Time Restrictions Research Articles

A protein-protein interaction network aligner study in the multi-objective domain

Background and ObjectiveThe protein-protein interaction (PPI) network alignment has proven to be an efficient technique in the diagnosis and prevention of certain diseases. However, the difficulty in maximizing, at the same time, the two qualities that measure the goodness of alignments (topological and biological quality) has led aligners to produce very different alignments. Thus making a comparative study among alignments of such different qualities a big challenge. Multi-objective optimization is a computer method, which is very powerful in this kind of contexts because both conflicting qualities are considered together. Analysing the alignments of each PPI network aligner with multi-objective methodologies allows you to visualize a bigger picture of the alignments and their qualities, obtaining very interesting conclusions. This paper proposes a comprehensive PPI network aligner study in the multi-objective domain. MethodsAlignments from each aligner and all aligners together were studied and compared to each other via Pareto dominance methodologies. The best alignments produced by each aligner and all aligners together for five different alignment scenarios were displayed in Pareto front graphs. Later, the aligners were ranked according to the topological, biological, and combined quality of their alignments. Finally, the aligners were also ranked based on their average runtimes. ResultsRegarding aligners constructing the best overall alignments, we found that SAlign, BEAMS, SANA, and HubAlign are the best options. Additionally, the alignments of best topological quality are produced by: SANA, SAlign, and HubAlign aligners. On the contrary, the aligners returning the alignments of best biological quality are: BEAMS, TAME, and WAVE. However, if there are time constraints, it is recommended to select SAlign to obtain high topological quality alignments and PISwap or SAlign aligners for high biological quality alignments. ConclusionsThe use of the SANA aligner is recommended for obtaining the best alignments of topological quality, BEAMS for alignments of the best biological quality, and SAlign for alignments of the best combined topological and biological quality. Simultaneously, SANA and BEAMS have above-average runtimes. Therefore, it is suggested, if necessary due to time restrictions, to choose other, faster aligners like SAlign or PISwap whose alignments are also of high quality.

Application of Internet of Things Technology in Computer Network Security and Remote-Control Analysis

Internet of things computer network technology can not only speed up the information transmission, but also help to break the previous time and space restrictions and improve the actual work efficiency. However, in the practical application and development of this technology, the realization of data security technology and remote control technology is the key to improve its application effect and ensure data security. Due to the obvious openness of the internet of things computer network itself, common security risks emerge one after another. Therefore, in practical application, it is necessary to pay more attention to security management and maintain network security.

Biovigilance systems: Cells, tissues, and organs donation and transplantation

Objective: to describe Biovigilance Systems and their associated management tools among member countries of the World Health Organization. Method: overview conducted following the population, concept, and context strategy to develop the research question and objective. Structured searches were conducted in PubMed, CINAHL, Embase, and Scopus. Snowballing procedure in Google Scholar and health authorities’ websites as World Health Organization and Pan American Health Organization during the first semester of 2023. Language and time restrictions were not applied. Results: we examined more than 70 studies and non-scientific works. Biovigilance systems were identified in 12 countries members of WHO in 3 of 6 regions: Pan-American Region (Brazil and Colombia, Canada), Europe (England, France, Germany, Italy, Netherlands, Poland, Portugal, and Spain), and Western Pacific Region (Australia). Conclusion: This overview achieved its objective by describing biovigilance systems and their management tools among World Health Organization member countries. This research, designed as an overview, refrains from generalizing results but holds significance for countries and health authorities developing biovigilance systems, offering benchmark opportunities and supporting system improvement. The study contributes directly to the biovigilance discourse, guiding efforts to enhance safety and quality globally.

