Tobacco Industry Research Articles

Non-additive expression genes play a critical role in leaf vein ratio heterosis in Nicotiana tabacum L.

Heterosis, recognized for improving crop performance, especially in the first filial (F1) generation, remains an area of significant study in the tobacco industry. The low utilization of leaf veins in tobacco contributes to economic inefficiency and resource waste. Despite the positive impacts of heterosis on crop genetics, investigations into leaf-vein ratio heterosis in tobacco have been lacking. Understanding the mechanisms underlying negative heterosis in leaf vein ratio at the molecular level is crucial for advancing low vein ratio leaf breeding research. This study involved 12 hybrid combinations and their parental lines to explore heterosis associated with leaf vein ratios. The hybrids displayed diverse patterns of positive or negative leaf vein ratio heterosis across different developmental stages. Notably, the F1 hybrid (G70 × Qinggeng) consistently exhibited substantial negative heterosis, reaching a maximum of -19.79% 80 days after transplanting. A comparative transcriptome analysis revealed that a significant proportion of differentially expressed genes (DEGs), approximately 39.04% and 23.73%, exhibited dominant and over-dominant expression patterns, respectively. These findings highlight the critical role of non-additive gene expression, particularly the dominance pattern, in governing leaf vein ratio heterosis. The non-additive genes, largely associated with various GO terms such as response to abiotic stimuli, galactose metabolic process, plant-type cell wall organization, auxin-activated signaling pathway, hydrolase activity, and UDP-glycosyltransferase activity, were identified. Furthermore, KEGG enrichment analysis unveiled their involvement in phenylpropanoid biosynthesis, galactose metabolism, plant hormone signal transduction, glutathione metabolism, MAPK signaling pathway, starch, and sucrose metabolism. Among the non-additive genes, we identified some genes related to leaf development, leaf size, leaf senescence, and cell wall extensibility that showed significantly lower expression in F1 than in its parents. These results indicate that the non-additive expression of genes plays a key role in the heterosis of the leaf vein ratio in tobacco. This study marks the first exploration into the molecular mechanisms governing leaf vein ratio heterosis at the transcriptome level. These findings significantly contribute to understanding leaf vein ratios in tobacco breeding strategies.

How Could We Establish Monitoring and Surveillance of Health-Harming Corporations and Can Governments Be Trusted to Do It? Comment on "National Public Health Surveillance of Corporations in Key Unhealthy Commodity Industries – A Scoping Review and Framework Synthesis"

In the context of growing interest in the commercial determinants of health (CDOH) which has been defined as "the systems, practices, and pathways through which commercial actors drive health and equity," Bennett et al propose that governments implement monitoring of unhealthy commodity industries (UCIs) (including tobacco, alcohol, and ultra-processed foods) as part of their routine public health surveillance. We explore the evidence underpinning that suggestion and provide details on how corporate monitoring might be practically implemented drawing on lessons from tobacco industry monitoring which has been an established part of tobacco control. While governments should actively support such an approach as part of efforts to address commercially driven health harms, we urge caution in governments undertaking monitoring and identify significant barriers to implementation, while also suggesting ways in which those barriers might be overcome.

New image, same tactics: global tobacco and vaping industry strategies to promote youth vaping.

E-cigarette use (or vaping) is widespread in young people and is a rapidly growing public health problem. While the tobacco and vaping industry has promoted vaping as a smoking cessation aid for adults, the industry has strategically targeted young people through marketing and appealing designs to orientate a new generation of consumers to use their products. These strategies are not new and replicate what we have previously seen employed by the tobacco industry in past decades to maintain and grow their tobacco profits. We review the evidence on tobacco and vaping industry interference, highlighting the calculated and strategic use of interference tactics as a discourse to curb tobacco control efforts. We demonstrate how these tried and tested strategies are now being purposefully re-used in the context of vaping. As Australia is currently undergoing significant policy reforms for the access and retail of vaping products, we also provide a case study of the industry response played out in this contemporary landscape. Government and public health advocates are in a key position to be one step ahead in proactively tackling the vaping crisis. We recommend that continued monitoring of industry activities and strategies, achieving political transparency and tightening loopholes in current regulations are all needed to identify and eliminate the tobacco and vaping industry's influence on policymaking. Given their previous track record, we emphasize the need to counter industry interference tactics with urgency to prevent a new generation of nicotine dependence and to support and protect future action in tobacco control.

