Time Of Movement Research Articles

Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease

Sleep disturbances are common in Alzheimer’s disease (AD) and AD-related dementia (ADRD). We performed a sleep study on Tg-SwDI mice, a cerebral amyloid angiopathy (CAA) model, and age-matched wild-type (WT) control mice. The results showed that at 12 months of age, the hemizygous Tg-SwDI mice spent significantly more time in non-rapid eye movement (NREM) sleep (44.6 ± 2.4% in Tg-SwDI versus 35.9 ± 2.5% in WT) and had a much shorter average length of wake bout during the dark (active) phase (148.5 ± 8.7 s in the Tg-SwDI versus 203.6 ± 13.0 s in WT). Histological analysis revealed stark decreases of orexin immunoreactive (orexin-IR) neuron number and soma size in these Tg-SwDI mice (cell number: 2187 ± 97.1 in Tg-SwDI versus 3318 ± 137.9 in WT. soma size: 109.1 ± 8.1 μm2 in Tg-SwDI versus 160.4 ± 6.6 μm2 in WT), while the number and size of melanin-concentrating hormone (MCH) immunoreactive (MCH-IR) neurons remained unchanged (cell number: 4256 ± 273.3 in Tg-SwDI versus 4494 ± 326.8 in WT. soma size: 220.1 ± 13.6 μm2 in Tg-SwDI versus 202.0 ± 7.8 μm2 in WT). The apoptotic cell death marker cleaved caspase-3 immunoreactive (Caspase-3-IR) percentage in orexin-IR neurons was significantly higher in Tg-SwDI mice than in WT controls. This selective loss of orexin-IR neurons could be associated with the abnormal sleep phenotype in these Tg-SwDI mice. Further studies are needed to determine the cause of the selective death of orexin-IR cells and relevant effects on cognition impairments in this mouse model of microvascular amyloidosis.

Role of K.H. Agus Salim in Educational Management in Koto Gadang 1912-1915

K.H. Agus Salim is an Indonesian national hero known as a scholar, politician, professional and journalist. Her activism can be traced from the time of the national movement to the period of defending independence. However, there is an experience that is so unique, namely when Salim fought for education in his hometown of Koto Gadang, West Sumatra. This writing uses the biographical research method of education to highlight Salim's historical role in the field of educational management. Since childhood, Agus Salim was known to be intelligent and studious. He took all of his education at the Dutch colonial school and always excelled and was fluent in many languages (polyglot). In the midst of a discriminatory colonial education system, he succeeded in establishing the private Hollandsche Inlandsche School (HIS) with the help of non-governmental organizations in 1912. He served as an advisor and teacher. Many of the school's alumni have been successfully accepted into government advanced schools, one of the reasons being that foreign language education (Dutch) is taught from an early age. Furthermore, "Studiefonds Koto Gadang" as the institution he founded helps outstanding students to get free education and continue their education. The basis of Agus Salim's contribution lies in the influence of Islamic modernism thought brought by Muhammad Abduh, that Muslims must achieve the pleasure of Allah with intellectual intelligence. Salim completes it by building awareness of nationalism and love for the motherland.

GABALAGEN Alleviates Stress-Induced Sleep Disorders in Rats.

(1) Background: Gamma-aminobutyric acid (GABA) is an amino acid and the primary inhibitory neurotransmitter in the brain. GABA has been shown to reduce stress and promote sleep. GABALAGEN (GBL) is the product of fermented fish collagen by Lactobacillus brevis BJ20 and Lactobacillus plantarum BJ21, naturally enriched with GABA through the fermentation process and characterized by low molecular weight. (2) Methods: The present study evaluated the GABAA affinity of GBL through receptor binding assay. The sedative effects of GBL were investigated through electroencephalography (EEG) analysis in an animal model of electro foot shock (EFS) stress-induced sleep disorder, and then we examined the expression of orexin and the GABAA receptor in the brain region using immunohistochemistry and an enzyme-linked immunosorbent assay (ELISA). (3) Results: We found that on the binding assay, GBL displayed high affinity to the GABAA receptor. Also, after treatment with GBL, the percentage of the total time in rapid eye movement (REM) and non-rapid eye movement (NREM) sleep was significantly and dose-dependently increased in EFS-induced rats. Consistent with behavioral results, the GBL-treated groups showed that the expression of GABAA receptor immune-positive cells in the VLPO was markedly and dose-dependently increased. Also, the GBL-treated groups showed that the expression of the orexin-A level in LH was significantly decreased. (4) Conclusions: GBL showed efficacy and potential to be used as an anti-stress therapy to treat sleep deprivation through the stimulation of GABAA receptors and the consequent inhibition of orexin activity.

