Time Interaction Research Articles

A novel adsorbent for the removal of chromium form aqueous solution by Acacia Fumosa seed shell activated carbon

In this experimental study, the activated carbon was synthesized by acid impregnation and digestion methods using Acacia Fumosa seed shell. The chromium removal was examined by altering the process conditions like carbon dose, chromium concentration, pH, and temperature and interaction time. The viability of the sorption process was examined using Freundlich and Langmuir equations. Evaluating the isotherm equations, the Langmuir equation shows more concordance compared with Freundlich equation. The feasibility of the adsorption was studied using Lagergren's kinetics equations of pseudo order equations of first and second order equations. Experimental investigation implies that the chromium removal follows pseudo-second order equation and it confines the investigation was subjected to time and concentration of chromium. The temperature effect was checked by chromium with Acacia Fumosa seed shell carbon. The Acacia Fumosa seed shell carbon alone was firmed using Gibbs free energy, enthalpy and entropy equations. The FTIR study of the synthesized activated carbon of before and after spectrum confirms the chromium adsorption. The SEM surface of the superficial layer change of carbon of initial and after chromium loaded state show viable change.

Minimal dose resistance training enhances strength without affecting cardiac autonomic modulation in menopausal women: a randomized clinical trial

The proposition of a minimal dose of resistance training (RT) to elicit health benefits, encompassing physiological and psychological aspects, has garnered attention. While empirical investigations have demonstrated the efficacy of low-volume RT protocols in inducing adaptations such as enhanced strength and functional capacity, further exploration of the effects of this paradigm across a broader spectrum of variables is warranted. Thus, this study aimed to investigate the effects of minimal dose RT on strength and functional capacity, cardiac autonomic modulation, and hemodynamic parameters in menopausal women. Twenty-six women were randomly assigned to the training (TG: 63.2 ± 9.3 years) or control group (CG: 59.3 ± 7.6 years). Anthropometric measurements, strength and functional performance tests, cardiac autonomic assessment, and hemodynamic parameters were performed before and after four weeks of intervention. The TG performed the minimum dose RT twice weekly for four weeks (2 sets of 8–12 repetitions in three dynamic exercises, plus three 1-min isometric planks), and the CG had a weekly meeting with lectures and stretching. Two-way ANOVA with repeated measures was applied to each variable. Regarding time comparisons, there was a significant increase for LniRR (F = 4.78; ω2 = 0.046; p = 0.04), one repetition maximum (1RM) bench press (F = 8.06; ω2 = 0,013; p = 0.01), and 1RM leg press (F = 17.3; ω2 = 0,098; p < 0.01). There was a group*time interaction only for the index LnRMSSD (F = 5.11; ω2 = 0.042; p = 0.03), and 1RM bench press (F = 9.52; ω2 = 0,016; p = 0.01). No between-group main effect for any variable was found. The minimal dose RT protocol improved muscle strength, while cardiac autonomic and hemodynamic variables, as well as functional capacity, remained stable over 4 weeks in menopausal women.

Nurse-led support impact via a mobile app for breast cancer patients after surgery: a quasi-experimental study (step 2).

Breast cancer patients may experience some health issues following surgery. Training patients about self-care plays a vital role in managing these symptoms. Mobile applications are a contemporary and appropriate approach to support patients about the potential symptoms following breast cancer surgery. This quasi-experimental study aimed to assess the impact of nurse-led support mobile application (NL-Mapp) delivered on breast cancer patients after surgery. Ninety participants were recruited, with 45 assigned to the intervention group and 45 to the control group. Subjects in the intervention group received NL-Mapp in addition to routine care, while those in the control group received only routine care over four weeks. The intervention included educational content on the postoperative period of breast cancer. Outcomes were assessed at baseline (M0), before discharge (M1), and one month after surgery (M2). The intervention group patients had significantly improved pain, affected shoulder functions, and anxiety owing to the effects of group, time, and group-time interaction. Body image and sexual adjustment were enhanced based on time and group-time interaction effects. During the follow-up period, experimental group patients experienced an improvement in body image and sexual adjustment, while those in the control group showed a decrease. This suggests that NL-Mapp may play a significant role in training breast cancer patients to manage their symptoms after surgery.