The effect of mixed microbial agents on tobacco black shank disease

Tobacco black shank disease is a soil-borne illness caused by fungi and is a significant factor limiting tobacco production. The use of microbial agents can effectively decrease the occurrence of tobacco black shank disease. In the prevention and management of soil-borne diseases, the activity of living microorganisms in bioagent products plays a crucial role, and its effectiveness is influenced by various factors, with the application method being a key factor. Studying the impact of different application methods on tobacco black shank disease occurrence using single and mixed microbial agents in the field. The findings revealed that both single and mixed microbial agents enhanced the antioxidant enzyme activity (PPO, POD, CAT, and PAL) in tobacco plant leaves, reduced pathogen numbers, improved tobacco growth status, and decreased the incidence of black shank disease in tobacco. The application of mixed microbial agents showed significantly better results than single microbial agents. Therefore, we recommend using mixed microbial agents in field applications to boost the antioxidant enzyme activity of tobacco plants, support healthy tobacco plant growth, manage tobacco black shank disease occurrence, and promote sustainable development in the tobacco industry.

The impact of the introduction of tobacco product plain packaging on consumer responses in Ireland: a real-world policy evaluation stratified by socioeconomic groups.

Smoking prevalence remains high in Europe and widening socioeconomic group differences are driving health inequalities. While plain packaging policies disrupt tobacco industry tactics that sustain smoking, evidence of their equity impact is sparse. This study evaluated the implementation of plain packaging in Ireland in 2018 on consumer responses, overall and by the socioeconomic group. Consecutive nationally representative cross-sectional surveys (2018, n = 7701 and 2019, n = 7382) measured changes in 13 consumer responses among respondents who smoked across three domains: product appeal, health warnings effectiveness, and perceived harmfulness of smoking. Multiple logistic regression-derived adjusted odds ratios with 95% confidence intervals to compare responses post- versus pre-implementation adjusting for age, gender, educational level, and heaviness of smoking. A stratified analysis examined changes by socioeconomic group indexed using educational level. There were statistically significant changes in consumer responses to plain packaging policy implementation across 7/13 outcomes studied. Five changes were aligned with expected policy impacts (2/6 product appeal outcomes and 3/4 health warning effectiveness outcomes). Two responses were also observed which were not expected policy impacts (1 appeal-related and 1 perceived harm-related outcome). There was no change in five outcomes. Differences in consumer responses between educational groups were generally small, mixed in nature, and indistinguishable when interval estimates of effect were compared. Implementation of plain packaging in Ireland had intended impacts on consumer responses. Including plain packaging requirements in revising the European Union's legislative frameworks for tobacco control will help build progress towards a Tobacco-Free Europe without exacerbating smoking inequalities.

Из истории развития табаководства как важнейшей отрасли торгового земледелия в губер-ниях Южного Кавказа во второй половине XIX – начале XX века

The article focuses on the evolution of tobacco cultivation in the South Caucasus over the research period. The author investigates the spread of this technological culture throughout all provinces in the specified region. Information is provided on the quantity of land occupied for tobacco cultiva-tion, tobacco types, industrial firms and their owners, tobacco products produced, and tobacco sales locations. The author examines the many causes of the shift in demand for tobacco products over this historical time, as well as the unequal level of tobacco production. The essay discusses the excellent conditions for the growth of tobacco production in the South Caucasus, which eventually became commodities. The report also underlined the Russian government’s interest in spreading this crop, which was the primary raw material for the tobacco sector. The government, which contributed to the region’s colonial exploitation by the Russian and foreign bourgeoisie, benefited financially from the expansion of the cultivation of technologi-cal and precious crops. The author finds that the tobacco business in the South Caucasus evolved, improved, and gradually adopted the characteristics of commercial agriculture, which included commodity rela-tions. It is emphasized that the quick expansion of commercial agriculture is closely tied to the emergence of capitalist relationships in agriculture.

