Tiny Dots Research Articles

Prevalence of visual snow and relation to attentional absorption.

Visual snow is a condition of unclear prevalence characterized by tiny flickering dots throughout the entire visual field. It appears to result from visual cortex hyperactivity and possibly correlates with propensity to be engrossed in sensory and imaginary experiences (absorption). The prevalence and correlates of visual snow, and emotional reactions to it, were explored in the general Portuguese population with three studies with online surveys. In Study 1, 564 participants were shown an animated graphic simulation of visual snow and asked to rate how frequently they have similar percepts on a scale anchored by 0% and 100% of their waking time. They also reported their degree of distress and fascination resulting from visual snow. Absorption was measured with the Modified Tellegen Absorption Scale. 44% of respondents reported they see visual snow at least 10% of the time, and 20% reported seeing it between 80% and 100% of the time. Similar to findings in clinical samples, the frequency of visual snow correlated with tinnitus frequency and entoptic phenomena, but not with ophthalmologic problems. It was confirmed that visual snow is related to absorption. Although distress caused by visual snow was generally absent or minimal in our samples, a substantial minority (28%) reported moderate to high levels of distress. High fascination with visual snow was reported by 9%. In Studies 2 and 3, visual snow was measured by means of verbal descriptions without graphic simulation ("visual field full of tiny dots of light" and "world seen with many dots of light", respectively). The results were similar to those in Study 1, but seeing visual snow 80%-100% of the time was less frequent (6.5% in Study 2 and 3.6% in Study 3). Visual snow has been insufficiently investigated. More research is needed to uncover underlying neurophysiological mechanisms and psychological and behavioral correlates.

Few-atom-layer metallene quantum dots toward CO2 electroreduction at ampere-level current density and Zn-CO2 battery

Electrocatalytic CO 2 reduction reaction (CO 2 RR) toward commodity chemicals and fuels presents an enticing prospect wherein the emerging metallenes as catalysts have aroused great interest. Here, we report the synthesis of a kind of tiny metallene quantum dot (QD) called the stanene QD (Sn-ene QD), which features a few atom layers and rich edge centers and provides superior CO 2 RR activity by delivering ampere-level current densities with near-unity selectivity for formate production. Operando attenuated total reflection-infrared (ATR-IR) spectroscopy and theoretical calculations deciphered that the rich edge centers of Sn-ene QDs hold high reactivity, and the residual cyano ligands with electron-withdrawing nature favor the stabilization of the CO 2 RR intermediate. Furthermore, the Zn-CO 2 battery assembled with Sn-ene QDs catalyst affords a high power density of 1.25 mW cm −2 and an outstanding stability of ∼100 h. This work highlights the great potential of metallene QDs as a new platform for heterogeneous catalysis and energy conversion. • Few-atom-layer stanene quantum dots (Sn-ene QDs) with rich edge centers were prepared • Sn-ene QDs afford a superior activity toward CO 2 electroreduction to formate • The rich edge centers of Sn-ene QDs were deciphered to hold a high reactivity • Sn-ene QDs show excellent Zn-CO 2 battery performance Metallenes, the newly emerging two-dimensional metallic materials of atomic thickness, have been regarded as ascendant CO 2 RR electrocatalysts because of their plentiful accessible atoms and unique catalytic properties. When the lateral size of metallenes reduces to less than 10 nm, producing metallene quantum dots (QDs), the edge atoms with lower coordination numbers will occupy a large portion of the total atoms, which could exhibit a higher catalytic performance. Here, we delicately fabricated the few-atom-layer stanene QDs with rich edge centers via an in situ electrochemical reduction strategy. Such a unique metallene QD catalyst affords an excellent performance for CO 2 electroreduction to formate and Zn-CO 2 batteries. Few-atom-layer stanene quantum dots with rich edge centers are pioneeringly fabricated by a fast electrochemical self-reconstruction strategy and are shown to afford an excellent electrocatalytic performance for CO 2 electroreduction to formate and Zn-CO 2 batteries.

