Introduction: Given the high incidence of colorectal cancer among patients at the Holguín Oncology Center and the insufficient interoperability that hinders data collection and analysis, affecting the accuracy of studies, the importance of a technological architecture that enables access to integrated clinical data is emphasized.Objective: To design and evaluate a technological interoperability architecture that optimizes the organization and analysis of clinical data to improve survival studies of colorectal cancer at the Territorial Oncology Center of Holguín.Methods: Using the architecture development method proposed by the TOGAF framework, an interoperability technology architecture was designed. The Kaplan-Meier method was employed for survival analysis, and a study was conducted with a sample of 206 patients diagnosed with colorectal cancer between 2019 and 2024, analyzing variables such as age, sex, histological type, and treatment regimen.Results: Improved interoperability was achieved, reflecting enhanced analysis in cancer survival studies. This allowed for a better understanding of treatment efficacy, disease demographics, and the impact of chemotherapy and surgical treatment.Conclusions: The designed interoperability architecture has facilitated data exchange between systems, improving the collection and organization of clinical information, which has had a significant impact on the optimization of treatments and patient outcomes