Peer-Led Versus Authority-Led Video Intervention Effects on Musculoskeletal Injury Help-Seeking Intentions in Reserve Officers' Training Corps.

Reserve Officers' Training Corps (ROTC) trainees are college students who complete military courses and participate in physical and tactical training under the direction of military Service Members assigned to ROTC programs to serve as faculty and staff at US colleges. ROTC trainees report musculoskeletal injuries (MSKIs) attributable to ROTC training in line with MSKI incidence in other training environments. However, concealment is prevalent, as 66% of MSKIs in ROTC go unreported. The current study investigated if a brief, online educational video could increase ROTC trainees' reporting intentions. In addition, we investigated if the message's source (i.e., peer or authority figure) affected reporting intentions. A repeated measures design was used to evaluate the impact of 2 MSKI educational interventions, one delivered by a high-achieving Army ROTC trainee (peer-led) and the other delivered by an Army ROTC battalion commander (authority-led), on MSKI reporting intentions, as compared to each other and a control intervention. Other than their personal introductions, both individuals had the same script addressing 4 areas: (1) MSKI prevalence in ROTC, (2) evidence of improved outcomes with early treatment, (3) encouraging injury reporting, and (4) addressing specific barriers and stigma beliefs previously identified in ROTC. The control condition consisted of a video demonstrating exercise technique with voiceover. A survey was developed to measure stigma regarding MSKI reporting and intentions to seek help for MSKI. ROTC trainees at 23 universities were invited to participate via an anonymous survey link. Participants completed the following using an online survey platform: (1) pre-intervention MSKI intentions scale, (2) randomly assigned intervention video, and (3) repeat MSKI intentions scale post-intervention. A two-way mixed, ANOVA was performed to assess interaction effects and main effects pre- and post-intervention. One-hundred ROTC trainees (39% female; age = 21 ± 2 years, ROTC experience = 2 ± 1 years) completed the study. Participants were primarily from Army ROTC programs (72 Army, 14 Air Force, and 14 Naval). Pre-intervention survey scores (possible score range 8-56 with lower scores indicating greater intention to seek help): authority-led (n = 31) 20.3 ± 9.4, peer-led (n = 32) 21.8 ± 8.7, control (n = 37) 19.1 ± 10.1, total 20.3 ± 9.4. Post-intervention scores: authority-led 20.9 ± 11.2, peer-led 20.2 ± 10.0, control 17.3 ± 7.7, total 19.7 ± 9.3. There was no significant group*time interaction (F2,97 = 0.92, P = .403, η2partial = 0.02). There were no significant main effects for time (F1,97 = 1.461, P = .230, η2partial =0.015) or group (F2,97 = 1.08, P = .342, η2partial = 0.02). Findings did not support the use of a single educational intervention video to influence MSKI help-seeking intentions of ROTC trainees. Intentions may already be ingrained such that a single intervention could not influence change. Previous research on concussion reporting indicates that concealment cultures may be systematic and indoctrination of concealment can influence one's reporting intentions. Our sample had already participated in ROTC for 2 years. Future research should evaluate if MSKI help-seeking intentions change over the course of ROTC participation, or even over a military career.

Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young males and females.

Exercise is a multipotent stimulus that results in large-scale dynamic changes to the systemic molecular profile. Alternative exercise prescriptions and doses would be expected to result in distinct signatures due to differences in duration and intensity. We tested two novel combined endurance and resistance exercise regimens to better understand how differing prescriptions alter the acute metabolomics response at multiple timepoints up to 24h post-exercise. Serum metabolomics for n=37 untrained individuals was analyzed for participants completing traditional combined exercise [TRAD; n = 20 (11M/9F)] or high-intensity tactical training [HITT; n= 17 (9M/8F)] before exercise (pre), and immediately (h0), 3 and 24 h post-exercise (h3 and h24, respectively). We found minimal metabolites had a group by time interaction (2 with FDR < 0.10; 31 with nominal p < 0.05;), but both stimuli resulted in large-scale within-group changes to the circulating metabolome. TRAD consistently had greater numbers of differentially abundant metabolites (FDR < 0.10) as compared to HITT at h0 (431 vs. 333), h3 (435 vs. 331) and h24 (168 vs. 76). The major metabolite classes altered were related to key energy substrates for both groups at h0 (e.g., glucose, pyruvate) and energy replenishment for h3 and h24 (e.g., 12,13 diHOME, palmitylcarnitine, free fatty acids). In summary, our data are the first to describe the acute changes in the circulating metabolome following combined endurance and resistance exercise. Additionally, we show the two distinct doses of combined exercise led to generally similar patterns of responses, with the longer duration TRAD dose resulting in a higher magnitude of change.