Sonographic findings in scabies

Scabies is a cutaneous infestation caused by Sarcoptes scabiei var. hominis, a small mite that performs its whole life cycle within the epidermis. In this case report, we provide images of the sonographic signs of scabies. We found that the adult mite can be seen as a hyperechoic well-defined ovoid area within the epidermal layer at the end of the hypoechoic burrow, while the eggs correspond to tiny heteroechoic dots along the burrow. In conclusion, ultrasound may prove useful to differentiate between inhabited vs non-inhabited scabiotic burrows.

Visual snow: A systematic review and a case series.

Visual Snow Syndrome is a recently recognized neurological condition presenting, continuous, tiny dots across the entire visual field, accompanied by nyctalopia, photophobia and palinopsia that persist for months. It may be part of migraine aura spectrum, yet its definition is still questionable. Diagnostic criteria for Visual Snow Syndrome are included in the supplemental material of ICHD-3. We aimed to summarize recent data to improve the understanding of Visual Snow Syndrome. After presenting four new cases, we conducted a PRISMA systematic search in PubMed/MEDLINE and Embase databases using the keyword "visual snow" with specific inclusion and exclusion criteria. From the 855 articles identified 30 were included for the qualitative analysis. These reports covered five aspects related to Visual Snow Syndrome: epidemiology, clinical features, comorbidities, pathophysiology, and treatment. We found limited data concerning Visual Snow Syndrome's epidemiology (one study). Clinical presentation (22 articles) and the comorbidities (migraine with aura and tinnitus most often, five reports) are described in detail. The pathophysiology of Visual Snow Syndrome is only approached with hypotheses, but several neuroimaging studies have been identified (seven articles). Treatment is based on single case reports only. Data for Visual Snow Syndrome are few and not strong enough to support Visual Snow Syndrome as a medical identity. Further investigation is needed.

A CASE REPORT OF ERUPTIVE SYRINGOMA: CLINICAL, DERMOSCOPIC AND HISTOLOGICAL FEATURES

Syringoma is a benign adnexal tumor that originates from the acrosyringium. Eruptive syringoma is a rare variant that manifests in the form of skin-colored or brownish, shiny, angulated papules that occur in successive crops. Dermoscopic evaluation reveals brownish regular pigment network and tiny whitish dots between adjacent papules that correspond histologically to multiple eccrine ducts lined by a double-layered epithelium, giving a paisley tie appearance. This case of eruptive syringomas highlights the importance of histopathological and dermoscopic evaluation.

SolO/EUI Observations of Ubiquitous Fine-scale Bright Dots in an Emerging Flux Region: Comparison with a Bifrost MHD Simulation

We report on the presence of numerous tiny bright dots in and around an emerging flux region (an X-ray/coronal bright point) observed with SolO’s EUI/HRIEUV in 174 Å. These dots are roundish and have a diameter of 675 ± 300 km, a lifetime of 50 ± 35 s, and an intensity enhancement of 30% ± 10% above their immediate surroundings. About half of the dots remain isolated during their evolution and move randomly and slowly (<10 km s−1). The other half show extensions, appearing as a small loop or surge/jet, with intensity propagations below 30 km s−1. Many of the bigger and brighter HRIEUV dots are discernible in the SDO/AIA 171 Å channel, have significant emissivity in the temperature range of 1–2 MK, and are often located at polarity inversion lines observed in SDO/HMI LOS magnetograms. Although not as pervasive as in observations, a Bifrost MHD simulation of an emerging flux region does show dots in synthetic Fe ix/x images. These dots in the simulation show distinct Doppler signatures—blueshifts and redshifts coexist, or a redshift of the order of 10 km s−1 is followed by a blueshift of similar or higher magnitude. The synthetic images of O v/vi and Si iv lines, which represent transition region radiation, also show the dots that are observed in Fe ix/x images, often expanded in size, or extended as a loop, and always with stronger Doppler velocities (up to 100 km s−1) than that in Fe ix/x lines. Our observation and simulation results, together with the field geometry of dots in the simulation, suggest that most dots in emerging flux regions form in the lower solar atmosphere (at ≈ 1 Mm) by magnetic reconnection between emerging and preexisting/emerged magnetic field. Some dots might be manifestations of magnetoacoustic shocks through the line formation region of Fe ix/x emission.

