Timing Of Events Research Articles

The timing of the ca-660 BCE Miyake solar-proton event constrained to between 664 and 663 BCE

Extreme solar energetic particle events, known as Miyake events, are rare phenomena observed by cosmogenic isotopes, with only six documented. The timing of the ca. 660 BCE Miyake event remains undefined until now. Here, we assign its occurrence to 664–663 BCE through new radiocarbon measurements in gymnosperm larch tree rings from arctic-alpine biomes (Yamal and Altai). Using a 22-box carbon cycle model and Bayesian statistics, we calculate the radiocarbon production rate during the event that is 3.2–4.8 times higher than the average solar modulation, and comparable to the 774–775 CE solar-proton event. The prolonged radiocarbon signature manifests a 12‰ rise over two years. The non-uniform signal in the tree rings is likely driven by the low rate of CO2 gas exchange between the trees and the ambient atmosphere, and the high residence time of radiocarbon in the post-event stratosphere. We caution about using the event’s pronounced signature for precise single-year-dating.

Multiple Logistic Regression Model for Assessing the Risk Factors of Traffic Accidents: Khon Kaen Model.

Thailand has consistently held the highest global ranking in traffic accidents since 2017, with Khon Kaen displaying the highest mortality rate in the Department of Disease Control Region 7. This study aims to utilize Injury Surveillance (IS) data to identify risk factors associated with emergency room (ER) outcomes at the Emergency Department of Khon Kaen hospital in Khon Kaen Municipality. Data from the Injury Surveillance system's (IS system) database were collected, focusing on severity outcomes, time of events, and risk behaviors from January 1, 2008, to December 31, 2021. Data analysis was conducted using the R program, employing the Chi-square or independent T test to compare results and analyze associations between potential risk factors and ER outcomes. Multiple logistic regression (MLR) was used for classification analysis, and a confusion matrix was applied to evaluate the performance of the models. MLR analysis revealed that being male, age, alcohol consumption, and nighttime driving were more likely to increase the probability of severity outcomes. Being male, age, alcohol consumption, and nighttime driving are identified as potential risk factors contributing to the development of severity outcomes following traffic accidents.

Phylogenetic evidence clarifies the history of the extrusion of Indochina

The southeastward extrusion of Indochina along the Ailao Shan-Red River shear zone (ARSZ) is one of two of the most prominent consequences of the India-Asia collision. This plate-scale extrusion has greatly changed Southeast Asian topography and drainage patterns and effected regional climate and biotic evolution. However, little is known about how Indochina was extruded toward the southeast over time. Here, we sampled 42 plant and animal clades (together encompassing 1,721 species) that are distributed across the ARSZ and are not expected to disperse across long distances. We first assess the possible role of climate on driving the phylogenetic separations observed across the ARSZ. We then investigate the temporal dynamics of the extrusion of Indochina through a multitaxon analysis. We show that the lineage divergences across the ARSZ were most likely associated with the Indochinese extrusion rather than climatic events. The lineage divergences began at ~53 Ma and increased sharply ~35 Ma, with two peaks at ~19 Ma and ~7 Ma, and one valley at ~13 Ma. Our results suggest a two-phase model for the extrusion of Indochina, and in each phase, the extrusion was subject to periods of acceleration and decrease, in agreement with the changes of the India-Asia convergence rate and angle from the early Eocene to the late Miocene. This study highlights that a multitaxon analysis can illuminate the timing of subtle historical events that may be difficult for geological data to pinpoint and can be used to explore other tectonic events.

Polymetamorphic evolution of the Vestfold Block in East Antarctica and implications for the amalgamation of terranes

