Timetable Research Articles

1084-P: Trends in Cardiovascular Risk Factors (CRF) for Youth with Incident Diabetes: The SEARCH for Diabetes in Youth Study

To examine CRF trends that may impact future CVD risk, the SEARCH study assessed CRF for diabetes-related complications in incident cohorts established from 2002 - 2016. Linear regression was used to assess trends over each incident year for non-HDL-c, LDL-c, VLDL-c, TG, BMI z-score, systolic and diastolic blood pressure (BP) z-scores, albumin/creatinine ratio (ACR) and eGFR. Models were stratified by diabetes type (Type 1, N=4600; Type 2, N=932) , adjusted for age at diagnosis, sex, DM duration and race/ethnicity. An interaction analysis was conducted to assess differential time trends by type. For youth with type 1, non-HDL-c, BP, BMI and ACR >30 decreased while HDL-c increased over time. For youth with type 2, non-HDL-c, and eGFR decreased, and BMI increased over time (table) . Significant time change interactions by type were seen for HDL-c and for BMI z-score and BP measures (table) .We observed small but significant changes in several CRFs over time in youth with incident DM, especially lipids, with greater improvements seen in youth with type 1. Youth with type 2 had worsening trends over time in BMI, BP, and kidney function. Further research is needed to better understand these trends and their implications for long term CVD risk. Disclosure R.A.Bell: None. A.D.Liese: None. E.Lustigova: None. S.M.Marcovina: None. L.Merjaneh: None. D.J.Pettitt: n/a. C.Pihoker: None. A.S.Shah: None. A.M.South: None. L.E.Wagenknecht: None. J.Rigdon: None. A.Bellatorre: None. D.Dabelea: None. R.Dagostino: Consultant; Aetion, Inc., AstraZeneca, Biogen, Bristol-Myers Squibb Company, Daiichi Sankyo, Merck & Co., Inc. J.Divers: None. L.M.Dolan: None. G.Imperatore: None. E.T.Jensen: Consultant; Regeneron Pharmaceuticals Inc. Funding Centers for Disease Control and Prevention U18DP006131

Observational study evaluating wait time and clinical outcomes in patients (pts) with diffuse large B-cell lymphoma (DLBCL) who received chimeric antigen receptor (CAR) T-cell therapy (T-CT).

e19577 Background: 5-year survival rates for DLBCL pts in the first-line setting range from 60% to 70%. Up to 50% of pts become refractory to or relapse (r/r) after treatment. Autologous CAR T-CT has shown efficacy in r/r DLBCL in ≥2 lines of treatment but faces significant challenges with cell collection and manufacturing that may delay pt treatment. This study assessed the impact of wait time for CAR T-CT (time between apheresis and CAR T-CT administration) on progression-free survival (PFS) in DLBCL pts. Methods: Data from pts in the electronic health record-derived de-identified US-based Flatiron Health database, who had a DLBCL diagnosis after Jan 1, 2011, and a documented CAR T-CT administration date, were included. Pts missing a documented apheresis date were excluded. Demographic and clinical characteristics were assessed within 6 months (mos) prior to index date (CAR T-CT administration). Pts were followed from index date to the first of pt death or end of data availability. Given no established clinically relevant cut points, short wait time was defined as < median time between apheresis and index date. Long wait time was defined as ≥ median time. 3-, 6-, and 12-mo PFS probabilities (95% confidence intervals [CIs]) by wait time were reported. Results: 91 DLBCL pts received CAR T-CT; 78 had a documented apheresis date. Median time from apheresis to index date was 37 days (interquartile range: 25, 116). 55% of pts experienced longer wait times (≥37 days). 45% experienced shorter times (<37 days). Pts were mostly white (80%–84%), male (57%–65%), and older (median: 60–67 years), with similar median follow-up time from index (4.0–4.7 mos). More pts with short wait times had stage 4 disease than those with long wait times (51% vs 28%). 71% of pts with shorter wait times received axicabtagene ciloleucel. Among those with long wait times, 72% received tisaggenlecleucel. More pts with long wait times received bridging therapy (66% vs 74%). Pts with short wait times had a higher 3-mo PFS probability than pts with long wait times. The 6- and 12-mo PFS probabilities were lower in those with shorter wait times (Table). No statistical comparisons were made due to small sample size. Conclusions: This real-world study showed no meaningful differences in PFS between wait times in DLBCL pts in the United States. Results from this study show evidence of channeling bias which is an important consideration for evaluating real-world data to construct external control arms. Future studies are needed to further evaluate the impact of delayed treatment in pts with r/r DLBCL. Funding: Takeda Development Center Americas, Inc.[Table: see text]

Modifiable risk factors for late mortality among five-year survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.