Visual snow: a neuro-ophthalmic syndrome

Background: The visual snow syndrome (VSS) is a rare disease characterized by persistent positive visual phenomena that are enigmatic and may be underestimated. It manifests as the perception of tiny, simultaneous, diffuse, and mobile dots frequently throughout the visual field. Although it affects brain networks, ocular examination is also indicated. This paper was aimed to review recent studies on VSS to identify the best clinical approach.&#x0D; Methods: In this narrative review, PubMed/Medline, Directory of Open Access Journals, and Embase were searched using the following terms: “Visual snow”, “Persistent aura”, “Persistent positive visual phenomena”, “Visual aura”, “Migraine”, “TV static”, “Migraine aura status”, and “Visual disturbance”. We searched relevant publications from January 2014 to January 2021 to find the best clinical approach. &#x0D; Results: VSS may be reconstituted as a distinct entity, although the symptoms may be consistent with typical migraine visual aura. For approximately two-thirds of patients, symptoms worsen and reduce their ability for activities of daily living. It often causes psychogenic detriment of the patient and their capacity to function socially and vocationally. Comprehensive history-taking and ocular examination are required to rule out other causes. However, all ocular and radiological findings may be normal. &#x0D; Conclusions: VSS is a neuro-ophthalmic disorder characterized by continuous chronic and recurrent visual disturbances that involve the entire visual field and may respond to empiric antimigraine or anti-seizure treatments. It may reduce the ability for activities of daily living; therefore, proper diagnosis by eye care professionals is necessary to determine its diagnosis and management.

Pruritic Papules on the Trunk, Extremities, and Face.

A 69-year-old woman presented in early summer in southeastern Michigan with several itchy bumps of 4 to 5 weeks’ duration that erupted and remitted over the trunk, extremities, and face. Later, the patient reported seeing 3 tiny black dots crawl across the screen of her cell phone as she read in bed.

Irradiation hardening of stainless steel model alloy after Fe-ion irradiation and post-irradiation annealing treatment

Microstructural observation with atom probe tomography, transmission electron microscopy, and mechanical examination with a nano-indenter were performed on stainless steel model alloy that had been irradiated with Fe ions and subjected to post-irradiation annealing treatment (PIA). Significant irradiation hardening occurred in the as-irradiated specimen and irradiation hardening recovery occurred at 400 °C of cumulative PIA, Tiny black dots, Frank loops and Ni-Si clusters formed in the as-irradiated specimen and their recovery was observed with the cumulative PIA. A classic dispersed-barrier hardening model was used to evaluate irradiation hardening connected to microstructural information by applying the density and size of defect variants. Ni-Si clusters and Frank loops contributed substantially to the increase of irradiation hardening, whereas the black dots contributed little for the stainless steel model alloy. The barrier strength factor of Ni-Si clusters, αSC, was obtained as 0.029 and 0.015 for two different obstacle strength model, which suggests that an individual Ni-Si cluster is a weak barrier obstacle to mobile dislocation on the dispersed-barrier hardening model, but that the dense formation of Ni-Si clusters controls irradiation hardening behavior. A quantitative analysis was performed of the increase in strength from the Ni-Si clusters that was caused by coherency strains, and an irradiation hardening mechanism for the stainless steel, including the solute atom clusters, is discussed.

Trying: On Teaching Empathy.

Trying: On Teaching Empathy.

Electron beam lithography with negative tone resist for highly integrated silicon quantum bits

Process technologies have been developed for electron-beam (EB) lithography aimed at silicon quantum devices and their large-scale integration. It is necessary to understand the proximity effect and construct a method for its correction to perform EB lithography of fine and complicated structures. In this study, we investigate the lithography of Si quantum devices with a point-beam EB system and a maN 2401 negative tone resist, in order to correspond to various types of device structures. We optimize temperatures for specialized pre- and post-exposure bakes for forming ∼20 nm fine patterns with small line-edge roughness. Further, we demonstrated the fabrication of Si-on-insulator device patterns that have some tiny dots connected with many large wires/pads in the layout, with the careful tuning of the dose assignment. In this tuning, we used the EB process simulation to estimate the cumulative dose distribution effectively. In addition, we reproduced the experimentally obtained resist patterns via the EB process simulation after considering the mid-range effect, which is a factors in the proximity effect but is not yet deeply understood. The results of this study are expected to provide useful process technologies for EB lithography, which will help drastically accelerate the research on Si quantum devices with a high degree of freedom.

