Residence Time Research Articles

Scheduling Dual-Arm Multi-Cluster Tools With Residency Time Constraints Beyond Swap-Based Strategies and Module-Bound Regions

Scheduling Dual-Arm Multi-Cluster Tools With Residency Time Constraints Beyond Swap-Based Strategies and Module-Bound Regions

Blood Cell Membrane-Coated Nanomaterials as a Versatile Biomimetic Nanoplatform for Antitumor Applications

The application of nanomaterials in tumor therapy is increasingly widespread, offering more possibilities for enhanced tumor therapy. However, the unclear biological distribution and metabolism of nanomaterials may lead to immune rejection or inflammatory reactions, posing numerous challenges to their clinical translation. The rich diversity and multifaceted functions of blood cells offer promising biological avenues for enhancing the application of nanoparticles in cancer therapy. Blood cell membranes, being made of naturally found components in the body, exhibit significant biocompatibility, which can reduce the body’s immune rejection response, extend the drug’s residence time in the bloodstream, and enhance its bioavailability. Integrating blood cell membranes with nanomaterials enhances tumor therapy by improving targeted delivery, prolonging circulation time, and evading immune responses. This review summarizes recent advancements in the application of blood cell membrane-coated nanomaterials for antitumor therapy, with a particular focus on their use in photodynamic and photothermal treatments. Additionally, it explores their potential for synergistic effects when combined with other therapeutic modalities.

2-D modeling of torrefaction of a large biomass particle: effect of L/D ratio, internal convection and shrinkage

ABSTRACT Torrefaction of a large biomass particle was investigated using a transient 2-D model, including primary and secondary reactions kinetics and heat transfer, internal convection, and shrinkage. The model predictions matched with the experimental results within +2%. Spatial and temporal distributions of temperature, residual mass fraction, velocity, and pressure inside the particle and the effect of reactor temperature, residence time, particle size, and shrinkage on the torrefaction behaviour were investigated. Evolution of moisture, volatiles and gases due to drying and torrefaction increase the pressure inside the particle, setting up a velocity field and internal convection. Average velocity and pressure reached a peak during the initial drying period due to moisture evolution, and a subsequent second peak due to the formation of volatiles and gases by torrefaction at a reactor temperature > 493 K. Internal convection influenced torrefaction significantly but the particle shrinkage did not impact it appreciably. The degree of overshoot of the particle center temperature above the reactor temperature increased with the reactor temperature and the particle diameter. Simulations suggest that a reactor temperature of 550 K and residence of about 30 min would be suitable for torrefaction of a particle with L = D = 25.4 mm.

Catalytic membrane with dual-layer structure for ultrafast degradation of emerging contaminants in surface water treatment

The catalytic membrane-based oxidation-filtration process integrates physical separation and chemical oxidation, offering a highly efficient water purification strategy. However, the oxidation-filtration process is limited in practical applications due to the short residence time of milliseconds within the catalytic layer and the interference of coexisting organic pollutants in real water. Herein, a dual-layer membrane containing a top selective layer and a bottom catalytic layer was fabricated using an in situ co-casting method with a double-blade knife. Experimental results demonstrated that the selective layer rejected macromolecular organic pollutants, thereby alleviating their interference with bisphenol A (BPA) degradation. Concurrently, the catalytic layer activated peracetic acid oxidant and achieved a high BPA degradation exceeding 90 % in milliseconds with reactive oxygen species (especially •OH). The finite-element analysis confirmed a high-concentration reaction field occupying the pore cavity of the catalytic layer, enhancing collision probability between reactive oxygen species and BPA, i.e., the nano-confinement effect. Additionally, the dual-layer membrane achieved a long-term stable performance for emerging contaminant degradation in surface water treatment. This work underscores a novel catalytic membrane structure design for high-performance oxidation-filtration processes and elucidates its mechanisms underlying ultrafast degradation.