Predictive Modeling and Experimental Validation for Assessing the Mechanical Properties of Cementitious Composites Made with Silica Fume and Ground Granulated Blast Furnace Slag

Using sustainable cement-based alternatives, such as secondary cementitious raw materials (SCMs), could be a viable option to decrease CO2 emissions resulting from cement production. Previously conducted studies to determine the optimal mix designs of concrete primarily focused on either experimental approaches or empirical modeling techniques. However, in these experimental approaches, few tests could be performed for optimization due to time restrictions and lack of resources, and empirical modeling methods cannot be relied on without external validation. The machine learning-based approaches are further characterized by certain shortcomings, including a smaller number of data points, a less robust connection among the controlling factors, and a lack of comparative analyses among machine learning models. Furthermore, the literature on predicting the performance of concrete utilizing binary SCMs (silica fume (SF) and ground granulated blast furnace slag (GGBS)) is not available. Therefore, to address these drawbacks, this research aimed to integrate ML-based models with experimental validations for accurate predictions of the compressive strength (CS) and tensile strength (TS) of concrete that includes SF and GGBS as SCMs. Three soft computing techniques, namely the ANN, ANFIS, and GEP methods, were used for prediction purposes. Eight major input parameters, including the W/B ratio, cement, GGBS, SF, coarse aggregates, fine aggregates, superplasticizer, and the age of the specimens, were considered for modeling. The validity of the established models was assessed by using external experimental validation criteria, statistical metrics, and performance measures. In addition, sensitivity and parametric analyses were performed. Based on statistical measures, the ANFIS models outperformed other models with higher correlation and lower statistical error values. However, the GEP models exhibited superior performance compared to ANFIS and ANN with respect to the closeness of the RMSE, MAE, RSE, and R2 values between the training, validation, and testing sets for both the CS and TS models. Experimental validation showed strong evidence for the applicability of the proposed models with an R2 of 0.88 and error percentages of less than 10%. Sensitivity and parametric investigations demonstrated that the input variables exhibited the patterns described in the experimental dataset and the available literature. Hence, the proposed models are accurate, have better prediction performance, and can be used for design purposes.

A Systemic Review of Adolescent Supracondylar Fractures: What Is the Surgical Treatment, Open Reduction With Internal Fixation (ORIF) or Closed Reduction With Percutaneous Pinning (CRPP)?

Supracondylar humerus (SCH) fractures represent the most frequent elbow injury in young children. These fractures can be treated through either closed reduction with percutaneous pinning (CRPP) or open reduction with internal fixation (ORIF). Yet, the optimal treatment option for adolescents remains unclear. This research contrasts the results of CRPP and ORIF treatments for distal humerus fractures in adolescents. In June 2023, we conducted a comprehensive search of PUBMED, OVID MEDLINE, Web of Science, Cochrane Central Register of Controlled Trials, and various trial registries without any time restrictions. We evaluated the quality of qualifying studies using the Methodological Index for Non-randomized Studies (MINORS) and Cochrane risk measures for bias. We extracted data particularly related to patient demographics, fracture details, medical procedures followed, complications encountered, and the resulting outcomes. Out of the 488 studies identified, only four satisfied the inclusion criteria. Both methods illustrated comparable outcomes in terms of range of motion, averaging approximately 118 degrees in the ORIF group versus a span of 114 to 128 degrees in the CRPP group. The immobilization period varied, spanning 10 to 13 days for ORIF versus 24 to 29 days for CRPP. Despite this, CRPP displayed a decreased necessity for additional surgery. Notably, one study indicated a higher frequency of heterotopic ossification within the ORIF group. This review indicates that both CRPP and ORIF are effective for treating supracondylar fractures in adolescents, yielding similar results. However, CRPP has a lower need for follow-up surgery. Future studies with larger sample sizes are needed to solidify these findings, providing stronger guidance for treatment.

Association between Periodontal Disease and Obesity: Umbrella Review.

Objective: Determine the association between periodontal disease (PD) and obesity through an umbrella review. Materials and Methods: A search for information until March 2024 was carried out in the following electronic databases: PubMed, Cochrane library, Scopus, SciELO, Web of Science, Google Scholar, Proquest Dissertations and Theses, and OpenGrey. We included studies that were systematic reviews (SR) with or without meta-analysis, without time or language restrictions, that evaluated primary studies that associated PD with obesity. Literary or narrative reviews, rapid reviews, intervention studies, observational studies, preclinical and basic research, summaries, comments, case reports, protocols, personal opinions, letters, and posters were excluded. The AMSTAR-2 tool was used to determine the quality and overall confidence of the included studies. Results: The preliminary search yielded a total of 419 articles, discarding those that did not meet the selection criteria, leaving only 14 articles. All studies reported that PD was associated with obesity, with an OR and RR ranging from 1.1 to 1.46 and 1.64 to 2.21, respectively. Conclusions: Based on the results and conclusions of the SR with a high overall confidence level, PD is associated with obesity.