The effects of spinal flexion exposure on lumbar muscle shear modulus and posture.

Spinal flexion exposure (SFE) leads to alterations in neuromuscular and mechanical properties of the trunk. While several studies reported changes in intrinsic trunk stiffness following SFE, there is a lack of studies evaluating the effects on lumbar muscle shear modulus (SM). Therefore, the aim of our study was to investigate the effects of SFE on lumbar muscle SM and posture. Sixteen young volunteers were included in this clinical study. Passive lumbar muscle SM, lumbar lordosis, lumbar flexion range of motion and sitting height were measured prior to and following a 60-min SFE protocol. For SM, our results did not show a significant muscle × time interaction effect (p = 0.40). However, we found increased SM (from 6.75 to 15.43%-all p < 0.02) and maximal lumbar flexion (15.91 ± 10.88%; p < 0.01), whereas lumbar lordosis ( - 7.67 ± 13.97%; p = 0.03) and sitting height ( - 0.57 ± 0.32%; p < 0.01) decreased following SFE. Our results showed no significant correlations between the changes in the included outcome measures (p = 0.10-0.83). We hypothesized that increased lumbar muscle SM following SFE might be a compensation for decreased passive stability due to viscoelastic deformations of connective tissues, which are indicated by increased maximal lumbar flexion and decreased sitting height. However, there were no significant correlations between the changes of the included outcome measures, which implies that increased muscle SM and reduced lumbar lordosis are more likely an independent consequence of SFE.

Mental health training for physicians supervising resident physicians: a cluster randomised controlled trial.

To evaluate an online training program for physician supervisors with the aim of promoting a mentally healthy workplace by improving their use of both responsive and preventive mental health support strategies. Cluster randomised, waitlist-controlled trial. Royal Australasian College of Physicians fellows who were supervising at least one resident physician in any of the 31 primary health networks in Australia and 20 district health boards in New Zealand (health network clusters). A brief online skills-based mental health training program, comprising twelve modules grouped into three topics: common mental illnesses; helping trainees you are concerned about (responsive strategies); and minimising mental health risks at work (preventive strategies). Change between baseline and the 3-month assessment in self-reported recommended supervisor behaviours; differences between intervention and control groups in recommended behaviour scores three weeks, three months, and six months after the program. Ninety physicians from 20 health network clusters were allocated to the intervention group, 88 physicians from 22 clusters to the control group. Intervention group participants reported greater positive change in behaviour across the study period than those in the control group (mixed model repeated measures analysis, group × time interaction: P < 0.001). The mean change in self-reported supervisory behaviour score was higher for the intervention than the control group at the 3-week (mean difference in score, 1.6; 95% confidence interval [CI], 0.8-2.4), 3-month (0.9; 95% CI, 0.2-1.6), and 6-month assessments (1.9; 95% CI, 1.1-2.7). The mean change in self-reported responsive behaviour score was also greater for the intervention group at the 3-week (mean difference, 2.3; 95% CI, 1.5-3.1), 3-month (1.0; 95% CI, 0.2-1.9), and 6-month assessments (2.0; 95% CI, 1.1-2.9); differences in the mean change in preventive behaviour scores were statistically significant at the 3-week (mean difference, 1.1; 95% CI, 0.1-2.2) and 6-month assessments (1.8; 95% CI, 0.8-2.8), but not the 3-month assessment (0.8; 95% CI, -0.1 to 1.7). Brief online mental health training for senior physicians can lead to changes in their self-reported behaviour for supporting the mental health needs of resident physicians. Whether this leads to better mental health for resident physicians should be investigated. Australian New Zealand Clinical Trials Registry, ACTRN12619001496101 (prospective).