Optimization of the route of the refueling machine to reduce the refueling time: Case study of the BN-800 reactor

Sodium-cooled fast reactors (SFR) are included in the list of fourth-generation nuclear energy systems, the so-called generation IV (GEN-IV). It is the only technology of GEN-IV that possesses the significant practical experience of design, construction, and operation of high-power reactors. Due to the high temperature of the coolant at the BN-600 and BN-800 reactor core outlets, the steam generator produces steam with higher enthalpy, and this significantly increases the efficiency of cogeneration at SFR power plants in comparison with pressured water reactor (PWR) or boiling water reactor (BWR) units. The primary nuclear fuel effectiveness rises due to cogeneration with higher efficiency of a sodium-cooled fast reactor nuclear power plant (NPP) in comparison with thermal reactors. In addition, it is necessary to reduce the reactor refueling outages to improve the nuclear power plant utilization factor.It is possible to reduce the duration of the reactor refueling by the route optimization of the refueling machine movement. The prevailing in the world thermal neutron reactors with water cooling have a refueling machine that points the certain fuel assembly using two coordinates. The fast neutron reactors use sodium as a coolant; thus, there is a problem with its violent reaction with water and air oxygen. Therefore, it is necessary to exclude the contact of sodium and surrounding air during the refueling. To achieve this, the system of refueling machine pointing is used, consisting of two or three eccentrically located rotating plugs with hydraulic locks. The article presents the results of the creation of mathematical models of refueling machine movement and fuel assembly gripping. The time-optimal algorithms for the operation of refueling machines with three rotating plugs are proposed. The use of the new algorithm allows to reduce the time of movement of the grip of the refueling machine by 30–37%.

СИНХРОНИЗАЦИЯ ПОДАЧИ СЕМЯН И РАБОЧЕЙ ЖИДКОСТИ В КАМЕРУ СМЕШИВАНИЯ ПРОТРАВЛИВАТЕЛЯ

The results of production tests of the PS-20K-4 seed dresser with a modified electrical control circuit in order to synchronize the supply of seeds and working fluid to the mixing chamber of the treater when it is put into operation are presented. At each start-up of the dressers, the supply of seeds to the chamber is ahead of the supply of working fluid to it due to the inertia of the working bodies of the hydraulic system, especially this is manifested on dressing machines equipped with centrifugal pumps for supplying working fluid (PS-20K-4, PS-22, etc.). To ensure the synchronization of the supply of seeds and working fluid to the mixing chamber, a device is proposed, the main part of which is the PVI-11 time delay relay for switching on the seed disc drive. Before starting the dresser, the time of movement of the liquid from the pump to the sprayer is determined. For the time obtained in this way, a delay is set on the PVI-11 attachment. Production tests have shown the advantage of the treater with changes made to the electrical control circuit. With the factory control scheme of the treater, the total weight of untreated seeds and seeds with reduced completeness of treatment, which are defective, increases with the increase in the installed capacity of the unit from 5 to 20 t/h, respectively from 26.4 to 48 kg at the beginning of each machine start-up. With the established synchronization of the supply of seeds and working fluid to the mixing chamber when starting the dressing machine, there were no defective seeds. Operational, technological, technical and economic evaluations of the unit showed that the shift time utilization factor was τ_c = 0.83, Shift productivity increased by 25 % due to a reduction in the time for additional treatment of untreated and insufficiently treated seeds. The indicators of technical and operational reliability were Ktn = 0.98 and Ken = 0.94, respectively. Reduced costs by 35%, reducing labor costs by 25%. The annual economic effect with 140 hours of operating amounted to 29915.6 thousand rubles.

