Types Of Tobacco Research Articles

Evaluation of the Effect of Parental Smoking on Gingival Melanin Pigmentation in Children.

The presence of melanin pigmentation of the gingiva has unfavorable effects on esthetics in children. Although there are several local and systemic factors that cause melanin pigmentation, they may also be induced by the stimulation of melanocytes by stimuli present in tobacco smoke. The aim of the study was to correlate the effect of parental smoking on the pigmentation of gingiva in children of Modinagar, Uttar Pradesh, India. The study was a cross-sectional observational study. The study sample was formed by all children between 8 and 14 years of age. Only medically compromised children were excluded from the study. The children were examined for the presence of gingival melanin pigmentation. The status was recorded as present or absent. Determination of the smoking status of family members was done by a self-formulated questionnaire. The presence of pigmentation was seen in 114 (82%) children, whereas pigmentation was absent in 26 (18%) children. Out of the total sample of 140 children, 95 had one or more family members who were smoking. The Chi-squared test performed to form an association between pigmentation and the type of tobacco used revealed high significance (p = 0.00) for the father who smokes bidi. There is a correlation between parental smoking and melanin pigmentation in the gingiva of children, and the correlation is very high when the father is a smoker, especially when he smokes bidi. Anand A, Raja T, Thakur V, et al. Evaluation of the Effect of Parental Smoking on Gingival Melanin Pigmentation in Children. Int J Clin Pediatr Dent 2024;17(2):173-175.

Prevalence of tobacco use among cancer patients in Iran: a systematic review and meta-analysis.

The prevalence of tobacco use among various cancer types in Iran remains a significant concern, necessitating a comprehensive analysis to understand the extent and patterns of consumption. This study aimed to systematically review and analyze existing literature to delineate the prevalence of tobacco use across different cancer types in Iran, thereby providing a robust basis for future interventions and policy formulations. Adhering to the PRISMA guidelines, we conducted a systematic review and meta-analysis of literature available in PubMed and Scopus databases. The initial search identified 351 records, out of which 44 studies were selected based on their relevance and design. These studies spanned various time frames, starting from the 2001s up until 2022, and encompassed diverse geographical locations and cancer types in Iran. To avoid bias and potential data overlap, we opted to incorporate a single comprehensive study from the Golestan Cohort, encompassing all data, while excluding 10 other studies. Our final analysis incorporated data from 34 studies, which accounted for 15,425 patients and 5,890 reported smokers. Statistical analyses were performed to calculate the overall proportion of tobacco consumption and to conduct subgroup analyses based on different variables such as cancer types, gender, geographical locations, and types of tobacco used. The analysis revealed a substantial prevalence of tobacco use among cancer patients in Iran, with an overall consumption rate of 43%. This rate varied significantly, ranging from 10 to 88% across individual studies. Subgroup analyses further highlighted disparities in tobacco consumption rates across different demographics, geographic areas, and cancer types. Notably, the 'ever' smokers category exhibited the highest prevalence of tobacco use. The study also identified a worrying trend of high cigarette smoking rates, along with variable consumption patterns of other forms of tobacco, including waterpipe, 'Naas', and 'Pipe'. This systematic review and meta-analysis underscores a significant association between tobacco consumption and various cancer types in Iran, with a prevalence rate among cancer patients being three times higher than the average Iranian population. The findings indicate substantial heterogeneity in tobacco use patterns, emphasizing the need for targeted interventions to address this pressing health issue. The study serves as a critical resource for shaping future policies and strategies aimed at curbing tobacco use and mitigating its adverse effects on cancer prevalence in Iran.

Waterpipe Tobaccos, Part I. Composition of Forty Brand-Styles of Contemporary Waterpipe Tobacco Available on the US Market in 2020–2022

Summary The compositions of waterpipe tobaccos available for retail sale on the US market are relatively unknown compared with more popular products such as cigarettes. Indeed, the phrase “waterpipe tobaccos” is used only in some governmental regulations and in journal articles dealing with regulatory aspects of those products. Commercially, the terms “shisha”, “hookah tobaccos”, and “flavored tobaccos” are used. In addition to the differences in commercial terminology, there is also confusion about the composition of such tobaccos, with the term “waterpipe tobacco” also being applied to products on the market that do not contain enough glycerol to prevent combustion during use. Therefore, during the past several years, 40 samples of shisha products on the US market were sent to an ISO 17025 accredited laboratory for the determination of glycerol, propylene glycol, fructose, glucose, and sucrose, in addition to the usual tobacco analytes and water using the Karl Fischer method. Moreover, two surrogate samples of shisha tobacco, one based on flue-cured tobacco and the other based on dark air-cured tobacco, were analyzed by the same laboratory along with samples of the starting tobaccos. The main finding from these analyses was that there were two very different types of shisha tobaccos on the market. One type was based on dark air-cured tobacco and the other type was based on flue-cured tobacco. Among the brand-styles based on flue-cured tobacco, some had higher levels of glycerol and lower levels of added sugars than others that had higher added sugars and lower levels of glycerol. Another important point of differentiation was that the products based on dark air-cured tobacco had much smaller tobacco particle sizes than did those based on flue-cured tobacco. The results of this research as well as other research that will be presented in two subsequent reports showed that waterpipe tobaccos cannot be considered as a single product category. This is particularly true for the determination of emissions using the instrumentation specified in ISO 22486:2019 (Water pipe tobacco smoking machine — Definitions and standard conditions).