Polymeric carbon dot/boehmite nanocomposite made portable sensing device (Kavach) for non-invasive and selective detection of Cr(VI) in wastewater and living cells

This work reports a handheld fluorometric probe, namely ‘Kavach’ for monitoring hexavalent chromium in industrial wastewater and living systems. Kavach is capable to detect chromium contamination in a rapid and facile way. The device is made of a thin layer (~1 mm) of carbon dot decorated boehmite nanostructure (BH@CD) incorporated in a layer of poly vinylidene fluoride-co-hexafluoropropylene (PVDF-HFP) membrane. The doped membrane has an excellent blue fluorescence upon UV excitation (355 nm) and alters its fluorescence level when exposed to Cr(VI). In reality, tiny carbon dots leach out from the nano-matrices to produce secondary contamination. Incorporation of the BH@CD into the polymeric matrix of PVDF-HFP significantly reduces such contamination and makes this material a potential sensing probe. This photoinduced electron transfer (PET) based sensor is tremendously selective and sensitive (LOD ~66 nM) towards aqueous chromium. The performance of the probe remains unaltered in different pH and water qualities. Additionally, this material can sense chromium in living cells, which has been validated theoretically using molecular docking and observed experimentally using fluorescence microscopy. Kavach is truly a handheld, reusable and non-invasive sensing probe against Cr(VI), which can be employed for on-site low-cost detection.

Updates on the Immunopathology in Idiopathic Inflammatory Myopathies.

To review recent advances in immunopathology for idiopathic inflammatory myopathies, focusing on widely available immunohistochemical analyses. Sarcoplasmic expression of myxovirus resistance protein A (MxA) is specifically observed in all types of dermatomyositis and informs that type I interferons are crucially involved in its pathogenesis. It is a more sensitive diagnostic marker than perifascicular atrophy. Diffuse tiny dots in the sarcoplasm highlighted by p62 immunostaining are characteristically seen in immune-mediated necrotizing myopathy. This feature is linked to a chaperone-assisted selective autophagy pathway. Myofiber invasion by highly differentiated T cells, a marker of which is KLRG1, is specific to inclusion body myositis and has a crucial role in its pathogenesis. The recent advances in immunopathology contribute to increased diagnostic accuracy and a better understanding of the underlying pathophysiology in different types of idiopathic inflammatory myopathies.

Ultrastructural study of closed macular hole- preliminary application of a novel high magnification module combining with OCT

BackgroundAs a novel high magnification module (HMM) combining with OCT (OCT-HMM) is able to detect the microstructure of retina, we apply it to explore the ultrastructure of the macula after closure of the idiopathic macular hole (IMH) by surgery.MethodsThis is an observational case series study in which patients with full-thickness IMHs who had undergone successful macular closure by vitrectomy and internal limiting membrane peeling and healthy subjects were recruited. After comprehensive ophthalmic examinations, the images of macular area were obtained and collected by professional operators using OCT-HMM. Then images were independently analyzed by 4 masked vitreoretinal specialists.ResultsA total of 24 IMH eyes and 42 healthy eyes were examined. HMM images were obtained in 10 IMH eyes. Among them, 4 eyes whose macula closed completely with recovery of photoreceptor layer presented a dark arc nasal to the fovea, oriented to the optic, and the notch of arc faced temporally. Six eyes in which the macula closed incompletely with photoreceptor cells loss revealed a dark ring with uneven bright spots inside. The other 14 eyes failed to obtain clear images by OCT-HMM. The contra lateral eyes of the patients and the healthy subjects’ eyes succeeded to obtain the HMM images which displayed evenly grey background thickly covered with tiny bright dots that was in similar size and evenly and widely distributed and there no dark arc or ring. OCT B-scan and IR images could be acquired in all of the IMH and healthy eyes.ConclusionThe preliminary application of HMM has supplied us a brand-new insight into the microstructure of closed IMH. A dark arc sign could be detected with OCT-HMM in the macula which was functionally closed after surgery that was probably the healing mark on a microstructure photoreceptors level. Its existence and shape indicated that the functional closure followed by a retinal displacement mainly horizontally from temporal side to nasal side but not symmetric centripetally.