Efficient High-Resolution Deep Learning: A Survey

Cameras in modern devices such as smartphones, satellites and medical equipment are capable of capturing very high resolution images and videos. Such high-resolution data often need to be processed by deep learning models for cancer detection, automated road navigation, weather prediction, surveillance, optimizing agricultural processes and many other applications. Using high-resolution images and videos as direct inputs for deep learning models creates many challenges due to their high number of parameters, computation cost, inference latency and GPU memory consumption. Simple approaches such as resizing the images to a lower resolution are common in the literature, however, they typically significantly decrease accuracy. Several works in the literature propose better alternatives in order to deal with the challenges of high-resolution data and improve accuracy and speed while complying with hardware limitations and time restrictions. This survey describes such efficient high-resolution deep learning methods, summarizes real-world applications of high-resolution deep learning, and provides comprehensive information about available high-resolution datasets.

Socially-supported sleep in older adults aged 50 and older: a concept analysis.

The population of older adults is growing disproportionately, constituting 13% of the global population in 2022, and is expected to double by 2050. One of public health's priorities is healthy aging, the maintenance of functional ability aligned with well-being. As many as 50% of older adults report poor sleep quality, leading to an increased risk of morbidity and mortality. The quality and quantity of social relationships may broadly benefit sleep in older adults. However, the concept of socially-supported sleep is underdeveloped as a basis for intervention. Existing literature was searched without time restriction in PubMed, CINAHL, PsycINFO, and Scopus ending in August 2022. Thematic analysis was used to determine the defining attributes, antecedents, and consequences of socially-supported sleep guided by Rodgers' evolutionary concept analysis. Twenty-nine articles written in English, peer-reviewed, and examined social support and sleep in participants aged ≥50 were included. The defining attributes reflect dimensions of sleep quality. The antecedents are safe and secure, belonging and connection, and warmth and comfort. The consequences of socially-supported sleep include improved regulatory capabilities, physical and emotional well-being, and quality of life. Socially-supported sleep has the potential to inform interventions that promote sleep in older adults. Ongoing research is needed to address the antecedents and mechanisms through which socially-supported sleep may promote sleep quality for healthy aging.

Home Service Transformation: The Impact of Digital Marketing and the Urban Company's Approach

Because of convenience, time restrictions, and shifting consumer lives, there is a greater need for home-based services as the service sector of the economy grows, especially through e-commerce platforms. But maintaining client happiness in this industry is still crucial, requiring attention to service quality and satisfying changing customer demands. One major participant in the Indian industry, Urban Company (UC), is unique in that it connects customers and service providers directly, cutting out middlemen and putting the customer's needs ahead of its own. The purpose of this study is to investigate how customer satisfaction is affected by the quality of services offered by UC, specifically in relation to Chennai. It looks at the special aspects of UC's business strategy, highlighting how it organizes the domestic services market and makes sure that its service providers are trustworthy and safe. Furthermore, the research explores consumer satisfaction and expectations, concentrating on beauty services in Pune. This highlights the need of surpassing client expectations in providing services.

Post-publication research integrity concerns in randomized clinical trials: A scoping review of the literature.

