Titanium Complexes Research Articles

A Novel Catalytic System of [O,O] Bidentate Titanium Complexes and Et2AlCl/Bu2Mg for the Production of Ultra‐High Molecular Weight Polyethylene

AbstractA bidentate ligand, 2,3‐dihydro‐2,2‐dimethyl‐7‐benzofuranol (ddbfOH), is used to synthesize the titanium complexes, ddbfOTi(OiPr)3(1) and (ddbfO)2Ti(OiPr)2(2). Combined with diethylaluminium chloride (Et2AlCl) and di‐n‐butylmagnesium (Bu2Mg), complexes 1 and 2 exhibit super high activity towards ethylene polymerization, and giving the ultra‐high molecular weight polyethylene (UHMWPE). After rationally optimizing the experimental conditions, the highest polymerization activity is achieved in both 1/ and 2/Et2AlCl/Bu2Mg catalytic systems (213.6×106 g‐PE⋅mol‐Ti−1 h−1, 142.8×106 g‐PE⋅mol‐Ti−1 h−1). The highest molecular weight (Mv =1905×104) can be achieved under a low polymerization temperature (−30 °C) at the expense of activity (3000 g‐PE⋅mol‐Ti−1 h−1). Additionally, through the investigation of various polymerization conditions on the activity and molecular weight of the catalytic system, we have found that the ratio of the catalyst and cocatalyst has a more significant impact on both activity and molecular weight.

Designing of imine thiophene-ligated metal-complexes and implication in ethylene polymerization

Polyethylene is the single largest volume polymer produced globally using Ziegler-type catalysts. Numerous modifications have been reported in search of a better catalyst that can control molecular weight, polydispersity, and branching. In our attempts to identify a suitable imine thiophene-ligated chromium complex, we examined 9 different titanium complexes computationally. The DFT investigations considered barriers for insertion, propagation, and termination by β-H elimination or chain transfer, and identified N-(4-methoxyphenyl)-2-phenyl-1-(thiophen-2-yl)ethan-1-imine(L9) as the most suitable ligand. Subsequently, L9 was prepared in good yield (70%) by condensing 2-phenyl-1-(thiophen-2-yl)ethan-1-one with 4-methoxyaniline. Ligand L9 was treated with early transition metal precursors (Ti, Cr, Zr) to generate a homogenous catalyst. The identity of these catalysts was unambiguously ascertained using a combination of NMR, ICP, FT-IR, UV-Vis spectroscopy, and ESI-MS. The performance of L9-ligated titanium complex [Cat.1] was examined in ethylene polymerization using MMAO as a co-catalyst. Insertion of ethylene was tracked using high-pressure NMR experiments and Cat.1 was found to be active in the polymerization. Ethylene polymerization conditions were optimized to obtain high activity and molecular weight polyethylene. The chromium complex [Cat.2] outperformed the Ti and Zr-derived catalysts with the highest TOF of 6294 mol of PE/mol of Cr/h. Cat.2 produced high molecular weight, high-density polyethylene.

A Comprehensive Review on the Development of Titanium Complexes as Cytotoxic Agents.

After the discovery of cis-platin, the first metal-based anticancer drugs, budotitane, and titanocene dichloride entered clinical trials. These two classes of complexes were effective against those cell lines that are resistant to cis-platin and other platinum-based drugs. However, the main limitation of these complexes is their low hydrolytic stability. After these two classes, a third generation titanium based complex, i.e. diaminebis(phenolato)bis(alkoxo) titanium(IV), was invented, which showed more hydrolytic stability and high cytotoxicity than budotitane and titanocene dichloride. The Hydrolytic stability of complexes plays an important role in cytotoxicity. Earlier research showed that hydrolytically less stable complexes decompose rapidly into non-bioavailable moiety and become inactive. The mechanism of Ti(IV) complexes of diaminebis(phenolato) bis(alkoxo) is under investigation and is presumed to involve Endoplasmic Reticulum (ER) stress, which leads to apoptosis. The proposed mechanism involves the removal of ligands from the titanium complex and the binding of the Ti center to transferrin protein and its release inside the cell. Also, the structure of the ligand plays a key role in the cytotoxicity of complexes; as the bulkiness of the ligand increased, the cytotoxic nature of complexes decreased.