Occurrence, residency, and habitat characterization of leopard seals in Chile

Leopard seals have traditionally been considered Antarctic predators with a Southern Ocean distribution. Historically, sightings north of the Antarctic Polar Front were considered extralimital. However, recent studies suggest a significant presence of leopard seals in subantarctic regions. Here, we assess the spatial occurrence, residency status, and temporal trends of leopard seals in Chile using historical records, stranding reports, standardized monitoring data, photo-identification (photo ID) catalogs, and sightings from four research expeditions. We also characterize glaciers where sightings are concentrated, identifying glaciological and geomorphic attributes that prolong iceberg residency time, which is linked to high leopard seal concentrations. Based on these attributes, we evaluated other potential suitable glacial habitats in Patagonia. We obtained 438 sighting records of leopard seals from 1927 to 2023. Over the last 15 years, we documented a 4-18% annual increase in stranding events reported to national authorities. Most sightings (75%) were concentrated in two hotspots: National Park San Rafael Lagoon, located in Northern Patagonia, and Parry Fjord in Tierra del Fuego. Using photo ID catalogs, we identified 19 resident leopard seals, including 16 multi-year residents observed between 2010-2023 (10 in San Rafael, 6 in Tierra del Fuego) and 3 potential residents (observed multiple months in the same year in Tierra del Fuego). San Rafael monitoring data showed no inter-annual trend, but seasonal trends were observed. We also provide evidence of breeding in Chile, with records of at least 14 pups born and at least two females giving birth in multiple years. Our habitat characterization suggests that calving flux, fjord sinuosity, and fjord width variation are crucial for prolonging iceberg residency in hotspot areas. Based on these attributes, we identified 13 additional fjords in Patagonia as “very likely” suitable for leopard seals. Our study confirms that Patagonia is part of the species’ breeding distribution, shifting the paradigm that leopard seals are merely visitors north of the Antarctic Polar Front. Given the limited number of suitable glaciers in Chile and the potential impacts of climate change, our assessment highlights glacial retreat as a major threat for the ecosystem of this pagophilic marine apex predator in South America.

Can Chitosan Be Depolymerized by Thermal Shock?

Chitosan is a biopolymer with a wide range of applications. It typically requires depolymerization to achieve a desired molecular weight for specific uses. This study investigated the potential for depolymerizing chitosan by thermal shock and grinding to produce nanochitosan. A series of thermal shock cycles combined with grinding were performed to assess the influence of drying temperature, residence time, and number of thermal cycles on the molecular weight, particle size, and crystallinity of chitosan. The thermal shock reduced the molecular weight and particle size of chitosan within the first hour of treatment, with optimal conditions achieved at a drying temperature of 90 °C and residence time inside the oven of 5 min. These conditions resulted in a molecular weight of 15.0 kDa with an average diameter of 136 nm. Thermal shock can be considered an effective method for chitosan depolymerization with grinding serving to standardize the particle size. This optimized process offers promising applications where low-molecular-weight chitosan is required, including biomedical, agricultural, and food industries, as well as the potential for reducing time and energy consumption.

Effect of High-Rate Aeration in the Electrocoagulation Treatment of Pharmaceutical and Synthetic Textile Industrial Wastewater Effluents

Despite the extensive literature on the effects of implementing aeration in the electrocoagulation (EC) treatment of industrial wastewater, few studies evaluate the performance of this technique at high aeration rates. In this work, we present the outcomes derived from EC treatment of pharmaceutical and synthetic textile wastewater effluents in two lab-scale reactors with and without aeration, each equipped with different electrode combinations of aluminium and iron (Al/Al, Al/Fe, and Fe/Fe). In the non-aerated EC reactor, maximum chemical oxygen demand (COD) reductions of 56% and 80% were achieved for the pharmaceutical and textile effluents, respectively, with up to 100% removal of turbidity and colour with the Al/Al combination. The installation of high-rate aeration to prevent sludge accumulation on the electrode surface markedly reduced residence times and enhanced the COD removal in the pharmaceutical effluent. However, this implementation potentially reduced the process efficiency for thesynthetic textile effluent as prolonged operation led to flocculation breakdown and subsequent re-dissolution of the contaminants in the water.

Hydrodynamic analysis of rectangular reactors With suspended bafles

Historically, contact tanks have been designed by empirical correlation, physical model studies or tracer studies conducted after the construction of the contact tank. Recently, the Lattice Boltzmann D2Q9 method, using a numerical code (LBM - FORTRAN) was applied to study the transport of fluxes and solutes in disinfection tanks. The objective of this article is to present the results of a numerical study undertaken to investigate the effect of the number of deflectors on the performance of a contact tank. Several two-dimensional, time-variable, steady state numerical simulations were performed with the LBM method for the standard k-e model in a contact tank geometry where a different number of deflectors was considered. Residence time distribution (RTD) curves were calculated for any number of deflectors to evaluate and compare their performance. Finally, we calculated the concentrations at the outlet of the tank as a function of time and of the size of the baffles for all cases.

