Research Article Titled Research Articles

A Correction to the Research Article Titled: "A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility" by T. L. Tollner, S. A. Venners, E. J. Hollox, A. I. Yudin, X. Liu, G. Tang, H. Xing, R. J. Kays, T. Lau, J. W. Overstreet, X. Xu, C. L. Bevins, Gary N. Cherr

A Correction to the Research Article Titled: "A Common Mutation in the Defensin <i>DEFB126</i> Causes Impaired Sperm Function and Subfertility" by T. L. Tollner, S. A. Venners, E. J. Hollox, A. I. Yudin, X. Liu, G. Tang, H. Xing, R. J. Kays, T. Lau, J. W. Overstreet, X. Xu, C. L. Bevins, Gary N. Cherr

A Clinical Translation of the Research Article Titled “Premigration Persecution, Postmigration Stressors and Resources, and Postmigration Mental Health: A Study of Severely Traumatized U.S. Arab Immigrant Women”

A Clinical Translation of the Research Article Titled “Premigration Persecution, Postmigration Stressors and Resources, and Postmigration Mental Health: A Study of Severely Traumatized U.S. Arab Immigrant Women”

A Clinical Translation of the Research Article Titled “Major Depressive Disorder in Persons Exposed to Trauma: Relationship Between Emotional Intelligence and Social Support”

A Clinical Translation of the Research Article Titled “Major Depressive Disorder in Persons Exposed to Trauma: Relationship Between Emotional Intelligence and Social Support”

A Correction to the Research Article Titled: “Amplification of the Driving Oncogene, KRAS or BRAF , Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells” by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P. A. W. Edwards, P. D. Smith, S. J. Cook

The acquisition of resistance to protein kinase inhibitors is a growing problem in cancer treatment. We modeled acquired resistance to the MEK1/2 (mitogen-activated or extracellular signal–regulated protein kinase kinases 1 and 2) inhibitor selumetinib (AZD6244) in colorectal cancer cell lines harboring mutations in BRAF (COLO205 and HT29 lines) or KRAS (HCT116 and LoVo lines). AZD6244-resistant derivatives were refractory to AZD6244-induced cell cycle arrest and death and exhibited a marked increase in ERK1/2 (extracellular signal–regulated kinases 1 and 2) pathway signaling and cyclin D1 abundance when assessed in the absence of inhibitor. Genomic sequencing revealed no acquired mutations in MEK1 or MEK2, the primary target of AZD6244. Rather, resistant lines showed a marked up-regulation of their respective driving oncogenes, BRAF600E or KRAS13D, due to intrachromosomal amplification. Inhibition of BRAF reversed resistance to AZD6244 in COLO205 cells, which suggested that combined inhibition of MEK1/2 and BRAF may reduce the likelihood of acquired resistance in tumors with BRAF600E. Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B; however, the combined inhibition of ERK1/2 and phosphatidylinositol 3-kinase signaling had little effect on AZD6244 resistance, suggesting that additional KRAS effector pathways contribute to this process. Microarray analysis identified increased expression of an 18-gene signature previously identified as reflecting MEK1/2 pathway output in resistant cells. Thus, amplification of the driving oncogene (BRAF600E or KRAS13D) can drive acquired resistance to MEK1/2 inhibitors by increasing signaling through the ERK1/2 pathway. However, up-regulation of KRAS13D leads to activation of multiple KRAS effector pathways, underlining the therapeutic challenge posed by KRAS mutations. These results may have implications for the use of combination therapies.

A Clinical Translation of the Research Article Titled “Adolescents’ Experiences With Uxoricide”

A Clinical Translation of the Research Article Titled “Adolescents’ Experiences With Uxoricide”

A Correction to the Research Article Titled: "Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index" by A. P. Feinberg, R. A. Irizarry, D. Fradin, M. J. Aryee, P. Murakami, T. Aspelund, G. Eiriksdottir, T. B. Harris, L. Launer, V. Gudnason, M. D. Fallin

A Correction to the Research Article Titled: "Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index" by A. P. Feinberg, R. A. Irizarry, D. Fradin, M. J. Aryee, P. Murakami, T. Aspelund, G. Eiriksdottir, T. B. Harris, L. Launer, V. Gudnason, M. D. Fallin

A Correction to the Research Article Titled: "Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens" by Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Lievano, Subroto Ghose, Mary Vernov, Mihaela Stavarache, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt

A Correction to the Research Article Titled: "Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens" by Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Lievano, Subroto Ghose, Mary Vernov, Mihaela Stavarache, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt

A Correction to the Research Article Titled: “Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels” by D. Tian, S. M. P. Jacobo, D. Billing, A. Rozkalne, S. D. Gage, T. Anagnostou, H. Pavenstaedt, H.-H. Hsu, J. Schlondorff, A. Ramos, A. Greka

The authors note that the correct spelling of author Hermann Pavenstaedt is Hermann Pavenstädt.