Prolinol‐Derived Phenoxy‐Amidine Titanium Complexes in Asymmetric Silylcyanation of Aldehydes

AbstractThree new tridentate phenoxy‐amidine ligands (FA) have been prepared via the ring‐opening of benzoxazole by 2‐(methylamino)ethanol, L‐prolinol and L‐diphenylprolinol. Coordination studies of these FA ligands with Ti have led to the synthesis of the complexes (L1–L3)Ti(OiPr)2 (1 a–3 a) and (L1–L3)TiCl2(thf) (1 b–3 b). The solid state structures of the dichlorido FA−Ti complexes revealed a distorted octahedral geometry around the metallic centre provided by the FA ligand in mer‐fashion, the two residual chloro ligands in cis arrangement and a THF molecule. The chiral Ti‐FA complexes were shown to promote the asymmetric silylcyanation reaction. With benzaldehyde as substrate, the best catalyst was the dichlorido Ti complex 3 b with a diphenylprolinol in the ligand backbone. It afforded the cyanhydrine with 68 % conversion and 74 % ee after 24 h in DCM at –20 °C. The diisopropoxy Ti complex 3 a was remarkably active with pivalaldehyde as substrate, yielding the cyanosilylated product with 99 % conversion and 61 % ee after only 30 min at −60 °C.

Epoxidation at Isolated Titanium Site Modeled by Ti‐Siloxy‐Polyoxometalates Built on [α–A–XW9O34]n− and [α–B–YW9O33]9−: Comparative Study of Their Hydrolytic Stability

AbstractThis report investigates the structural differences in a series of titanium complexes constructed from silanol functionalized polyoxometalate (SiloxPOMs) derivatives, designed to create a constrained coordination site for titanium (IV) cations, namely (THA)3[PW9O34(tBuSiO)3Ti(OiPr)] and (THA)3[SbW9O33(tBuSiO)3Ti(OiPr)]. The complexes serve as structural and functional models for titanium silicates, facilitating the epoxidation of allylic alcohols and alkenes by aqueous hydrogen peroxide solutions. The different activity and selectivity observed between the two derivatives are attributed to variations in the polyoxotungstic platform used, A‐type–[XW9O34]n− versus B‐type –[YW9O33]3−. A combined experimental and theoretical investigation highlights the influence of these structural differences on water interaction and hydrolytic stability, with A‐type structures proving more susceptible to hydrolysis. In addition, the study also delves into the nuclearity of the active sites, a monomeric titanium (IV)‐hydroperoxide [Ti]–(OOH) active species evidenced by diffusion NMR spectroscopy, and the influence of the presence of water on catalytic performance in epoxidation reaction, thus shedding light on the relationship between catalyst stability, intermediates formed and reaction pathway. The study finally demonstrates the suitability of B‐type SiloxPOM derivatives as models for titanium silicates, offering insights into their stability and catalytic activity for epoxidation reactions.

Conversion of limonene to limonene diol over activated carbon supported Ti catalyst

AbstractA series of activated carbon supported Ti-3,3′-ethylen bis(3,4-dihydro-2H-1,3-benzoxazine) complex catalysts (denoted Ti-Bz (0.25)/AC, Ti-Bz(0.37)/AC, and Ti-Bz (0.5)/AC) was evaluated in the conversion of limonene to limonene diol using H2O2 as oxidant. The opening of oxazine ring as a step to the titanium complex formation was highlighted, as far as we are aware, for the first time, by NMR analysis. A range of characterization methods, including SEM–EDS, nitrogen physisorption, ATR-FTIR, and XRD, showed that the procedure used in the preparation of these materials was reproducible. Parameters affecting the catalytic performances in the production of limonene diol, such as reaction temperature, amount of catalyst tested, and its catalytic stability, were studied. Ti-Bz (0.5)/AC was the most performant catalyst leading to limonene diol yield of 36.7%. The recyclability of the catalyst was evaluated along three catalytic consecutive tests that showed no significant difference of performance compared with that of fresh catalyst.

From Coordination to Noncoordination: Syntheses and Substitution Lability Studies of Titanium Triflato Complexes.

