Time Of Emergence Research Articles

Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia.

General anesthesia has been used in surgical procedures for approximately 180 years, yet the precise mechanism of anesthetic drugs remains elusive. There is significant anatomical connectivity between the ventral tegmental area (VTA) and the prelimbic cortex (PrL). Projections from VTA dopaminergic neurons (VTADA ) to the PrL play a role in the transition from sevoflurane anesthesia to arousal. It is still uncertain whether the prelimbic cortex pyramidal neuron (PrLPyr ) and its projections to VTA (PrLPyr -VTA) are involved in anesthesia-arousal regulation. We employed chemogenetics and optogenetics to selectively manipulate neuronal activity in the PrLPyr -VTA pathway. Electroencephalography spectra and burst-suppression ratios (BSR) were used to assess the depth of anesthesia. Furthermore, the loss or recovery of the righting reflex was monitored to indicate the induction or emergence time of general anesthesia. To elucidate the receptor mechanisms in the PrLPyr -VTA projection's impact on anesthesia and arousal, we microinjected NMDA receptor antagonists (MK-801) or AMPA receptor antagonists (NBQX) into the VTA. Our findings show that chemogenetic or optogenetic activation of PrLPyr neurons prolonged anesthesia induction and promoted emergence. Additionally, chemogenetic activation of the PrLPyr -VTA neural pathway delayed anesthesia induction and promoted anesthesia emergence. Likewise, optogenetic activation of the PrLPyr -VTA projections extended the induction time and facilitated emergence from sevoflurane anesthesia. Moreover, antagonizing NMDA receptors in the VTA attenuates the delayed anesthesia induction and promotes emergence caused by activating the PrLPyr -VTA projections. This study demonstrates that PrLPyr neurons and their projections to the VTA are involved in facilitating emergence from sevoflurane anesthesia, with the PrLPyr -VTA pathway exerting its effects through the activation of NMDA receptors within the VTA.

HUBUNGAN POSISI APOKOL DALAM PERKECAMBAHAN AREN (Arenga pinnata Merr.) DENGAN PERTUMBUHAN KECAMBAH DAN KERAGAMAN GENETIK

Sugar palm seed germination does indicate by the appearance of a tissue that extends like a sponge called apokol which is penetrating the hard seed coat and can occur in several positions in germinated sugar palm seeds. No research reports discuss the relationship between this apokol position and the phenology of sugar palm seed germination. This research aims to study the relationship between apokol position and the growth of sugar palm seedlings and their genetic diversity. The research applies Experiment in Completely Random Design with four treatments, each repeated five times. The four treatments are the apokol position, namely A: Apokol in right-center, B: Apokol in left-center, C: Apokol in left-bottom, and D: Apokol in right-bottom. The results showed that the fastest time for the coleoptile emergence was 40 days after transplanting in the right-center apokol position. Morphologically, there was no significant difference in the sugar palm seedling growth with each apokol position. On the other hand, we found that there were genetic diversities among them revealed by Simple Sequence Repeat (SSR) markers. The palm seeds with the right-center apokol position included the first cluster, and the second cluster consisted of left-center apokol, right- bottom apokol, and left-bottom apokol.

A statistical study of magnetic flux emergence in solar active regions prior to strongest flares

Abstract Using the data on magnetic field maps and continuum intensity for Solar Cycles 23 and 24, we explored 100 active regions (ARs) that produced M5.0 or stronger flares. We focus on the presence/absence of the emergence of magnetic flux in these ARs 2-3 days before the strong flare onset. We found that 29 ARs in the sample emerged monotonously amidst quiet-Sun. A major emergence of a new magnetic flux within pre-existing AR yielding the formation of a complex flare-productive configuration was observed in another 24 cases. For 30 ARs, an insignificant (in terms of the total magnetic flux of pre-existing AR) emergence of a new magnetic flux within the pre-existing magnetic configuration was observed; for some of them the emergence resulted in a formation of a configuration with a small $\delta$-sunspot. 11 out of 100 ARs exhibited no signatures of magnetic flux emergence during the entire interval of observation. In 6 cases the emergence was in progress when the AR appeared on the Eastern limb, so that the classification and timing of emergence were not possible. We conclude that the recent flux emergence is not a necessary and/or sufficient condition for strong flaring of an AR. The flux emergence rate of analyzed here flare-productive ARs was compared with that of flare-quiet ARs analyzed in our previous studies. We revealed that the flare-productive ARs tend to display faster emergence than the flare-quiet ones do.