Post-publication handling of integrity concerns in randomized clinical trials (RCTs) is a contentious matter. We undertook a scoping systematic review to map the literature regarding post-publication integrity issues in RCTs. Following prospective registration (https://osf.io/pgxd8) we initially searched PubMed and Scopus but subsequently extended it to include the Cochrane Library, and Google Scholar databases without language, article type or publication time restriction until November 2022. Reviewers independently selected published articles covering any aspect of post-publication research integrity concerns in RCTs. The study findings grouped within domains relating to issues concerning post-publication integrity were extracted in duplicate, verified by a third reviewer, and then tabulated. The initial search captured 3159 citations, of which 89 studies were included in the review. Cross-sectional studies constituted the majority of included studies (n = 34, 38.2%), followed by systematic reviews (n = 10, 11.2%), methodology reviews/studies (n = 9, 10.1%) and other types of descriptive studies (n = 8, 9.0%). A total of 21 articles (23.6%) covered the domain on general issues, 25 (28.1%) in the journal's instructions and policies domain, eight (9.0%) in the editorial and peer review domain, one (1.1%) in the correspondence and complaints (post-publication peer review) domain, 12 (13.5%) in the investigation for concerns domain, six (6.7%) in the post-investigation decisions and sanctions domain, none in the critical appraisal guidance domain, five (5.6%) in the integrity assessment in systematic reviews domain, and 26 (29.2%) in the recommendations for future research domain. A total of 12 of the selected articles (13.5%) covered two (n = 9) or three (n = 3) different domains. Various research integrity domains and issues covering post-publication aspects of RCT integrity were captured and gaps were identified, mostly related with the necessary implications for all stakeholders to improve research transparency. There is an urgent need for a multistakeholder consensus towards creating specific statements for addressing post-publication integrity concerns in RCTs.

Clinical features in rotator cuff calcific tendinopathy: A scoping review

Introduction The main goal of this scoping review is to highlight the clinical features of subjects with rotator cuff calcific tendinopathy (RCCT), in order to identify and map this condition clinical criteria, and thus to be able to hypothesize such pathology before imaging investigations. Methods Four databases were consulted up to January 2023. The obtained results were reported following the PRISMA-ScR and the Joanna Briggs Institute reviewer's manual was used as guideline for conducting the review. No time and geographical restrictions were applied. Results A total of 851 records have been identified, with 50 studies meeting the inclusion criteria. Subjects with RCCT mostly reported nightly, acute and severe pain with spontaneous onset. Symptoms were mostly unilateral. Subjects were mostly women aged between 30 and 60. Deficit in active and passive range of motion was reported, mainly during abduction and forward flexion. Endocrine and metabolic disorders were described as comorbidity, in particular diabetes and thyroid disorders. Conclusion In this scoping review, the most relevant RCCT clinical features were detected. These clinical criteria, predictive for shoulder RCCT, can be crucial to help all clinicians suspect this musculoskeletal disease early and with certainty, thus allowing for an appropriate and prompt diagnosis path. Level of evidence III.

The Combined Effect of Diets with Different Time Restriction and Low-intensity Aerobic Exercise on Metabolic Factors and Anthropometry in Overweight Middle-aged Men

The Combined Effect of Diets with Different Time Restriction and Low-intensity Aerobic Exercise on Metabolic Factors and Anthropometry in Overweight Middle-aged Men

Time dedicated to physical activity among medical residents: are there differences based on gender or specialty type?

IntroductionPhysical activity (PA) is associated with positive health outcomes such as prevention of chronic diseases, psychological well-being and improved work performance. Medical residents are subjected to sleep deprivation, extended work schedule and high burnout prevalence. These conditions may lead to the neglect of personal health and the restriction of time dedicated to PA. The objective of the present study was to analyze the time dedicated to PA of medical residents, comparing women vs men residents and surgical vs clinical residents. MethodsIt is a cross-sectional study performed in a Spanish third-level university hospital. All medical residents from our institution were invited to voluntarily participate in the study answering a web-based questionnaire on June 2022. Data regarding demographics, residency and PA practice was recorded. ResultsThe response rate was 20.73% (114/550). The 32.5% of the residents considered themselves to be physically inactive and mean time dedicated to PA in a regular week was 3.62 ± 2.22 h. Men residents dedicated more time to PA than women residents (4.23 ± 2.42 h vs 3.14 ± 1.95 h, p = 0.012) and surgical residents dedicated more time than clinical residents (4.33 ± 2.36 h vs 3.23 ± 2.05 h, p = 0.01). ConclusionsOne third of the medical residents consider themself physically inactive. Women and clinical residents practice PA less time than men and surgical residents. Efforts should be made to encourage PA among residents, especially in women and non-surgeons.