Abstract 3569: Using AI to automatically process data from unstructured health records of patients with lung cancer

Abstract Introduction: Structured databases created from electronic health records (EHR) are crucial for cancer research. Manual data entry into databases is both labor-intensive and error-prone. We aimed to develop an artificial intelligence (AI)-driven approach for automatically inputting patient information from EHRs. Methods: A REDCap database for 53 patients with advanced lung cancer treated with first line immuno+/-chemotherapy at Gustave Roussy between 02/2021-06/2023 was manually populated by physicians with demographics, risk factors, cancer history, and treatment data, with 137 variables/patient. Given unstructured medical letters and a schematic description of each variable, generative AI was used to find, quote and process variables into a structured form. We directed large language model actions with prompt engineering and tailored few-shot examples. Mortality data were auto-extracted from the French public registry, INSEE. We assessed consistency between manual (MDE) and automated data entry (ADE), with a secondary manual review for mismatches performed by a senior physician. Results: In total, 7,261 data points were assessed. ADE averaged 10 minutes per patient inclusive of quality checks vs 1 h for MDA. The concordance rate between ADE and MDE was 90.2% (6,550/7,261) with a discordance of 6.8% (496/7,261). Data was missing in 0.8% (59/7,261) of cases for both methods, 1% (73/7,261) for ADE and 1,1% (83/7,261) for MDA. After checking discordances, ADE correctness was 95.3% (6,922/7,261) (Table), MDE was 93.8% (6,809/7,261). Errors in ADE (207/7,261) were due to algorithm refinement needs (70%) and missing EHR information (30%). Conclusion: Generative AI has a strong potential for identifying and structuring data from EHRs, yielding consistency superior to manual entry by physicians and 85% reduced amount of time. This may enhance the efficiency, accuracy, and scalability of EHR-to-database conversions. ADE for >1000 patients will be presented at the meeting. ADE correctness 100% 95-99% 90-94% 80-89% Sex; Age; Life status; Last follow-up; Metastatic from diagnosis Molecular alterations; Metastatic sites; Progression sites; Treatment type Tobacco & cannabis consumption; Histology; PDL1 score; Progression event Pack years; Date of diagnosis & first metastasis; Stage; Date of start treatment Citation Format: Mihaela Aldea, Pierre Rolland, Solenne Simon, Aliette Poplu, Muriel Wartelle, Benjamin Vignal, Jean-Charles Louis, Francois Lion, Arnaud Borie, David Planchard, Caroline Robert, Stefan Michiels, Fabrice Andre, Fabrice Barlesi, Franck Le Ouay, Benjamin Besse. Using AI to automatically process data from unstructured health records of patients with lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3569.

Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case–control study

Smoking is a major risk factor for the global burden of stroke. We have previously reported a global population attributable risk (PAR) of stroke of 12.4% associated with current smoking. In this study we aimed to explore the association of current tobacco use with different types of tobacco exposure and environmental tobacco smoke (ETS) exposure on the risk of stroke and stroke subtypes, and by regions and country income levels. The INTERSTROKE study is a case-control study of acute first stroke and was undertaken with 13,462 stroke cases and 13,488 controls recruited between January 11, 2007 and August 8, 2015 in 32 countries worldwide. Association of risk of tobacco use and ETS exposure were analysed with overall stroke, ischemic and intracerebral hemorrhage (ICH), and with TOAST etiological stroke subtypes (large vessel, small vessel, cardioembolism, and undetermined). Current smoking was associated with an increased risk of all stroke (odds ratio [OR] 1.64, 95% CI 1.46-1.84), and had a stronger association with ischemic stroke (OR 1.85, 95% CI 1.61-2.11) than ICH (OR 1.19 95% CI 1.00-1.41). The OR and PAR of stroke among current smokers varied significantly between regions and income levels with high income countries (HIC) having the highest odds (OR 3.02 95% CI 2.24-4.10) and PAR (18.6%, 15.1-22.8%). Among etiological subtypes of ischemic stroke, the strongest association of current smoking was seen for large vessel stroke (OR 2.16, 95% CI 1.63-2.87) and undetermined cause (OR 1.97, 95% CI 1.55-2.50). Both filtered (OR 1.73, 95% CI 1.50-1.99) and non-filtered (OR 2.59, 95% CI 1.79-3.77) cigarettes were associated with stroke risk. ETS exposure increased the risk of stroke in a dose-dependent manner, exposure for more than 10h per week increased risk for all stroke (OR 1.95, 95% CI 1.69-2.27), ischemic stroke (OR 1.89, 95% CI 1.59-2.24) and ICH (OR 2.00, 95% CI 1.60-2.50). There are significant variations in the magnitude of risk and PAR of stroke according to the types of tobacco used, active and ETS exposure, and countries with different income levels. Specific strategies to discourage tobacco use by any form and to build a smoke free environment should be implemented to ease the global burden of stroke. The Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Stroke Network, Swedish Research Council, Swedish Heart and Lung Foundation, The Health & Medical Care Committee of the Regional Executive Board, Region Västra Götaland, and through unrestricted grants from several pharmaceutical companies with major contributions from Astra Zeneca, Boehringer Ingelheim (Canada), Pfizer (Canada), MERCK, Sharp and Dohme, Swedish Heart and Lung Foundation, UK Chest, and UK Heart and Stroke.