Drying process of an ink-dot analyzed using both digital holographic microscopy and tackiness measurement

This paper proposes a novel method to investigate the property of a tiny ink dot in its drying process from its gelation to solidification using digital holographic microscopy and tackiness measurement. The method can analyze a variation of an ink dot having a diameter of a few hundred micrometers by using temporal variations of volume, height and contact angle of the ink dot calculated from reconstructed complex amplitudes of the light transmitted through the ink dot. In addition, the tackiness of the ink dot is evaluated using a handmade measurement device having a micro cantilever as the sensing probe. The experimental results using a commercially available water-based magenta ink ejected on a glass plate are presented.

The Pandemic Blenny, Coralliozetus clausus, a new species of tube blenny endemic to Isla del Coco, Costa Rica (Teleostei: Chaenopsidae).

Coralliozetus clausus, a new species of chaenopsid blenny, endemic to Isla del Coco, Costa Rica, is described. This small species, not exceeding 15 mm SL, is a short-bodied member of the genus along with Coralliozetus cardonae (Caribbean), Coralliozetus angelicus, and Coralliozetus springeri (both eastern Pacific). It differs from its closest relative, C. springeri, known from mainland waters from Costa Rica to Ecuador, in having a single tiny supraorbital cirrus and dark dots on the operculum and branchiostegal membrane of males while C. springeri has paired supraorbital cirri (one of which is substantial in size) and no dots on the operculum. Although two other species of Coralliozetus have been reported from Isla del Coco, this appears to be only member of the genus present on the island. It is the second chaenopsid endemic to Isla del Coco and brings the number of cryptobenthic fishes endemic to Isla del Coco to twelve.

Design of Metal@Titanium Oxide Nano-heterodimers by Laser-Driven Photodeposition: Growth Mechanism and Modeling.

In order to circumvent the usual nucleation of randomly distributed tiny metallic dots photodeposited on TiO2 nanoparticles (NPs) induced by conventional UV lamps, we propose to synthesize well-controlled nanoheterodimers (NHDs) using lasers focused inside microfluidic reactors to strongly photoactivate redox reactions of active ions flowing along with nanoparticles in water solution. Since the flux of photons issued from a focused laser may be orders of magnitude higher than that reachable with classical lamps, the production of electron-hole pairs is tremendously increased, ensuring a large availability of carriers for the deposition and favoring the growth of a single metallic dot as compared to secondary nucleation events. We show that the growth of single silver or gold nanodots can be controlled by varying the beam intensity, the concentration of the metallic salt, and the flow velocity inside the microreactor. The confrontation to a build-in model of the metallic nanodot light-induced growth onto the surface of TiO2 NPs shows the emergence of a predictable "master behavior" on which individual growths obtained from various tested conditions do collapse. We also characterized the associated quantum yield. Eventually, we successfully confronted our model to growth data from the literature in the case of silver on TiO2 and gold on II-VI semiconducting NPs triggered by UV lamps. It shows that for the photosynthesis of NHDs the efficiency of the electron-hole pair production rate matters much more than the number of pairs produced and that the use of laser light can provide a photodeposition-based synthesis at the nanoscale.

Analysis of Poverty of Different Countries of the World

Analysis of Poverty of Different Countries of the World

DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line

While carbon-based materials have spearheaded numerous breakthroughs in biomedicine, they also have procreated many logical concerns on their overall toxicity. Carbon dots (CDs) as a respectively new member have been extensively explored in nucleus directed delivery and bioimaging due to their intrinsic fluorescence properties coupled with their small size and surface properties. Although various in vitro/in vivo studies have shown that CDs are mostly biocompatible, sufficient information is lacking regarding genotoxicity of them and underlying mechanisms. This study aims to analyze the real-time cytotoxicity of super tiny CDs (2.05 ± 0.22 nm) on human breast cancer cells (MCF7) and human primary dermal fibroblast cell cultures (HDFa) by xCELLigence analysis system for further evaluating their genotoxicity and clastogenicity to evaluate the anti-tumor potential of CDs on breast adenocarcinoma. As combined with flow cytometry studies, comet assay and cytokinesis-block micronucleus assay suggest that the CDs can penetrate to the cell nuclei, interact with the genetic material, and explode DNA damage and G0/G1 phase arrest in cancer cells even at very low concentrations (0.025 ppm) which provide a strong foundation for the design of potentially promising CD-based functional nanomaterials for DNA-damage induced treatment in cancer therapy.