Prediction of typical gas components in cigarette smoke based on transformer

Abstract Harm reduction of cigarette products has become one of the primary objectives of the entire tobacco industry. The prediction of typical gas components (TGC) and dynamic adjustment of process parameters are crucial for cigarette coke reduction and harm reduction. In this study, a deep learning (DL)-assisted TGC prediction framework is proposed to predict CO and NI simultaneously. Firstly, a large number of experimental and simulation parameters of cigarette process are collected as the data base for subsequent model construction. Then, the feature importance analysis of the process parameters was carried out by combining the mechanism of the combustion process through the mutual information method. Finally, DL models based on Multilayer Perceptron, One-Dimension Convolutional Neural Network and Transformer (TF) was developed as data-driven surrogate models to establish the mapping relationship between process parameters and TGC. The results show that TF model generalizes best and can predict TGC quickly and accurately with R2 over 0.99. This work will provide a valuable predictive and decision-making tool for cigarette harm reduction.

Reform of Article 46 Paragraph (3) Letter C of the Broadcasting Law Regarding the Phrase "Prohibition of Advertisements Demonstrating the Form of Cigarettes": Comparative Study With Singapore

<em>This study has been motivated by the weaknesses in the formulation of the Article 46 Paragraph (3) Letter c of Broadcasting Law No. 32 of 2002, which bans only those cigarette ads showing the shapes of cigarettes and leaves room for the tobacco industry to practice indirect advertisement. The focus of this research is to assess the enforcement of limitations on cigarette promotion in broadcasting law and to explore the legal modification of c of Broadcasting Law Article 46 paragraph 3. The method of the study is a normative juridical approach and comparative law method. The findings reveal that current laws in Indonesia have been ineffective in controlling the increase of the smoking population, among the youth in particular, due to a number of issues that the tobacco industry exploits. In contrast, smoking problems are much less prevalent in Singapore which has imposed more stringent policies. Most importantly, the research also discusses that ineffective regulation in Indonesia results from poor enforcement and light punishments offered for violations of the law. Therefore,there is need for restructuring section Article 46 Paragraph (3) Letter c of the Broadcasting Law, by promoting a bitter pill approach towards cigarette advertising, in addition to the current ineffectual position interrogated, to enhance public health.</em>

A FACILE METHOD TO PRODUCE HIGH-BULK AND HIGH-STRENGTH ROLLED RECONSTITUTED TOBACCO SHEET WITH REFINED TOBACCO CELLULOSE FIBERS

The rolling method is a pivotal means for reconstituted tobacco sheet (RTS) production due to its cost-effectiveness. However, the traditional rolling method is limited by its raw material grinding processes and yields of rolled RTS (RRTS) with subpar strength and bulk. Therefore, it is a challenge to develop a method to produce high-strength and high-bulk RRTS. Here, by replacing traditional raw materials grinding processes with papermaking refining processes, we present a facile and practical method to produce RRTS with elevated bulk and strength. This method separately refines tobacco leaves and stems into long and coarse leave and stem cellulose fibers. These fibers were subsequently reconstructed into RRTS. The detailed process parameters were optimized. The comparative RRTS with flax fibers instead of stem fibers was investigated. The optimal formula of new RRTS was determined. The updated processes, along with the use of refined cellulose fibers, led the RRTS to a significant improvement in strength and bulk, with a 5.3-fold increase in strength, and a 0.7-fold increase in bulk, while smoking qualities were preserved, which surpassed the smoking experience of RRTS with flax fibers. We anticipate this work will enhance the qualities of RTS and facilitate the transition of traditional tobacco industries toward healthier directions.

Global rapid review of interventions to tackle the harms of illicit tobacco

ObjectiveThis review aimed to assess interventions designed to reduce harm from illicit tobacco (IT). We evaluated health outcomes, cost-effectiveness, the advantages and disadvantages of interventions, and contextual factors affecting implementation.Data...