Innovative Long-Acting Bisoprolol Patch: Synergistic Ion-Pair Skin Adsorption for Drug Delivery Control Coupled with Dynamic Modulation of Penetration Enhancers.

This study aims to develop a sustained release patch for bisoprolol (BSP) to address the issue of blood pressure fluctuations caused by traditional dosing methods, ensuring continuous drug release and efficient utilization. Long-chain saturated fatty acids (C6-C12) were chosen as counterions to precisely control BSP's permeation rate in the patch formulation, and the ion-pairing strategy's mechanism in drug delivery was thoroughly investigated. Molecular docking results revealed significant differences in the adsorption capacities of different ion pairs in the stratum corneum (SC) and epidermis, directly influencing their residence times and thereby regulating BSP's passive diffusion rate. Particularly, the BSP-C10 ion pair successfully reduced BSP's permeation rate to one-third of its baseline. To enhance drug delivery efficiency and reduce costs, chemical permeation enhancers (CPEs) are typically added to sustained release patches. In contrast to traditional static analyses based on cumulative permeation, this study utilized ATR-FTIR dynamic detection of isopropyl myristate (IPM) as a preferred enhancer, studying its disruptive effects on the skin barrier during drug delivery. The study observed that during drug delivery, the interaction between IPM and skin lipids follows a U-shaped trend: initially increasing, then decreasing, with the peak occurring at 10 h. Similarly, the drug delivery rate displays a comparable pattern. The addition of IPM as CPE increased the patch utilization rate from 39.8 ± 4.31 to 79.8 ± 7.27%. This strategy aims to rapidly reduce blood pressure in the initial phase with subsequent weakening of IPM disruption, allowing the ion-pairing strategy to dominate drug delivery control and maintain stable long-term therapeutic effects. Pharmacokinetic studies demonstrated that the newly developed BSP sustained release patch maintains stable blood drug concentrations, reduces burst release effects, increases bioavailability to 84.679%, doubles MRT0-t, halves Cmax, and significantly reduces the occurrence of blood pressure fluctuations.

Targeted isolation of extracellular vesicles from cell culture supernatant using immuno-affinity chromatography

Extracellular vesicles (EVs) have emerged as promising therapeutics with broad clinical applications as diagnostic biomarkers and therapeutic drug delivery systems. Yet, these biopharmaceuticals pose a challenge in terms of manufacturing due to their complexity and heterogeneity. Despite advancements in the field, current purification technologies lack scalability and/or selectivity. Affinity chromatography (AC) − coupling unmatched specificity and scalability − could be used to simplify purification processing and generate clinical-grade EVs with higher titers and purity.In the present work, we report the implementation of an immuno-AC resin to capture and purify EVs directly from clarified cellular feedstocks. Firstly, to guide and support marker selection, vesicle phenotype characterization was conducted using single particle interferometric reflectance image sensing (SP-IRIS) coupled with immunofluorescence. CD81 was the marker which shown to be more present and more likely to have the other markers (CD63 and CD9). Thus, anti-CD81 VHH ligand was generated and evaluated towards recombinant CD81 protein and CD81 bearing EV particles using surface plasmon resonance (SPR). Different chromatographic studies with Anti-CD81 ligand immobilized onto agarose beads resin were conducted to optimize the process parameters (residence time, dynamic binding capacity and impurity clearance). At residence time of 2 min, on average 40 % of pure triple tetraspanin-positive EV fraction was recovered. The enrichment in EV particles herein obtained, based on scale-up calculations, it would be possible to produce 1 × 1013 EVs from a 1L cell culture, while meeting impurity requirements in a single-step purification process (impurity removal over 2 log reduction value). A single-step purification process is possible, enabling the successful isolation of homogeneous EVs population, counting with a final HCP titer of 60 ng/mL and 9 ng/mL of dsDNA impurities. EV’s morphological integrity and internalization ability were also demonstrated, showcasing elution’s efficiency under mild conditions.Overall, this work contributes to the development of a novel, highly specific, AC technology using a camelid-derived affinity ligand which, bridging the scalability requirements demanded of large-scale production, could potentiate the advent of EV-based therapies.