PTZ KINDLING MODEL: EVALUATION OF EEG FACTOR AND BIOCHEMISTRY PARAMETERS UNDER THE INFLUENCE OF RAMELTEON

Many selective synthetic melatonin receptor agonists have anticonvulsant/anti-epileptogenic properties. These agonists bind to melatonin receptor 1 (MT1) and receptor 2 (MT2), causing their activation. Therefore, we evaluated the anticonvulsant effect of Ramelteon (RMLT) as a melatonin agonist in the PTZ (Pentylenetetrazol)-kindling model. In the study, 36 male Wistar Albino rats were assessed in 6 groups (Sham, PTZ, dimethylsulphoxide (DMSO), Valproic acid (VPA) (150 mg/kg) + PTZ, RMLT (30 mg/kg)+PTZ, VPA+RMLT+PTZ). Cortical electroencephalography (EEG) data were recorded for all groups. Seizures were scored according to the Racine scale. Seizure scores and onset times of the first myoclonic movements were compared in EEG traces. Total antioxidant status (TAS), total oxidant status (TOS), catalase, myeloperoxidase (MPO), and Thiol levels were measured in serum samples. Also, Calcineurin (CaN), Neuropeptide-Y (NPY), Neuron Specific Enolase (NSE), and S100B levels were measured in brain tissue samples. There was a significant difference between the PTZ and PTZ+Valproic acid+RMLT groups for the onset of the first myoclonic movements and the rate of spikes in the EEG traces in Racine's convulsion stages (P 0.05). RMLT has anticonvulsant properties. Additionally, the receptor preference of RMLT can be investigated.

Quantifying the Impact of C7 Spinal Nerve Harvest on Spontaneous, Patient-Initiated Movement of the Donor Upper Extremity.

Transfer of a healthy C7 spinal nerve is a tool for upper extremity reanimation in patients with severe brachial plexus injury (BPI). Its use remains controversial owing to concern for neurological injury to the donor arm. Utilizing wearable motion-sensor technology, we aimed to quantify donor arm morbidity after C7 spinal nerve harvest in patients with pan-BPI, reporting both the time and magnitude of donor arm movement in a real-world setting compared to healthy controls. Seventeen patients who underwent contralateral C7 (CC7) transfer for traumatic pan-BPI at least 2 years prior were compared to 14 healthy controls. Each participant wore an accelerometer on both arms for 7 consecutive days. The vector time (VT), or time of movement measured in hours/day, and the vector magnitude (VM), or magnitude of arm movement measured as a single vector magnitude per second, were collected and compared between groups. The correlation between VT and VM and time from C7 spinal nerve harvest was also calculated. At mean 7.7 years after C7 spinal nerve harvest, there was no difference between donor and control arms for VT (5.76±1.55] vs 5.45±1.22 hours, P = 0.56) or VM (2242236±753853 vs 1919223±579723 activity counts, P = 0.20), regardless of donor arm dominance. The C7 harvest cohort used the injured arm 53% of the time and with 27% of the power of the donor arm. There was no significant difference in time or magnitude of arm movement between donor arms and the arms of healthy controls.

Laboratory work in physics "The study of uniformly accelerated motion without initial velocity" using a robotic kit LEGO MINDSTORMS EDUCATION EV3

The article presents an example of using a robotic kit at physics and informatics lessons — a laboratory work "The study of uniformly accelerated motion without initial velocity" using the LEGO MINDSTORMS EDUCATION EV3 kit. This work is intended for students in 9–10th grades when studying uniformly accelerated motion in a physics course. During the laboratory work, it is necessary to: assemble an experimental setup and create a program for the EV3 control module, which should record the time of movement of a ball along an inclined chute with output to the EV3 module screen; enter the obtained measurement results into a calculation table compiled in an electronic spreadsheet, into which formulas for automatic calculation of acceleration and instantaneous velocity of the ball are preliminarily entered. The laboratory work can be carried out both in a physics and an informatics lessons, and in an optional lesson, you can also conduct an integrated physics and informatics lesson. The use of robotic modeling introduces students to the modern process of conducting physical research (experiments), helps to increase students' interest in experimental work, develop their skills in using robots in research and motivation for engineering and technical creativity.