Prevalence and Associated Factors Related to Tobacco Consumption Among University Students in Malaysia.

Tobacco consumption is one of the major public health concerns worldwide. Moreover, alternative tobacco and nicotine products (ATNPs) are growing in popularity, especially among young adults in the past decade. The study aimed to determine the prevalence and associated sociodemographic factors of tobacco consumption among university students. A cross-sectional study was carried out among 338 university students of a private Malaysian university from March to April 2021. Data was collected using a self-administered online questionnaire with items including sociodemographic information, user status of tobacco consumption and types of tobacco product used. Descriptive statistics, Pearson's chi-square test, Fisher's exact test and simple and multiple logistic regression analyses were performed using the IBM SPSS version 26.0 to analyse the data. The prevalence of tobacco consumption in this study was 8.6% and the main tobacco product used was manufactured cigarettes. In Pearson's chi square test and Fisher's exact test, current use of tobacco was significantly associated with nationality, ethnicity, religion, school, current level of education and parents, siblings and friends use of tobacco (p<0.05). In simple and multiple logistic regression analysis, being non-Malaysian, Indian, Muslim, year 4 student and having parents or siblings who used tobacco, all had statistically significant associations with the current use of tobacco (p<0.05). Findings of this study showed that the use of tobacco among university students is concerning and warrants the need to develop and implement a strategic anti-tobacco program to limit this behaviour among university students.

Partially knocking out NtPDK1a/1b/1c/1d simultaneously in Nicotiana tabacum using CRISPR/CAS9 technology results in auxin-related developmental defects

The eukaryotic AGC protein kinase subfamily (protein kinase A/ protein kinase G/ protein kinase C-family) is involved in regulating numerous biological processes across kingdoms, including growth and development, and apoptosis. PDK1(3-phosphoinositide-dependent protein kinase 1) is a conserved serine/threonine kinase in eukaryotes, which is both a member of AGC kinase and a major regulator of many other downstream AGC protein kinase family members. Although extensively investigated in model plant Arabidopsis, detailed reports for tobacco PDK1s have been limited. To better understand the functions of PDK1s in tobacco, CRISPR/CAS9 transgenic lines were generated in tetraploid N. tabacum, cv. Samsun (NN) with 5–7 of the 8 copies of 4 homologous PDK1 genes in tobacco genome (NtPDK1a/1b/1c/1d homologs) simultaneously knocked out. Numerous developmental defects were observed in these NtPDK1a/1b/1c/1d CRISPR/CAS9 lines, including cotyledon fusion leaf shrinkage, uneven distribution of leaf veins, convex veins, root growth retardation, and reduced fertility, all of which reminiscence of impaired polar auxin transport. The severity of these defects was correlated with the number of knocked out alleles of NtPDK1a/1b/1c/1d. Consistent with the observation in Arabidopsis, it was found that the polar auxin transport, and not auxin biosynthesis, was significantly compromised in these knockout lines compared with the wild type tobacco plants. The fact that no homozygous plant with all 8 NtPDK1a/1b/1c/1d alleles being knocked out suggested that knocking out 8 alleles of NtPDK1a/1b/1c/1d could be lethal. In conclusion, our results indicated that NtPDK1s are versatile AGC kinases that participate in regulation of tobacco growth and development via modulating polar auxin transport. Our results also indicated that CRISPR/CAS9 technology is a powerful tool in resolving gene redundancy in polyploidy plants.

Study of waterpipe smoking topography in Fars province of Iran

Despite a sharp increase in the use of the waterpipe (WP) has been noted recently in Iran, no information is available for the smoking behavior and topography parameters. The present study is intended to obtain the inhalation and smoking topography parameters for the Iranian WP smokers. The smoking data collected from 122 smoking sessions, including 192 WP smokers in the Iranian Fars province have been used to perform smoking topography assessments. The influence of demographic and smoking parameters on puffing data is obtained. Results have indicated that gender and tobacco type strongly affect puff volume and duration. Women smokers inhale smaller volume of smoke than men and puff duration is significantly increased for regular smokers than occasional smokers. However, the results of the present study have not revealed a major effect of age, residence and setting on the puffing behavior.