The Impact of a Six-Hour Light-Dark Cycle on Wheat Ear Emergence, Grain Yield, and Flour Quality in Future Plant-Growing Systems.

Cultivating wheat (Triticum aestivum) in a closed environment offers applications in both indoor farming and in outer-space farming. Tailoring the photoperiod holds potential to shorten the growth cycle, thereby increasing the annual number of cycles. As wheat is a long-day plant, a night shorter than a critical length is required to induce flowering. In growth chambers, experiments were conducted to examine the impact of a 6 h light-dark cycle on the timing of wheat ear emergence, grain yield, and flour quality. Under equal daily light-integral conditions, the 6 h light-dark cycle promoted growth and development, resulting in accelerated ear emergence when compared to a 12 h cycle, additionally indicating that 12 h of darkness was excessive. To further stimulate heading and increase yield, the 6 h cycle was changed at the onset of stem elongation to a 14 h-10 h, mimicking spring conditions, and maintained until maturity. This successful transition was then combined with two levels of light intensity and nutrient solution, which did not significantly impact yield, while tillering and grain ripening did increase under higher light intensities. Moreover, it enabled manipulation of the baking quality, although lower-end falling numbers were observed. In conclusion, combining a 6 h light-dark cycle until stem elongation with a 14 h-10 h cycle presents a promising strategy for increasing future wheat production in closed environments. The observation of low falling numbers underscores the importance of factoring in flour quality when designing the wheat-growing systems of the future.

Growth and production of sweet corn (Zea mays saccharata Sturt.) as an intercrop in immature oil palm plantations (TBM 2) on dystrudepts soil given MB green manure (Mucuna bracteata) and NPK fertilizer

This research aims to examine the interaction, the main effects of Mucuna bracteata green fertilizer, NPK and obtain a combination that produces the highest production of sweet corn. The research was carried out in Kembang Damai Village, Pagaran Tapah Darussalam District, Rokan Hulu Regency from April to July 2023. The research was carried out experimentally using a factorial randomized block design, where factor I was the provision of Mucuna bracteata green fertilizer consisting of 3 levels, namely 4.18 . t.ha -1 , 8.36 t.ha -1 and 12.54 t.ha -1 . Factor II is the provision of NPK which consists of 3 levels, namely 0.1 t.ha -1 , 0, 2 t.ha -1 and 0.3 t.ha -1 , so there are 9 treatment combinations and they are repeated 3 times, so there are 27 experimental units. The parameters observed were the amount of chlorophyll, photosynthesis rate, transpiration rate, stomatal conductivity, and CO2 concentration in cells, plant height, time when female flowers appeared, harvest age, weight of cobs with husks, and weight of cobs without husks. The variance data was further tested using Duncan's multiple distance test at the 5% level. The results of the research showed that there was an interaction between Mucuna bracteata and NPK green manure treatment on the parameters of female flower emergence time, harvest age and husk ear weight, but not on other parameters . The application of Mucuna bracteata green fertilizer had a significant effect on the time the female flowers appeared, the age of harvest, and the weight of the husk cobs. NPK fertilizer has a significant effect on harvest age and husk cob weight. Providing Mucuna bracteata green fertilizer 12.5 t.ha -1 and NPK 0.2 t.ha -1 is a combination that provides higher production results in the weight parameter of husk cobs, namely 527,833 g per plant.