Centering the Most Marginalized: Black Women Movement Actors and Misogynoir in the Movement for Black Lives

This research evaluates the extent to which 30 Black women movement actors (e.g., leaders, organizers, and protestors) narrate their intersectional experiences in the Movement for Black Lives (M4BL) in the District of Columbia and Maryland. Specifically, through the narratives and experiences of Black women movement actors (BWMAs) within contemporary social movements, this work uses sociological intersectionality as a theoretical conceptualization and analytical method to link misogynoir to movement literature. Misogynoir was a recurring, embedded concept that had a sustaining effect on movement goals. Also, the amount of time in movement acted as an important identifier of a structural analysis for BWMAs intersectional interpretations. Joya Misra, Celeste Vaughan Curinton, and Venus Mary Green proffer six tenets of sociological analysis that help to illuminate the tools BWMAs use to challenge local organizations to decenter male-centric goals and center women, queer, and differently abled needs for liberation, toward a more comprehensive movement. Implications for future research are discussed.

Improving the Accuracy of mmWave Radar for Ethical Patient Monitoring in Mental Health Settings.

Monitoring patient safety in high-risk mental health environments is a challenge for clinical staff. There has been a recent increase in the adoption of contactless sensing solutions for remote patient monitoring. mmWave radar is a technology that has high potential in this field due it its low cost and protection of privacy; however, it is prone to multipath reflections and other sources of environmental noise. This paper discusses some of the challenges in mmWave remote sensing applications for patient safety in mental health wards. In line with these challenges, we propose a novel low-data solution to mitigate the impact of multipath reflections and other sources of noise in mmWave sensing. Our solution uses an unscented Kalman filter for target tracking over time and analyses features of movement to determine whether targets are human or not. We chose a commercial off-the-shelf radar and compared the accuracy and reliability of sensor measurements before and after applying our solution. Our results show a marked decrease in false positives and false negatives during human target tracking, as well as an improvement in spatial location detection in a two-dimensional space. These improvements demonstrate how a simple low-data solution can improve existing mmWave sensors, making them more suitable for patient safety solutions in high-risk environments.

Cervical Sensorimotor Function Tests Using a VR Headset-An Evaluation of Concurrent Validity.

Sensorimotor disturbances such as disturbed cervical joint position sense (JPS) and reduced reaction time and velocity in fast cervical movements have been demonstrated in people with neck pain. While these sensorimotor functions have been assessed mainly in movement science laboratories, new sensor technology enables objective assessments in the clinic. The aim was to investigate concurrent validity of a VR-based JPS test and a new cervical reaction acuity (CRA) test. Twenty participants, thirteen asymptomatic and seven with neck pain, participated in this cross-sectional study. The JPS test, including outcome measures of absolute error (AE), constant error (CE), and variable error (VE), and the CRA test, including outcome measures of reaction time and maximum velocity, were performed using a VR headset and compared to a gold standard optical motion capture system. The mean bias (assessed with the Bland-Altman method) between VR and the gold standard system ranged from 0.0° to 2.4° for the JPS test variables. For the CRA test, reaction times demonstrated a mean bias of -19.9 milliseconds (ms), and maximum velocity a mean bias of -6.5 degrees per seconds (°/s). The intraclass correlation coefficients (ICCs) between VR and gold standard were good to excellent (ICC 0.835-0.998) for the JPS test, and excellent (ICC 0.931-0.954) for reaction time and maximum velocity for the CRA test. The results show acceptable concurrent validity for the VR technology for assessment of JPS and CRA. A slightly larger bias was observed in JPS left rotation which should be considered in future research.