Abstract C007: Building capacity in health clinics and community organizations serving LGBTQ+ communities on tobacco prevention

Abstract Background. Tobacco use remains a significant public health issue, particularly among the LGBTQ+ community. Los Angeles County, which is home to the second-largest LGBTQ+ population in the US, has notably higher prevalence of tobacco use compared to the general population, partly due to targeted marketing by the tobacco industry, social stressors, and discrimination. These factors contribute to higher rates of smoking and tobacco-related health disparities; however, little is known about the capacity of community-based organizations, clinical providers, support staff, and other personnel that work closely with the LGBTQ+ community to provide smoking cessation services. Methods. Cedars Sinai Cancer Center Community Outreach and Engagement (COE) assisted in the facilitation of conducting a needs assessment, Clinical Provider and Staff Survey, to assess the opinions of clinical providers and community leaders about tobacco cessation-related topics related to 1) Building culturally competent tobacco cessation services; 2) Reducing health disparities in tobacco cessation services; 3) Improving access to care (Medicaid/Medi-Cal access and uptake) for diverse populations that are affected by tobacco-related disparities; 4) Improving the utilization of tobacco cessation services. The survey was administered online from December 2022 to April 2023 with providers throughout Los Angeles County. Results. A total of 261 surveys were collected which revealed several key issues at the organization level: they do not prioritize tobacco screening, treatment, or referrals; there is no standardized process for client management; staff have limited knowledge on tobacco prevention and patient navigation; and there is limited staff capacity and funding. To address organizational-focused barriers, COE trained 147 clinical providers and staff from 4 local health clinics and organizations and on capacity building, including the basics of tobacco, evidence-based interventions like "Ask, Advice, Refer," and lung cancer screening. Additionally, to address Client/Patient-Focused Barriers for Organizations, such as: lack of motivation to quit, low perception of the severity of smoking, and a lack of culturally competent or targeted cessation resources, COE staff assisted in navigating resources, ensuring both providers and clients were aware of and could access relevant support services. This involved sharing LGBTQ+ affirming resources, including medical care, behavioral health, and housing, and referred smokers to gender-affirming cessation support groups. Conclusion. The survey highlighted the need to enhance service delivery and support for the LGBTQ+ community. With these findings, our COE staff were able to increase organizational capacity through training and education for clinical providers and staff to enhance their knowledge and skills in tobacco cessation and share gender-affirming resources and navigation, which are crucial towards improving the overall effectiveness of tobacco cessation services for LGBTQ+ populations. Citation Format: Victor Cristanto, Alexandra Caro, Reener Balingit, Zul Surani. Building capacity in health clinics and community organizations serving LGBTQ+ communities on tobacco prevention [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr C007.

Statement of Continued Commitment to the Issue of Tobacco Industry Money

Statement of Continued Commitment to the Issue of Tobacco Industry Money

Is India on a path to reduce the tobacco industry's influence in tobacco control? Insights from the Global Tobacco Industry Interference Index (2019-2023).

The tobacco industry (TI), driven by profit motives, consistently conceals health risks through deceptive strategies, notably in countries like India. These tactics create vulnerabilities that hinder effective tobacco control measures and enable the TI to exploit legal gaps. Understanding these TI strategies is essential for policymakers to take appropriate preventive and corrective measures in order to limit tobacco industry interference (TII) in policy-making. The study aims at understanding the trend of TII in India between 2019 and 2023. The secondary data from the Global Tobacco Industry Interference report, consisting of seven major domains of the TII index, viz. policy participation, corporate social responsibility (CSR) activities, industry benefits, unnecessary interaction, transparency, conflict of interest, and preventive measures, were retrieved. A composite score was obtained after adding scores of different domains, for each year. The findings of the study demonstrated an initial improvement in India's implementation of WHO FCTC Article 5.3, as evidenced by a decreasing score between 2019 and 2021. However, this trend halted in 2023, with data showing a slight increase in the score. When compared with other Asian countries, India shows marginal improvement in score than Cambodia, China, Indonesia, Lao PDR, Malaysia, Myanmar, Nepal, Philippines, Thailand, and South Korea. Some of the countries in the region, including India, Pakistan, Bangladesh, Sri Lanka, Myanmar, Brunei, China, and Vietnam experienced a decline in TII. There has been a rise in CSR activities, forms of unnecessary interactions of TII with policymakers, and participation in policy development; however, improvements are observed in providing benefits to the TI, conflict of interest, and preventive measures. In order to fortify the regulatory framework, it is imperative to create awareness among stakeholders on conflict of interest, denormalize corporate social responsibility (CSR) initiatives by the TI, provision of a watchdog for TII in the country and "whole of government" approach in implementation of FCTC Article 5.3.

