Helical cruciform fuel (HCF) has the advantages of larger heat transfer area, enhanced coolant mixing and self-supporting, which contribute to increasing power density and safety margins. Compared with the square lattice configuration, the hexagonal arrangement of HCF assembly is more compact, which can help achieve a higher power density. In this paper, the flow characteristics and heat transfer behaviors of HCF in hexagonal lattice were predicted at high and low vapor quality during boiling crisis based on Eulerian two-fluid model. The influence of twist pitches and cross-sections of the fuel rod on heat transfer efficiency and fuel temperature was also studied. The cross-flow intensity changed periodically with a 30° cycle at low vapor quality, and did not fluctuate periodically at high vapor quality, which decreased with the increase of flow resistance. The highest heat flux of HCF rod was the at the blade root and the lowest was at the blade tip, and the maximum to average heat flux ratio was about 1.8. The peak vapor fraction and temperature occurred at leeside side of the fuel rods. The increase of the twist pitch reduced the critical heat flux (CHF), and the increase of blade length enhanced the non-uniformity of heat flux distribution. During boiling crisis, the maximum temperature of the fuel was lower than the phase transition temperature of U-50 wt%Zr alloy, which means the cladding meltdown caused by boiling crisis will occur before phase transition of the fuel.