Comparison of narrow band imaging versus white light imaging in detecting non muscle invasive bladder cancer.

In the present study, we compared Narrow Band Imaging (NBI) and White Light Cystoscopy (WLC) in Non-muscle invasive bladder cancer (NMIBC) for detection and its impact on recurrence. This prospective study was conducted in the department of Urology at a tertiary institution from August 2021 to April 2023. The main aim was to determine the benefit of addition of NBI during TURBT in NMIBC. All patients with Urinary Bladder Mass (size less than 5 cm on USG/CT) aged >18 years of age planned for TURBT were included. Amongst 63 patients, the mean age was 59.84 ± 11.3 years; 80% were males. Sixty percent of patients had history of Tobacco consumption and Type II DM was the most common comorbidity (59%). Commonest symptom was gross haematuria. Posterior wall was most commonly involved and papillary lesions were commonest. A total of 125 lesions were identified on WLI, with mean 1.98 ± 1.75 and 78 additional lesions were identified only on NBI with mean 1.24 ± 1.63 lesions. Four patients had intra-operative complications. Five patients had recurrence at 6 weeks and eight patients had recurrence at 3 months. NBI had detected more lesions in patients who developed recurrence at 6 weeks and 3 months (mean: 1.41 and 1.43). NBI has additive role in detecting NMIBC lesions missed on WLI. NBI has significant role in preventing recurrence at 3 months and more so by detecting high grade tumours.

Association between nucleus accumbens volume and future tobacco and Marijuana use in early adolescence

IntroductionNucleus accumbens (NAc), a crucial component of the brain's reward network, plays a role in reward-related behaviors like substance use. However, limited knowledge exists about sex differences in the predictive power of NAc volume for the initiation of tobacco and marijuana use among children transitioning into early and middle adolescence. Our aim was to compare the predictive utility of NAc volume for adolescents' initiation of tobacco and marijuana use over a three-year period. MethodsData from the Adolescent Brain Cognitive Development study (ABCD), a longitudinal study of pre-adolescents aged 9–10 years, were utilized. The study included 9–10 pre-adolescents (n = 11,795) who were followed for 36 months. Cox regression was employed to examine whether NAc volume predicts subsequent initiation of tobacco and marijuana during the follow-up period. Covariates included age, race/ethnicity, puberty, parental composition, parental education, and area-level median income. Sex was the moderator. ResultsWhile NAc volume predicted future substance use, this association varied based on substance type (tobacco vs. marijuana), sex (male vs. female), and laterality (brain hemisphere). A larger right NAc volume (mm^3) inversely associated with subsequent tobacco use initiation for female youth (HR = 0.998; 95% CI: 0.996–1.000), while it showed no association for male youth (p = 0.385). Larger left NAc volume (mm^3) did not associate with subsequent tobacco use initiation for female youth (p = 0.108) but showed a positive association for male youth (HR = 1.002; 95% CI: 1.001–1.003). NAc volume did not show an association with subsequent marijuana use initiation for either sex. ConclusionsThe predictive impact of right and left NAc volumes on future tobacco or marijuana use may differ for male and female adolescents, suggesting that the salience of NAcc in regulating the reward system is influenced by sex, substance type, and brain hemisphere.

The Diversity in Tobacco Use Among Women of Reproductive Age (15-49 Years) in Pakistan: A Secondary Analysis of a Multiple Indicator Cluster Survey 2016-2018.

Tobacco use in women of reproductive age group (15-9 years) may contribute to poor maternal and child health outcomes. We estimated the prevalence of smokeless tobacco (ST), cigarette, and waterpipe use among these women in Pakistan and explored associations with socio-economic differences and birth weights after recent childbirths (past 2 years). We used the Multiple Indicator Cluster Surveys datasets from three provinces in Pakistan. Prevalence was generated for current use of tobacco among women with recent childbirth (WWRC) and without recent childbirth (WWoRC). We further compared socio-economic status and birth weights between tobacco users and non-users. The prevalence of current ST use was 1.4% and 2.5%, and waterpipe smoking was 1.2% and 1.8%, in WWRC and WWoRC, respectively. ST use varied across Pakistan's provinces by 13 percentage points in WWRC and WWoRC while waterpipe smoking by 10 and 15 percentage points, respectively. The odds of using any form of tobacco were significantly lower with higher levels of education or wealth index. Compared to children born to mothers who did not use tobacco, the birth weight of children born to mothers who smoked waterpipe was on average 0.83 kg (95% CI -1.6 to -0.1) lower whereas it was 0.33 kg (95% CI -0.9 to 0.3) higher for ST users. Tobacco use among women of reproductive age in Pakistan varied significantly based on province and tobacco type. Waterpipe smoking was associated with a reduction in birth weight. Raising awareness of the harms of tobacco use among women of reproductive age and targeting interventions in high-burden regions of Pakistan should be prioritized. The prevalence of current smokeless tobacco use and waterpipe smoking varied significantly in Pakistan (~13 and ~15 percentage points, respectively) among women of reproductive age, and there seems to be little change in tobacco use behavior around pregnancy and early motherhood. The study highlights a need to better understand the prevalence of tobacco use in Pakistan, and further contextual research is warranted to understand the reasons for such high tobacco use in certain areas. This information highlights the need for improving current tobacco control interventions and policies, including measures that could help reduce its use and prevent its uptake. Furthermore, compared to children born to mothers who did not use any form of tobacco, we found a statistically significant difference (830 g) in birth weight for babies born to mothers who at the time of the interview smoked waterpipe and a non-statistically significant difference of about 330 g for children born to mothers who at the time of the interview used smokeless tobacco. In addition to our findings, some literature suggests the association of waterpipe smoking with low birth weight. A possible explanation could be the exposure to smoke that contains toxicants from the tobacco product itself in addition to the burning of charcoal, which is required when using waterpipe. Waterpipe smoking also results in high exposures to carbon monoxide and polycyclic aromatic hydrocarbons, which are known to be carcinogenic and teratogenic. In terms of smokeless tobacco use, further research is warranted to understand its impact on birth outcomes through longitudinal studies accounting for diverse products, its constituents and the amount of consumption.