Oral mucosal changes caused by nicotine pouches: case series

Oral nicotine pouches are the latest products in the tobacco industry. They are manufactured by large tobacco companies and entice tobacco or nicotine addicts, although the products are presented as a ‘harmless choice.’ Nevertheless, dentists and oral health specialists worry about oral mucosal changes due to product interactions with the oral mucosa. Unfortunately, there are no case reports of oral mucosal changes from nicotine pouches that are also investigated histopathologically. The aim of the present study was to visually and histopathologically investigate oral mucosal changes in nicotine pouch users. An online retrospective survey regarding medical and dental health, dietary habits, and tobacco consumption habits was conducted (n = 50). Respondents were selected for further intraoral and histopathological investigation based on the inclusion criteria. All five respondents had oral lesions that were histopathologically analyzed. Visually, the lesions varied in form and intensity, but all appeared white at the location where the pouches were placed. Histopathological analyses revealed parakeratosis with acanthotic epithelium, intraepithelial and connective tissue oedema, and chronic inflammatory infiltration with lymphocytes and macrophages. Participants received information about nicotine cessation and oral health recommendations. In conclusion, nicotine pouches significantly impacted oral mucosa with white lesions that revealed important changes at the cellular level.

Enhanced lipid production of Auxenochlorella pyrenoidosa using biochar-pretreated tobacco industry wastewater

Tobacco industry wastewater, containing high levels of nicotine, organic carbon, dyes, and other pollutants, presents significant environmental and health challenges. This study evaluates the combined application of wood-derived biochar and microalgal biorefineries for effective treatment of this wastewater. A 3 % biochar dosage was determined to be optimal, achieving complete nicotine removal, enhancing wastewater transmittance from 12.29 % to 88.8 %, and reducing chemical oxygen demand (COD) levels by 87.7 % to 1757.3 mg/L, creating conditions favorable for the growth of Auxenochlorella pyrenoidosa. The pretreatment preserved key nutrients, such as sugars, total nitrogen (TN), and total phosphorus (TP), which supported enhanced microalgal photosynthesis and led to significant increases in biomass and lipid accumulation, particularly in unsaturated fatty acids. This shift in lipid composition contributed to a significant reduction in the cold filter plugging point value, improving the suitability of microalgae-derived biodiesel for use in cold climates. Transcriptomic analysis revealed upregulation of pathways involved in photosynthesis, carbon fixation, and fatty acid biosynthesis, while downregulation of the tricarboxylic acid (TCA) cycle minimized acetyl-CoA consumption, further promoting lipid synthesis. This integrated approach not only effectively detoxifies tobacco industry wastewater but also converts it into valuable biofuels, offering a promising and sustainable strategy for waste management and biofuel production.

An analysis of flavor descriptors on tobacco products in the Philippines: Regulatory implications and lessons for low- and middle-income countries

BackgroundHistorically, tobacco companies have used flavored tobacco products to enhance the appeal of tobacco consumption, encourage initiation and experimentation of tobacco use, and contribute to sustained tobacco use. While flavored tobacco products are regulated in several countries, there is no existing regulation on flavored tobacco products in the Philippines, specifically for cigarettes and cigars. This study aims to update evidence on the flavored tobacco product landscape in the Philippines by assessing both the flavor descriptors and flavor imagery featured on cigarette and cigar packaging.ResultsWe collected 106 cigarette and cigar products from four major cities in the National Capital Region, Balanced Luzon, Visayas, and Mindanao. Of these 106 cigarette and cigar products, 62 (58.49%) had flavor descriptors. Three crushable capsule products did not feature any flavor descriptor but were included for flavor imagery examination. We identified five categories of flavor descriptors: menthol, concept descriptors, tobacco, beverages, and other flavors. Out of 62 packs, ten featured more than one flavor descriptor on the packaging. Menthol flavor descriptors comprised the majority of flavor descriptors. Imagery and other graphic elements closely resonate with and enhance the flavor descriptors found on these packs.ConclusionsThis study aimed to update the evidence on the flavored tobacco product landscape in the Philippines and address their absence of regulation. Regulating flavored tobacco products requires a comprehensive policy approach complemented by complete enforcement. Flavor substances, flavor descriptors, and flavor imagery must be regulated altogether; however, it is ideal to enforce a ban on flavored tobacco products in compliance with the WHO FCTC, to which the Philippines is a signatory. Policymakers should consider plain packaging as an intervention to eliminate the appeals associated with flavored tobacco products.