The effect of therapeutic touch on colic symptoms in infantile colic infants: A randomised controlled study.

This study aimed to examine the effects of therapeutic touch (TT) on infantile colic symptoms (Infant Colic Scale (ICS) score, crying time and sleep time). This randomised controlled trial included infants aged 4-12 weeks diagnosed with infantile colic in a pediatric unit of a hospital. Infants were assigned to intervention or control groups using a stratified randomisation method. The intervention group received TT sessions six times, 3 days a week, in addition to usual care for 2 weeks. The control group received the usual care. Data were collected using Mother-Infant Information Form, ICS, Crying and Sleep Time Follow-Up Forms. The infants were followed up for two weeks. A total of 64 infants who met the criteria were included in the study, including intervention (n = 32) and control (n = 32) groups. There was a statistically significant difference between the groups (intervention and control) in terms of ICS scores (U = 4.5; P < 0.001; d = 3.252; 95% confidence interval (CI) = 2.505-3.999), crying time (F = 57.097; ŋp 2 = 0.461; P < 0.001) and sleep time (F = 17.884; ŋp 2 = 0.211; P < 0.001). When the intervention group was compared with the control group at all time points, the size of the effect (group × time interaction) was found to be high. TT effectively relieved symptoms, decreased crying time and increased sleep time in infants with infantile colic. TT is recommended to relieve colic in infants.

Improving Milk Yield, Milk Quality, and Follicular Functionality Behavior in Dairy Cows from the Implementation of Microencapsulated Chili Pepper Supplements in Their Diets.

The present study evaluates the effect of including microencapsulated hot chili pepper (MHCP) in the diet of crossbred dairy cows on the volume and quality of milk and on ovarian morphofunctionality. Twenty-four crossbred females in their lactating period were used. The cows were divided into two experimental groups, a control (CT) and an MHCP -supplemented group (CP) given 1 g a day per animal of microencapsulated hot chili in concentrate for 42 days. Over seven weeks of daily milk production was measured, and sample milk was collected weekly for composition analysis. Animals were subject to an ovulation synchronization protocol on day 0 (D0), and an intravaginal progesterone (P4) implant, estradiol benzoate, and prostaglandin (PGF2α) were administered. On D8, the P4 implant was removed and PGF2α, equine chorionic gonadotropin, and estradiol cypionate were administered to the animals. The ovarian dynamics were evaluated in B mode and color Doppler. There were significant differences (p < 0.05) in the group X time interaction, the volume of milk produced, and the amount in kg/day of milk components. There was a higher percentage of vascularization in the preovulatory follicle in the CP group (p ≥ 0.10). The findings show that the inclusion of MHCP in the diet of dairy cows does influence their milk production and reproduction.

Sex x time interactions in Lp(a) and LDL-C response to Evolocumab

Sex x time interactions in Lp(a) and LDL-C response to Evolocumab

The Effects of Cold Exposure, Hypoxia, and Fatigue on Pistol Marksmanship and Target Engagement Decision Making in Trained Marksmen.