ОБҐРУНТУВАННЯ ПОКАЗНИКА ЕФЕКТИВНОСТІ ФОРСУВАННЯ ВОДНОЇ ПЕРЕШКОДИ БРОНЕТРАНСПОРТЕРАМИ ПІД ЧАС ВЕДЕННЯ БОЙОВИХ ДІЙ

The work substantiates the relevance of solving the problem of determining the efficiency indicator of the use of armored wheeled vehicles when carrying out measures to overcome water obstacles during hostilities, taking into account the fact that combat vehicles may receive various types of damage from the enemy's weapons when performing their assigned tasks. To determine the effectiveness of the forcing task of water obstacles by armored personnel carriers during the conduct of hostilities, it is proposed to use a new coefficient of effectiveness of the execution of the combat task, which consists of the coefficients of effectiveness, efficiency and resource provision of the execution of the task. The paper proposes a mathematical model for determining the efficiency indicator of forcing through a water obstacle by armored personnel carriers during combat operations actions if they have combat damage. An armored personnel carrier has stability on water if the metacenter lies above its center of mass. If the total flow of water entering due to damage to the body of the armored personnel carrier is less than or equal to the total productivity of the means of water pumping, then the time of movement of the armored personnel carrier and the distance that it passes in a damaged state, not limited, and the car will reach the shore. If the total flow of water is greater than the productivity of the means of water pumping, then there will be a gradual accumulation of water in the body of the armored personnel carrier. As the water accumulates, the static pressure and the total flow of water due to damage will increase, and the speed of the armored personnel carrier will decrease, the time for forcing the water obstacle will increase. The given dependencies for evaluating the effectiveness of the tasks of forcing the water obstacle by armored personnel carriers during hostilities in the presence of combat damage, allow to determine the influence on the efficiency index of various components and outline the ways to meet the specified requirements for modern models of floating vehicles. The work gives examples of calculations using a mathematical model for determining the efficiency indicator of forcing through a water obstacle by armored personnel carriers during combat operations in the presence of combat damage.

Time-independent relationship between digits closure velocity and hand transport acceleration during reach-to-grasp movements

Prehension movements in primates have been extensively studied for decades, and hand transport and hand grip adjustment are usually considered as the main components of any object reach-to-grasp action. Evident temporal patterns were found for the velocity of the hand during the transport phase and for the digits kinematics during pre-shaping and enclosing phases. However, such kinematics were always analysed separately in regard to time, and never studied in terms of dependence one from another. Nevertheless, if a reliable one-to-one relationship is proven, it would allow reconstructing the digit velocity (and position) simply by knowing the hand acceleration during reaching motions towards the target object, ceasing the usual dependence seen in literature from time of movement and distance from the target. In this study, the aim was precisely to analyse reach-to-grasp motions to explore if such relationship exists and how it can be formulated. Offline and real-time results not only seem to suggest the existence of a time-independent, one-to-one relationship between hand transport and hand grip adjustment, but also that such relationship is quite resilient to the different intrinsic and extrinsic properties of the target objects such as size, shape and position.

People's Multi-party Democracy: A Success Story of the Communist Movement of Nepal

The 1990s was a crucial time in the global communist movement that faced a serious setback after the collapse of the USSR and other East European communist and socialist governments. In Nepal, communist parties allied with the Nepali Congress, a democratic party to stage the people’s movement to end active monarchy and restore democracy. The call for the people’s movement by the parties appealed the people and they took part in the movement in a historic way. That movement succeeded to restore democracy and end the active monarchy. Madan Bhandari, the secretary-general of the Communist Party of Nepal (Marxist and Leninist) witnessed this unprecedented participation of the people in a peaceful democratic movement and realized the need to democratize the communist movement, so that, they could build people’s trust towards communist parties. In the general election held in 1991, communist parties won forty percent of the seats in the parliament and popular votes as well. In this context, Bhandari presented the document of people’s multi-party democracy in the fifth national congress of the Communist Party of Nepal (Marxist and Leninist) held in 1993, and it was passed overwhelmingly in the congress. This article attempts to make a textual analysis of the document of People’s multi-party democracy to examine the major aspects of the document and to see how successful it has become in democratizing the communist movement in Nepal.

