Introduction: stroke is one of the leading causes of mortality in Brazil and worldwide, however, the literature lacks studies analyzing stroke mortality in the state of Amazonas. Objective: to analyze stroke mortality in the state of Amazonas from 2000 to 2021. Methods: the study is an ecological time-series study with secondary data from 2000 to 2021 obtained from the Department of Health Information and Informatics of the Unified Health System (DATASUS) for the state of Amazonas. Results: the year 2021 recorded the highest number of stroke deaths over the analyzed historical series, with a total of 851 deaths. The mortality rate in 2021 was the highest compared to 2015 through 2021, reaching 31.84. The male sex had a higher mortality rate compared to the female sex for most years. The mortality rate was higher for individuals aged over 60. The mortality rate among people aged 80 or older has been increasing, with an Annual Percent Change (APC) of 2.34% (95% CI: 0.18; 4.54). For the entire population, as well as the age groups 20-29 and 30-39, the mortality rate remained constant. Conclusion: the mortality rate for the total population remained stable. For individuals over 80 years old, there was a growth trend.