Segovia, M, Salmon, OF, Ugale, C, and Smith, CM. The effects of cold exposure, hypoxia, and fatigue on pistol marksmanship and target engagement decision making in trained marksmen. J Strength Cond Res XX(X): 000-000, 2024-This study aimed to examine the effects of cold exposure, hypoxia, and fatigue on pistol marksmanship and target engagement in trained marksmen. Twelve healthy subjects (mean ± SD age: 28.8 ± 4.0 years) performed 3 testing visits under normal/normoxic [Norm21] (24° C; 21% FiO2), cold/normoxic [Cold21] (10° C; 21% FiO2), and cold/hypoxic [Cold14] (10° C; FiO2: 14.3) conditions. Pistol marksmanship and target engagement were assessed through draw time (DT) and shoot-no-shoot (SNS) courses of fire. The 2 protocols were performed before (TpreF) and immediately after (TpostF) a sandbag deadlift fatiguing protocol. Significance was set at p < 0.05. Significant condition × time interactions (p = 0.01-0.03) were found for accuracy SNS (SNSacc), misses SNS (SNSmiss), and total shots SNS (SNStot). Follow-up analyses indicated that SNSacc increased by 14.3% (p = 0.03), SNSmiss decreased by 34.7% (p = 0.02), and SNStot decreased by 10.6% (p = 0.04) from TpreF to TpostF during the Cold21 condition alone. No significance was found for these in the Norm21 (p = 0.08-0.22) or Cold14 (p = 0.18-0.47) conditions. Total time (SNST) to completion of the SNS (p = 0.09) and DT (p = 0.14) showed no significance across time or condition. Significant difference across time for Cold14 (p = 0.03-0.02) for reaction time was found. Exercise likely resulted in increased thermogenesis that improved tactically relevant motor skills including SNSacc, decreased SNSmiss, and SNStot in Cold21, but not Cold14. The additive effect of hypoxia coupled with exercise in the Cold14 condition did not improve tactical performance, suggesting multi-stressor environments result in competing physiological responses. Tactical strength and conditioning specialists as well as operators should aim to improve thermoregulation during Cold21 conditions, with exercise as a possible intervention.

Are there potential costs for humility in a pluralistic democracy?: A longitudinal investigation of immigrants in the New Zealand attitudes and values study.

In this longitudinal study, we examine the potential costs and benefits of humility for well-being and civic trust among immigrants in a pluralistic democracy. With data from 14,864 immigrant participants from a nationwide random sample in New Zealand, we used multilevel modeling to examine the associations of general humility (i.e., honesty-humility modesty) with well-being (life satisfaction and meaning) and civic trust (trust in police) over time in contexts with varying levels of ethnic deprivation and perceived religious discrimination. We hypothesized that (a) humility would correlate positively with well-being and civic trust (Hypothesis 1), (b) these associations would be attenuated in the contexts where perceptions of ethnic deprivation and religious discrimination are high (Hypothesis 2), and (c) these interaction effects would become more pronounced when cultural identities are salient (Hypothesis 3). Multilevel modeling revealed partial support for these hypotheses. Although humility correlated positively with well-being and trust in police over time, the two-way and three-way interactions did not yield substantial support for Hypotheses 2 and 3, respectively. The context of religious discrimination did, however, marginally attenuate the positive association between humility and trust in police. Collectively, these results demonstrate that humility is associated with multiple benefits to well-being and civic trust and has few-if any-potential drawbacks.

Time-dependent prognostic impact of circumferential resection margin in T3 thoracic esophageal squamous cell carcinoma.

Esophageal cancer presents a clinical challenge due to its high incidence and unfavorable prognosis. The prognostic role of the circumferential resection margin (CRM) remains highly controversial, potentially due to its temporal dynamics coupled with variability in follow-up durations across studies. We aimed to explore the time-dependent prognostic significance of CRM in T3 esophageal squamous cell carcinomas (ESCCs). We systematically reviewed literature from 1990 to 2023 to determine how follow-up duration influences the prognostic role of CRM in esophageal cancer. Concurrently, we performed a retrospective examination of 354 patients who underwent treatment at the National Cancer Center between 2015 and 2018. Integrating a time interaction term in the Cox regression analyses enabled us to not only identify independent risk factors affecting overall survival (OS) but also to specifically scrutinize the potential temporal variations in CRM's prognostic impact. Our literature review suggested that CRM's influence on prognosis diminishes with longer follow-up durations for both classifications, namely the Royal College of Pathologists (RCP) (β= -0.003, P< 0.001) and the College of American Pathologists (CAP) (β= -0.007, P< 0.001). Time-dependent multivariate Cox regression analysis emphasized the evolving nature of CRM's prognostic effect, and the inclusion of the time interaction term enhanced model accuracy. In conclusion, CRM is an independent prognostic factor for T3 thoracic ESCC patients. Its influence appears to decrease over extended follow-up periods, shedding light on the heterogeneity seen in previous studies. With the time interaction term, CRM becomes a more precise post-operative prognostic indicator for esophageal cancer.