First Report of Cercospora nicotianae Causing Frog Eye Spot in Cigar Tobacco in Hainan, China.

Cigar tobacco (Nicotiana tabacum L.), sun air-cured tobacco, originally from South America, with a main use to rolling cigar wrapper that is different from flue-cured tobacco. In April, 2018, diseased leaves were observed in cigar tobacco in some fields in Danzhou city (109.58°E, 19.53°N) and Wuzhishan city (109.52°E, 18.78°N), Hainan. 20 to 40% of plants were infected (total 8 ha), thereby affecting local leaf production. The symptoms appeared as small, circular or irregular, sunken, brown patches developing into white centers and obvious dark brown margins with necrotic spots of 0.2-0.8 cm in most middle and lower leaves at mature stage. To determine the causal agent, ten leaves from five cigar tobacco plants (cv. Nuowei 2) collected from Danzhou were used for pathogen isolation (Fig. 1). Sections of infected leaf tissues were surface-sterilized by 5% NaClO for 3 min, 70% ethanol for 40 sec, rinsed in sterilized distilled water (SDW) and then placed onto potato dextrose agar (PDA) plates, under aseptic conditions and incubated at 28°C. After 7 days, predominant and consistent colonies that were nearly circular, smooth edges, generally hard, leathery and wrinkled surface, dense aerial hyphae, producing red pigment, were obtained and purified by picking hyphal tips to PDA at 28℃ (Fig. 2). One culture, HN4-1-7 from Hainan were deposited in Chinese General Microbial Cultural Center (CGMCC, NO. 3.19604). Frogeye lesions can be coved by tiny black dots on two sides and the fruiting bodies was amphigenous. Conidiophores were bluish yellow brown and gradually lighten at tips, 0-4 knee points, apical or subapical section, 0-14 septa, measured 45.1-506.4×2.3-11.7 μm in size. Conidia were needle-shaped to clavate, colorless, erect or curved, measured 37.2-169.6×1.9-5.5μm (Fig. 2). Further comparisons were completed with CGMCC 3.19604 by PCR and BLAST sequence analyses of the patial ITS rDNA region (GenBank accession nos. MK752900), TEF gene (GenBank accession nos. MK881748), ACT gene (GenBank accession nos. MK881749), CAL gene (GenBank accession nos. MT127561), and HIS gene (GenBank accession nos. MT185579) as described by Groenewald et al (2012). The results showed high identity of all the five sequences to the Cercospora nicotianae isolates, DQ835073, DQ835099, DQ835119, DQ835146, DQ835173. Based on the microscopic observation and molecular characteristics, isolate CGMCC 3.19604 were identified as C. nicotianae. The pathogenicity of CGMCC 3.19604 was evaluated in greenhouse experiments. Twenty sixty-day old cigar tobacco leaves (cv. H211) and flue cured tobacco leaves (Honghuadajinyuan) were sprayed with hyphae suspensions of CGMCC, NO. 3.19604 until runoff, respectively, and the experiment was repeated once. For controls, leaves of two cultivars were similarly wounded and inoculated with SDW. All plants were incubated under 90% humidity and 28°C with a 12 h photoperiod/day. After 9 days, the same diseased symptom (Fig.3) was observed on inoculated leaves of cigar tobacco were identical to the natural infected leaves respectively, but not on control leaves. C. nicotianae was re-isolated from lesions by cultural and morphological characteristics, fufilling Koch's postulates. All tests were repeated once. To the best of our knowledge, this is the first report of C. nicotianae causing frog eye spot in cigar tobacco in Hainan, China. As we all known, appearance integrity and uniformity are playing an important role in high quality of cigar-wrapper, but the incidence of frog eye spot can seriously affect appearance quality of cigar-wrapper and led to increase direct losses to local cigar tobacco production. In addition, symptom of frog eye spot is similar to brown spot disease caused by Alternaria alternata, often cause their symptoms confused and then delay prevention at the right time. Since the cigar tobacco is a major industry in Hainan, better understanding of its diseases is relevant in order to establish disease control strategies.