In the era of nanotechnology and advanced manufacturing, many industrial applications involve the flow control over the rotating disk. Rotating machineries, computer storage devices, dynamic filtration processes, gas turbine engines, bio inspired electro-catalysis processes are a few of them. Considering the wide applications of flow over rotating permeable disks, this paper presents the investigation of flow, temperature and pressure characteristics of water-based titanium oxide nanofluid with temperature dependent properties. The quadratic Boussinesq approximation is considered to incorporate the density variations due to temperature change. The numerical computation is carried out using metaheuristic based hybrid shooting technique. Temperature dependent dynamic viscosity and thermal conductivity models for nanofluid are considered and the numerical results for velocity components, pressure and temperature distributions are investigated. The investigation unveiled reduction in skin friction and heat transfer rate with increasing value of quadratic convection parameter. The suction parameter is found to be very significant in terms of increasing heat transfer rates. An 80% increase in local Nusselt number is observed for a small change in suction parameter from −1 to −1.5.