The Relationship between Basal Ganglia Volume and Audiovisual Reaction Time in Turkish Elite Athletes

Background: In this study involving young adult elite athletes and healthy sedentary individuals, volumetric analyses were performed on basal ganglia (BG) involved in the coordination of motor movements. Aims and Objectives: In a group of athletes with high coordination speed, potential relationship between BG volumes and audiovisual reaction time of acquired-trained hand movements was explored by examining whether these individuals had significant differences in terms of BG volumes. Materials and Methods: Nineteen elite athletes aged between 19 and 25 years (9 male and 10 female) and 20 sedentary subjects (10 male, 10 female) were included. Gender, age, height, weight, and body-mass index (BMI) were recorded. In each group, audiovisual reaction time and stereological basal ganglia volumes were assessed and statistically analyzed. Results: Elite athletes react more rapidly to auditory stimuli than visual stimuli. As compared to sedentary individuals, elite athletes exhibited significantly shorter visual reaction time and only numerically shorter (statistically insignificant) visual reaction time. Left BG volume was higher in both groups, compared to right side). Conclusion: Our data may contribute to the construction of a database of normal BG morphology and provide useful information for clinicians and athletes.

Novel Approaches for Early Detection of Retinal Diseases Using Artificial Intelligence.

An increasing amount of people are globally affected by retinal diseases, such as diabetes, vascular occlusions, maculopathy, alterations of systemic circulation, and metabolic syndrome. This review will discuss novel technologies in and potential approaches to the detection and diagnosis of retinal diseases with the support of cutting-edge machines and artificial intelligence (AI). The demand for retinal diagnostic imaging exams has increased, but the number of eye physicians or technicians is too little to meet the request. Thus, algorithms based on AI have been used, representing valid support for early detection and helping doctors to give diagnoses and make differential diagnosis. AI helps patients living far from hub centers to have tests and quick initial diagnosis, allowing them not to waste time in movements and waiting time for medical reply. Highly automated systems for screening, early diagnosis, grading and tailored therapy will facilitate the care of people, even in remote lands or countries. A potential massive and extensive use of AI might optimize the automated detection of tiny retinal alterations, allowing eye doctors to perform their best clinical assistance and to set the best options for the treatment of retinal diseases.

Auricular point acupressure for managing postoperative pain and reducing anxiety in patients with perianal abscesses

ObjectiveThe objective of this study is to assess the efficacy of auricular point acupressure in relieving postoperative pain and reducing anxiety among patients with perianal abscesses. MethodsWe included 61 patients with perianal abscesses who were admitted to the Nantong First People's Hospital between July 2019 and June 2020 and were scheduled to undergo one-stage radical surgery. We divided them into the treatment group (n = 31), where patients were administered preoperative auricular acupressure targeting the bilateral Shenmen, subcortical, and other points. They were instructed to apply pressure five to six times per day, each time for about 3–5 min. Patients in the control group (n = 30) received routine preoperative preparation. The treatment duration for both groups was one week. We compared the two groups using the pain visual analog scale (VAS) scores, the use of additional postoperative analgesics, and scores on the Hamilton anxiety and depression scales pre- and post-surgery at 6 h, 24 h, 48 h, 72 h, and 1 week after surgery, as well as at the time of the first bowel movement. ResultsPatients in the treatment group reported lower VAS scores than those of the control group at 48 h, 72 h, 1 week, and at the first defecation post-surgery, and the differences were statistically significant (all P < 0.05). Additional postoperative analgesics were used in seven patients in the treatment group (22.58 %) and in 10 patients in the control group (33.33 %). The difference between the two groups was not statistically significant (χ2 = 0.88, P = 0.35). Postoperative scores for the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D) in the treatment group were significantly lower than those in the control group (P < 0.05). ConclusionThe results of this study demonstrated that auricular point acupressure was effective in alleviating postoperative pain in patients with perianal abscesses and simultaneously reduced their postoperative psychological stress reactions. This dual effect provided both pain relief and a reduction of anxiety with fewer adverse reactions, making it a safe and effective treatment option.