The Vestfold Block, a typical polymetamorphic Archean terrane in East Antarctica, is a key area to understand amalgamations of Rodinia and East Gondwana continents. However, multiphase overprinting makes it difficult to determine the timing and nature of each tectonothermal event. In this study, we present P–T estimates, zircon, monazite U(–Th)–Pb and biotite/K–feldspar Rb–Sr isochron ages of paragneisses from the SE Vestfold Block. One paragneiss sample, which is assigned to the Chelnok Paragneiss, has experienced a protracted metamorphism from the Neoarchean to the early Paleoproterozoic. Phase equilibria modeling constrained the peak P–T conditions to 7.2–9.6 kbar and 850–880 ℃, and the post–peak metamorphism to 4.2–5.6 kbar and 720–790 ℃, respectively. On the other hand, a paragneiss sample close to the ice sheet documented a high–grade metamorphic event at 918 ± 23 Ma, with peak P–T conditions of 6.0–8.0 kbar and 860–880 ℃. Biotite/K–feldspar Rb–Sr dating for these two samples yields isochron ages of 474 ± 12 and 442 ± 7 Ma, respectively, representing the cooling ages of the Pan–African reworking. Collectively, an integrated application of diverse chronometers, combined with published data, indicates that the Vestfold Block may have experienced at least three major thermal events with variable intensities and extents. Initially, the supracrustal rocks in this region pervasively underwent a protracted high–grade thermal event from the Neoarchean to the early Paleoproterozoic, which formed the backbone of the block. Thereafter, the southern Vestfold Block experienced a Grenvillian granulite facies metamorphism, indicating that the Vestfold Block has been locally involved in the Rayner orogeny (i.e. the late Mesoproterozoic/early Neoproterozoic collision between the Indian craton and East Antarctica). Ultimately, the whole Vestfold Block may have been reworked under relatively low temperatures during the Pan–African Prydz tectonic event.

The superposition of Cretaceous mineralization events leading to the formation of the large Baiyinnuoer Pb–Zn deposit in NE China

The Baiyinnuoer Pb–Zn deposit, estimated at 26.57 million metric tonnes (Mt) with grades of 1.77% Pb and 5.21% Zn, is situated in the southern Great Xing'an Range (SGXR) of northeast China. The deposit comprises southern and northern ore belts. The southern belt primarily contains skarn ore bodies (32% of reserves) associated with Triassic granodiorite, while the northern belt is dominated by skarn ore bodies (30% of reserves) related to Triassic diorite porphyry. In addition to Triassic skarn‐type mineralization, the deposit also exhibits Early Cretaceous mineralization. This includes vein‐type occurrences (36% of reserves) within volcanic tuff and syenite porphyry, alongside a small amount of skarn ore bodies (2% of reserves) related to syenite porphyry. LA‐ICP‐MS U–Pb dating of intrusive rocks and garnets was conducted to investigate the timing and genesis of these mineralization events, revealing two distinct stages of skarn‐type mineralization. The first stage, associated with Early Triassic granitoids, dates to 254.6 ± 1.4–241.7 ± 2.7 Ma, while the second stage is closely associated with Early Cretaceous syenite porphyry, constrained to 135.4 ± 1.1–135.2 ± 1.6 Ma. Garnet U–Pb dating in the syenite porphyry‐related skarn yielded an age of 134.9 ± 4.7 Ma; however, due to low U content, reliable dating of garnets associated with Early Triassic granitoid‐related skarn was not feasible. Micro‐thermometry and Laser Raman analyses of fluid inclusions within vein‐type ore bodies highlighted distinct differences between vein‐type mineralization and Early Triassic skarn‐type mineralization. Additionally, in situ sulfur isotope analyses of sphalerite from both Early Triassic and Early Cretaceous ore bodies indicate a magmatic origin for sulfur in both stages. Through comprehensive geological, geochronological, in situ sulfur isotope and fluid inclusion studies, the Baiyinnuoer Pb–Zn deposit is conclusively identified as a large deposit characterized by two distinct periods of mineralization (Early Triassic and Early Cretaceous), akin to several other significant polymetallic deposits in NE China.

Resistance of grassland productivity to drought and heatwave over a temperate semi-arid climate zone