Characterizing Tobacco Usage in Otolaryngology Patients to Target Smoking Cessation Efforts.

Smoking cessation is critical in reducing incidence of head and neck cancers (HNC) and improving postoperative outcomes. Accurate documentation of tobacco usage is necessary to understand prevalence in patients to target smoking cessation. This study aims to characterize tobacco usage documentation, including electronic nicotine delivery systems (ENDS) use, among otolaryngology patients. Retrospective chart review. Penn State Health Milton S. Hershey Medical Center (PSHMC). A retrospective chart review was conducted on adult otolaryngology patients seen from January 1, 2020 - December 31, 2020. Patient demographics, details of alcohol and tobacco usage, including type of tobacco, and subspecialty seen were collected. Associations were evaluated using chi-square tests and a multivariable logistic regression model. Patients (n = 2137) were an average of 58.4years old ±18.0, 59.3% female, and 78.0% white. Of participants with documented tobacco history (n = 944), 56.7% were never users, 28.9% were former users, and 14.4% were current users. Among current users (n = 308), 86.4% used cigarettes, and 5.2% used ENDS. The remainder used chew (4.9%) and cigars (3.25%). Odds of tobacco use were 1.5x greater for males (95% CI 1.19-2.00), 1.6x greater for unmarried patients (95% CI 1.24-2.09), 2.1x greater for those with no insurance vs government (95% CI 1.43-3.18), and 2.4x greater for those diagnosed with HNC (95% CI 1.64-3.49). Most patients report cigarette smoking when asked about tobacco use. Taking into consideration the rise of ENDS use, our sample showed ENDS use that was higher than the national average. There is significant opportunity for improved history taking, especially within general and head and neck oncology subspecialties for more comprehensive treatment.

Study on the Chemical Composition of the Mainstream Cherry-red Tobacco Smoke

Introduction: Cherry-red tobacco is a flue-cured variant that possesses a distinctive “sticky rice” flavor, which is highly valued by the tobacco industry. However, the value of cherryred tobacco is dubious due to the possible health risks associated with tobacco-specific nitrosamines (TSNAs). Objective: This study aimed to investigate the chemical origin of the “sticky rice” flavor and to assess the potential health hazards of TSNAs. Method: An optimized untargeted analysis with gas chromatography-mass spectrometry and a targeted analysis with liquid chromatography-tandem mass spectrometry were conducted. Result: Over one hundred compounds were identified and quantified. Cherry-red tobacco and the normal control showed significant differences in forty-three of these compounds. Pyridine alkaloids and their derivatives constituted the main difference. Nornicotine, a demethylated product of nicotine in cherry-red tobacco, was confirmed to be pyrolyzed to 3-ethylpyridine, 3-methylpyridine, and other homologues, and transferred to the smoke during smoking. The smoke of cherry-red tobacco was found to contain much higher levels of N’-nitrosonornicotine, a TSNA derived from nornicotine, than that of normal flue-cured tobacco, while the levels of the other detected TSNAs were lower. The two types of tobacco had similar total amounts of the four TSNAs. Conclusion: The pyrolysis of nornicotine into 3-ethylpyridine and its homologues during smoking may be the main cause of the “sticky rice” flavor of cherry-red tobacco. The level of TSNAs does not reflect the difference in health risk between cherry-red tobacco and the control.

