Timed Walk Test Research Articles

Effect of Self-perceived Fatigue on Balance and Functional Mobility in Middle-Aged Obese Women.

The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p<0.05). The reported exercise habits of the fatigue group were found to be significantly lower than their non-fatigued peers (p<0.05). The level of functional mobility (Timed Up and Go Test), static balance (One-Legged Stance Test with Eyes Open) and dynamic balance (Functional Reach Test and the 3-meter Timed Tandem Walk Test) were measured, and statistically significant differences were found between fatigue and non-fatigue groups on all of them (p<0.05). In addition, correlations were found between the sub-parameters of the CIS-T scale and the functional tests at.

High-intensity interval ergometer training improves aerobic capacity and fatigue in patients with multiple sclerosis

Moderate endurance training leads to a significant improvement of aerobic fitness and fatigue in patients with multiple sclerosis (MS). However, the effects of high-intensity interval training (HIIT) have not systematically investigated. To determine the effects of short-term HIIT on aerobic fitness and fatigue in MS patients. Prospective monocentric, randomized, simple blinded cohort study. Participants exercised for 8 weeks on a bicycle ergometer three times weekly for 8 weeks. Forty patients with relapsing–remitting MS and an extended disability status score (EDSS) of < 3.5 participated. For 8 weeks, participants exercised three times weekly for 30 min according to two different protocols (HIIT versus moderate endurance training). Measurements were taken at baseline and after 8 weeks of training. Individual aerobic fitness (VO2peak) was assessed via a stepwise ramp protocol, fatigue by the Fatigue Severity Scale (FSS), and ambulation was measured by the Timed 25-Foot Walk Test (T25-FW). Data were analysed according to the intention-to-treat (ITT) approach. Aerobic fitness increased significantly in the HIIT group (pre: 26.7 ± 6.1, post: 29.7 ± 6.6 ml/min/kg; p < 0.04). No changes with regard to FSS and T25FW were detected in both groups. However, sub-group analysis revealed a significant decrease of fatigue in patients with elevated baseline fatigue (pre: 5.00 ± 0.7, post: 4.7 ± 1.2; p = 0.03). HIIT is a promising time-efficient approach in subjects with MS leading to rapid improvement of aerobic fitness.

Oxygen compared to air during exercise training in COPD with exercise-induced desaturation.

Almost half the patients referred to pulmonary rehabilitation with chronic obstructive pulmonary disease (COPD) desaturate during exercise. Although oxygen supplementation may ameliorate oxygen desaturation, the effects on outcomes of exercise training have not been rigorously evaluated. This study aimed to determine whether supplemental oxygen during exercise training was more effective than medical air in improving exercise capacity and health-related quality of life (HRQoL) in people with COPD.People with COPD who demonstrated oxygen desaturation <90% during the 6-min walk test were recruited to this multicentre trial with randomisation (independent, concealed allocation) to either an Oxygen group or Air group, blinding (participants, exercise trainers and European Respiratory Journal assessors) and intention-to-treat analysis. Both groups received the respective gas from concentrators via nasal prongs at 5 L·min-1 during exercise training consisting of treadmill and cycle exercise, three times per week for 8 weeks. Primary outcomes were the endurance shuttle walk test (ESWT) time and Chronic Respiratory Disease Questionnaire (CRQ)-Total score.111 participants (60 males), mean±sd age 69±7 years, with moderate to severe COPD were recruited and 97 completed (Oxygen group n=52; Air group n=45). At the end of the 8-week training programme there were no between-group differences in change in ESWT (mean difference 15 s (95% CI -106-136 s) or change in CRQ-Total (0.0 points (95% CI -0.3-0.3 points)). Within-group changes at end-training were significant for ESWT and CRQ-Total (all p<0.01).Exercise capacity and HRQoL improved in both groups, with no greater benefit from training with supplemental oxygen than medical air.

Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults

Growth and differentiation factor 15 (GDF-15) has been associated with obesity, muscle wasting, and cachexia. The receptor for GDF-15 was recently identified in the brainstem and regulates food intake and metabolism. The relationship of plasma GDF-15 with the age-associated decline of muscle mass and strength, gait speed, and physical performance in adults has not been well characterized. Plasma GDF-15, grip strength, 6-m gait speed, 400-m walking test time, lower extremity physical performance score, appendicular lean mass, and fat mass were measured in 194 healthy adult participants, aged 22-93 years, of the Baltimore Longitudinal Study of Aging. Plasma GDF-15 concentrations increased with age (p < .001) and were higher in whites compared with blacks and Asians (p = .04). Adults with higher plasma GDF-15 had slower 6-m gait speed, longer 400-m walking time, and lower physical performance score in multivariable analyses adjusting for age and race. Plasma GDF-15 was not associated with grip strength, appendicular lean mass, or fat mass. Elevated plasma GDF-15 is associated with slower gait speed, higher 400-m walking time, and lower physical performance in very healthy community-dwelling adults. The relationship between plasma GDF-15 and sarcopenia-related outcomes may be stronger in the population not selected to be healthy, and this hypothesis should be tested in a representative population.

The Effectiveness of Driving Game on Trunk Control and Gait Ability in Stroke

Patients who require neurological rehabilitation often do not comply with conventional programs because they find the therapy uninteresting. As a result, specialized interactive video games have been designed to be more enjoyable than conventional therapy (CT) tasks. This study aimed to assess the trunk control and gait ability of patients with chronic stroke after participation in driving-based interactive video games (DBIVG). Participants included 24 chronic stroke patients allocated to an experimental group (n = 13, CT + DBIVG) or a control group (n = 11, CT + treadmill walking training). Both groups received CT five days/week; the experimental and control groups participated in DBIVG and treadmill walking training, respectively, three days/week for four weeks. The primary outcome of trunk control was measured by the trunk impairment scale (TISall) and TIS subscales, including static sitting balance (TISssb), dynamic sitting balance (TISdsb), and trunk co-ordination (TISco). Gait ability was measured by the dynamic gait index (DGI), timed walking test (TWT), and time up and go test (TUGT). Both groups demonstrated significant improvements in TISall, TISdsb, and TUGT results. The experimental group showed significantly greater improvement in TISssb, TISco, and DGI than the control group. Our findings indicate that DBIVG can improve trunk control and gait ability in patients with chronic stroke.

Value of gait analysis for measuring disease severity using inertial sensors in patients with multiple sclerosis: protocol for a systematic review and meta-analysis

BackgroundGait impairment is a hallmark of multiple sclerosis (MS) which significantly endangers the quality of life of the individual. Inertial measurement units (IMUs) are small, light wearable sensors that can be used in routine neurological practice. InertiaLocoGraphy (ILG), the quantification of gait with IMUs, has proven useful to detect early changes in MS undetectable with standard stopwatch-timed measures. Still, whether such markers are useful for evaluating the severity of the disease remains unknown. Therefore, the correlation between ILG and disease progression would be worth exploring.MethodsWe will search MEDLINE via PubMed, Cochrane, and EMBASE electronic databases to identify articles published before May 2, 2018 that measure gait using IMUs in MS patients. In addition, grey literature will be searched. Inclusion criteria will be adults with a clinical diagnosis of MS and gait measured by using inertial sensors. We will exclude from the meta-analysis articles that do not provide sufficient data for evaluating the correlations between ILG parameters and disease severity as measured by at least one of the six following tests: the Expanded Disability Status Scale (EDSS), the Multiple Sclerosis Walking Scale-12 (MSWS), the Multiple Sclerosis Severity Score (MSSS), the Multiple Sclerosis Impact Scale (MSIS-29), the Multiple Sclerosis Functional Composite (MSFC), and the Timed 25-ft Walk Test (T25FW). Extracted data from included articles will be presented descriptively, and effect sizes will be computed based on the recommendations from the Cochrane Collaboration handbook and RevMan software.DiscussionIdentifying changes in disease state throughout the course of MS is essential for optimal care. Current clinical and performance tests allow for identifying advanced gait alteration but lack sensitivity to detect subtle gait change. IMUs can be easily used in clinical practice to quantify gait in MS patients. Nevertheless, whether these outcomes are clinically relevant is uncertain because no study has evaluated their correlation with disease severity across different settings. This systematic review and meta-analysis would bring insight into the potential of this outcome as a marker of disease evolution.Systematic review registrationThis review was registered with the International Prospective Register of Systematic Reviews on May 2, 2018 (Registration: CRD42018092651). Both the search strategy and study protocol are available at https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=92651.