Atomistic insights into the K+/Na+ separation across amino modified graphene nanopore: The assisting role of Cl−

K+/Na+ separation has always been considered the most challenging. We adopted molecular dynamics to compare graphene nanopores modified with positively charged amino groups and their pristine counterparts to unravel the mechanism underlying the effect of positively charged amino groups on K+/Na+ separation and evaluate the assisting effect of Cl−. Two pore diameters of approximately 1 nm were selected. Results demonstrated that nanopore modification can effectively improve the K+/Na+ selectivity, and the spatial distribution and residence time of Cl− near the nanopores indicated that modification with positively charged amino groups can induce the dynamical adsorption of Cl− around the nanopores. In the studied nanopores, the prolongation of the residence time of Cl− at the pore mouths can increase the difference between K+ and Na+ dehydration and thus can increase their transport resistance difference. The latter effect is conducive to improving the selectivity for K+. Our findings can provide useful insight for the further design of K+ separating two-dimensional materials as sensors and ion separators.

Revealing membrane integrity and cell size from diffusion kurtosis time dependence.

The nonmonotonic dependence of diffusion kurtosis on diffusion time has been observed in biological tissues, yet its relation to membrane integrity and cellular geometry remains to be clarified. Here we establish and explain the characteristic asymmetric shape of the kurtosis peak. We also derive the relation between the peak time , when kurtosis reaches its maximum, and tissue parameters. The peak shape and its position qualitatively follow from the adiabatic extension of the Kärger model onto the case of intra-cellular diffusivity time-dependence. This intuition is corroborated by the effective medium theory-based calculation, as well as by Monte Carlo simulations of diffusion and exchange in randomly and densely packed spheres for various values of permeability, cell fractions and sizes, and intrinsic diffusivity. We establish that is proportional to the geometric mean of two characteristic time scales: extra-cellular correlation time (determined by cell size) and intra-cellular residence time (determined by membrane permeability). When exchange is barrier-limited, the peak shape approaches a universal scaling form determined by the ratio . Numerical simulations and theory provide an interpretation of a specific feature of kurtosis time-dependence, offering a potential biomarker for in vivo evaluation of pathology by disentangling the functional (permeability) and structural (cell size) integrity in tissues. This is relevant as the time-dependent diffusion cumulants are sensitive to pathological changes in membrane integrity and cellular structure in diseases, such as ischemic stroke, tumors, and Alzheimer's disease.

Comparative analysis of Zero Pressure Geometry and prestress methods in cardiovascular Fluid-Structure Interaction

Background and Objective:Modelling patient-specific aortic biomechanics with advanced computational techniques, such as Fluid–Structure Interaction (FSI), can be crucial to provide effective decision-making indices to enhance current clinical practices. To effectively simulate Ascending Thoracic Aortic Aneurysms (ATAA), the stress-free configuration must be defined. The Zero Pressure Geometry (ZPG) and the Prestress Tensor (PT) are two of the main approaches to tackle this issue. However, their impact on the numerical results is yet to be analysed. Computed Tomography Angiography (CTA) and Magnetic Resonance Imaging (MRI) data were used to develop patient-specific 2-way FSI frameworks. Methods:Three models were developed considering different tissue prestressing approaches to account for the reference configuration and their numerical results were compared. The selected approaches were: (i) ZPG, (ii) PT and (iii) a combination of the PT approach with a regional mapping of material properties (PTCAL). Results:The pressure fields estimated by all models were equivalent. The estimation of Wall Shear Stress (WSS) based metrics revealed good correspondence between all models except the Relative Residence Time (RRT). Regarding ATAA wall mechanics, the proposed extension to the PT approach presented a closer agreement with the ZPG model than its counterpart. Additionally, the PT and PTCAL approaches required around 60% fewer iterations to achieve cycle-to-cycle convergence than the ZPG algorithm. Conclusion:Using a regional mapping of material properties in combination with the PT method presented a better correspondence with the ZPG approach. The outcomes of this study can pave the way for advancing the accuracy and convergence of ATAA numerical models using the PT methodology.