Drought and heatwave are the primary climate extremes for vegetation productivity loss in the global temperate semi-arid grassland, challenging the ecosystem productivity stability in these areas. Previous studies have indicated a significant decline in the resistance of global grassland productivity to drought, but we still lack a systematic understanding of the mechanisms determining the spatiotemporal variations in grassland resistance to drought and heatwave. In this study, we focused on temperate semi-arid grasslands of China (TSGC) to assess the spatiotemporal variations of grassland productivity resistance to different climate extremes: compound dry-hot events, individual drought events, and individual heatwave events that occurred during 2000–2019. Based on the explainable machine learning model, we explored the resistance to the interaction of drought and heatwave and identify the dominant factors determining the spatiotemporal variations in resistance. The results revealed that grassland resistance to climate extremes had decreased in Xilingol Grassland and Mu Us Sandy Land, and had a not significant increase in Otindag Desert during 2000–2019. Human activities and the increase in CO2 concentration causes a decline in resistance in Mu Us Sandy Land, and the increase of VPD and shift of vegetation loss event timing caused a decline in resistance in Xilingol Grassland, while the weakening of climate extremes, especially the shortening of drought duration, increase the resistance in Otindag Desert. Mean annual temperature dominates the spatial differences in resistance among different grasslands. When drought and heatwave occur simultaneously, there is an additive effect on resistance and causes lower resistance to compound dry-hot events compared to individual drought and heatwave events. Our analysis provides crucial insights into understanding the impact of climate extremes on the temperate semi-arid grasslands of China.

Sex-specific effects of chronic stress prior to cocaine exposure on cue- vs drug-induced relapse after prolonged abstinence

The comorbidity between cocaine use disorder (CUD) and trauma/stressor-related disorders suggests a connection between neurophysiological changes induced by stress and those that lead to cocaine use. Due to the unexpected and sometimes uncontrollable nature and timing of stressful life events, their capacity to induce drug use poses a significant challenge for the administration of cocaine relapse therapy. This study aims to investigate the impact of chronic stress applied prior to cocaine acquisition on the development of cocaine-seeking behavior after different periods of drug abstinence in male and female rats. Rats were exposed to five days of inescapable footshocks (chronic stress) before undergoing extended access cocaine self-administration. Different groups then underwent forced abstinence periods of 1, 15, or 30 days before cue- and cocaine-induced seeking tests. Results showed that, after 30 days of abstinence, stressed females exhibited higher cue-induced, but not cocaine-induced seeking, compared to female controls and to males. In contrast, at 30 days, stressed males showed higher cocaine-, but not cue-induced seeking, versus controls. Such sex-dependent alterations in motivation and drug effects following prolonged abstinence highlight the importance of considering sex-specific differences in stress-related addiction research. Ongoing work should evaluate other stressors and self-administration models to elucidate neurophysiological and hormonal mechanisms underlying the incubation of cocaine craving. Identifying shared pathways between chronic stress and addiction could offer novel strategies for treating trauma/stress-related substance use disorders in a sex-specific manner.

Paleostress evolution of the Outer Kwanza basin (offshore Angola); comparison with the Congo basin and implications for the tectonic history of the Central segment of the West Africa passive margin

This study aims at reconstructing the paleostress history of the Outer (offshore) Kwanza basin (West African passive margin) and at comparing it to stress results acquired further north in the Congo basin. Three oriented borehole cores provided by TotalEnergies and reaching the syn-rift, Barremian-Aptian pre-salt carbonates offshore Angola were investigated. Paleopiezometry based on the Stylolite Roughness Inversion Technique (SRIT) and Calcite Twin Inversion Technique (CSIT) was combined with fracture analysis, U–Pb geochronology of carbonates and burial modelling to unravel the orientations and magnitudes of horizontal and vertical stresses affecting the pre-salt carbonates over time. Calcite twins were measured from a primary sparite matrix, and the inversion process unravelled a polyphase stress history, comprising ∼ E-W and NE-SW extensional trends that we associate to the rifting (130-112 Ma) that led to the opening of the South Atlantic ocean. The ∼ E-W extension is consistent with the early occurrence of N-S striking normal faults which developed in relation to the reactivation of inherited basement structures. This ∼ E-W extension evolved during the Barremian-Aptian (?) into the dominant regional NE-SW extension marked by large-scale NW-SE striking normal faults. The stress history also comprises compressional and strike-slip stress regimes associated with a ∼N-S trending σ1 which can be related to the transfer of orogenic stresses from the distant Africa-Eurasia plate boundary at ∼67-60 Ma. Finally, compressional and strike-slip stress regimes associated with a ENE-WSW to ∼E-W trending σ1 dominated since at least ∼17-15 Ma (possibly ∼34 Ma); they are interpreted as the expression of the mid-Atlantic ridge push. These (paleo)stress results are compared and combined with earlier paleostress reconstructions in the northern offshore Lower Congo basin (also belonging to the Central segment of the margin) and in the onshore Congo basin in order to refine the stress record and the timing of tectonic events since the early Cretaceous, thus providing unprecedented constraints on the tectonic history of the West Africa passive margin. This tectonic history includes both extensional and compressional events, and was driven mainly by far-field stresses, either gravitational or tectonic in origin, which are related to interactions between the African plate and surrounding plates.