Socio-Demographic and Behavioral Predictors of Admission for Kidney Disease in an Urban Hospital in Northwest Indiana

Background: The CDC estimates more than 1 in 7 American adults have Chronic Kidney Disease (CKD) and nearly 800,000 live with End-Stage Renal Disease (ESRD); the majority of whom require dialysis. Current literature demands further exploration on how social determinants of health (SDOH) influence inpatient and emergency services utilization for CKD/ESRD-related exacerbations. This study examined socio-demographic and behavioral factors associated with hospital admission for CKD/ESRD. It is part of a three-phased Community-Based Participatory Research (CBPR) partnership between IUSM-NW and St. Mary Medical Center (SMMC) to examine and address relationships between SDOH, patient demographics, health behaviors, and health outcomes from January 2022-January 2025.&#x0D; Methods: This retrospective study analyzed a limited dataset generated by SMMC from EPIC™ with SDOH, demographic, health behavior, and health outcomes data obtained from adult inpatients between January 2021 and March 2023. CKD/ESRD was determined by admission diagnosis ICD-10 Code N18. Data analysis utilized SPSS 29.0 to produce frequencies, Chi-Square tests (p&lt;0.05), and a binary logistic regression (p&lt;0.05). This study was exempted by Indiana University Human Research Protection Program (IRB # 14040).&#x0D; Results: This study included 10,953 inpatient admissions involving predominantly white (78.4%) and older adult (68 ± 21) patients. CKD/ESRD represented 96 admissions. The bivariate analysis found a significant association between CKD/ESRD admissions and age (p&lt;0.001), race (p&lt;0.001), sex (p=0.008), insurance type (p=0.030), and smoking tobacco use (p=0.004). After adjusting for all factors, being Asian (OR=12.172, p&lt;0.001), Black (OR=3.702; p&lt;0.001), female (OR=0.518; p=0.003), publicly insured (OR=2.76; p=0.014), and former smoking (OR=1.606; p=0.045) were significantly associated with CKD/ESRD admission.&#x0D; Conclusions: This study revealed several demographics, SDOH, and health behaviors associated with CKD/ESRD admission in an urban hospital. Uncovering predictors of CKD/ESRD admission enables focused interventions to decrease admissions. The next CBPR phases will apply advanced statistical analyses to further explore these relationships and codevelop interventions.

Identifying Socio-Demographic and Behavioral Predictors of Prolonged Hospital Stay in an Urban Hospital in Northwest Indiana

Background: Hospital length of stay (LOS) is a crucial metric that impacts patient outcomes, healthcare resource utilization, and financial burden. In 2019 the CDC reported the average LOS in community hospitals was 5.4 days. Prolonged LOS is associated with an increased risk of hospital-acquired infections, decreased hospital bed availability limiting patient access to care, and cognitive impairment, particularly among the elderly. This indicates the importance of addressing LOS as a healthcare priority. This study examined the relationship between LOS and social determinants of health (SDOH), patient demographics, health behaviors, and health outcomes as part of a long-term Community Based Participatory Research partnership between IUSM-NW and St. Mary Medical Center (SMMC).&#x0D; Methods: This retrospective study analyzed EPIC™-generated data for adult inpatient visits at an urban hospital in Northwest Indiana from January 2021 to March 2023. Data analysis was performed using SPSS 28.0, consisting of descriptive statistics, bivariate analysis (One-way ANOVA, Independent T-tests, Kruskal Wallis H; p&lt;0.05), and Simple Linear Regression. This study was granted an exemption by the Indiana University Human Research Protection Program (IRB #14040).&#x0D; Results: The sample comprised of 10,916 predominantly white (77.7%) patients with a median age of 65 (IQR=22) and a median LOS of 4 days (IQR= 5). Bivariate analysis revealed LOS was significantly associated with age (p&lt;0.001), race (p&lt;0.033), sex (p&lt;0.012), insurance type (p&lt;0.001), physical inactivity (p&lt;0.001), and smoking tobacco (p&lt;0.001). After controlling for all factors in the multivariate analysis, age (p&lt;0.020), physical inactivity (p&lt;0.013), and insurance type (p&lt;0.013) retained their significance.&#x0D; Conclusions: These findings highlight the significance of demographic, behavioral, and social factors in relation to hospital LOS. Understanding these factors holds immense potential to guide the development of targeted interventions and healthcare strategies to optimize patient care and reduce LOS.

Cigarette smoking and urinary bladder cancer: The danger alarm is screaming!