Understanding the impact of COVID-19 Outbreak on Primary School-aged Children in Sindh: A Contextual Analysis of Post-Pandemic Education

COVID-19 has changed the way we lived, worked and learnt. It has adversely impacted everyone, especially the most vulnerable groups: people with disabilities, senior citizens and children. The negative effects on children's health, socio-psychological development, and intellectual advancement are regarded to be unprecedented in recent human history. This paper examines the educational system of Hyderabad, a city in Sindh, Pakistan during COVID-19 and it investigates the negative effects on children and their school learning. This study is interdisciplinary, focusing on Applied Anthropology and Education policy and pedagogy. Mixed methods both qualitative as well as quantitative are used to collect and analyse the data. For qualitative data collection, ethnographic research methods such as participant observation, semi-structured interviews and case study are used. Surveys through digital sources such as email, WhatsApp, Facebook and SMS are implied to collect quantitative data. Ethnographic fieldwork was conducted in a Government Primary School (GPS), Hyderabad, Pakistan. The findings of the study reveal that post COVID-19 has impacted the school learning and experience of educational attainment in multiple ways to the primary school aged going children. Moreover, it has also revealed the uneven socio-economic opportunities for learning, and discloses the government's inability to reach out to the most vulnerable class of the society in the time of emergency.

Influence of tillage methods and soil crust breakers on cotton seedling emergence in silty-loam soil

Soil crusting is a common problem that affects crop emergence and growth worldwide across different soil and climate conditions. This study aimed to investigate the impact of various tillage methods on soil crust formation and assess the effectiveness of soil crust breakers in enhancing cotton seedling emergence. The research was conducted on Silty-Loam soil, examining the impact of four tillage methods: Method A, a conventional tillage approach employing a moldboard plow, disc harrow, and roller; Method B, a conservation tillage method involving a chisel plow, disc harrow and roller; Method C, another conventional tillage method utilizing a chisel plow, powered rotary tiller, and roller; and Method D, another conservation tillage approach utilizing a disc harrow and roller. Two types of crust breakers, a rolling type, and a skid blade type, were tested. The results showed significant variations in soil crusting hardness among the tillage methods, with conservation tillage methods B and D being the most effective in reducing penetration resistance. The post-crust-breaking penetration resistance declined, decreasing from 305 to 408 kPa in the control plots to 60–93 kPa in the treated plots. Breaking the soil crust with the crust breakers considerably reduced penetration resistance, improving soil conditions for seedling emergence and root growth. Seedling emergence was significantly influenced by tillage methods, with conservation tillage methods B and D promoting the highest emergence rates. The mean percent emergence of subplots (with crust breaker applications) was 77.8% when the chisel plow, disc harrow, and roller were applied (Method B) and 78.2% when the disc harrow and roller were applied for tillage (Method D). The percentage of emerged cotton seedlings in the control plots ranged from 51.1% to 86.2%, with the tillage method order of C < A < B < D. However, the soil crust-breaking treatments were effective in increasing the percentage of emerged cotton seedlings for all tillage methods. The rolling-type crust breaker was particularly effective in breaking the crust and enhancing emergence for methods A and C. It increased the emergence percentage by 27.1% for method A and 34% for method C. The study also revealed that the hardness of the soil crust significantly affected emergence time and emergence rate index. Harder soil crusts resulted in longer mean emergence times and lower emergence rate indices. The conventional tillage method involved a chisel plow, powered rotary tiller, and roller, contributing to a harder soil crust with the highest penetration resistance recorded at 408 kPa for the control plot (without soil crust breaking). This resulted in the longest emergence time of 9.8 days and the lowest emergence rate index of 0.38 seedlings/m·day. However, after the soil crust-breaking treatment, the differences in emergence time and emergence rate indices among different tillage methods and crust breakers became statistically insignificant (P>0.05).

Views of Nigerian civil servants about compulsory COVID-19 vaccination: A qualitative study.