Entrainment echoes in the cerebellum

Evidence accumulates that the cerebellum's role in the brain is not restricted to motor functions. Rather, cerebellar activity seems to be crucial for a variety of tasks that rely on precise event timing and prediction. Due to its complex structure and importance in communication, human speech requires a particularly precise and predictive coordination of neural processes to be successfully comprehended. Recent studies proposed that the cerebellum is indeed a major contributor to speech processing, but how this contribution is achieved mechanistically remains poorly understood. The current study aimed to reveal a mechanism underlying cortico-cerebellar coordination and demonstrate its speech-specificity. In a reanalysis of magnetoencephalography data, we found that activity in the cerebellum aligned to rhythmic sequences of noise-vocoded speech, irrespective of its intelligibility. We then tested whether these "entrained" responses persist, and how they interact with other brain regions, when a rhythmic stimulus stopped and temporal predictions had to be updated. We found that only intelligible speech produced sustained rhythmic responses in the cerebellum. During this "entrainment echo," but not during rhythmic speech itself, cerebellar activity was coupled with that in the left inferior frontal gyrus, and specifically at rates corresponding to the preceding stimulus rhythm. This finding represents evidence for specific cerebellum-driven temporal predictions in speech processing and their relay to cortical regions.

Feasibility of deescalating postoperative care in enhanced recovery after cardiac surgery.

Enhanced Recovery After Surgery (ERAS) prioritizes faster functional recovery after major surgery. An important aspect of postoperative ERAS is decreasing morbidity and immobility, which can result from prolonged critical care. Using current clinical data, our aim was to analyze whether a six-hour monitoring period after Minimally Invasive Cardiac Surgery (MICS) might be sufficient to recognize major postoperative complications in a future Fast Track pathway. Additionally, we sought to investigate whether it could be possible to deescalate the setting of postoperative monitoring. 358 patients received MICS and were deemed suitable for an ERAS protocol between 01/2021 and 03/2023 at our institution. Of these, 297 patients could be successfully extubated on-table, were transferred to IMC or ICU in stable condition and therefore served as study cohort. Outcomes of interest were incidence and timing of Major Adverse Cardiac Events (MACE; death, myocardial infarction requiring revascularization, stroke), bleeding requiring reexploration and Fast Track-associated complications (reintubation and readmission to ICU). Patients' median age was 63 years (IQR 55-70) and 65% were male. 189 (64%) patients received anterolateral mini-thoracotomy, primarily for mitral and/or tricuspid valve surgery (n = 177). 108 (36%) patients had partial upper sternotomy, primarily for aortic valve repair/replacement (n = 79) and aortic surgery (n = 17). 90% of patients were normotensive without need for vasopressors within 6 h postoperatively, 82% of patients were transferred to the general ward on postoperative day 1 (POD). Two (0.7%) MACE events occurred, as well as 4 (1.3%) postoperative bleeding events requiring reexploration. Of these complications, only one event occurred before transfer to the ward - all others took place on or after POD 1. There was one instance of reintubation and two of readmission to ICU. If MICS patients can be successfully extubated on-table and are hemodynamically stable, major postoperative complications were rare in our single-center experience and primarily occurred after transfer to the ward. Therefore, in well selected MICS patients with uncomplicated intraoperative course, monitoring for six hours, possibly outside of an ICU, followed by transfer to the ward appears to be a feasible theoretical concept without negative impact on patient safety.

Characterization of the complete mitochondrial genome of a newly discovered torrent catfish, Liobagrus geumgangensis, and their phylogenetic relationships.