The cancer of urinary bladder is a very common cause of cancer related mortality all over the world and approximately more than half patients suffering from bladder cancer had been smokers. In addition to this, in such patients the cancer is more intense, higher in grade and stage and does not respond well to chemotherapy (Jin et al., 2017). Cigarette smoking is a major risk factor for respiratory and extra respiratory cancers in human body. While the oral and lung cancer result on account of direct contact with the tobacco products, the urinary bladder mucus membrane is exposed to a number of metabolites of tobacco products and if this exposure is sustained for a longer duration, a deadly cancer results (Omare et al., 2022). Over 7000 chemical compounds have been found in tobacco smoke and more than 50 of these have been a labelled as carcinogenic. When tobacco burns, it releases carbon monoxide, benzene, formaldehyde and polycyclic aromatic hydrocarbons (PAH), hydrogen, cyanide, nitrosamine, etc. Recent studies have shown that the bladder cancer patients who have been smoker have been found to have altered metabolanomics of urinary bladder epithelium in variety of ways. Firstly, some metabolites of tobacco create hyper methylation while many types of nitrosamines and nicotine metabolites create genotoxicity resulting in DNA damage, DNA adducts, mutations and ultimately carcinogenesis (Jin et al., 2017; Fuller et al., 2028; Suzuki et al., 2020). Some years ago, an impression was created that if one uses electronic cigarettes, the incidence of urinary bladder cancer can be lowered, but recent studies have refuted that (Fuller et al., 2028). Although tobacco industry is exploring to create less toxic types of tobacco, but the danger of high grade, urinary bladder cancer is still looming large on humanity (Stephen and Hatsukami, 2022) and therefore, one must respond to this alarm. The temptation to adopt smoking is increasing in younger population in developing countries and therefore not only a greater emphasis on laboratory and clinical research is needed but also a wide spread campaign on social media to warn people about the association of cigarette smoking and bladder cancer are the need of hour. Tobacco addiction in various forms is not confined to a particular group, strata, or gender. Every year, ‘World No Tobacco Day” is celebrated on May 31st to draw attention to the adverse effects of tobacco consumption. Despite being labeled as a potent carcinogen and the health risks associated with it, people find it difficult to get out of tobacco addiction. Similarly, there are numerous other toxic substances used daily that are directly linked to health issues like allergies, infertility, birth defects, learning disabilities, different types of cancers, and several more. Across the world, extensive research is being conducted on Environmental Health Toxicology to assess the adverse effects of various chemicals on human health. Journal of Environmental Biology publishes research on different aspects of Environmental Sciences, Biological Sciences and Toxicology, however, to expand our horizon we now provide a forum for Medical and Pharmaceutical researchers to showcase their research pertinent to Toxicants and their impact on human and animal health. ournal of Environmental Biology is of interest to toxicologist, pharmacologist, zoologist, botanist, ecologist, environmental scientist, industry R&amp;D organizations and others engaged in environmental research and consultation. We welcome new submissions (Original Research Articles, Research Reviews &amp; Case Studies) from researchers working in the areas of Environmental Health Toxicology and also encourage scientists to curate Theme-based Special Issues.

Awareness and Knowledge of Tobacco Use and Its Relation to Oral Cancer Among Patients Visiting Stomatology Teaching Hospital.

Oral cancer (OC) is a major global health issue, with tobacco use being one of the most significant preventable risk factors. Despite its strong association with OC, public awareness about the harmful effects of tobacco remains limited. This study aims to evaluate the awareness and knowledge of tobacco use related to oral cancer among patients referred to the Stomatology Teaching Hospital. A cross-sectional survey was conducted at the Stomatology Teaching Hospital of Kabul University of Medical Sciences (KUMS) between January 1 and July 30, 2023. Using a convenience sampling method, the study included 435 patients aged 15 to 76 years. Logistic regression analysis was employed to determine factors associated with tobacco use, and the data were analyzed using SPSS version 26.0. Participants were divided into two groups: tobacco users and non-tobacco users. Most of them were young (18 to 30 years old) with a significant difference in oral cancer knowledge between the two groups (p < 0.001). Cigarettes were the most common tobacco type among users (62.1%), which was also statistically significant (p < 0.001). Tobacco users were 3.04 times more likely to have knowledge about oral cancer (OR: 3.04, p < 0.001, 95% CI: 1.93-4.80), indicating a significant association. The study reveals a general lack of awareness about oral cancer in our study population, particularly regarding specific risk factors. To improve awareness, it is essential for both public awareness campaigns and dentists to play a more active role in educating the public about oral cancer.

Tobacco and Alcohol Content in Top Vietnamese YouTube Music Videos: Content Analysis.

Seeing portrayals of tobacco and alcohol in music videos (MVs) may reduce perceived risks, increase susceptibility, and lead to the initiation of tobacco and alcohol use among adolescents and young adults. Previous studies have predominantly concentrated on assessing tobacco and alcohol contents in English-language MVs within Western countries. However, many other countries have not only been influenced by the English music market but have also produced music in their native languages, and this content remains underexamined. This study aims to investigate the prevalence of tobacco- and alcohol-related content in top Vietnamese MVs on YouTube from 2013 to 2021, to describe how tobacco and alcohol are portrayed in these MVs, and to examine associations between these portrayals and MV characteristics. A total of 410 Vietnamese MVs, including the top 40 or 50 most viewed released each year between 2013 and 2021, were analyzed. General information, such as the song name, its release date and ranking, age restriction, musical genre, and type of MV, was collected. We examined tobacco and alcohol content in the MVs, with specific details such as tobacco types, their brands, as well as the number, age, sex, and roles of individuals smoking or drinking. Among the 410 MVs, 36 (8.8%) contained tobacco-related content and 136 (33.2%) featured alcohol-related content. Additionally, 28 (6.8%) out of 410 MVs included both tobacco and alcohol content. The prevalence of videos with tobacco and alcohol content fluctuated over the years. In MVs with tobacco-related content, a higher proportion of hip-hop or rap songs contained tobacco-related content (n=6, 30%) compared to other music genres. In MVs with tobacco-related content, cigarettes were the most frequently shown product (n=28, 77.8%), and smoking scenes were often depicted at parties (n=13, 36.1%) and during dancing and singing scenes (n=12, 33.3%). Among the 31 MVs portraying actual tobacco use, tobacco use was typically depicted with 1 person, often a young adult male, while 38.7% (n=12) showed singer(s) smoking. For MVs with alcohol-related content, there was a high proportion showing alcohol images at parties, bars, or pubs (n=96, 70.6%). Among 87 MVs containing drinking scenes, 60.9% (n=53) involved groups of young adults of both sexes, and 64% (n=56) depicted singers drinking. Additionally, only 2 (5.6%) MVs included health warnings about tobacco harm, and 2 MVs (1.5%) included warnings about drinking restricted to individuals 18 years and above. The notable prevalence of tobacco and alcohol content in leading Vietnamese YouTube MVs raises concerns, especially as most of this content is portrayed without any warnings. The study underscores a regulatory gap in addressing such content on the internet, emphasizing the urgent need for stricter regulations and age restrictions on platforms such as YouTube.

