hirasawa, Tatsuo Gondo, Go Nagao, Takashi Mima, Takeshi Kashima, Yoshihiro Nakagami, Yoshio Ono, Kazunori Namiki, Rie Inoue, and Takashi Nagao Kazuki HasamaKazuki Hasama More articles by this author , Makoto OhoriMakoto Ohori More articles by this author , Yosuke HirasawaYosuke Hirasawa More articles by this author , Tatsuo GondoTatsuo Gondo More articles by this author , Go NagaoGo Nagao More articles by this author , Takashi MimaTakashi Mima More articles by this author , Takeshi KashimaTakeshi Kashima More articles by this author , Yoshihiro NakagamiYoshihiro Nakagami More articles by this author , Yoshio OnoYoshio Ono More articles by this author , Kazunori NamikiKazunori Namiki More articles by this author , Rie InoueRie Inoue More articles by this author , and Takashi NagaoTakashi Nagao More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3064AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previously, we developed the postoperative nomogram to predict the non-biochemical recurrence in patients with open and RARP (IJU 21:479, 2014). However, we found the significant differences of pathological and prognostic outcomes between open and RARP (AUA2016 Hirasawa). Therefore, we up-dated and developed the postoperative nomogram to predict the non-biochemical recurrence rate using the Japanese patients treated with RARP. METHODS A total of 1000 Japanese patients with T1-3N0M0 prostate cancer who underwent RARP and pelvic lymph node dissection at Tokyo Medical University hospital from 2009 to 2015 were studied. Patients with neoadjuvant therapy were excluded. A nomogram was constructed based on Cox hazard regression analysis evaluating the prognostic significance of serum PSA and pathological factors in the RARP specimens. The discriminating ability of the nomogram was assessed by the concordance index (C-index), and the predicted and actual outcomes were compared with a bootstrapped calibration plot. RESULTS With a mean follow up of 32.0 months, a total of 145 patients (14.5%) experienced biochemical recurrence with a 5-year non-biochemical recurrence rate of 80.0%. A Cox hazard regression analysis showed that preoperative PSA (p<0.0005), prostatectomy Gleason score (p<0.0005), pathological stage (p=0.001), surgical margins (p<0.0005), and lymphovascular invasion (p=0.0024) were significant factor to predict biochemical recurrence. Based on this analysis, a nomogram was constructed to predict non-biochemical recurrence using PSA level and pathological features in RARP specimens. The concordance index was 0.80, and the calibration plots appeared to be accurate. CONCLUSIONS Since RARP became most popular procedure in Japan, our postoperative nomogram can provide valuable information to many patients regarding the need for adjuvant/salvage radiation or hormonal therapy after RARP. To our knowledge, our nomogram may be the first nomogram for the non-Caucasian Asian population who were treated with RARP © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1311 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Kazuki Hasama More articles by this author Makoto Ohori More articles by this author Yosuke Hirasawa More articles by this author Tatsuo Gondo More articles by this author Go Nagao More articles by this author Takashi Mima More articles by this author Takeshi Kashima More articles by this author Yoshihiro Nakagami More articles by this author Yoshio Ono More articles by this author Kazunori Namiki More articles by this author Rie Inoue More articles by this author Takashi Nagao More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...