The quantity of deposited environmental DNA in plant–arthropod interactions depends on taxon, abundance and interaction time

Abstract Environmental DNA (eDNA) metabarcoding holds great promise as a simple and efficient tool to detect plant–insect interactions. However, the influence of both abiotic and biotic factors on eDNA deposition in these interactions is not well understood. It especially remains to be tested how much eDNA abundances reflect the frequency or intensity of interactions between insects and plants. We experimentally analysed the quantitative deposition of eDNA from three insect species (the southern green stink bug Nezara viridula, the mustard beetle Phaedon cochleariae and the fall armyworm Spodoptera frugiperda) on leaves of two host plants of varying attractiveness: savoy cabbage (Brassica oleracea var. sabauda, preferred host) and tomato (Solanum lycopersicum, less preferred host). We tested for the effects of insect taxonomy, host plant, exposure time and abundances of interacting insects on the plant material. Our data show a clear quantitative ecological signal in eDNA deposition. Insect abundance and interaction time are reflected in the amount of deposited eDNA. Moreover, significantly more eDNA was deposited on cabbage, the preferred host plant. Besides these ecological drivers, a very strong taxonomic eDNA deposition bias between different insect taxa was observed. eDNA detection is strongly influenced by the ecological interactions of the targeted taxa, highlighting the utility of the tool to specifically detect trophic interactions between plants and arthropods. However, taxonomic biases in eDNA deposition preclude comparative analyses of interactions at the community level.

The influence of scaffolding on intrinsic motivation and autonomous adherence to a game-based, sparsely supervised home rehabilitation program for people with upper extremity hemiparesis due to stroke. A randomized controlled trial

BackgroundThis parallel, randomized controlled trial examined intrinsic motivation, adherence and motor function improvement demonstrated by two groups of subjects that performed a 12-week, home-based upper extremity rehabilitation program. Seventeen subjects played scaffolded games, presenting eight to twelve discrete levels of increasing difficulty. Sixteen subjects performed the same activities controlled by success algorithms that modify game difficulty incrementally.Methods33 persons 20–80 years of age, at least 6 months post stroke with moderate to mild hemiparesis were randomized using a random number generator into the two groups. They were tested using the Action Research Arm Test, Upper Extremity Fugl Meyer Assessment, Stroke Impact Scale and Intrinsic Motivation Inventory pre and post training. Adherence was measured using timestamps generated by the gaming system. Subjects had the Home Virtual Rehabilitation System (Qiu in J Neuroeng Rehabil 17: 1–10, 2020) placed in their homes and were taught to perform rehabilitation games using it. Subjects were instructed to train twenty minutes per day but were allowed to train as much as they chose. Subjects trained for 12 weeks without appointments and received intermittent support from study staff. Group outcomes were compared using ANOVA. Correlations between subject demographics and adherence, as well as motor outcome, were evaluated using Pearson Correlation Coefficients.ResultsThere were 5 dropouts and no adverse events. The main effect of time was statistically significant for four of the five clinical outcome measures. There were no significant training group by time interactions. Measures of adherence did not differ significantly between groups. The combined groups improved their UEFMA scores on average by 5.85 (95% CI 4.73–6.98). 21 subjects from both groups demonstrating improvements in UEFMA scores of at least 5 points, exceeding the minimal clinically important difference of 4.25. IMI scores were stable pre to post training.ConclusionsScaffolding challenges during game based rehabilitation did not elicit higher levels of adherence when compared to algorithm control of game difficulty. Both sparsely supervised programs of game-based treatment in the home were sufficient to elicit statistically significant, clinically meaningful improvements in motor function and activities of daily living.Trial registration: Clinical Trials.gov—NCT03985761, Registered June 14, 2019.