COVID-19 caused unforeseen global burden, although vaccine strategy rapidly stalled transmission and protected those at risk. Many governments made vaccination mandatory for public space access. This study aimed to elucidate perception of Nigerian civil servants towards mandatory COVID-19 vaccination and elicited their recommendations. This study was conducted in twelve purposively selected states in the six geopolitical zones and the Federal Capital Territory (FCT), Nigeria. Relevant ministries, departments and agencies were selected within the study sites. It was a qualitative study that interviewed consenting civil servants. Ethical approval was obtained from the National Health Research Ethics Committee. Interviews were conducted in person, following a pre-test. Data was analysed using NVivo software version 12. Most participants were willing to take the vaccine if their safety was assured. However, enforcement to do so was a hindrance. Most participants commended the government for the effort to curb COVID-19 transmission and create awareness but were displeased with planning and handling of misconceptions. They recommended a more committed approach to vaccine production and funding by the government. Participants were willing to take the COVID-19 vaccines because the gains of protection outweighed the risks. They suggested a less involuntary approach through reinforcing awareness creation and avoiding threats.Contribution:There is limited qualitative research on perception of Nigerian civil servants regarding mandatory COVID-19 vaccination. Being the main driving force of Nigeria's public service, their views are invaluable. Findings could contribute to future policies in times of emergency.

Like a bridge over troubled water: Wellbeing and trust in governance during turbulent times

The COVID-19 pandemic extended interest in the relationships between citizens and governments in turbulent times of crises and emergencies. While the pandemic generated a critical existential threat to the lives of many, it also had a significant effect on the quality of life and on the wellbeing of even larger populations. This paper deals with the relationship between the wellbeing of citizens and three types of trust in governance (i.e. trust in political institutions, trust in public administration, trust in enforcement institutions) during the pandemic. We aim at advancing knowledge on both wellbeing and trust during crises, and more specifically on direct and indirect patterns of these important relationships. To do so, we suggest alternative models and a series of hypotheses aimed at examining them empirically. Two datasets on Israeli citizens are used. They were collected over two points in time during the heat of the pandemic and toward its decline and end (Study 1/t1; N = 1026 and Study 2/t2; N = 3024) and largely represent major sectors and ethnicities in the population. The findings generally support a positive relationship between wellbeing and trust, but more importantly indicate that during crisis, trust in public administration and enforcement institutions mediates the relationship between wellbeing and trust in political institutions. We thus argue that the public service may act as a bridge between citizens’ wellbeing and political trust. In our view, the findings testify to the complexity of the wellbeing–trust relationship, especially in challenging times. Implications and directions for future studies are suggested. Points for practitioners Trust in governance is different for various political institutions and for different public administration organizations, especially in turbulent times Civil servants should be aware of citizens’ wellbeing during crises as it affects trust in governance Citizen trust and wellbeing are significantly related in times of emergency and crises

Impact of anthropogenic warming on emergence of extreme precipitation over global land monsoon area

Human activities have led to a global temperature increase, and the primary objective of the Paris Agreement is to limit this rise to 1.5 °C of warming level. Understanding the impact of global warming beyond preindustrial conditions on precipitation intensity is crucial for devising effective adaptation and mitigation strategies, particularly in densely populated global land monsoon (GLM) regions. However, the time of emergence (ToE) of extreme summer monsoon precipitation and its dependency on global warming targets has rarely been investigated. Using large ensemble simulations forced by the SSP3–7.0 scenario, we reveal that the impacts of anthropogenic forcing on extreme precipitation intensity become evident in GLM regions before 2050, accompanied by a sudden expansion in areas where the ToE of extreme precipitation occurs. Furthermore, our study demonstrates that achieving the Paris Agreement goal at 1.5 °C of global warming level can prevent the ToE of extreme precipitation in Asian and African monsoon regions. This, in turn, has the potential to halve the number (over one billion) of individuals exposed to extreme precipitation. These findings highlight the urgent need for action to mitigate the risk associated with anthropogenic warming induced climate change.

“I Just Know if I Keep Going, I’ll End Up Hating Nursing.” Lived Experiences of Emergency Nurses Three Years Into the Global COVID-19 Pandemic