Changes in integration and wellbeing by educational background among migrants in Kristiansand

Abstract Background Integration levels and wellbeing of newly arrived migrants change according to their everyday activities in their new home country. Although migrants have very different educational backgrounds and expectations regarding work in Norway, the compulsory educational activities are the same for all, disregarding their educational background. Aims To examine the changes in integration and wellbeing among newly arrived migrants participating in a compulsory integration program in Norway, according to their educational background. Methods As part of the Integration for Health project (I4H) we collected information from participants in Kristiansand municipality through a self-filled questionnaire in 2023 (N = 102) repeated six months apart, including questions from the Immigrant Policy Lab Index and the WHO-5 Well Being Index. For both screening tools, higher scores indicate better integration and wellbeing. Information on educational background was dichotomized into either health or non-health (natural and technical) sciences, using health sciences as the reference. We used generalized estimating equations to calculate relative risks (RR) with 95% confidence intervals (CI) adjusted for age and gender. Results The mean age was 34 years (SD 8.3) and 59% were women. Mean residency time was 3 years (SD 0.14). In terms of education, 14% had health sciences, and 86% had other educational backgrounds. We did not find change in wellbeing over the six-month period (RR 1.0 (95% CI 0.9-1.1), and this trend was similar for both educational groups (RR 0.9 (95% CI 0.8-1.1). Integration score slightly increased after six months (RR 1.0 (95% CI 1.0-1.1). However, there was no difference by educational background (RR 1.0 (95% CI 0.9-1.0). Conclusions Changes in wellbeing and integration among participants in the compulsory introductory program with short residency time, do not seem to vary by educational background in a six-month period. Key messages • Schools and introductory programs in the host country can be used as a arena to enhance both the integration and wellbeing of newly arrived migrants. • Strengthening migrants’ educational opportunities in the new host country is also of importance.

Hydrogeochemical Processes in Basement Areas Using Principal Component in Burkina Faso (West African Sahel)

The basement aquifers in Burkina Faso are increasingly exposed to groundwater pollution, largely due to socio-economic activities and climatic fluctuations, particularly the reduction in rainfall. This pollution makes the management and understanding of these aquifers particularly complex. To elucidate the processes controlling this contamination, a methodological approach combining principal component analysis (PCA) and multivariate statistical techniques was adopted. The study analyzed sixteen physicochemical parameters from 58 water samples. The primary objective of this research is to assess groundwater quality and deepen the understanding of the key factors influencing the spatial variation of their chemical composition. The results obtained will contribute to better planning of preservation and sustainable management measures for water resources in Burkina Faso. The results show that three principal components explain 72% of the variance, identifying anthropogenic inputs, with two components affected by mineralization and one by pollution. The study reveals that the groundwater is aggressive and highly corrosive, with calcite saturation. Water-rock interactions appear to be the main mechanisms controlling the hydrochemistry of groundwater, with increasing concentrations of cations and anions as the water travels through percolation pathways. PCA also revealed that the residence time of the water and leaching due to human activities significantly influence water quality, primarily through mineralization processes. These results suggest that rock weathering, coupled with reduced rainfall, constitutes a major vulnerability for aquifer recharge.

Air cleaner prototype: Reduction of airborne viruses and effects of UV-C irradiation on virus concentration and RNA copy numbers considering modeled residence times and doses

Air cleaner prototype: Reduction of airborne viruses and effects of UV-C irradiation on virus concentration and RNA copy numbers considering modeled residence times and doses

Gating residues govern ligand unbinding kinetics from the buried cavity in HIF-2α PAS-B.

While transcription factors have been generally perceived as "undruggable," an exception is the HIF-2 hypoxia-inducible transcription factor, which contains an internal cavity that is sufficiently large to accommodate a range of small-molecules, including the therapeutically used inhibitor belzutifan. Given the relatively long ligand residence times of these small molecules and the lack of any experimentally observed pathway connecting the cavity to solvent, there has been great interest in understanding how these drug ligands exit the buried receptor cavity. Here, we focus on the relevant PAS-B domain of hypoxia-inducible factor 2α (HIF-2α) and examine how one such small molecule (THS-017) exits from the buried cavity within this domain on the seconds-timescale using atomistic simulations and ZZ-exchange NMR. To enable the simulations, we applied the weighted ensemble path sampling strategy, which generates continuous pathways for a rare-event process [e.g., ligand (un)binding] with rigorous kinetics in orders of magnitude less computing time compared to conventional simulations. Results reveal the formation of an encounter complex intermediate and two distinct classes of pathways for ligand exit. Based on these pathways, we identified two pairs of conformational gating residues in the receptor: one for the major class (N288 and S304) and another for the minor class (L272 and M309). ZZ-exchange NMR validated the kinetic importance of N288 for ligand unbinding. Our results provide an ideal simulation dataset for rational manipulation of ligand unbinding kinetics.

Molecular dynamics insights into the dynamical behavior of structurally modified water in aqueous deep eutectic solvents (ADES).