10014 Background: The impact ofmodifiable lifestyle and cardiovascular risk factors (CVRFs) on risk for late mortality in adult survivors of childhood cancer is not well established. Methods: All-cause and health-related late (>5 years from cancer diagnosis) mortality (HRM; excludes death from primary cancer and external causes) were evaluated in five-year survivors diagnosed <21 years of age using the National Death Index through 2017. Modifiable lifestyle (smoking status, alcohol use, physical activity, body mass index [BMI]; combined to create a score [0-4] and categorized as unhealthy [0-2], moderate [2.5 or 3], healthy [3.5 or 4]) and CVRFs (hypertension [HTN], diabetes [DM], dyslipidemia) were assessed as time-varying covariates. Standardized mortality ratios (SMRs) and absolute excess risk of death per 1000 person-years (AER) with 95% confidence intervals (CIs) were estimated. Multivariable models estimated the relative risk (RR) of death adjusted for demographic and socioeconomic variables. Results: Among 20,051 adult survivors (median age 40.0 years, range 18.7 – 67.7), 19% reported ≥1 CVRF (13% HTN, 9% dyslipidemia, 5% DM) and few reported a healthy lifestyle (29% healthy, 40% moderate, 31% unhealthy). There were 1476 deaths due to health-related causes. While all survivors experienced an increased risk of HRM compared to the US population, risk was lower among those with a healthy vs. unhealthy lifestyle (SMR 3.5, 95% CI 3.1-3.9 vs. 6.2, 5.7-6.7) and very high among underweight survivors (11.1, 9.3-13.3) and those with both HTN and DM (13.0, 9.2-18.0). Stratified by lifestyle score, the excess risk of HRM was lowest in those with a healthy lifestyle across survival time (Table). Similar trends were seen when stratified by 0, 1 and 2 CVRFs. In multivariable models, compared to survivors with no CVRFs and healthy lifestyle, no CVRFs and unhealthy lifestyle was associated with a 50% increased risk of HRM (RR 1.5, 95% CI 1.2-1.8) and unhealthy lifestyle plus HTN a 2-fold increased risk of HRM (2.2, 1.6-2.8). Regardless of lifestyle group, ≥2 CVRF increased risk for HRM at least 2-fold (p-values <0.001). Conclusions: A reduction in excess deaths is observed among adult survivors of childhood cancer with a healthy lifestyle and no CVRFs as they age. Interventions that target improved lifestyle choices and prevention or aggressive treatment of modifiable CVRFs may reduce risk for late mortality. [Table: see text]

813-P: Treatment Satisfaction and Health Status in People with T2D Treated with Insulin Glargine 300 U/mL (Gla-300) : Patient-Reported Outcomes (PRO) from ATOS Study