IntroductionAs the coronavirus disease 2019 pandemic continues globally, the personal and professional pressure on health care workers continues to accumulate. Literature suggests that as the pandemic evolves, nurses are experiencing increased levels of anxiety, depression, and post-traumatic stress, ultimately leading them to voice intentions to leave the profession, if they have not done so already. MethodsInformed by an interpretive hermeneutic phenomenological approach, this longitudinal study was designed to capture how the lived experiences of 9 emergency nurses evolved over the coronavirus disease 2019 pandemic, highlighting their feelings, attitudes, and perceptions toward working in the emergency department at this time in history. Interviews were undertaken in June 2022 and were analyzed using a thematic analysis approach. ResultsData analysis resulted in a total of 2 major themes and 8 minor themes. The 2 major themes included “exposed wounds” and “Band-Aid solutions.” Levels of burnout increased during the pandemic, with most of the emergency nurse participants dropping their hours, moving roles within the profession, or leaving the profession entirely. Findings elucidate where and how concerns may arise in clinical practice and holistic well-being among emergency nurses, particularly surrounding professional boundaries and protecting work-life balance and professional identity. DiscussionAs the world moves to managing coronavirus disease 2019 as a recognized common respiratory illness, providing time and space for emergency nurses to voice their concerns, design their well-being interventions, set professional boundaries, and reconnect with their professional passion may see lower attrition rates and higher levels of professional satisfaction in emergency nurses globally.

Comparison of Opioid-Based Versus Opioid-Sparing Anesthesia in Patients Undergoing Glioma Surgery.

Background In the neurosurgical population, opioids may cause respiratory depression, leading to hypercapnia, increased cerebral blood flow (CBF), and ultimately increased intracranial pressure (ICP), which can mask early signs of intracranial complications and delayed emergence. This study was designed to compare perioperative hemodynamic stability, analgesia, and recovery parameters in opioid-based (fentanyl) general anesthesia versus opioid-sparing (dexmedetomidine) general anesthesia in patients undergoing glioma surgeries. Methodology This prospective observational comparative study compared 52 patients in two groups. Twenty-six (50%) patients in group F received Inj. fentanyl IV (intravenous; bolus 2 mcg/kg 10 minutes before induction and then infusion 1 mcg/kg/hour till 30 minutes before skin closure), whereas 26(50%) patients in group D received Inj. dexmedetomidine IV (0.5 mcg/kg infusion 10 minutes before induction and then maintenance with a 0.5 mcg/kg/hour infusion till 30 minutes before skin closure). Perioperative heart rate (HR), mean arterial pressure (MAP), Numerical Rating Scale for Pain (NRS) assessment and postoperative emergence time, modified Aldrete score,patient satisfaction, and surgeon satisfaction score were estimated and compared in both groups. Results The mean HR was less in group D compared to group F at following time points - 10 minutes after infusion (P= 0.006), laryngoscopy and intubation (P= 0.003), pinning of the skull (P< 0.001), one hour after dura opening (P= 0.007), two hours after dura opening (P = 0.006), five minutes after extubation (P< 0.001), and 30 minutes after extubation (P= 0.011). MAP was lower in group D compared to group F at the following time intervals: 10 minutes after infusion (P= 0.008), five minutes after extubation (P= 0.007), 30 minutes after extubation (P< 0.001), and one hour after extubation (P= 0.023). A significant decrease in emergence time in group D compared to group F (P< 0.001) was noted. NRS was lower in group D at eight hours (P= 0.005) and 12 hours (P< 0.001) post-extubation. Conclusions Dexmedetomidine can be used as an alternative to fentanyl in terms of perioperative hemodynamic stability, perioperative analgesia, smooth early recovery from anesthesia, patient satisfaction, and surgeon satisfaction.

Comparing Perioperative Outcomes of Total Intravenous Anesthesia (TIVA) With Volatile Anesthesia in Patients With Obesity: A Systematic Review.

In this systematic review, the perioperative outcomes of total intravenous anesthesia (TIVA) and volatile anesthesia were compared in obese adults (BMI ≥ 30 kg/m²) undergoing elective surgery. The review analyzed data from 12 randomized-controlled trials involving 935 patients, sourced from PubMed/MEDLINE (Medical Literature Analysis and Retrieval System Online), Cochrane, Scopus, and Web of Science databases. The focus was on intraoperative vital signs, emergence time, postoperative nausea and vomiting (PONV), duration of post-anesthesia care unit (PACU) stay, and ICU admission rates. Findings showed that TIVA (using propofol) might reduce PONV, but there were no significant differences in other outcomes compared to volatile anesthesia (with desflurane as the most common agent). The review highlights the need for more research, especially comparing sevoflurane with TIVA, to establish clear clinical guidelines for anesthesia in obese patients.