A new concept for obtaining cationic complexes with triflate counteranions from coordinating triflato ligands was developed. Various routes are leading to titanium(IV) and titanium(III) triflato complexes efficiently. The reactions of pentafulvene titanium complexes with either triflic acid or silver triflate give the corresponding titanium(IV) triflato complexes in excellent yields. Hydrolysis of the titanium(IV) bistriflato complexes leads to cationic aqua complexes via displacement of the triflato ligand, which consequently acts as a noncoordinating anion. A functionalized titanium(IV) monotriflato complex was synthesized by insertion of a nitrile into the Ti-C bond and the triflato ligand was displaced by an NHC. While the titanium(IV) complexes are mostly inert toward substrates, the donor-free titanium(III) triflato complex is a strong Lewis acid and forms various adducts with monodentate Lewis bases. The titanium(III) complex was oxidized by reaction with TEMPO, resulting in a diamagnetic titanium(IV) complex. The reaction with bidentate ligands results in cationic titanium(III) complexes due to displacement of the triflato ligand by the bidentate ligands. Treatment with acetone leads to an aldol reaction of two acetone molecules and the formation of a cationic diacetone alcohol complex.

Catalytic Investigation of ε-caprolactone Polymerization through Schiff BaseTitanium (IV) Complexes

Background: The ring-opening polymerization (ROP) reaction has provided an efficient and convenient route to prepare polyesters of high molecular weight, low polydispersity index, and high optical purity. The poly(ε-caprolactone) (PCL) and poly(lactide) (PLA) were prepared through ROP reaction of ε-caprolactone and D, L-lactide, respectively. These compounds have a huge industrial demand and become an interest among the scientific community to develop more economically and eco-friendly catalysts for ROP reactions. Methods: Three Schiff base ligands, 2-((benzo[d]thiazole-2-ylimino)methyl)phenol, L1; 2-(1-benzo[d]thiazole-2-ylimino)ethyl)phenol, L2; and 2- ((benzo[d]thiazole-2-ylimino)methyl)-5-methoxyphenol, L3; were prepared by the reaction of 2-aminobenzothiazole with 2-hydroxybenzaldehyde, 2-hydroxyacetophenone and 2-hydroxy-4-methoxybenzaldehyde in 1:1 molar ratio. In anticipation of interesting stereochemistry, reactivity, and catalytic potential against ε-caprolactone polymerization, three Titanium(IV) complexes (1 – 3) of these Schiff base ligands were synthesized. All the prepared compounds were characterized by elemental analysis, molar conductance, FT-IR, UV-Vis, 1H-NMR, 13C{1H}-NMR and FAB-Mass spectroscopic technique. Geometry was optimized with the help of DFT. Results: Complex 3 gives a much higher yield (87.7%) in comparison to 1 and 2. The order of catalytic efficiency for complexes is 3>1>2. With the increase in temperature, the % yield was found to decrease, and results are in support of moderate to good potency of synthesized catalysts. Conclusion: Complexes were screened for catalytic potency against ε-Caprolactone polymerization reaction. A most plausible mechanism for the polymerization was also proposed.

Sol–gel synthesis of iron titanates for the photocatalytic degradation of cyanide

Iron titanate mixed metal oxides were synthesized by the sol–gel method through four different routes. The effect of (i) the solvent of iron precursor, (ii) the addition of the chelating agent to the titanium or iron solution and (iii) the molar ratio between the chelating agent and the titanium or iron precursor over the overall percentage of obtained iron titanates was evaluated. Fourier-transform infrared spectroscopy (FTIR) and UV–Vis spectroscopy (UV–Vis) performed on the reaction medium evidenced the formation of acetate complexes of titanium (IV) or iron (III) during the different routes. X-ray diffraction (XRD) patterns of the obtained materials showed the formation of ilmenite (FeTiO3), pseudorutile (Fe2Ti3O9) and pseudobrookite (Fe2TiO5) in different proportions, as well as hematite (Fe2O3), rutile [TiO2 (R)] and anatase [TiO2 (A)]. The materials with the highest content of iron titanates obtained in each route were characterized and evaluated in the photocatalytic degradation of cyanide using visible light irradiation. UV–Vis Diffuse Reflectance Spectroscopy (UV–Vis DRS) showed that the samples exhibited energy bandgap values between 2.31 and 2.90 eV, which agrees with the values reported for iron titanates and evidence the possible activation of the materials under visible light. Scanning electron microscopy (SEM) and nitrogen physisorption results showed that the synthesized materials exhibited nanometric particle size and lower surface area (36.7 ± 4.8 m2·g-1) than TiO2 Degussa P-25 (72–155 m2·g-1). The photocatalytic performance of the synthesized materials toward oxidation of CN− exceeded by 56% the activity of pure TiO2. The content of iron titanates in the synthesized materials was found to be the variable with the greatest influence on the photodegradation of cyanide. In addition, an inversely proportional relationship between the pseudorutile content of the materials and their photocatalytic activity was observed.