To Know the Effectiveness of Rocker Board Training Programe on Trunk Balance and Gait in Subjects with Stroke

Stroke is a clinical syndrome with signs of focal or global disturbance of cerebral functions with apparent causes of vascular origin. Stroke is one of the leading causes of death and disability in India. As per available literature, in India 104.39 deaths per 1’00’000 populations. The incidence rate was 99.54 per 1,00,000 in men and 149.49 per 1,00,00 in women. 80 percent of stroke patents didn’t survive after 10 years. Moreover stroke patients face balance problems which limit lower limb functional activities which demand rapid and optimal improvement of postural control for their independence, social participation and general health. Balance training, on Rocker Board in sitting position has proved to be effective in improving balance in stroke patients, but there is no available study evaluated effectiveness of balance training program on Rocker Board in standing position which is an urgent need for stroke patients with difficulty in standing balance. To fill this gap, the present research work studied the effectiveness of Rocker Board training program on balance and gait in stroke patients with the help of‘Berg balance scale’(BBS), ‘Functional reach test’(FRT) and ‘Timed walking test’(TWT).Values obtained were compared by using a paired t-test. According to obtained values the pre and posttest values of BBS, FRT, TWT had shown a significant effect on ‘p’ values <0.05 in experimental group and after 6 weeks of intervention protocol, the present study concludes that the trunk balance and gait have significant improvement in experimental group than the control group

Impact of Nutritional Intake on Function in People with Mild-to-Moderate Multiple Sclerosis.

We sought to assess the associations between nutrition and ambulation, daily activity, quality of life (QOL), and fatigue in individuals with mild-to-moderate disability with multiple sclerosis (MS). This cross-sectional pilot study included 20 ambulatory adult volunteers with MS (14 women and 6 men; mean ± SD age, 57.9 ± 10.2 years; mean ± SD Expanded Disability Status Scale score = 4.1 ± 1.8). Primary outcome variables included dietary assessment and the 6-Minute Walk Test (6MWT). Secondary measures included the Timed 25-Foot Walk test, Timed Up and Go test, daily activity, and three self-report questionnaires: the 12-item Multiple Sclerosis Walking Scale, the 36-item Short Form Health Survey (SF-36), and the Modified Fatigue Impact Scale. Significant correlations were seen between the percentage of diet comprising fats and the 6MWT (r = 0.51, P = .02) and the physical functioning component of the SF-36 (r = 0.47, P = .03). The percentage of carbohydrates was significantly correlated with the 6MWT (r = -0.43, P = .05), daily activity (r = -0.59, P = .005), and the physical functioning component of the SF-36 (r = -0.47, P = .03). Cholesterol, folate, iron, and magnesium were significantly positively correlated with the physical functioning component of the SF-36 and the 6MWT. These findings indicate better ambulation, daily function, and QOL with increased fat intake, decreased carbohydrate intake, and increased intake of the micronutrients cholesterol, folate, iron, and magnesium in people with mild-to-moderate MS. This pilot study highlights the potential impact of diet on function and QOL in MS.

Clinical assessment of motor imagery and physical function in mild stroke patients.

[Purpose] The aim of this study was to clarify whether the motor imagery of walking and physical function are related in mild hemiplegic stroke patients. [Participants and Methods] Sixteen mild hemiplegic stroke patients were included in this study. We evaluated motor imagery with a 10-m walking, the estimation error and the kinesthetic and visual imagery questionnaire. Physical function was evaluated with the actual 10-m walk test time, Brunnstrom recovery stage, stroke impairment assessment set, and functional independent measure. The correlation coefficient was calculated using Spearman’s correlation coefficient for all evaluation methods. [Results] The 10-m walking motor imagery took an average of 23.36 ± 22.14 s. The actual 10-m walk test averaged 24.87 ± 21.41 s. The 10-m walking motor imagery and the 10-m walking speed were significantly correlated. There was a significant correlation between the 10-m walking motor imagery and the Brunnstrom recovery stage, stroke impairment assessment set, and functional independent measure. There were no significant correlations between the estimation error and all the assessments. [Conclusion] These results show that the motor imagery of walking is related to physical function in mild hemiplegic stroke patients.