Health-related outcomes with supervised exercise and myofascial release versus only supervised exercise in subacromial pain syndrome: a randomized controlled single-blind study

BackgroundMyofascial tissue plays a critical role in shoulder joint mobility disorders. Myofascial release therapy (MFR) is frequently utilized to restore the extensibility of fascial tissue and is considered beneficial for various clinical conditions such as low back pain and ankle injuries. However, no studies have yet evaluated the effects of MFR on periscapular muscles activation and shoulder mobility in patients with subacromial pain syndrome(SAPS).ObjectiveThe purpose of this study was to compare the effectiveness of MFR combined with supervised exercise(SE) and SE alone in patients with SAPS.DesignAssessor-blinded randomized controlled trial.SettingSir Run Run Shaw Hospital, Zhejiang University School of Medicine.SubjectsSubacromial pain syndrome patients.MethodsFifty participants were divided into two groups: SE group and MFR + SE group, each group 25 cases. Both treatment methods were performed 5 times a week for 4 weeks.Main measuresShoulder pain severity was assessed by visual analog scale (VAS); shoulder range of motion (ROM) by a goniometer; functionality by shoulder Pain and Disability Index (SPADI); and periscapular muscles activation by sEMG. All measurements were evaluated both pre- and post-treatment.ResultsAn ANOVA analysis indicated no significant group by time interactions for flexion ROM and resting VAS (p > 0.05). However, significant group by time interactions were found for SPADI, abduction and external rotation ROM, and activity VAS (p < 0.05). Post-hoc tests revealed significant improvements in SPADI, abduction and external rotation ROM, and activity VAS in both groups compared to pre-treatment (p < 0.05). Additionally, there were significant group by time interactions for the sEMG values of the upper trapezius and serratus anterior (p < 0.05). Post-hoc tests showed that compared to pre-treatment, the MFR + SE group had decreased upper trapezius sEMG values and increased serratus anterior sEMG values(p < 0.05), while the SE group showed increased serratus anterior sEMG values(p < 0.05). After the 4-week intervention, there were significant between-group differences in SPADI, abduction and external rotation ROM, activity VAS, and sEMG values of the upper trapezius and serratus anterior(p < 0.05).ConclusionFour weeks of MFR combined with SE can increase shoulder ROM, improve pain, and thus enhancing functional activities in patients with SAPS. Additionally, it can further improve the balance between the upper trapezius and serratus anterior to improve the dynamics of the periscapular muscles.Trial registry numberChiCTR2200061054. Date of registration 15/06/2022.

Predicting Cognitive Decline in Amyloid-Positive Patients With Mild Cognitive Impairment or Mild Dementia.

Cognitive decline rates in Alzheimer disease (AD) vary greatly. Disease-modifying treatments may alter cognitive decline trajectories, rendering their prediction increasingly relevant. We aimed to construct clinically applicable prediction models of cognitive decline in amyloid-positive patients with mild cognitive impairment (MCI) or mild dementia. From the Amsterdam Dementia Cohort, we selected amyloid-positive participants with MCI or mild dementia and at least 2 longitudinal Mini-Mental State Examination (MMSE) measurements. Amyloid positivity was based on CSF AD biomarker concentrations or amyloid PET. We used linear mixed modeling to predict MMSE over time, describing trajectories using a cubic time curve and interactions between linear time and the baseline predictors age, sex, baseline MMSE, APOE ε4 dose, CSF β-amyloid (Aβ) 1-42 and pTau, and MRI total brain and hippocampal volume. Backward selection was used to reduce model complexity. These models can predict MMSE over follow-up or the time to an MMSE value. MCI and mild dementia were modeled separately. Internal 5-fold cross-validation was performed to calculate the explained variance (R2). In total, 961 participants were included (age 65 ± 7 years, 49% female), 310 had MCI (MMSE 26 ± 2) and 651 had mild dementia (MMSE 22 ± 4), with 4 ± 2 measurements over 2 (interquartile range 1-4) years. Cognitive decline rates increased over time for both MCI and mild dementia (model comparisons linear vs squared vs cubic time fit; p < 0.05 favoring a cubic fit). For MCI, backward selection retained age, sex, and CSF Aβ1-42 and pTau concentrations as time-varying effects altering the MMSE trajectory. For mild dementia, retained time-varying effects were Aβ1-42, age, APOE ε4, and baseline MMSE. R2 was 0.15 for the MCI model and 0.26 for mild dementia in internal cross-validation. A hypothetical patient with MCI, baseline MMSE 28, and CSF Aβ1-42 of 925 pg/mL was predicted to reach an MMSE of 20 after 6.0 years (95% CI 5.4-6.7) and after 8.6 years with a hypothetical treatment reducing decline by 30%. We constructed models for MCI and mild dementia that predict MMSE over time. These models could inform patients about their potential cognitive trajectory and the remaining uncertainty and aid in conversations about individualized potential treatment effects.