Syntheses, Characterization, and Redox Activity of Ferrocene-Containing Titanium Complexes.

The chemistry of bis(π-η5:σ-η1-pentafulvene)titanium complexes is characterized by a broad range of E-H activation and Ti-C functionalization reactions, whereas ferrocene derivatives are easily accessible and redox-active compounds. The reaction of ferrocenealdehyde and -ketones with bis(π-η5:σ-η1-pentafulvene)titanium complexes result in the formation of bimetallic complexes via insertion of the C=O double bond of the aldehyde/ketone into the Ti-Cexo bond of the pentafulvene moiety. The reaction of bis(π-η5:σ-η1-pentafulvene)titanium complexes with ferrocenyl alcohols leads to alcoholate complexes via deprotonation of the OH group by the pentafulvene ligand. Because of the one remaining pentafulvene unit, further functionalization of the complexes is possible. In this work, we proceeded with 1,1'-bifunctionalized ferrocene derivatives for intramolecular follow-up reactions. 1,1'-Ferrocenedimethanol reacts with bis(π-η5:σ-η1-pentafulvene)titanium complexes in a double O-H deprotonation reaction to yield the dialcoholate complex. 1,1'-bis(phenylphosphine)ferrocene reacts differently as the double P-H deprotonation reaction results in the formation of a P-P linked phosphine. Therefore, we studied the reactivity of 1,1'-bis(phenylphosphine)ferrocene toward Rosenthal's reagent. As Rosenthal's reagent is regarded as a masked titanocene(II) species, it undergoes redox reactions toward H-acidic substrates, forming a paramagnetic Ti(III) complex.

New bioactive titanium(IV) derivatives with their DFT, molecular docking, DNA/BSA interaction, antioxidant and in-vitro investigations

A set of four new metallacyclic complexes titanium(IV) associated with Schiff bases (SBs) (1a- 1d) obtained by the specific reactions of β-diketones such as acetylacetone (acacH) and benzyl acetone (bzacH) and aminophenol derivatives while treating Ti(OPri)4 and these SBs individually in 1:2 stoichiometry under 8 h reflux condition in anhydrous benzene to afford as reddish powder (2a-2d). These products have been purified in repeated washings of dry n-hexane afterwards, subjected to characterization by suitable spectroscopic techniques (NMR, IR, UV–Vis and HRMS). These hexacoordinated complexes appeared as distorted octahedral geometry from computational data studies. The synthesized titanium(IV) complexes were screened for their antioxidant abilities where 2c and 2d exhibited remarkable activity as IC50 values. The DNA & BSA binding properties of the complexes (2a-2d) have also been investigated through electronic absorption and molecular docking analysis. The obtained results indicated clearly that the complexes got bound with DNA via groove binding mode according to the intrinsic binding constant values (Kb = 1.5 × 104 M−1 to 7.5 × 105 M−1). Derivative 2c was examined in-vitro on a panel of cancerous cell line − breast cancer and human colon cell lines MCF-7 to reflect IC50 results as 53.92 μg/mL and HT-29 33.43 μg/mL, respectively.

Synthesis, Structural Characterization of Substituted Phenoxyimine Based Ti(IV) Complexes for Ring Opening Polymerization and DFT Studies

AbstractA series of 4 new titanium complexes bearing phenoxyimine ligands that differ in their steric and electronic properties have been synthesized and investigated for the polymerization of ethylene and rac‐lactide. X‐ray crystal structures of these catalysts reveal compounds 1–3 exhibit distorted octahedral geometry while complex 4 shows distorted trigonal bipyramidal. The substituents on the phenoxyimine framework have a profound influence on the catalytic activities of these compounds in the polymerization reactions. All four complexes afforded polylactide with a heterotactic bias in ring opening polymerization of rac‐lactide. In addition to this, density functional theory calculations using (B3LYP) with the 6‐311++G (d, p) basis set and no constraints were used while doing geometry optimizations and compared with experimental results. Hirshfeld surface analysis, MEP and Mulliken charge also reported an unexpected relationship between the nitrogen, oxygen on the ligands, titanium isopropoxide, and good relation between the experimental findings.