Effects of computer-assisted cognitive rehabilitation in benign multiple sclerosis

Background/aim: Benign multiple sclerosis (BMS) patients display preserved somatic neurological functions but nevertheless may develop cognitive dysfunction. Our aim was to explore the impact of computer-assisted cognitive rehabilitation (CCR) on cognitive functions of BMS patients. Materials and methods: Age- and sex-matched BMS patients (n = 21), non-BMS patients (n = 22), and healthy individuals (n = 38) were recruited for evaluation of cognitive functions. CCR was administered to 10 BMS patients and a panel of neuropsychological tests were employed at baseline and 6 months. CCR was based on mental exercise software containing attention, memory, reasoning, visual, and verbal task modules. Results: BMS and non-BMS patients showed impaired selective reminding, spatial recall, symbol digit modalities (SDMTs), controlled oral word association (COWAT), paced auditory serial addition-3 (PASAT-3), and Stroop tests. Timed 25-foot walk and 9-hole peg test results of BMS patients were comparable to those of healthy controls. BMS patients with CCR showed significantly improved SDMTs, COWAT, and Stroop test results compared to those without CCR. Conclusion: Several cognitive domains including memory and executive functions are impaired in BMS patients. CCR has an ameliorating impact particularly on sustained attention, information processing speed, verbal fluency, categorical reasoning, and executive functions of BMS patients.

Postural control quantification in minimally and moderately impaired persons with multiple sclerosis: The reliability of a posturographic test and its relationships with functional ability

BackgroundPostural control has been associated with the functional impairment in persons with multiple sclerosis (pwMS). However, there is a need for reliable methods to assess postural control in early stages of the disease, when subtle changes can be difficult to detect. The aims of this study were to assess the absolute and relative reliability of a standing and a sitting posturographic protocol in minimally (Expanded Disability Status Scale ≤ 2) and moderately (2.5 ≤ Expanded Disability Status Scale ≤ 4) impaired pwMS, and to analyze relationships among postural control and functional mobility and gait performance. MethodsTo assess postural control in an upright stance, 14 minimally and 16 moderately impaired pwMS performed six 70 s trials in tandem stance, 3 with their weaker leg behind (TSWL) and 3 with their stronger leg behind (TSSL). Additionally, participants completed five 70 s trials using an unstable sitting protocol (US) to assess trunk stability. The mean radial errors of TSWL, TSSL, and US trials were calculated as postural control indexes. Furthermore, participants performed the Timed Up and Go test (TUG) and the Timed 25-foot Walk test (T25FW) to measure their functional mobility and gait speed, respectively. Reliability was evaluated using the intraclass correlation coefficient (ICC3,1) and the standard error of measurement (SEM). Analyses of variances were carried out to assess between-group differences. Hedges’ g index (dg) was used to estimate the effect size of differences. Pearson correlation analyses (r) were performed to examine the relationships among the postural control and the functional tests. ResultsPosturographic tests showed a high reliability in both minimally (0.87 ≤ ICC ≤ 0.92; 9.32% ≤ SEM ≤ 11.76%) and moderately (0.80 ≤ ICC ≤ 0.92; 10.33% ≤ SEM ≤ 15.33%) impaired pwMS. Similarly, T25FW and TUG displayed a high consistency in minimally (0.89 ≤ ICC ≤ 0.94; 3.43% ≤ SEM ≤ 5.17%) and moderately (0.85 ≤ ICC ≤ 0.93; 5.57% ≤ SEM ≤ 6.56%) impaired individuals. Minimally impaired pwMS showed a better performance on the TUG, T25FW, and TSWL than moderately impaired individuals (p < 0.05; dg ≥ 0.8). The TSWL, TSSL, and US variables correlated with TUG scores (0.419 ≤ r ≤ 0.604; p < 0.05), but TSWL also correlated with T25FW scores (r = 0.53; p < 0.01). Furthermore, US scores correlated with both tandem stance parameters (TSWL: r = 0.54, p < 0.01; TSSL: r = 0.43, p < 0.05). ConclusionTandem and sitting posturographic tests provide reliable measures of postural control in pwMS, even in individuals with a homogeneous disease profile. Gait speed, functional mobility, and weaker leg status seem decisive in assessing the degree of physical activity limitation in pwMS. Finally, although trunk stability does not seem to be so affected by the course of the disease, it remains relevant for postural control and functional capacity.