A Multipurpose Sustainable Farming System for Tobacco Crops in the Mediterranean Area

The present study aimed to test a multipurpose sustainable tobacco farming system allowing more efficient use of production factors (e.g., mineral N fertilizer) thanks to larger commercial yields, albeit diversified (smoke products, bioactive compounds for nutraceutical and cosmeceutical uses, energy), per unit of land area. Three tobacco types (dark air-cured, IBG; light air-cured, Bu; dark fire-cured, Ky) were grown in the field in 2021 on three different soils (sandy clay loam, SCL; sandy loam, SL; clay loam, CL). The total waste biomass (WB, kg dry weight, d.w. ha−1) was measured. Commercial leaves yield (CLY, kg d.w. ha−1), N agronomic efficiency (NAE, kg d.w. kg−1 N), total polyphenols content (TP, mg kg−1 d.w.), antioxidant activity (ABTS, DPPH and FRAP, mmol Trolox Equivalent, TE, kg−1 d.w.) and yield of polyphenols (PY, kg ha−1) were determined. The calorific value (CV, MJ kg−1 d.w.), volatile matter (VM, %) and ash contents (%) were also measured, and biomass energy yield (BEY, GJ ha−1 yr−1) was then calculated. Very high percentages (&gt;40%) of total biomass produced by the different tobacco types were pre-harvest waste. NAE increased by 2- to more than 8-fold thanks to a greater potential commercial biomass produced with the same amount of N fertilizer used. Four main components were found in the tobacco polyphenols profile, namely 3-O-CQA, luteolin 7 rutinoside, rutin and quinic acid, which accounted for more than 80% of TP. BEY ranged between 122.3 GJ ha−1 yr−1 (Bu) and 29.9 GJ ha−1 yr−1 (Ky). Both polyphenols yield and energy potential per unit land area and/or per growing season appeared competitive with those from other herbaceous crops. The proposed multipurpose system appeared as a production circuit characterized by a virtuous and sustainable flow of resources.

The association between cultural and social occasions and smoking cessation: The case of Saudi Arabia.

Tobacco use remains high in Saudi Arabia, necessitating an understanding of the influence of cultural and social events on smoking cessation. This study examined whether cultural and social events like Ramadan, Eids, and birthdays, motivate Saudi adults to quit smoking. Convenience sampling of 742 Saudi tobacco users was conducted between July 2021 and May 2022. A cross-sectional survey was used to assess self-reported desire to quit (1 = 'least desire' to 10 = 'highest desire') and behaviors in relation to special occasions. Multiple linear regression was performed to examine the association between cultural and social occasions and the desire to quit, while logistic regression was used to assess the relationship between cultural and social occasions and historical quit attempts, medicinal nicotine product use, visiting smoking cessation clinics, and calling the national Quitline. Demographic variables and tobacco types were controlled for in the analyses. Considering quitting during Ramadan, Eids, and birthdays was associated with a higher desire to quit (Ramadan: B=2.99; 95% CI: 2.51-3.47, Eids: B=2.83; 95% CI: 2.12-3.54, and birthdays: B=2.76; 95% CI: 1.93-3.60, p<0.01) and a greater likelihood of past quit attempts (Ramadan: AOR=8.2; 95% CI: 5.5-12.1, Eids: AOR=5.8; 95% CI: 3.2-10.5, and birthdays: AOR=4.8; 95% CI: 2.4-9.4). Only considering quitting during Ramadan was associated with calling the national Quitline (AOR=2.9; 95% CI: 1.8-4.9). Cultural and social events like Ramadan and Eids motivate adults in Saudi Arabia to attempt tobacco cessation. Targeting interventions around meaningful cultural occasions may promote successful quitting. These findings highlight the importance of understanding cultural and religious influences on cessation behaviors in Saudi Arabia and in other countries.