Patients' satisfaction is a key determinant of treatment adherence and persistence, for optimal management of T2D. ATOS, a 12-month prospective observational study conducted in Asia, Middle East, North Africa, Latin America, and Eastern Europe, showed that initiation of Gla-300 in insulin-naïve people with T2D resulted in improved glycemic control with low rates of hypoglycemia. This analysis evaluated changes in treatment satisfaction and health status among participants. Data was collected using PRO questionnaires - Diabetes Treatment Satisfaction Questionnaire status (DTSQs) and change versions (DTSQc) , EuroQoL 5-dimension scale version 3L (EQ-5D-3L) at baseline, Month 3, 6 and 12. Overall, 3931 participants completed the questionnaires. Mean ±SD age was 57.5 ±10.6 years, duration of diabetes was 10.1 ±6.2 years and baseline HbA1c was 9.3 ±1.0 %. Treatment satisfaction improved over time (DTSQs score of 21.7 at baseline to 29.8 and 31.3 at Month 6 and 12, respectively) and perceived frequency of hyperglycemia decreased over 12 months. DTSQc results were aligned with DTSQs. EQ-5D-3L results showed that proportion of people with better health status increased over time (Table) . Results showed that initiating Gla-300 in insulin-naïve people with T2D across multiple geographic regions improved treatment satisfaction and health status. Disclosure N.Khan: None. G.R.Galstyan: n/a. A.Tirosh: Advisory Panel; Abbott Diagnostics, AstraZeneca, Boehringer Ingelheim International GmbH, Merck & Co., Inc., Novo Nordisk, Sanofi, Consultant; Bayer AG, DreaMed Diabetes, Ltd., Research Support; Medtronic, Speaker's Bureau; Eli Lilly and Company. A.Bhansali: None. H.Vargas-uricoechea: Advisory Panel; Sanofi, Speaker's Bureau; Abbott. S.B.Harris: Consultant; Abbott, AstraZeneca, Eli Lilly and Company, Novo Nordisk, Sanofi, Other Relationship; Abbott, AstraZeneca, Bayer Inc., Dexcom, Eli Lilly and Company, HLS Therapeutics, Janssen Pharmaceuticals, Inc., Novo Nordisk, Sanofi, Research Support; Applied Therapeutics Inc., AstraZeneca, Canadian Institutes of Health Research, Juvenile Diabetes Research Foundation (JDRF) , Novo Nordisk, Sanofi, The Lawson Foundation. A.Roborel de climens: Employee; IQVIA Inc., Sanofi. M.N.Mabunay: Employee; Sanofi. M.Coudert: Employee; Sanofi. V.Pilorget: None. Funding Sanofi

Statins reduce mortality of patients with myelodysplastic syndromes.

e19063 Background: Statins can inhibit cholesterol synthesis through inhibition of mevalonic acid synthesis, and reduce prenylation of proteins involved in tumor growth. Their anti-neoplastic potential has been explored for many malignancies (e.g., multiple myeloma) with improvement in progression free- and overall- survival. Preclinical data support anti-neoplastic activity of statins for myeloid malignancies. In this study, we examined the effect of statins on mortality of patients with myelodysplastic syndromes (MDS) in this nationwide retrospective cohort study. Methods: We identified patients diagnosed with MDS through ICD-O-03 codes in the SEER-Medicare database between 2007 and 2017. Statins users were required to have at least one claim for a statin prescription within 6 months prior to MDS diagnosis. Propensity score matching was done to identify non-statin users with a similar cardiovascular risk profile. We analyzed the effect of statins on mortality (from any cause) in a Cox proportional hazards model that adjusted for demographics, SEER-Medicare MDS Risk Score ( SMMRS comprises of age, comorbidities, MDS histological subtype, cytopenias, transfusion-dependence and hospital admissions), treatments for lower risk MDS (growth factors or lenalidomide), and higher risk MDS (hypomethylating agents/stem cell transplant). Results: Our cohort of 6878 MDS patients (3439 statin users and 3439 non-statin users) had a median age of 80 years at diagnosis, and most were Caucasians. Non-statin users were more likely to have higher risk MDS (by SMMRS) at diagnosis. Statins users had a 33% {95% Confidence Interval (CI) 25%-40%; p <.001} lower risk of death than non-statin users. The beneficial effect of statins on mortality diminished over time (Table). Sub-group analysis (data not shown) showed a significant reduction in mortality with statin use in both patients with lower risk {low or intermediate-1 risk: Adjusted hazards ratio (aHR) 0.72; 95% CI 0.58-0.90; p = 0.003)} and higher risk {intermediate-2 or high-risk: aHR 0.67; 95% CI 0.59-0.76; p < 0.001)} MDS (categorized by SMMRS). Conclusions: Use of statins at time of MDS diagnosis is associated with reduced mortality among these patients. The beneficial effect of statins on death from cardiovascular events and myeloid malignancy should be further explored in clinical trials enrolling MDS patients.[Table: see text]