A new Liobagrus fish was reported from the Korean Peninsula, but research on this taxon is lacking. Moreover, existing research on the mitogenome of the genus Liobagrus in Korea is very limited, and no studies have been conducted on structural characteristics of transfer RNA (tRNA) or gene order comparisons between taxa; instead, research has been restricted to basic phylogeny. The complete mitochondrial genome of Liobagrus geumgangensis was analyzed for the first time. We then aimed to reconstruct the phylogenetic relationships of the genus Liobagrus and estimate the divergence time of speciation events. We used a dissected fin clip from an adult of Liobagrus geumgangensis. Genomic DNA was extracted and analyzed with whole genome sequencing (WGS) and assembled by the NOVOPlasty method. The mitogenome sequence was annotated, and a genome map, tRNA structure, and phylogenetic tree were constructed using maximum likelihood analysis. In addition, divergence time was estimated. The mitochondrial genome was 16,522bp in length and comprised 37 genes. The overall base composition was 30.5% A, 25.5% T, 28.4% C, and 15.7% G. Most tRNAs exhibited the typical clover leaf shape, except trnS1. Phylogenetic analysis revealed that Liobagrus geumgangensis clustered within a clade with four other Liobagrus species exclusive to the southern region of the Korean Peninsula. Its divergence was estimated to have occurred during the late Miocene. Characteristics of Liobagrus geumgangensis mitogenome were consistent with those of other torrent catfish species. Time scale estimation revealed distinct groupings, with some distributed across mainland Asia and others in the southern region of the Korean Peninsula. Notably, the Korean Peninsula group was identified as its own lineage, comprising entirely endemic species.

Rapid phenotypic and genotypic change in a laboratory schistosome population.

Genomic analysis has revealed extensive contamination among laboratory-maintained microbes including malaria parasites, Mycobacterium tuberculosis and Salmonella spp. Here, we provide direct evidence for recent contamination of a laboratory schistosome parasite population, and we investigate its genomic consequences. The Brazilian Schistosoma mansoni population SmBRE has several distinctive phenotypes, showing poor infectivity, reduced sporocysts number, low levels of cercarial shedding and low virulence in the intermediate snail host, and low worm burden and low fecundity in the vertebrate rodent host. In 2021 we observed a rapid change in SmBRE parasite phenotypes, with a ~10x increase in cercarial production and ~4x increase in worm burden. To determine the underlying genomic cause of these changes, we sequenced pools of SmBRE adults collected during parasite maintenance between 2015 and 2023. We also sequenced another parasite population (SmLE) maintained alongside SmBRE without phenotypic changes. While SmLE allele frequencies remained stable over the eight-year period, we observed sudden changes in allele frequency across the genome in SmBRE between July 2021 and February 2023, consistent with expectations of laboratory contamination. (i) SmLE-specific alleles rose in the SmBRE population from 0 to 41-46% across the genome between September and October 2021, documenting the timing and magnitude of the contamination event. (ii) After contamination, strong selection (s = ~0.23) drove replacement of low fitness SmBRE with high fitness SmLE alleles. (iii) Allele frequency changed rapidly across the whole genome, except for a region on chromosome 4 where SmBRE alleles remained at high frequency. We were able to detect contamination in this case because SmBRE shows distinctive phenotypes. However, this would likely have been missed with phenotypically similar parasites. These results provide a cautionary tale about the importance of tracking the identity of parasite populations, but also showcase a simple approach to monitor changes within populations using molecular profiling of pooled population samples to characterize fixed single nucleotide polymorphisms. We also show that genetic drift results in continuous change even in the absence of contamination, causing parasites maintained in different labs (or sampled from the same lab at different times) to diverge.

Statistical approaches for component-wise censored composite endpoints.

Composite endpoints defined as the time to the earliest of two or more events are often used as primary endpoints in clinical trials. Component-wise censoring arises when different components of the composite endpoint are censored differently. We focus on a composite of death and a non-fatal event where death time is right censored and the non-fatal event time is interval censored because the event can only be detected during study visits. Such data are most often analysed using methods for right censored data, treating the time the non-fatal event was first detected as the time it occurred. This can lead to bias, particularly when the time between assessments is long. We describe several approaches for estimating the event-free survival curve and the effect of treatment on event-free survival via the hazard ratio that are specifically designed to handle component-wise censoring. We apply the methods to a randomized study of breastfeeding versus formula feeding for infants of mothers infected with human immunodeficiency virus.