Copolymerization of norbornene with 1-hexene catalyzed by sulfur-containing Schiff base titanium complex and density functional theory analysis

Sulfur-containing salicylaldimine ligand and corresponding titanium complex were synthesized and characterized this work, indicating structural conformity with the design. By using diethylaluminum chloride (EADC) as a cocatalyst, the titanium complex exhibited high activity (∼106 g·mol−1·h−1) in the copolymerization of norbornene (NB) and 1-hexene (1-C6), producing oligomer with a molecular weight of approximately 500. The catalytic copolymerization results were interpreted by combining experimental analysis and density functional theory (DFT). The results indicated that the insertion of norbornene and 1-hexene into Ti catalysts was thermodynamically feasible. Although the reaction barrier for norbornene monomer insertion into the metal active center was lower than that of 1-hexene, the strong steric hindrance between NBE monomer and NBE units in the oligomer chain hindered continuous NBE insertion. By comparing the reaction rates in equimolar systems, the initial insertion step of 1-hexene monomer into the Ti-Et structure was found to be much easier than norbornene insertion, resulting in a lower quantity of norbornene groups in the copolymerization product than 1-hexene groups.

Electrochemical Behavior of Niobium and Titanium Complexes in Chloride-Fluoride Melts with Addition of Alkaline Earth Metal Cations

The standard rate constants of charge transfer (k s) for the Nb(V)/Nb(IV) redox couple in the NaCl-KCl(equimol.)-NaF(10 wt%)-K2NbF7 melt with addition of alkaline Earth metal cations (Mg2+, Ca2+, Sr2+, Ba2+) were determined. It was found that addition of alkaline Earth metal cations resulted in increasing of k s to the certain ratio of Me2+/Nb(V) for the all alkaline Earth metal cations due to substitution of Na+ and K+ cations by Me2+ in the second coordination sphere of niobium complexes that leads to decreasing of niobium fluoride complexes stability. Further addition brought to some decrease of the standard rate constants because the viscosity of melts increasing, which brings to decrease of the diffusion coefficients. The standard rate constants increase with increasing of the ionic potential and reach maximum values for the complexes with outer-sphere magnesium cations. Comparative analysis of the electrochemical behavior of Nb(V)/Nb(IV) and Ti(IV/Ti(III)) redox couples in the NaCl-KCl(equimol.)-NaF(10 wt%) melt without and with addition of alkaline Earth metal cations has been done. It was determined that mechanism of electron transfer from the cathode to niobium and titanium complexes in melts containing alkaline Earth metal cations is the same and has a bridge nature.

Fabrication of conductive Nb-doped anatase TiO2 thin films by mist chemical vapor deposition using aqueous solutions of water-soluble Ti and Nb compounds

Electrically conductive Nb-doped anatase TiO2 (Ti1−x Nb x O2: TNO) films can be fabricated through mist CVD using aqueous precursor solutions of water-soluble oxo-peroxo-glycolato titanium complex and ammonium niobium oxalate. Post-deposition annealing in vacuum crystallizes the as-deposited amorphous films into a conductive anatase phase, leading to the fabrication of conductive TNO films. Notably, the addition of H2O2 to the precursor solutions enhances both the crystallinity and conductivity of the annealed TNO films. A Ti0.77N0.23O2 film, annealed at 700 °C, exhibits a resistivity of 2.0 × 10−2 Ω cm at ambient temperature. In general, the solution-based fabrication of TiO2 films relies on organic solvents, which are sometimes toxic and explosive. Here, we demonstrate for the first time that conductive TNO films can be prepared from less toxic and nonflammable aqueous solutions. These findings mark a significant advancement towards a more environmentally compatible process for fabricating TNO films with sufficient conductivity.

Ethylene/Propylene Copolymerization and Their Terpolymerization with 5-Ethylidene-2-norbornene over Catalytic Systems Based on Half-Sandwich Titanium Complexes with Organoaluminum and Organoboron Activators

Ethylene/Propylene Copolymerization and Their Terpolymerization with 5-Ethylidene-2-norbornene over Catalytic Systems Based on Half-Sandwich Titanium Complexes with Organoaluminum and Organoboron Activators

Development of Eco-Friendly Ag Embedded Peroxo Titanium Complex Solution Based Thin Film and Electrical Behaviors of Resistive Random Access Memory

Development of Eco-Friendly Ag Embedded Peroxo Titanium Complex Solution Based Thin Film and Electrical Behaviors of Resistive Random Access Memory

Thermal-Robust Phenoxyimine Titanium Catalysts Bearing Bulky Sidearms for High Temperature Ethylene Homo-/Co- Polymerizations.