Research on Quantum Annealing Integer Factorization Based on Different Columns

The majority of scholars believe that Shor’s algorithm is a unique and powerful quantum algorithm for RSA cryptanalysis, so current postquantum cryptography research has largely considered only the potential threats of Shor’s algorithm. This paper verifies the feasibility of deciphering RSA public key cryptography based on D-Wave, which is the second most effective RSA attack method after Shor’s algorithm. This paper proposes the influence of different column methods on the final integer factorization, puts forward a new dimension reduction formula, simplifies the integer factorization model based on quantum annealing, simulates it with the qbsolv quantum computing software environment provided by D-Wave, and factors the integer 1630729 (an 11-bit prime factor multiplied by an 11-bit prime factor). The research results show that choosing an appropriate number of columns and column width in the binary integer factorization multiplication table is very important for studying the optimization ability of the quantum annealing algorithm. In fact, Science, Nature, IEEE Spectrum, and the National Academies of Sciences (NAS) are consistent in asserting that the practical application of general-purpose quantum computers is far in the future. Therefore, although D-Wave computers were initially mainly purchased by Lockheed Martin, Google, etc., for purposes such as image processing, machine learning, combinatorial optimization, and software verification, post quantum cryptography research should further consider the potential of the D-Wave quantum computer in deciphering RSA cryptosystems in the future, and a discussion of this potential is one of the contributions of this paper.

Factors Responsible for Poor Performance of Students’ in English Language in the West Africa Senior High School Certificate Examination in Ghana Senior High School, Tamale

The poor performance of students in English language in the West Africa Senior High School Certificate Examination in Ghana Senior High School, Tamale is a great concern to key stakeholders of the School. Many factors are responsible for this poor performance. This study therefore seeks to establish the factors responsible for poor performances of students in English language. The investigation collected information on factors responsible for the poor performance of students in English language in the West Africa Senior High School Certificate Examination and the ranking of these factors. It revealed that the factors include: non-availability of qualified teachers, attitude of teachers in teaching English Language, students’ attitude to studying English Language, use of teaching and learning materials, allocation of time for teaching English language and methods of teaching English Language. It was also observed that non-availability of qualified teachers of English language (40%) ranked highest while students attitude to the study of English language and the allocation of time for teaching English language on the schools time table ranked lowest (5%) Keywords: factors, poor, performance, responsible DOI: 10.7176/JLLL/89-03 Publication date: June 30 th 2022

Web based application for Automatic Timetable Generation

Abstract: The manual means of getting ready time table in schools is exceptionally tedious and drawn- out task which typically winds up with different classes conflicting either at indistinguishable room or with same educators having more than each class in turn. Because of manualmethodology, legitimate utilization of assets is neither viable nor productive. To conquer this large number of issues we propose to make a mechanized framework with PC helped plan generator. The framework will take different sources of info like number of subjects, instructors, maximal talks an educator can direct, need of subject and points to be canvassedin a week or a talk, contingent on these information sources it will produce conceivable time tables for working days of the week, utilizing all assets such that will best suit the limitations.A suitable schedule is then looked over the ideal arrangements generated. Timetable creation is an extremely laborious and tedious assignment. To make plan it takes loads of persistence and worker hours. Time table is made for different purposes like to arrange addresses in school and universities, to make timing diagrams for train and transport plan and some more. To make schedule it requires loads of time and labor supply .In our paper we have attempted to diminish these hardships of producing plan by Heuristic Algorithm.

3-Parameter Generalized Quaternions

In this article, we give a general form of the quaternions algebra depending on 3-parameters. We define 3-parameter generalized quaternions (3PGQs) and study various properties and applications. Firstly we present the definiton, the multiplication table and algebraic properties of 3PGQs. We give matrix representation and Hamilton operators for 3PGQs. We derive the polar represenation, De Moivre’s and Euler’s formulas with the matrix representations for 3PGQs. Additionally, we derive relations between the powers of the matrices associated with 3PGQs. Finally, Lie groups and Lie algebras are studied and their matrix representations are given. Also the Lie multiplication and the Killing bilinear form are given.