Attorneys' Questions About Time in Criminal Cases of Alleged Child Sexual Abuse.

In cases of alleged child sexual abuse, information about the timing of events is often needed. However, published developmental laboratory research has demonstrated that children struggle to provide accurate and reliable testimony about time and there is currently a lack of field research examining how attorneys actually question child witnesses about time in court. The current study analyzed 130 trial transcripts from cases of alleged child sexual abuse containing a child witness between the ages of 5-17years old to determine the frequency, style, and content of attorneys' questions and child responses about time. We found that attorneys primarily ask closed-ended temporal location questions (i.e., asking when an event took place using a temporal construct such as day, month, and year) to child witnesses. Additionally, children, of all ages, rarely said "I don't know" or expressed uncertainty in response to temporal questions. These findings are concerning as researchers find that children tend to struggle with temporally locating past events.

Exact test and exact confidence interval for the Cox model.

The Cox proportional hazards model is commonly used to analyze time-to-event data in clinical trials. Standard inference procedures for the Cox model are based on asymptotic approximations and may perform poorly when there are few events in one or both treatment groups, as may be the case when the event of interest is rare or when the experimental treatment is highly efficacious. In this article, we propose an exact test of equivalence and efficacy under a proportional hazard model with treatment effect as the only fixed effect, together with an exact confidence interval that is obtained by inverting the exact test. The proposed test is based on a conditional error method originally proposed for sample size reestimation problems. In the present context, the conditional error method is used to combine information from a sequence of hypergeometric distributions, one at each observed event time. The proposed procedures are evaluated in simulation studies and illustrated using real data from an HIV prevention trial. A companion R package "ExactCox" is available for download on CRAN.

The social construction of time and its influence on medical education.

Few sociocultural constructs exist that are so deeply embedded in our daily lives and able to influence our thoughts, behaviours and interactions than time itself. Time spans all cultures, and yet many of us have not critically engaged with how time effects what we do, how we perceive and the ways in which we interact. As such, our relationship to time remains almost invisible running in the background nearly unnoticed until it is somehow brought into conscious awareness. In this paper, we draw on Levine's concepts of clock time and event time as different perspectives on time, demonstrating how they play out in medical education and clinical practice within the United States and Brazil. Clock time treats time as something external to our lives, fixed by the natural world and measured by clocks. Event time is conceptualised more flexibly, where the duration of activities depends on internal cues related to the flow and progression of events rather than strict schedules. By contrasting these differences, we hope to make visible the way that time influences our choices for educating physicians and provide a foundation for medical education to begin questioning how time is positioned, experienced and understood as a powerful force in the shaping of our profession. Additionally, we consider these perspectives within the concepts of Taylorism and Slow Medicine to better understand their links to medicine's formal and hidden curriculum in hopes of raising awareness and create new visions for medical education.

A deep neural network for positioning and inter-crystal scatter identification in multiplexed PET detectors: a simulation study

Objective. High-resolution positron emission tomography (PET) relies on the accurate positioning of annihilation photons impinging the crystal array. However, conventional positioning algorithms in light-sharing PET detectors are often limited due to edge effects and/or the absence of additional information for identifying and correcting scattering within the crystal array (known as inter-crystal scattering). This study explores the feasibility of deep neural network (DNN) techniques for more precise event positioning in finely segmented and highly multiplexed PET detectors with light-sharing. Approach. Initially, a Geant4 Application for Tomographic Emission (GATE) simulation was used to study the spatial and statistical properties of inter-crystal scatter (ICS) events in finely segmented LYSO PET detectors. Next, a DNN for crystal localisation was designed, trained and tested with light distributions of photoelectric (P) and Compton + photoelectric (CP) events simulated using optical GATE and an analytical method to speed up data generation. Using the statistical properties of ICS events, an energy-guided positioning algorithm was then built into the DNN. The positioning algorithm enables selection of the unique or first crystal of interaction in P and CP events, respectively. Performance of the DNN was compared with Anger logic using light distributions from simulated 511 keV point sources placed at different locations around a single PET detector module. Main results. The fraction of events forward and backward scattered in the LYSO detector was 0.54 and 0.46, respectively, whereas naïve application of the Klein–Nishina formulation predicts 70% forward scatter. Despite coarse photodetector data due to signal multiplexing, the DNN demonstrated a crystal classification accuracy of 90% for P events and 82% for CP events. For crystal positioning, the DNN outperformed Anger logic by at least 34% and 14% for P and CP events, respectively. Further improvement is somewhat constrained by the physics—specifically, the ratio of backward to forward scattering of gamma rays within the crystal array being close to 1. This prevents selecting the first crystal of interaction in CP events with a high degree of certainty. Significance. Light sharing and multiplexed PET detectors are common in high-resolution PET, yet their traditional positioning algorithms often underperform due to edge effects and/or the difficulty in correcting ICS events. Our study indicates that DNN-based event positioning has the potential to enhance 2D coincidence event positioning accuracy by nearly a factor of 3 compared to Anger logic. However, further improvements are difficult to foresee without additional information such as event timing.