A family of titanium complexes (Ti1-Ti7) with the general formula LTiCl3, supported by tridentate phenoxyimine [O-NO] ligands (L1-L7) bearing bulky sidearms, were synthesized by treating the corresponding ligands with stoichiometric amount of TiCl4. All the ligands and complexes were well characterized by 1H and 13C NMR spectroscopies, in which ortho- methoxyl groups on N-aryl moieties shifted to downfield, corroborating the successful coordination reaction. Structural optimization by DFT calculations revealed that one of the phenyl groups on dibenzhydryl moiety could form π-π stacking interaction with the salicylaldimine plane, because of which the obtained titanium complexes revealed good thermal stabilities for high-temperature polymerization of ethylene. The thermal robustness of the complexes was closely related to the strength of π-π stacking interactions, which were mainly influenced by the substituents on the dibenzhydryl moieties; Ti1, Ti4 and Ti5 emerged as the three best-performing complexes at 110 °C. With the aid of such π-π stacking interactions, the complexes were also found to be active at >150 °C, although decreased activities were witnessed. Besides homopolymerizations, complexes Ti1-Ti7 were also found to be active for the high-temperature copolymerization of ethylene and 1-octene, but with medium incorporation percentage, demonstrating their medium copolymerization capabilities.

Ethylene/Polar Monomer Copolymerization by [N, P] Ti Complexes: Polar Copolymers with Ultrahigh-Molecular Weight.

A series of novel titanium complexes (2a-2e) bearing [N, P] aniline-chlorodiphenylphosphine ligands (1a-1e) featuring CH3 and F substituents have been synthesized and characterized. Surprisingly, in the presence of polar additive, the complexes (2a-2e) all displayed high catalytic activities (up to 1.04 × 106 gPolymer (mol·Ti)-1·h-1 and produced copolymer with the ultrahigh molecular weight up to 1.37 × 106 g/mol. The catalytic activities are significantly enhanced by introducing electron-withdrawing group (F) into the aniline aromatic ring. Especially, the increase in activity based on different complexes followed the order of 2e > 2d > 2c > 2b > 2a. Simultaneously, density functional theory (DFT) calculations have been performed to probe the polymerization mechanism as well as the electronic and steric effects of various substituents on the catalyst backbone. DFT computation revealed that the polymerization behaviors could be adjusted by the electronic effect of ligand substituents; however, it has little to do with the steric hindrance of the substituents. Furthermore, theoretical calculation results keep well in accordance with experimental measurement results. The article provided an appealing design method that the employment of fluorine atom as electron-withdrawing to be studied is the promotive effect of transition-metal coordination polymerization.

Antidiabetic and antioxidant studies of novel synthesized titanium (IV) complex: Design, synthesis, in‐silico docking and in‐vitro studies

[{TiCl3}2(C3N3S3H)] (where C3N3S3H is Trithiocyanuric acid) was designed and synthesized by the reaction of TiCl4 and trithiocyanuric acid in 2:1 M ratio under stirring and refluxing condition using THF solvent. The synthesized Titanium (IV) complex was characterized by various spectroscopic techniques like FT‐IR, NMR, MASS, XRD, UV–visible spectrophotometer and elemental analysis (CHNSO). Moreover, in‐silico docking studies of the ligand and its Ti (IV) complex were carried out by AutoDockTools‐1.5.6 to study interactions of the complex under study with the receptor protein. Afterwards, both ligand and synthesized Ti (IV)complex were screened for the antioxidant and antidiabetic potential by in‐vitro method. The antioxidant potential was investigated by using DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) radical scavenging assay where ligand exhibited moderate activity while Ti (IV) complex presented significant antioxidant activity. Following, alpha‐amylase enzyme inhibition was investigated using iodine‐starch inhibition assay. It was found that the ligand was inactive (showed no α‐amylase inhibition activity) while the Ti (IV)complex was a potent α‐amylase inhibitor. Furthermore, the experimentally obtained results were also complimented by the in‐silico results.