Plethoric Classes and Academic Performances in Cartography Among Senior Secondary Learners in Cameroon

Teaching and learning cartography greatly influence the standard and quality of geographic knowledge since the use of cartography tools impacts the teaching-learning process at all levels. This paper seeks to investigate the influence of plethoric classes on learners’ academic performances in cartography in Cameroon. There is an observed negative effect of plethoric classes on learners’ academic performances in cartography in Forms 4 and 5 in Cameroon. Empirical data from four secondary high schools in Yaounde VI Subdivision based on qualitative and quantitative methods was used for the analysis. Data collection methods were field surveys, key informant interviews and direct observations. Analyses were carried out using Microsoft Excel 2016 and SPSS 16 software. Findings revealed that Forms 4 and 5 classrooms are overcrowded with student-teacher ratio >60:1; impeding the proper teaching-learning of cartography and that teachers use the teacher-centred rather than the student-centred approach which undermines the acquisition of cartographic skills. This leads to poor results during trimestral and regional examinations. ANOVA test revealed that there was a significant difference (p<0.05) between learners’ performances in schools with plethoric classes and schools with normal classroom student-teacher ratio. The study suggests that the splitting of plethoric classrooms into smaller tutorial groups with different time tables, stressing on group work and more practical cartographic exercises remain the appropriate approaches to teach cartography in plethoric classes.

Structure of a finite non-commutative algebra set by a sparse multiplication table

Four-dimensional finite non-commutative associative algebras represent practical interest as algebraic support of post-quantum digital signature algorithms, especially algebras with two sided global unit, set by sparse basis vectors multiplication tables. A new algebra of the latter type, set over the field GF(p), is proposed and its structure is investigated. The studied algebra is described as a set of p2 + p + 1 commutative subalgebras of three different types. All subalgebras intersect strictly in the subset of scalar vectors. Formulas are derived for the number of subalgebras of each type.

THE DYNAMICS OF THE CHALLENGES OF FEMALE ACADEMICS DURING THE COVID-19 PANDEMIC

The purpose of this study was to analyze the problems of women working in the education sector, because in the era of the COVID-19 pandemic there were many changes, especially women who had multiple burdens. The research was conducted at two universities, Universitas Prof. Dr., Moestopo (Beragama) and Universitas Swadaya Gunung Jati (Unswagati) Cirebon. The research method used is a qualitative research method through a descriptive study approach, with a case study approach at two universities as an empirical investigation effort to explore and analyze the phenomenon of female academics during the Covid-19 pandemic. Informants interviewed female lecturers from two universities in depth (in-depth interview). The results of the research show that female lecturers tend to accept the double burden they experience; female lecturers do not yet have a time table agenda that is implemented properly to ensure that their academic work priorities go well; and the Key to Dexterity of Female Lecturers in the Pandemic Period Although accompanied by strong motivation, several lecturers admitted that they were still having difficulties with the double burden condition which experienced a double burden role, still seeing the importance of the role of the household and placing it as a top priority.

Managerial and Administrative Accidents

With good intentions, managers and administrators may cause professional accidents by overloading, overcrowding, overriding or overtrusting. (1)They may overload themselves and their subordinates; (2) They may overcrowd their time table; (3)They may shortcut and override some necessary details which their subordinates or business partners have painstakingly made; (4) In communist or post-communist countries, they may over-trust "official" specialists without any system of quality control.

Anterior hilum anastomosis versus posterior hilum anastomosis in a mouse lung transplantation model.

ObjectivesThe mouse orthotopic lung transplantation (LTx) model is of enormous research value in lung transplantation. This study compares 2 anastomotic methods (anterior and posterior hilum anastomosis) of mouse LTx in term of difficulty, operation time, and postoperative effects.MethodsTwenty mice received LTx with slipknots for anterior hilum anastomosis (AH group), and 28 received LTx with a microvessel clip for posterior hilum anastomosis (PH group), all by a single surgeon. The operation time was recorded and the grafts were evaluated 24 hours after surgery.ResultsThe success rates in the recipient animals were 85% (17/20) in AH group and 89% (25/28) in PH group (P > .05). The recipient operation time and back table time in AH group were longer than those in PH group (52.8 ± 5.0 vs 47.3 ± 5.7 minutes, 27.8 ± 3.9 vs 25.3 ± 2.8 minutes, P < .05), but the warm ischemia time did not differ significantly (13.1 ± 2.1 vs 12.2 ± 2.6 minutes, P = .258), meaning that the time discrepancies predominantly originated from the hilum treatment. In AH group, 2 cases failed due to pulmonary venous thrombosis and atelectasis respectively at 24 hours after LTx, but none failed in PH group. No significant difference was observed in the postoperative performance of the successful recipients (thoracic radiographs, macroscopic appearance, oxygenation index, pulmonary compliance, pathologic changes) between the 2 groups.ConclusionsCompared with anterior hilar anastomosis, posterior hilum anastomosis with a microvessel clip is less complicated and less time-consuming in the management of hilar structures and causes fewer postoperative complications.