Functional exercise capacity evaluated by timed walk tests in myasthenia gravis

We sought to evaluate the test-retest reliability and construct validity of the 6- and 2-minute walk tests (6mWT and 2mWT, respectively) in patients with myasthenia gravis (MG). Thirty-one patients with generalized MG were enrolled in this study. The 6mWT, 2mWT, MG-specific quality of life questionnaire Turkish version (MG-QoL15T), quantitative myasthenia gravis test (QMG), and pulmonary function tests were administered. The intraclass correlation coefficients of 2mWT and 6mWT were 0.894 and 0.932, respectively. The 6mWT and 2mWT had moderate correlations with forced vital capacity, maximal inspiratory pressure, QMG score, and MG-QoL15T score (ρ for 6mWT: 0.579, 0.539, -0.572, and -0.474; ρ for 2mWT: 0.460, 0.446, -0.532, -0.457). Both tests had similar performances for predicting disease severity (area under the curve = 0.761 for 6mWT and 0.759 for 2mWT). The 6mWT and 2mWT have excellent test-retest reliability as well as moderate construct validity for the evaluation of functional exercise capacity patients with MG. Muscle Nerve 59:208-212, 2019.

The Role of Wearable Devices in Multiple Sclerosis.

Multiple sclerosis (MS) is the most common neurological disorder in young adults. The prevalence of walking impairment in people with MS (pwMS) is estimated between 41% and 75%. To evaluate the walking capacity in pwMS, the patient reported outcomes (PROs) and performance-based tests (i.e., the 2-minute walk test, the 6-minute walk test, the Timed 25-Foot Walk Test, the Timed Up and Go Test, and the Six Spot Step Test) could be used. However, some studies point out that the results of both performance-based tests and objective measures (i.e., by accelerometer) could not reflect patient reports of walking performance and impact of MS on daily life. This review analyses different motion sensors embedded in smartphones and motion wearable device (MWD) that can be useful to measure free-living walking behavior, to evaluate falls, fatigue, sedentary lifestyle, exercise, and quality of sleep in everyday life of pwMS. Caveats and limitations of MWD such as variable accuracy, user adherence, power consumption and recharging, noise susceptibility, and data management are discussed as well.

Physical function tests predict incident falls: A prospective study of 2969 men in the Swedish Osteoporotic Fractures in Men study

Aims: Falls are common in the elderly population, and fall-related injuries are a major health issue. We investigated the ability of simple physical tests to predict incident falls. Methods: The Swedish Osteoporotic Fractures in Men (MrOS) study includes 3014 population-based men aged 69-81 years at the start of the study. These men performed five different physical tests at baseline: right-hand grip strength, left-hand grip strength, timed stand test, 6 m walking test (time and steps) and narrow walking test. During the first study year, we asked participants to fill out questionnaires regarding falls 4, 8 and 12 months after baseline. A total of 2969 men completed at least one questionnaire and were included in this study. We used generalised estimating equations and logarithmic regression models to estimate odds ratios for fallers and recurrent fallers (more than one fall during the one-year examination period) in each quartile of men for each physical test. Results: The proportions of fallers and recurrent fallers were higher in the lowest quartile of the physical tests than in the other three quartiles combined for all physical tests. A reduction of one standard deviation in respective physical test resulted in a 13-21% higher risk of becoming a faller and a 13-31% higher risk of becoming a recurrent faller. Conclusions: Low results on simple physical tests is a risk factor for incident falls in elderly Swedish men and may facilitate identification of high-risk individuals suitable for fall-intervention programs.

36-Months follow-up assessment after cessation and resuming of enzyme replacement therapy in late onset Pompe disease: data from the Swiss Pompe Registry.

Although not curative, enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase enzyme has shown to be effective in the treatment of late-onset Pompe disease (LOPD). For this potentially life-long treatment, little is known on the clinical effect of cessation and resuming ERT. Due to a Swiss supreme court decision on ERT reimbursement, a temporary stop of ERT occurred in our study population. The aim of this study was to report the 36-months follow-up assessments after resuming ERT. After resuming ERT, seven patients suffering from genetically and enzymatically confirmed LOPD had periodic, mandatory, prospective assessments of pulmonary function tests, muscle strength summary scores, distances walked in timed walking tests, and patient-reported questionnaires. Data were statistically analyzed for significant differences between time points at ERT cessation, at ERT resuming, and 36 months thereafter. After resuming ERT forced vital capacity (p = 0.007) and distance walked in the 6min walk test (6-MWT, p = 0.011) significantly increased at 36 months. Compared to before ERT cessation, distance walked in 6-MWT at 36 months still remained significantly lower (p = 0.005). Self-reported scores in the fatigue severity scale significantly declined at 36 months after resuming ERT (p = 0.019). No other functional or reported parameter significantly changed at 36 months after resuming ERT. Our data suggests that long-term interruption of ERT in LOPD may lead to deterioration of clinical meaningful parameters and quality of life. In addition, a clinical restoration after ERT cessation is possible for most of the LOPD patients within a 36 months follow-up.