Research hot spots and trends of keratoconus in China: a bibliometric analysis

Objective: To review the studies related to keratoconus in China, investigate research hotspots and development trends in this field, and provide reference for future research. Methods: This is a bibliometrics study. The relevant literature written in Chinese was retrieved from the WanFang DATA and the China National Knowledge Infrastructure, English articles were collected from the Web of Science Core Collection database. Searched for journal articles related to keratoconus VOSviewer software, CiteSpace, and Bibliometrix in the R language were employed to create the knowledge map. The analysis encompassed the distribution of published journals, research collaboration networks of countries/regions, institutions, and authors. Additionally, core authors, high-frequency keyword co-occurrence, keyword topic maps, and keyword emergence time ranking were examined. Results: The study ultimately included 1 100 Chinese articles and 668 English articles. Chinese literature and English literature began to increase in 1997 and 2009, respectively, indicating that the field is currently in a developmental stage. The publications involved 244 Chinese journals and 150 English journals, predominantly in the field of ophthalmology. The United States collaborated the most with China, contributing to 123 articles, followed by other countries such as the United Kingdom and Switzerland. Chinese literature and English literature involved 552 and 883 institutions, respectively. The institution with the highest number of Chinese literature publications was the Eye Institute of Shandong First Medical University (63 papers), while Wenzhou Medical University had the highest number of English literature publications (91 papers). Chinese literature involved 2 435 authors, and English literature involved 2 073 authors. The largest collaboration cluster in Chinese literature was formed by the teams of Xie Lixin and Shi Weiyun, while the Gao Hua team formed the largest cluster in English literature. However, collaboration between authors was primarily limited to within each team. A total of 622 and 1 611 keywords were extracted from Chinese and English literature, respectively. The node centrality of the four Chinese keywords, "keratoconus", "cornea", "corneal transplantation" and "myopia" as well as the three English keywords, "keratoconus", "collagen cross-linking" and "penetrating keratoplasty" was greater than 0.1. "Collagen", "riboflavin", "corneal transplantation" and "ultraviolet A" were identified as common core hotspots and important research topics in Chinese and English literature on keratoconus. Keyword emergence analysis indicated that the keywords with the highest intensity of emergence in Chinese and English literature were "myopia" (13.54) and "penetrating keratoplasty" (9.99), respectively. The longest emergence time was observed for "contact lenses" (1995-2006) and "penetrating keratoplasty" (2003-2014). Conclusions: At present, research on keratoconus in China is on the rise, with research hotspots including pathogenesis, various new surgical methods, and improvement in quality of life. The future research trend mainly focuses on early diagnosis and screening methods, artificial intelligence, biomechanical examination, subclinical keratoconus, and small incision lenticule extraction.

Phylogenetics, Epidemiology and Temporal Patterns of Dengue Virus in Araraquara, São Paulo State.

Dengue virus (DENV) is a prominent arbovirus with global spread, causing approximately 390 million infections each year. In Brazil, yearly epidemics follow a well-documented pattern of serotype replacement every three to four years on average. Araraquara, located in the state of São Paulo, has faced significant impacts from DENV epidemics since the emergence of DENV-1 in 2010. The municipality then transitioned from low to moderate endemicity in less than 10 years. Yet, there remains an insufficient understanding of virus circulation dynamics, particularly concerning DENV-1, in the region, as well as the genetic characteristics of the virus. To address this, we sequenced 37 complete or partial DENV-1 genomes sampled from 2015 to 2022 in Araraquara. Then, using also Brazilian and worldwide DENV-1 sequences we reconstructed the evolutionary history of DENV-1 in Araraquara and estimated the time to the most recent common ancestor (tMRCA) for serotype 1, for genotype V and its main lineages. Within the last ten years, there have been at least three introductions of genotype V in Araraquara, distributed in two main lineages (L Ia and L Ib, and L II). The tMRCA for the first sampled lineage (2015/2016 epidemics) was approximately 15 years ago (in 2008). Crucially, our analysis challenges existing assumptions regarding the emergence time of the DENV-1 genotypes, suggesting that genotype V might have diverged more recently than previously described. The presence of the two lineages of genotype V in the municipality might have contributed to the extended persistence of DENV-1 in the region.