Integrated Framework for Bus Timetabling and Scheduling in Multi-Line Operation Mode

Bus service is of great significance to urban residents. With the convergence of bus lines and the formation of bus hubs, a multi-line operation mode which can realize the centralized management of vehicles is applied to the daily bus service planning. To solve the bus service planning problem systematically in the multi-line operation mode, we propose an integrated framework for bus timetabling (TT) and vehicle scheduling (VS), which are the two fundamental processes of bus service planning. Firstly, the determination processes of TT and VS are correlated by constructing the multiple vehicles’ trip-link chains with departure time information to facilitate simultaneous optimization. Secondly, a multi-objective optimization model is constructed, which considers higher service quality and lower operating costs as objectives. Logic and operational rules are also considered as constraints to ensure the implementation of the solutions. Thirdly, we propose and implement a heuristic solution algorithm based on neighborhood search to achieve high-performance solutions. Finally, we validate the efficiency and effectiveness of our framework under the actual bus operation scenario in Chongqing, China. The Pareto frontier solutions are provided to bus operators as alternative operation schemes.

Online Teaching–Learning Assessment Practices

Introduction: Various modalities had been adopted by educational institutes, after declaration of pandemic of COVID-19 by the World Health Organization. Students of higher education cannot be prevented for their right to education due to this severe pandemic and its fallout thereat. All the educators across the Globe started with some or other modality of online learning to keep the pace of teaching–learning activities including examination. School of allied health sciences also tried various modes of teaching. To evaluate this, an online survey was conducted to find out the usefulness and effectivity of this modality. Materials and Methods: The study was cross-sectional which was conducted among students of the School of Allied Health Sciences, DMIMS, Wardha, during April–May 2021. The undergraduate and postgraduate students from first and second graduation years were randomly selected and all 200 students were approached through WhatsApp group after Institutional Ethics Committee approval. The responses received, were collated and analyzed in the form of descriptive statistics. Results: Out of 200 students, 186 had responded to survey questionnaire with response rate of 93%. For communication regarding time table, examination schedule, or interactions or participation, the mean percentage for accepting was 66.9%. However, their satisfaction with online mode was 40.89% only. Perception of helpfulness related to learning or flexibility was about 52%. Conclusions: Although some of the students had good perception for online teaching–learning assessment modalities, some of them did not agree for it and they wanted face-to-face teaching. This may be attributed to Internet connectivity issue or residing at rural places where specified bandwidth was not available.

Mentoring First-Generation and Underrepresented in Medicine Physician-Scientists by Expanding Conversations.

Mentoring First-Generation and Underrepresented in Medicine Physician-Scientists by Expanding Conversations.

P13: CAN PATIENT-REPORTED OCULAR SYMPTOMS GUIDE DOSE MODIFICATIONS IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA RECEIVING BELANTAMAB MAFODOTIN?