The phenology of Eucalyptus camaldulensis (Dehnh, 1832) and Eucalyptus coolabah (Blakely & Jacobs, 1934) in the northern Murray–Darling Basin and implications for recruitment on floodplains

Context Published evidence suggests recruitment of floodplain trees is declining in the northern Murray–Darling Basin (MDB) and that this is linked to river flow. Aims We investigated the reproductive phenology of Eucalyptus camaldulensis and Eucalyptus coolabah to better understand tree reproductive cycles and the influence of rainfall and flow on seed production. Methods We surveyed phenological events (bud, flower and fruit production) over 6 years, at nine sites along the Condamine–Balonne River and examined correlations between these events and meteorological parameters. Key results For both species, event timing was consistent across sites and years and event relative abundance scores were different between years. Bud abundance was correlated with rainfall, flooding and warming temperatures and E. coolabah produced additional bud crops after floods. Conclusions The timing of events did not differ significantly from published results for the southern MDB. Rainfall, river flows and flooding in spring resulted in more abundant bud crops in E. camaldulensis and E. coolabah, and subsequently more abundant fruit crops. Fruit dehiscence coincided with summer–autumn flooding, which provides seed for germination. Genetic and physiological factors may also influence the observed pattern. Implications These results will inform water planning in Queensland, Commonwealth Environmental Water Holder watering actions and long-term watering plans in the northern MDB.

Papillary Fibroelastoma of the Aortic Valve:Acute Coronary Syndrome Due to Dynamic Obstruction of the Right Coronary Artery Ostium.

A 59-year-old woman, who had a history of acute coronary syndrome (ACS) but without obstructive coronary lesions 2 years previously, presented with vertigo. MRI revealed a left cerebellar embolism. TEE detected a mobile aortic valve tumor, suggesting a papillary fibroelastoma (PFE). Reviewing previous echocardiograms, it was discovered that the tumor was present at the time of the ACS event. At surgery, the PFE was present on the right coronary cusp. When the aortic valve was opened, it was found that the tumor was obstructing the right coronary artery (RCA) ostium. ACS was probably caused by PFE's dynamic obstruction of the RCA ostium.

Diminishing warming effects on plant phenology over time.

Plant phenology, the timing of recurrent biological events, shows key and complex response to climate warming, with consequences for ecosystem functions and services. A key challenge for predicting plant phenology under future climates is to determine whether the phenological changes will persist with more intensive and long-term warming. Here, we conducted a meta-analysis of 103 experimental warming studies around the globe to investigate the responses of four phenophases - leaf-out, first flowering, last flowering, and leaf coloring. We showed that warming advanced leaf-out and flowering but delayed leaf coloring across herbaceous and woody plants. As the magnitude of warming increased, the response of most plant phenophases gradually leveled off for herbaceous plants, while phenology responded in proportion to warming in woody plants. We also found that the experimental effects of warming on plant phenology diminished over time across all phenophases. Specifically, the rate of changes in first flowering for herbaceous species, as well as leaf-out and leaf coloring for woody species, decreased as the experimental duration extended. Together, these results suggest that the real-world impact of global warming on plant phenology will diminish over time as temperatures continue to increase.