Climate change impacts on regional fire weather in heterogeneous landscapes of central Europe

Abstract. Wildfires have reached an unprecedented scale in the Northern Hemisphere. The summers of 2022 and 2023 demonstrated the destructive power of wildfires, especially in North America and southern Europe. Global warming leads to changes in fire danger. Specifically, fire seasons are assumed to become more extreme and will extend to more temperate regions in northern latitudes in the future. However, the extent to which the seasonality and severity of fire danger in regions of central Europe will change in the future remains to be investigated. Multiple studies claim that natural variability and model uncertainty hide the trend of increasing fire danger in multi-model climate simulations for future potentially fire-prone areas. Such a trend might be isolated with single-model initial-condition large ensembles (SMILEs), which help scientists to distinguish the forced response from natural variability. So far, the SMILE framework has only been applied for fire danger estimation on a global scale. To date, only a few dynamically downscaled regional SMILEs exist, although they enhance the spatial representation of climatic patterns on a regional or local scale. In this study, we use a regional SMILE of the Canadian Regional Climate Model version 5 Large Ensemble (CRCM5-LE) over a region in central Europe under the RCP8.5 (Representative Concentration Pathway) scenario from 1980 to 2099 to analyze changes in fire danger in an area that is currently not fire prone. We use the Canadian Forest Fire Weather Index (FWI) as a fire danger indicator. The study area covers four heterogeneous landscapes, namely the Alps, the Alpine Foreland, the lowlands of the South German Escarpment, and the Eastern Mountain Ranges of the Bavarian Forest. We demonstrate that the CRCM5-LE is a dataset suitable for disentangling climate trends from natural variability in a multi-variate fire danger metric. Our results show the strongest increases in the median (50th) and extreme (90th) quantiles of the FWI in the northern parts (South German Escarpment and Eastern Mountain Ranges) of the study area in the summer months of July and August. There, high fire danger becomes the median condition by the end of the century, and levels of high fire danger occur earlier in the fire season. The southern parts (Alps and Alpine Foreland) are less strongly affected by changes in fire danger than the northern parts. However, these regions reach their time of emergence (TOE) in the early 2040s because of very low current fire danger. In the northern parts, the climate change trend exceeds natural variability only in the late 2040s. We find that today's 100-year FWI event will occur every 30 years by 2050 and every 10 years by the end of the century. Our results highlight the potential for severe future fire events in central Europe, which is currently not very fire prone, and demonstrate the need for fire management even in regions with a temperate climate.

Expanded, compressed, or equal? Interactions between spawning window and stream thermal regime generate three responses in modeled juvenile emergence for Pacific salmon

Climate warming poses challenges to native fish, particularly at high latitudes. We used incubation models to explore how interactions between spawning timing and daily varying water temperature affected emergence timing for five species of Pacific salmon in 33 thermally diverse streams in south-central Alaska. Interactions between spawning timing and stream thermal regime led to three different emergence timing responses: (1) “expanded” by typically 2–3 times the duration of the spawning window for summer spawning salmon at streams with a large annual water temperature range; (2) “equal” in duration to the spawning window, regardless of spawning timing, at streams with upwelling groundwater; and (3) “compressed” for late-spawning salmon where water temperature was cooler at spawning than at emergence. Across all sites, a ±15-day range in spawning timing had influence similar to anomalously warm winters (+2 °C to +3 °C) on the emergence timing window. Differences among species, spawning timing, and thermal regimes suggest that a range of adaptations in spawning behavior will likely enable Pacific salmon populations to accommodate shifting thermal regimes during their early life history.