Mixed integer linear programming models to measure the economic impact of Zero-Buffers in Heijunka Flow Shop Scheduling

A classic production line for mixed models with a fixed cycle time is transformed into a flowshop by removing the time restrictions at the workstations. In the new production line, the Heijunka concept of Just in Time manufacturing is applied, imposing on the sequences of products that they preserve the production mix through linear constraints. In this work, we propose a MILP model for the new problem which is solved with the IBM-CPLEX solver using the set of 23 Nissan-9Eng.I instances. It is concluded that the economic impact due to production losses is very significant when the buffers between the stations of the engine production line are suppressed (1224 €/day), while the economic impact generated by Heijunka is negligible (9.83 €/day) compared to the economic and management advantages it offers.

Surgical and critical care management of earthquake musculoskeletal injuries and crush syndrome: A collective review.

Earthquakes are unpredictable natural disasters causing massive injuries. We aim to review the surgical management of earthquake musculoskeletal injuries and the critical care of crush syndrome. We searched the English literature in PubMed without time restriction to select relevant papers. Retrieved articles were critically appraised and summarized. Open wounds should be cleaned, debrided, receive antibiotics, receive tetanus toxoid unless vaccinated in the last 5 years, and re-debrided as needed. The lower limb affected 48.5% (21.9%-81.4%) of body regions/patients. Fractures occurred in 31.1% (11.3%-78%) of body regions/patients. The most common surgery was open reduction and internal fixation done in 21% (0%-76.6%), followed by plaster of Paris in 18.2% (2.3%-48.8%), and external fixation in 6.6% (1%-13%) of operations/patients. Open fractures should be treated with external fixation. Internal fixation should not be done until the wound becomes clean and the fractured bones are properly covered with skin, skin graft, or flap. Fasciotomies were done in 15% (2.8%-27.2%), while amputations were done in 3.7% (0.4%-11.5%) of body regions/patients. Principles of treating crush syndrome include: (1) administering proper intravenous fluids to maintain adequate urine output, (2) monitoring and managing hyperkalemia, and (3) considering renal replacement therapy in case of volume overload, severe hyperkalemia, severe acidemia, or severe uremia. Low-quality studies addressed indications for fasciotomy, amputation, and hyperbaric oxygen therapy. Prospective data collection on future medical management of earthquake injuries should be part of future disaster preparedness. We hope that this review will carry the essential knowledge needed for properly managing earthquake musculoskeletal injuries and crush syndrome in hospitalized patients.

Care Needs of Children with Inborn Errors of Metabolism and Their Parents: An Integrative Review

Background: Inborn errors of metabolism (IEMs) are a group of congenital and chronic diseases that cause many difficulties for children and their parents. Objectives: This review aims to identify the needs that they are faced in caring. Methods: This is an integrative review using the method of Whittemore and Knafl (2005). The databases of PubMed, Web of Science (ISI), SID, and Google Scholar were searched in English and Persian without any time and methodology restrictions in October and November 2022. Results: After screening the documents, 19 articles, consisting of 9 quantitative, 7 qualitative, and 3 review studies, were retrieved. Three categories of needs, including children, parents, and the healthcare system, were identified. The most reported needs were related to diet, psychological, social, and financial support dimensions and the necessity of implementing a multidisciplinary and coordinated care approach. Conclusions: Children with IEMs and their parents have many needs that can be satisfied through a multidisciplinary, patient-centered, and coordinated care approach.

