In Ref. [1, 2] a formalism to deal with high-order perturbations of a general spherical background was developed. In this article, we apply it to the particular case of a perfect fluid background. We have expressed the perturbations of the energy-momentum tensor at any order in terms of the perturbed fluid's pressure, density and velocity. In general, these expressions are not linear and have sources depending on lower order perturbations. For the second-order case we make the explicit decomposition of these sources in tensor spherical harmonics. Then, a general procedure is given to evolve the perturbative equations of motions of the perfect fluid for any value of the harmonic label. Finally, with the problem of a spherical collapsing star in mind, we discuss the high-order perturbative matching conditions across a timelike surface, in particular the surface separating the perfect fluid interior from the exterior vacuum.