Associations of individual characteristics and socioeconomic status with heated tobacco product harmfulness perceptions in Japan: A nationwide cross-sectional study (INFORM Study 2020).

IntroductionIn Japan, heated tobacco products (HTPs) are promoted by the tobacco industry as reduced-risk tobacco products despite the lack of evidence for this claim. This study determined the distribution of HTP-harmfulness perception and identify the explanatory factors associated with the perception of HTP as less harmful than conventional cigarettes.MethodsA nationwide cross-sectional survey was conducted with Japanese people aged 20 years or older (INFORM Study 2020) using a self-administered questionnaire. We performed descriptive analysis and weighted logistic regression analysis to examine the relationship between explanatory factors (e.g., individual characteristics, socioeconomic status, and trusted sources of cancer information) and the perception of HTPs as less harmful.ResultsAmong 3,420 participants (response rate: 35.2%), the proportions of those who perceived HTPs as less harmful were 40.3% and 18.3% for users and non-users of tobacco, respectively. For participants aged 20-39 years, the proportion were 49.9% and 30.4%, respectively. Among 1,160 non-tobacco users who were familiar with HTPs, male, aged under 39 years, and had lower education were associated with the perception of HTPs as less harmful. Trusted sources of cancer information were not associated with the perception of HTPs as less harmful.ConclusionsThis study showed that, among non-tobacco users, being male, aged under 39 years, and lower education were associated with a perception of HTPs as less harmful. Public health stakeholders should provide the latest evidence about HTP harmfulness in their daily practice, and strengthen the regulations on HTP marketing directed at both tobacco- and non-tobacco users.

Fossil fuel industry influence in higher education: A review and a research agenda

AbstractThe evolution of fossil fuel industry tactics for obstructing climate action, from outright denial of climate change to more subtle techniques of delay, is under growing scrutiny. One key site of ongoing climate obstructionism identified by researchers, journalists, and advocates is higher education. Scholars have exhaustively documented how industry‐sponsored academic research tends to bias scholarship in favor of tobacco, pharmaceutical, food, sugar, lead, and other industries, but the contemporary influence of fossil fuel interests on higher education has received relatively little academic attention. We report the first literature review of academic and civil society investigations into fossil fuel industry ties to higher education in the United States, United Kingdom, Canada, and Australia. We find that universities are an established yet under‐researched vehicle of climate obstruction by the fossil fuel industry, and that universities' lack of transparency about their partnerships with this industry poses a challenge to empirical research. We propose a research agenda of topical and methodological directions for future analyses of the prevalence and consequences of fossil fuel industry–university partnerships, and responses to them.This article is categorized under: Social Status of Climate Change Knowledge > Climate Science and Decision Making Climate, Nature, and Ethics > Ethics and Climate Change Social Status of Climate Change Knowledge > Sociology/Anthropology of Climate Knowledge Social Status of Climate Change Knowledge > Climate Science and Social Movements

Peran Inovasi Teknologi dalam Transformasi Industri Rokok: Dampaknya Terhadap Produksi, Distribusi, dan Penggunaan Produk Rokok

Generation Z, born between 1997 and 2012, exhibits a significant trend in adopting vape or electronic cigarettes as an alternative to conventional tobacco cigarettes. This study aims to investigate the influence of vape use on the tobacco industry in Indonesia, focusing on production, distribution, and consumer behavior. The research employs a qualitative approach through literature review and interviews. Data were collected from scholarly literature, primary data analysis via questionnaires, and direct interviews with cigarette manufacturers and vape users. Findings indicate that Generation Z tends to adopt vape due to its perceived modernity, diverse flavors, and perceived safety compared to traditional cigarettes. However, vape use also faces negative perceptions from some sectors of society regarding potential health impacts. Moreover, despite the rising popularity of vape, traditional tobacco cigarettes remain favored due to habit, tranquility, and personal preferences.

Tobacco industry interference to undermine the development and implementation of graphic health warnings in Bangladesh

BackgroundIn Bangladesh, the 2013 Amendment of the Tobacco Control Act made graphic health warnings (GHWs) on the upper 50% of all tobacco packs obligatory. However, at the time of writing...