Teaching Grammar Through Project based Learning: Empowering Students' English Proficiency

Project based Learning (PjBL), which emphasizes experiential learning, introduces a contrast between the structure of grammar and the open-ended nature of projects. This combination offers teachers with numerous hurdles, changing standard grammar education paradigms. English communication is essential in an increasingly international society. This study investigates the difficulties in incorporating PjBL into English grammar instruction in higher education. It investigates the contradictions between structured grammar and project flexibility, reconciling thorough comprehension with project constraints, and cultivating both grammar mastery and critical thinking. Managing time restrictions and providing direction are critical concerns. To overcome these obstacles, projects must be aligned with curriculum goals, and resources must be available to assist students' investigation. Virtual project experiences via learning platforms and Web 2.0 tools are among the future directions. The success of grammar projects is dependent on proper topic selection, skill integration, and proficiency alignment. They go beyond solitary practice by immersing pupils in real-life language skills. This comprehensive approach connects theoretical grammar understanding with practical language application. Finally, the combination of PjBL and grammar instruction brings education into a new era of transformation. This trip enriches language training by providing learners with communication skills and problem-solving abilities in preparation for the dynamic world ahead.

Criteria for choosing prosthetic biomaterials according to their physicochemical properties for anterior and posterior sectors. a comprehensive review.

To describe the existing knowledge about metal-free prosthetic biomaterials according to their physicochemical properties and based on this, define criteria for their placement in both the anterior and posterior sectors. A digital search was carried out in the databases: PubMed/Medline, Scopus, Web of Science and Google Scholar of the literature published in the English language without time restrictions and included original articles such as case reports, retrospective and prospective studies, narrative, comprehensive, systematic reviews and meta-analysis. Meanwhile, short communications, editorials and articles in a language other than English were excluded. 40 articles were evaluated, published between 2000 and 2023. The main characteristics and physicochemical properties of ceramic biomaterials such as zirconia, feldspathic based ceramics, lithium disilicate and alumina, among others, were analyzed and summarized. In addition, certain criteria were defined based on the available scientific evidence on the use of different ceramic systems both in the anterior sector and in the posterior sector for patients who need some type of prosthetic restoration. Among the different metal-free materials used for the construction of fixed dental prostheses, zirconia has been shown to have better aesthetic, biomechanical and biocompatibility properties, which makes it a candidate material for the rehabilitation of partially edentulous patients.

GLP-1 Receptor Agonists: A New Treatment in Parkinson's Disease.

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Recent data highlight similarities between neurodegenerative diseases, including PD and type 2 diabetes mellitus (T2DM), suggesting a crucial interplay between the gut-brain axis. Glucagon-like peptide-1 receptor (GLP-1R) agonists, known for their use in T2DM treatment, are currently extensively studied as novel PD modifying agents. For this narrative review article, we searched PubMed and Scopus databases for peer-reviewed research, review articles and clinical trials regarding GLP-1R agonists and PD published in the English language with no time restrictions. We also screened the references of the selected articles for possible additional articles in order to include most of the key recent evidence. Many data on animal models and preclinical studies show that GLP1-R agonists can restore dopamine levels, inhibit dopaminergic loss, attenuate neuronal degeneration and alleviate motor and non-motor features of PD. Evidence from clinical studies is also very promising, enhancing the possibility of adding GLP1-R agonists to the current armamentarium of drugs available for PD treatment.

Assessing the implications of short-term exemption clauses for insurers in Chinese fishery mutual insurance contracts

The exemption clauses in China’s Insurance Law delineate the scope of obligations, performance standards, and certification requirements pertaining to fishery mutual insurance and supplementary coverage. However, the legal validity of time-limited exemption clauses remains contentious in Chinese legal theory, with judicial practice evidencing inconsistent interpretation standards. This paper argues that the application of such clauses enables insurers to potentially restrict or deny liability to some extent, promoting moral hazard and violating public order and good customs. Through analysing current theories and judicial judgments, the paper examines threats and rationale underlying the incorporation of these clauses in fishery mutual insurance policies. It contends that time-limited exemption clauses essentially function as implicit coverage exemptions and should, therefore, be deemed invalid, precluding insurers from refusing claims based on time limits. The paper concludes by recommending insurers fully disclose the liability time restrictions imposed by this clause when formulating contracts to ensure policyholder awareness.