Emergent Time and Time Travel in Quantum Physics

Entertaining the possibility of time travel will invariably challenge dearly-held concepts in fundamental physics. It becomes relatively easy to construct multiple logical contradictions using differing starting points from various well-established fields of physics. Sometimes, the interpretation is that only a full theory of quantum gravity will be able to settle these logical contradictions. Even then, it remains unclear if the multitude of problems could be overcome. Yet as definitive as this seems to the notion of time travel in physics, such recourse to quantum gravity comes with its own, long-standing challenge to most of these counter-arguments to time travel: These arguments rely on time, while quantum gravity is (in)famously stuck with the problem of time. One attempt to answer this problem within the canonical framework resulted in the Page–Wootters formalism, and its recent gauge-theoretic reinterpretation as an emergent notion of time. Herein, we will begin a program to study toy models implementing the Hamiltonian constraint in quantum theory, with an aim toward understanding what an emergent notion of time can tell us about the (im)possibility of time travel.

The Safety of the Laryngeal Mask Airway in Adenotonsillectomy: A Systematic Review and Meta-Analysis.

Adenotonsillectomy is one of the most common surgical procedures worldwide. The current standard for securing the airway in patients undergoing adenotonsillectomy is endotracheal tube (ETT) intubation. Several studies have investigated the use of the laryngeal mask airway (LMA) in this procedure. We conducted a systematic review and meta-analysis to compare the safety and efficacy of the LMA versus ETT in adenotonsillectomy. Databases were searched from inception to 2022 for randomized controlled trials and comparative studies. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The primary outcome is the rate of perioperative respiratory adverse events (PRAEs). Secondary outcomes included the rate of conversion to ETT, desaturations, nausea/vomiting, and surgical time. A subgroup analysis, risk of bias, publication bias, and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessments were also performed. Twelve studies were included in the analysis (4176 patients). The mean overall conversion to ETT was 8.36% [95% confidence interval (CI) = 8.17, 8.54], and for the pediatric group 8.27% (95% CI = 8.08, 8.47). The mean rate of conversion to ETT secondary to complications was 2.89% (95% CI = 2.76, 3.03) while the rest was from poor surgical access. Overall, there was no significant difference in PRAEs [odds ratio (OR) 1.16, 95% CI = 0.60, 2.22], desaturations (OR 0.79, 95% CI = 0.38, 1.64), or minor complications (OR 0.89, 95% CI = 0.50, 1.55). The use of LMA yielded significantly shorter operative time (mean difference -4.38 minutes, 95% CI = -8.28, -0.49) and emergence time (mean difference -4.15 minutes, 95% CI = -5.63, -2.67). For adenotonsillectomy surgery, LMA is a safe alternative to ETT and requires less operative time. Careful patient selection and judgment of the surgeon and anesthesiologist are necessary, especially given the 8% conversion to ETT rate.

Seasonal phenology of the little brown bat (Myotis lucifugus) at 60° N

AbstractTo investigate the impact of short summers and long summer solar periods at high latitudes on the behavior of a nocturnal, hibernating mammal, we recorded the phenology of Myotis lucifugus (little brown myotis) at 60° N in the Northwest Territories (NWT), Canada. In particular, we assessed the timing of spring emergence from, and autumn entry into, hibernation, reproduction, and seasonal mass fluctuations. We used a combination of acoustic monitoring and capture surveys at two hibernacula and two maternity roosts during 2011 and 2012. Myotis spp. were active at the hibernacula from late April to late September/early October, suggesting that the “active” season length is similar to that of populations farther south. At maternity colonies, we detected M. lucifugus activity from early May to early October, with peaks during mid‐July in both years. Lactation, fledging, and weaning all occurred later in the NWT than at more southern locations, and reproductive rates were significantly lower than rates observed farther south. The average mass of individuals fluctuated throughout the season, with an initial decline immediately following emergence from hibernation likely reflecting increased energy expenditure due to flight and decreased use of torpor, coupled with relatively low prey intake due to low prey abundance associated with cool temperatures. Females did not appear to have lower pre‐hibernation masses than those in more southern populations, suggesting that despite the cool spring and autumn temperatures, and short summer nights, bats are able to obtain enough energy for reproduction and mass accumulation for hibernation. However, the lower reproductive rates may indicate that there are limitations to life at the northern limits of the species' range.