The Use of Rhythmic Auditory Stimulation to Optimize Treadmill Training for Stroke Patients: A Randomized Controlled Trial.

The use of functional music in gait training termed rhythmic auditory stimulation (RAS) and treadmill training (TT) have both been shown to be effective in stroke patients (SP). The combination of RAS and treadmill training (RAS-TT) has not been clinically evaluated to date. The aim of the study was to evaluate the efficacy of RAS-TT on functional gait in SP. The protocol followed the design of an explorative study with a rater-blinded three arm prospective randomized controlled parallel group design. Forty-five independently walking SP with a hemiparesis of the lower limb or an unsafe and asymmetrical walking pattern were recruited. RAS-TT was carried out over 4 weeks with TT and neurodevelopmental treatment based on Bobath approach (NDT) serving as control interventions. For RAS-TT functional music was adjusted individually while walking on the treadmill. Pre and post-assessments consisted of the fast gait speed test (FGS), a gait analysis with the locometre (LOC), 3 min walking time test (3MWT), and an instrumental evaluation of balance (IEB). Raters were blinded to group assignments. An analysis of covariance (ANCOVA) was performed with affiliated measures from pre-assessment and time between stroke and start of study as covariates. Thirty-five participants (mean age 63.6 ± 8.6 years, mean time between stroke and start of study 42.1 ± 23.7 days) completed the study (11 RAS-TT, 13 TT, 11 NDT). Significant group differences occurred in the FGS for adjusted post-measures in gait velocity [F(2, 34) = 3.864, p = 0.032; partial η2 = 0.205] and cadence [F(2, 34) = 7.656, p = 0.002; partial η2 = 0.338]. Group contrasts showed significantly higher values for RAS-TT. Stride length results did not vary between the groups. LOC, 3MWT, and IEB did not indicate group differences. One patient was withdrawn from TT because of pain in one arm. The study provides first evidence for a higher efficacy of RAS-TT in comparison to the standard approaches TT and NDT in restoring functional gait in SP. The results support the implementation of functional music in neurological gait rehabilitation and its use in combination with treadmill training.Clinical Trial Registration: https://www.drks.de/drks_web/, identifier DRKS00014603

Pilot randomized controlled trial of functional electrical stimulation cycling exercise in people with multiple sclerosis with mobility disability

BackgroundExercise training has been shown to be beneficial for persons with multiple sclerosis (MS). Adapted exercise modalities are needed to accommodate those with severe mobility impairment (Expanded Disability Status Scale [EDSS] scores 5.5–6.5). Functional electrical stimulation (FES) cycling is one such exercise modality; however, few studies have examined the feasibility and potential benefits of FES cycling for people with MS with severe mobility impairment. ObjectiveDetermine the feasibility of FES cycling exercise for people with MS with severe mobility impairment, and the efficacy of FES cycling exercise for improving mobility and physiological fitness. Methods11 participants with MS with mobility impairment (EDSS = 5.5–6.5) were randomly allocated to FES cycling exercise (n = 6) or passive leg cycling (PLC; n = 5). Feasibility metrics included participant recruitment, retention, adherence, safety, and satisfaction. The primary mobility outcome was walking speed assessed by the Timed 25-Foot Walk (T25FW) test. The primary physiological fitness outcome was peak oxygen consumption (VO2peak), assessed using a cardiopulmonary exercise test. ResultsEight participants completed the intervention (FES n = 4; PLC n = 4) with an adherence rate ≥80%. Three participants (FES n = 2, PLC n = 1) withdrew due to a lack of time. Six Grade 1 (i.e., mild) adverse events were experienced by participants in the FES group. Participants in the FES cycling condition demonstrated small-to-moderate improvements on T25FW performance (Cohen's d = 0.40; 22.9%) and VO2peak (Cohen's d = 0.34; 13.8%) compared to participants in the PLC condition. ConclusionsWe provide evidence that FES cycling exercise is feasible for individuals with MS with severe mobility impairment, and might have positive effects on mobility and physiological decondition. These results will inform the design of future efficacy trials of FES cycling exercise for persons with MS with mobility disability.