Recent studies have demonstrated that the presence of water in deep eutectic solvents (DESs) significantly affects their dynamics, structure, and physical properties. Although the structural changes due to the addition of water are well understood, the microscopic dynamics of these changes have been rarely studied. Here, we performed molecular dynamics simulation of 30% (v/v) (∼0.57 molar fraction) water mixture of DES containing CH3CONH2 and NaSCN/KSCN at various salt fractions to understand the microscopic structure and dynamics of water. The simulated results reveal a heterogeneous environment for water molecules in aqueous DES (ADES), which is influenced by the nature of the cation. The diffusion coefficients of water in ADESs are significantly lower than that in neat water and concentrated aqueous NaSCN/KSCN solution. When Na+ ions are replaced by K+ ions in the ADES system, the diffusion coefficient increases, which is consistent with the measured nuclear magnetic resonance data. Self-dynamic structure factor for water and other simulated dynamic quantities, such as reorientation, hydrogen-bond, and residence time correlation functions, show markedly slower dynamics inside ADES than in the neat water and aqueous salt solution. Moreover, these dynamics become faster when Na+ ions in ADES are replaced by K+ ions. The results suggest that the structural environment of water in Na+-rich ADES is rigid due to the presence of cation-bound water and geometrically constrained water. The medium becomes less rigid as the KSCN fraction increases due to the relatively weaker interaction of K+ ions with water than Na+ ions, which accelerates the dynamical processes.

Improvement of Properties of Bio-Oil from Biomass Pyrolysis in Auger Reactor Coupled to Fluidized Catalytic Bed Reactor

The goal of this research work was to investigate the improvement of bio-oil issued from beechwood biomass through catalytic de-oxygenation. Pyrolysis was conducted in an auger reactor and the catalytic treatment was performed in a fluidized catalytic bed reactor. Lab-synthesized Fe-HZSM-5 catalysts with different iron concentrations were tested. BET specific surface area, BJH pore size distribution, and FT-IR technologies were used to characterize the catalysts. Thermogravimetric analysis was used to measure the amount of coke deposited on the catalysts after use. Gas chromatography coupled to mass spectrometry (GC-MS), flame ionization detection (GC-FID), and thermal conductivity detection (GC-TCD) were used to identify and quantify the liquid and gaseous products. The pyrolysis temperature proved to be the most influential factor on the final products. It was observed that a pyrolysis temperature of 500 °C, vapor residence time of 18 s, and solid residence time of 2 min resulted in a maximum bio-oil yield of 53 wt%. A high percentage of oxygenated compounds, such as phenolic compounds, guaiacols, and the carboxylic acid group, was present in this bio-oil. Catalytic treatment with the Fe-HZSM-5 catalysts promoted gas production at the expense of the bio-oil yield, however, the composition of the bio-oil was strongly modified. These properties of the treated bio-oil changed as a function of the Fe loading on the catalyst, with 5%Fe-HZSM-5 giving the best performance. A higher iron loading of 5%Fe-HZSM-5 could have a negative impact on the catalyst performance due to increased coke formation.

Boosting Photocatalytic Hydrogen Evolution by a Light Coupling and Charge Carrier Confinement Strategy

AbstractHigh‐performance photocatalysis requires efficient light absorption and low charge carrier recombination rates. Herein, a light coupling and charge carrier confinement strategy is demonstrated to simultaneously enhance the light absorption efficiency and suppress the charge carrier recombination for high‐performance photocatalysis. The strategy is achieved by the delicate incorporation of catalysts into a dual‐core‐shell structure (e.g., CdS@SiO2@NaYF4:Yb/Tm), in which CdS (catalyst), SiO2, and NaYF4:Yb/Tm serve as shell, outer core, and inner core, respectively. Interestingly, the absorbed light can be confined within the CdS layer through multiple reflections between the CdS and SiO2 interfaces, achieving light confinement. This confinement endows a longer light residence time, enhanced light reabsorption and reutilization efficacy, and a higher concentration of photogenerated charge carriers per unit of time. Moreover, the insulating SiO2 can confine the photogenerated charge carriers within CdS layer, thus shortening their diffusion length for reduced recombination rates. Notably, when employed as the photocatalyst, this dual‐core‐shell structure showed a superb photocatalytic hydrogen evolution rate up to 74.67 mmol g−1 h−1, which is 11 times higher than that of pristine CdS. This work provides a new strategy for the design and synthesis of high‐performance photocatalysts.