A Clinical Translation of the Research Article Titled “How Persons With Chronic Hepatitis C in Residential Substance Abuse Treatment Programs Think About Depression and Interferon Therapy”

A Clinical Translation of the Research Article Titled “How Persons With Chronic Hepatitis C in Residential Substance Abuse Treatment Programs Think About Depression and Interferon Therapy”

A Correction to the Research Article Titled: "Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens" by Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Llievano, Subroto Ghose, Mary Vernov, Mihaela Stavarche, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt

A Correction to the Research Article Titled: "Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens" by Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Llievano, Subroto Ghose, Mary Vernov, Mihaela Stavarche, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G. Kaplitt

A Correction to the Research Article Titled: "Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence" by D. Duma, J. B. Collins, J. W. Chou, J. A. Cidlowski

The authors correct an error in panel B of Figure S8 of the Supplementary Materials.

A Correction to the Research Article Titled: ” Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis” by Zandra K. Pinnix et al .

A Correction to the Research Article Titled: ” Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis” by Zandra K. Pinnix <i>et al</i> .

A Clinical Translation of the Research Article Titled, “Alcohol and Violence-Related Injuries Among Emergency Room Patients in an International Perspective”

A Clinical Translation of the Research Article Titled, “Alcohol and Violence-Related Injuries Among Emergency Room Patients in an International Perspective”

A Correction to the Research Article Titled: "Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation" by L. Poliseno, L. Salmena, L. Riccardi, A. Fornari, M. S. Song, R. M. Hobbs, P. Sportoletti, S. Varmeh, A. Egia, G. Fedele, L. Rameh, M. Loda, P. P. Pandolfi

A Correction to the Research Article Titled: "Identification of the <i>miR-106b~25</i> MicroRNA Cluster as a Proto-Oncogenic <i>PTEN</i> -Targeting Intron That Cooperates with Its Host Gene <i>MCM7</i> in Transformation" by L. Poliseno, L. Salmena, L. Riccardi, A. Fornari, M. S. Song, R. M. Hobbs, P. Sportoletti, S. Varmeh, A. Egia, G. Fedele, L. Rameh, M. Loda, P. P. Pandolfi

A Correction to the Research Article Titled: "Systems Pharmacology of Arrhythmias" by S. I. Berger, A. Ma’ayan, R. Iyengar

A Correction to the Research Article Titled: "Systems Pharmacology of Arrhythmias" by S. I. Berger, A. Ma’ayan, R. Iyengar

A Correction to the Research Article Titled: "Gα i1 and Gα i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway" by C. Cao, X. Huang, Y. Han, Y. Wan, L. Birnbaumer, G.-S. Feng, J. Marshall, M. Jiang, W.-M. Chu

A Correction to the Research Article Titled: "Gα _i1 and Gα _i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway" by C. Cao, X. Huang, Y. Han, Y. Wan, L. Birnbaumer, G.-S. Feng, J. Marshall, M. Jiang, W.-M. Chu

A Correction to the Research Article Titled: "Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development" by Y. He, H. Zhang, L. Yu, M. Gunel, T. J. Boggon, H. Chen, W. Min

A Correction to the Research Article Titled: "Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development" by Y. He, H. Zhang, L. Yu, M. Gunel, T. J. Boggon, H. Chen, W. Min

A Clinical Translation of the Research Article Titled “Antisocial Behavioral Syndromes and Additional Psychiatric Comorbidity in Posttraumatic Stress Disorder Among U.S. Adults: Results From Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions”

A Clinical Translation of the Research Article Titled “Antisocial Behavioral Syndromes and Additional Psychiatric Comorbidity in Posttraumatic Stress Disorder Among U.S. Adults: Results From Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions”

A Clinical Translation of the Research Article Titled, “Exploring the Impact of Race on Mental Health Service Utilization Among African Americans and Whites With Severe Mental Illness”

A Clinical Translation of the Research Article Titled, “Exploring the Impact of Race on Mental Health Service Utilization Among African Americans and Whites With Severe Mental Illness”

Titles or Headlines? Anticipating Conclusions in Biomedical Research Article Titles as a Persuasive Journalistic Strategy to Attract Busy Readers

This paper evidences the progressive adoption of a journalistic approach in title writing in certain scientific fields and suggests the reasons why this evolution has not affected all disciplines. The study is based on an analysis of 8,000 scientific research articles published over the last 25 years. The corpus was carefully selected following the advice of scientific researchers from several university departments. Factors such as the position of the journals in their impact list and the multidisciplinary or specific profile of the publication were considered. The results indicate that anticipating the conclusions in the title has become common practicein experimental works of biomedical research. An analysis of the linguistic characteristics of these conclusive titles is included to identify their basic components. It is suggested that instruction on the use of journalistic strategies is advisable for non-native writers and readers of biomedical research articles in highranking publications.