Validity and reproducibility of the Functional Gait Assessment in persons after stroke

Objective: To evaluate construct validity and reproducibility of the Functional Gait Assessment (FGA) for measuring walking balance capacity in persons after stroke. Design: Cross-sectional study. Setting: Inpatient and outpatient rehabilitation center. Subjects: Fifty-two persons post-stroke (median (25% and 75% percentiles)) time post-stroke 6 (5–10) weeks) with independent walking ability (mean gait speed 1.1 ± .4 m/s). Methods: Subjects completed a standardized FGA twice within one to eight days by the same investigator. Validity was evaluated by testing hypotheses on the association with two timed walking tests, Berg Balance Scale, and the mobility domain of the Stroke Impact Scale using correlation coefficients (r), and with Functional Ambulation Categories using the Kruskal–Wallis test. Reproducibility of FGA scores was assessed with intraclass correlation coefficient and standard error of measurement. Results: Subjects scored a median of 22 out of 30 points at the first FGA. Moderate to high significant correlations (r .61–.83) and significant differences in FGA median scores between the Functional Ambulation Categories were found. Eight hypotheses (80%) could be confirmed. Inter-rater, intra-rater, and test–retest reliability of the total scores were excellent. The standard error of measurement and minimal detectable change were 2 and 6 points, respectively. No relevant ceiling effect was observed. Conclusion: The FGA demonstrated good measurement properties in persons after stroke and yielded no ceiling effect in contrast to other capacity measures. In clinical practice, a measurement error of 6 points should be taken into account in interpreting changes in walking balance.

Effects of multidisciplinary therapy on physical function in Huntington's disease

The primary objective of this trial was to evaluate the effects of outpatient multidisciplinary therapy, compared to usual care, on measures of physical function and muscle strength in patients with manifest Huntington's disease (HD). Twenty-two patients with clinically verified HD were randomized to receive 36weeks of outpatient multidisciplinary therapy or usual care. Outpatient multidisciplinary therapy comprised 9months of supervised exercise, cognitive therapy and self-directed home-based exercise. Usual care consisted of standard medical care. Patients were assessed at 0 and 36weeks by blinded assessors. The primary outcome was changed in mobility as measured by the 10-m Timed Walk Test. Secondary outcome measures included changes in manual dexterity (Timed Nut and Bolt Test), balance (Berg Balance Scale), cardiorespiratory endurance (6-Minute Walk Test) and upper and lower extremity muscle strength (isokinetic and isometric muscle strength and 10 Repetition Sit-to-Stand Tests). Patients receiving outpatient multidisciplinary therapy demonstrated significantly enhanced manual dexterity (P<0.05) and lower extremity muscle strength (P<0.05) than patients receiving usual care. No significant differences in mobility, balance, cardiorespiratory endurance and upper extremity strength outcomes were observed between groups after the intervention period. There were no adverse events associated with multidisciplinary therapy. Our findings suggest that outpatient multidisciplinary therapy has positive effects on manual dexterity and muscle strength, but no meaningful effects on mobility, balance, cardiorespiratory endurance and upper extremity muscle strength in patients with HD. Larger randomized controlled trials are needed to confirm these preliminary findings.

The reliability and validity of the Figure of 8 Walk test in older people with knee replacement: does the setting have an impact?

ObjectiveTo determine the reliability and validity of the Figure of 8 Walk test (F8W) for older people after knee replacement surgery in the home setting. DesignObservational repeated measures. SettingA specialist orthopaedic hospital and participants homes. ParticipantsSeventy-four older adults aged over 55 years one year following knee replacement surgery participated in two assessments more than one week apart. Main Outcome MeasureThe time to complete, steps, boundary limits and smoothness score from the Figure of 8 Walk test (F8W), the time to complete the Timed Up and Go (TUG) test and the time to complete the Timed Walk Test (TWT). ResultsOverall, on 95% of occasions, the difference between the measurements for intra-rater reliability were within 1.8second of the two test times. The difference between the measurements for inter-rater reliability were found to be narrower than for intra-rater reliability with scores within 1.2second overall on 95% of occasions. The time to perform the F8W was highly correlated to the Timed Up and Go (overall sample r=0.921) and the variability spread within narrow limits (−0.8 to 0.8 z-scores). This was also true for the Timed Walk Test (overall sample r=0.834) with a narrow limit of variability on almost all of the observations (−1.16 to 1.16 z-scores). ConclusionsThe F8W test has good reliability and validity when used in either a clinical or home setting for patients around one year following knee replacement surgery.