Chronic constipation: current options of pathogenetic therapy

Symptoms of constipation such as derangements of the motor, secretory and/or evacuation functions of the colon are recorded occasionally or for a long period in at least 20% of the population in economically developed countries. QoL is significantly impaired in patients with chronic constipation. The frequency, time of bowel movement and stool consistency is, in large part, determined by the motor function of the colon. The primary approach to the treatment algorithm for chronic constipation (CC) is modification of a lifestyle and a diet rich in dietary fiber. If dietary measures provide poor efficacy, laxatives are prescribed to the patients. According to the current guidelines, therapeutic approaches to the treatment of CC should include the sequential administration of laxatives that increase the volume of contents and stimulate the motor function of the colon. According to the Russian Gastroenterological Association guidelines for the diagnosis and treatment of chronic diseases in adult patients, it is reasonable to use stimulant laxatives as second-line drugs. Contact laxatives, which increase intestinal peristalsis due to stimulation of nerve endings in the intestinal mucosa, have been shown to be more effective in treating chronic constipation than placebo. Among the drugs in this group, Bisacodyl®, a diphenylmethane derivative, and Regulax® Picosulfate, a sodium picosulfate derivative, are the most studied ones. These substances are hydrolyzed into bis-(p-hydroxyphenyl)-pyridyl-2-methane in the intestine, which, on contact with the receptors in colonic mucosa, stimulates propulsive activity and increases intestinal secretions. Regulax® Picosulfate is effective and safe in patients with acute and chronic constipation of various origin.

Physiological Profiling of Agitation in Dementia: Insights From Wearable Sensor Data.

The number of people with dementia is expected to triple to 152 million in 2050, with 90% having accompanying behavioral and psychological symptoms (BPSD). Agitation is among the most critical BPSD and can lead to decreased quality of life for people with dementia and their caregivers. This study aims to explore objective quantification of agitation in people with dementia by analyzing the relationships between physiological and movement data from wearables and observational measures of agitation. The data presented here is from 30 people with dementia, each included for 1 week, collected following our previously published multimodal data collection protocol. This observational protocol has a cross-sectional repeated measures design, encompassing data from both wearable and fixed sensors. Generalized linear mixed models were used to quantify the relationship between data from different wearable sensor modalities and agitation, as well as motor and verbal agitation specifically. Several features from wearable data are significantly associated with agitation, at least the p < .05 level (absolute β: 0.224-0.753). Additionally, different features are informative depending on the agitation type or the patient the data were collected from. Adding context with key confounding variables (time of day, movement, and temperature) allows for a clearer interpretation of feature differences when a person with dementia is agitated. The features shown to be significantly different, across the study population, suggest possible autonomic nervous system activation when agitated. Differences when splitting the data by agitation type point toward a need for future detection models to tailor to the primary type of agitation expressed. Finally, patient-specific differences in features indicate a need for patient- or group-level model personalization. The findings reported in this study both reinforce and add to the fundamental understanding of and can be used to drive the objective quantification of agitation.

Visual behavior of racing bike cyclists in multi-tasking situations

Distracted biking can have serious repercussions for the rider such as accidents. The purpose of the present experiment was to determine the effect of visually monitoring two parameters, the cadence, and the heart rate on a bike computer fixed on a racing bike, and simultaneously detect hazardous traffic situations. Individuals (n = 20) were instructed to ride a racing bike that was fitted onto a roller trainer. After conducting a bicycle step test to assess the maximal heart rate (HFmax), participants were assigned to a within subject-design on a separate day. They were instructed to perform the riding task in two single-task conditions (only watching the traffic at the video with occluded or without occluded bike computer), two multi-tasking conditions (monitoring the cadence of 70 RPM or 90 RPM, monitoring the heart rate, and observing the traffic) and one control condition (no instructions). Percentage dwell time of the eye movements, the constant error from the target cadence, keeping the heart rate in an interval of 50% - 70% of the HFmax, and percentage of the recognized hazard traffic situations were analyzed. The analysis indicated that monitoring the parameters on the bike computer induced no significant decline in perceived hazardous traffic situations.