Effects and optimization of hydrolysis conditions on the diameter distance ratio for metatitanic acid

Controlling and predicting the narrow particle size distribution of metatitanic acid could help to improve pigment and application performances of TiO2. To prepare metatitanic acid with narrow particle size distribution, the hydrolysis conditions of industrial TiOSO4 solution were optimized by using the response surface methodology of Box-Behnken design method. The effects of hydrolysis conditions such as TiO2 concentration, aging time and hydrolysis time on the diameter distance ratio and structure of metatitanic acid were investigated. The prediction model including the hydrolysis variables with good fitting result was established to predict the diameter distance ratio or optimize the hydrolysis variable values. The regression equation model was significant and reliable with actual correlation coefficient R2 of 0.9989. The hydrolysis conditions greatly influenced the quality and quantity of hydrolysis induced crystal nucleus, hydrolysis rate, completeness degree of hydrolysis, crystallization growth and aggregation rate, and eventually affected the particle size distribution of metatitanic acid. The synergistic interaction for TiO2 concentration and hydrolysis time was very significant. The verification experiments confirmed that the diameter distance ratio could reach the average value of 1.100 under the optimal conditions. The prepared metatitanic acid had anatase TiO2 phase structure, with average particle size of 1.621–1.819 µm. And this helped to improve the high quality and green development of the titanium dioxide industry.

Interaction time of Schrödinger cat states with a periodically driven quantum system: Symplectic covariance approach

Interaction time of Schrödinger cat states with a periodically driven quantum system: Symplectic covariance approach

Comparison of the dynamic characteristics of GFRP, CFRP, and hybrid composites subjected to repeated low‐velocity impact

AbstractThe current study used the vacuum‐assisted hand lay‐up method (VAHLM) to manufacture glass fiber‐reinforced polymer (GFRP), carbon fiber‐reinforced polymer (CFRP), and glass/carbon fiber‐reinforced hybrid composites to examine the influences of fiber materials and hybridization on the repeated low‐velocity impact (LVI) responses. In this regard, the manufactured composites were exposed to repeated LVI loading at 3 m/s under 25.2 J impact energy, and thus dynamic characteristics such as total impulse, contact/bending stiffness, interaction time, peak force/displacement, and absorbed‐rebounded energies depending on the impact number were acquired. LVI tests were continued until penetration was observed in the composites, at which point the penetration threshold numbers for each composite type were acquired. Furthermore, the macro‐scale damage analyses depending on the impact number were gradually examined, and the impacts of hybridization and fiber material on the damage mechanisms were determined. The study found that GFRP, hybrid and CFRP composites had the highest impact resistance, respectively, and that glass fiber‐reinforcement is well‐suited for applications that require higher impact resistance. When the average penetration threshold numbers for the composites were examined, it was observed that GFRP composites had approximately five times higher penetration threshold numbers than CFRP composites and that hybrid specimens exhibited similar properties to CFRP composites in terms of impact resistance. This scenario was linked to the various deformation capabilities of glass and carbon fibers, and it was concluded that the high‐deformation capability of the fibers improved the penetration threshold numbers.Highlights Effects of hybridization and fiber material on LVI responses were examined. Fiber material has a significant influence on impact resistance. Penetration threshold number can be associated with the fibers' strain capability. The adhesion factor plays an active role in the damage of hybrid specimens.