Introduction: Belantamab mafodotin (belamaf) is a B-cell maturation antigen (BCMA)-targeting antibody-drug conjugate approved as a monotherapy for triple-class refractory adult patients with relapsed/refractory multiple myeloma (RRMM). This hypothesis generating post hoc analysis of DREAMM-2 trial (NCT03525678) data examined relationships between corneal exam findings, best-corrected visual acuity (BCVA) changes and direct patient-reported ocular symptoms per the Ocular Surface Disease Index (OSDI) questionnaire. This approach may provide insight into relationships between corneal exam findings, BCVA, ocular symptoms, impact on quality of life to determine if BCVA decline and symptoms can guide dosing. Surrogate marker identification for results from corneal exam findings would help providers determine if dosing adjustments are necessary. Methods: Snellen chart BCVA assessment and corneal eye exams were performed on all patients receiving belamaf (2.5 mg/kg, q3w) by ECPs at baseline (BL) and before each dose. Corneal exam findings (keratopathy) and BCVA were assessed per protocol-defined criteria. Grade (GR) assessment, relative to BL, was based on the worst finding in the worse eye. Patient-reported ocular symptoms and vision-related functioning, as per the OSDI, were used to evaluate the impact of treatment-related ocular toxicity. The OSDI patient-reported outcome questionnaire assesses eye symptoms/effects on vision-related function and was performed in all patients before each belamaf dose. Items 1–5 address the frequency of eye-related symptoms and items 6–9 address functional limitation frequency. OSDI was considered positive, clinically meaningful and potentially treatment associated when at least one question 1–5 (sensitivity to light, gritty/painful eyes, blurred or poor vision) was reported as experienced “all of the time” and at least one question 6–9 (driving at night, reading, working with PC or watching TV) was reported as experienced “most of the time.” Results: GR 3–4 (severe) keratopathy was observed 5% of the time in patients not reporting frequent ocular symptoms measured by the OSDI questionnaire (no items 1–9 ≥ “most of the time”). In patients who reported no items 1–5 “all of the time” AND no items 6–9 ≥ “most of the time” (OSDI negative), GR 3–4 keratopathy was observed 6.5% of the time (Table). In patients who reported “no deterioration from BL” for any OSDI eye-related symptoms or functional limitations, GR 3–4 keratopathy was observed ~3%–7% of the time and GR 0–2 (mild) keratopathy ~23%–34% of the time. Similar results were observed in patients with BL BCVA ≤20/30 who reported “no deterioration from BL” for any eye-related adverse events (AEs) or functional limitations (GR 3–4 keratopathy: ~2%–6% of the time; GR 0–2 keratopathy: ~19%–28% of the time); patients with worse BL visual acuity (BCVA >20/30) who reported “no deterioration” for items 1–9 had lower incidence of GR 3–4 (~0%–1%) and GR 0–2 keratopathy (~3%–8%). Conclusions: These results suggest that hematologists/oncologists may be able to use ocular symptoms and the OSDI tool as potential surrogate markers for eye exam results to help determine whether dosing changes are needed. Validation with other belamaf dose regimens is ongoing. Funding Source: GSK(205678) Encore statement: Previously presented as Poster 2746 at the American Society of Hematology Annual Meeting, 11–14 December 2021; submitted with permission and on behalf of the original authors.

The Witch in the Closet: Disney's Frozen as Adaptation and Its Potential for Queer and Feminist Readings

The Witch in the Closet: Disney's <i>Frozen</i> as Adaptation and Its Potential for Queer and Feminist Readings

A system for real-time multivariate feature combination of endoscopic mitral valve simulator training data

PurposeFor an in-depth analysis of the learning benefits that a stereoscopic view presents during endoscopic training, surgeons required a custom surgical evaluation system enabling simulator independent evaluation of endoscopic skills. Automated surgical skill assessment is in dire need since supervised training sessions and video analysis of recorded endoscope data are very time-consuming. This paper presents a first step towards a multimodal training evaluation system, which is not restricted to certain training setups and fixed evaluation metrics.MethodsWith our system we performed data fusion of motion and muscle-action measurements during multiple endoscopic exercises. The exercises were performed by medical experts with different surgical skill levels, using either two or three-dimensional endoscopic imaging. Based on the multi-modal measurements, training features were calculated and their significance assessed by distance and variance analysis. Finally, the features were used automatic classification of the used endoscope modes.ResultsDuring the study, 324 datasets from 12 participating volunteers were recorded, consisting of spatial information from the participants’ joint and right forearm electromyographic information. Feature significance analysis showed distinctive significance differences, with amplitude-related muscle information and velocity information from hand and wrist being among the most significant ones. The analyzed and generated classification models exceeded a correct prediction rate of used endoscope type accuracy rate of 90%.ConclusionThe results support the validity of our setup and feature calculation, while their analysis shows significant distinctions and can be used to identify the used endoscopic view mode, something not apparent when analyzing time tables of each exercise attempt. The presented work is therefore a first step toward future developments, with which multivariate feature vectors can be classified automatically in real-time to evaluate endoscopic training and track learning progress.