Sedentary Behavior Time Research Articles

Physical activity, sedentary behaviour, and sleep in the Thai population: A compositional data analysis including 135,824 participants from two national time-use surveys.

To determine the amounts of time spent in physical activity (PA), sedentary behaviour (SB), and sleep in the Thai population, as well as their sociodemographic correlates and changes over time. We analysed cross-sectional data collected in a population-representative, stratified random sample of 135,824 Thais aged 10 years and over as part of the two most recent Thai National time-use surveys (2009 and 2015). Daily activities reported by the participants were coded using the International Classification of Activities for Time-Use Statistics (ICATUS) and categorised as PA, SB, or sleep. In the latest survey, participants spent on average the largest amount of time sleeping (geometric mean [g] = 9.44 h/day; 95% confidence interval [CI]: 9.42, 9.47), followed by PA (g = 8.60 h/day; 95% CI: 8.55, 8.64) and SB (g = 5.96 h/day; 95% CI: 5.93, 6.00). The time spent in PA was higher on weekdays, while the amounts of SB and sleep were higher on weekends (p < 0.05). Males, older age groups, and unemployed people spent less time in PA and more time in SB, compared with other population groups (p < 0.05). We found a relatively large increase in SB (mean difference [d] = 39.64 min/day; 95% CI: 36.18, 42.98) and decrease in PA (d = 54.33 min/day; 95% CI: -58.88, -49.30) over time. These findings were consistent across most sociodemographic groups, with the most concerning shifts from active to sedentary lifestyle found among people with a higher education degree and on weekends. Our findings revealed a shift to a more sedentary lifestyle in the Thai population. Public health interventions should focus on improving time use among males, older age groups, and unemployed people, while preventing the rapid decrease in PA and increase in SB among those with a higher education degree and on weekends.

Accelerometer-Measured Physical Activity and Sedentary Time among Children in Japan before and during COVID-19: A Cross-Sectional and Longitudinal Analysis.

This study examined changes in physical activity (PA), sedentary behavior (SB), screen time, sleep, and executive function among Japanese preschoolers between COVID-19 pre-pandemic and pandemic periods, using cross-sectional and longitudinal data. Accelerometer data from 63 children aged 5-6 years were collected from three kindergartens in Tokyo, Japan, in late 2019 (pre-COVID-19). This was compared to the data of 49 children aged 5-6 years from the same kindergartens, collected in late 2020 (during COVID-19). Sixteen children in the pre-COVID-19 cohort also participated in the 2020 survey and provided data for the longitudinal analysis. The mean minutes of PA, SB, screen time, and sleep duration, as well as executive function, were compared between the pre- and during COVID-19 cohorts. After adjusting for school, sex, and accelerometer wear time, there were no significant differences in any of the measured outcomes between the two cohorts. However, the analysis of longitudinal data revealed significant increases in time spent in SB and on screens, and a decrease in light-intensity PA and sleep duration during the pandemic compared to the pre-pandemic period. Results suggest that, despite the COVID-19 pandemic, young children's activity levels and SB did not significantly differ from pre-pandemic levels. However, school-aged children's SB, light PA, and sleep time were affected, although this cannot be disentangled from the effects of the transition to school.

Associations between activity, sedentary and sleep behaviours and psychosocial health in young children: a longitudinal compositional time-use study

BackgroundGood quality sleep, regular physical activity, and limited time spent sedentary are all considered individually important in promoting good mental health in children. However, few studies have examined the influence of each behaviour simultaneously, using compositional analysis which accounts for the closed nature of the 24-h day. Our aim was to determine how compositional time use in early childhood is prospectively related to mental and psychosocial health at 5 years of age.MethodsA total of 392 children wore Actical accelerometers 24-h a day for one week at 2, 3.5 and 5 years of age to examine time in sleep, physical activity, and sedentary behaviour. Psychosocial and mental health were assessed at age 5 using both laboratory based (researcher-assessed) and questionnaire (parental-report) measures. Associations were estimated using regression models with isometric log-ratios of time-use components as predictors.ResultsCross-sectionally, 5-year old children who spent 10% (64 min) more time asleep than average had better inhibitory control (standardised mean difference [d]; 0.19; 95% confidence interal [CI]: 0.02, 0.36 for Statue test and d = 0.16; 95% CI: − 0.01, 0.33 for Heads–Toes–Knees–Shoulders task). A greater proportion of time spent active (10%, 31 min) was associated with poorer inhibitory control (d = − 0.07; 95% CI: − 0.13, − 0.02 for Statue test, d = − 0.06; 95% CI: − 0.11, − 0.01 for Heads–Toes–Knees–Shoulders task). By contrast, differences in time-use were not found to be significantly associated with any measure of self-regulation or mental health at 5 years of age, nor were any significant longitudinal relationships apparent.ConclusionsWe did not find a significant association between 24-h time use in the preschool years and any measure of psychosocial or mental health at 5 years of age, although some relationships with inhibitory control were observed cross-sectionally.Trial registration: ClinicalTrials.gov number NCT00892983, registered 5th May 2009.

Associação do sexo e fase de formação com atividade física e comportamento sedentário em universitários de enfermagem

Abstract Physical Insufficient levels of physical activity and sedentary behavior are highly prevalent worldwide and associated with cardiometabolic diseases and may vary according to gender and academic training. The objective was to investigate the association of sex and academic training with the level of physical activity and time spent in sedentary behavior in nursing students. It is a cross-sectional study with 286 nursing students from a public university. A sociodemographic and academic characterization instrument and an extended version of the International Physical Activity Questionnaire were applied. Data were analyzed descriptively and by Pearson's Chi-Square/Fisher's Exact test. The significance level was 5%. 65.7% of university students were active. Men were more active in leisure (p=0.000) and commuting (p=0.03). There was no association between sex and semester and total physical activity level. The prevalence of time in sedentary behavior ≥ 8 h/day for seven, five days, and weekends were 39.3%, 57.1%, and 21.4% for men and 55.0%, 65.1%, and 43.0% for women. A more significant proportion of women showed time in sedentary behavior ≥ 8 h/day on weekends (p=0.015) than men. A higher proportion between the 1st and 5th semesters remained ≥ 8 h/day in sedentary behavior on seven (p=0.024) and five days (p=0.001) week compared to those between the 6th and 10th semesters. The prevalence of insufficient physical activity levels and a long time in sedentary behavior were high and influenced by gender and training phase. Men were more active in commuting and leisure than women. Sedentary behavior is associated with gender and a training phase.

Association between dietary patterns and subjective and objective measures of physical activity among Japanese adults aged 85 years and older: a cross-sectional study.

A healthy diet and regular physical activity (PA) are delineated as healthy behaviours. Their implementation is associated with better health outcomes and improved quality of life. There is less evidence of a relationship between dietary patterns (DP) and PA, especially in adults aged ≥ 85. Hence, this cross-sectional study investigates the association between DP and PA in people of this age group, using the data from The Kawasaki Aging and Well-Being Project. Brief-type self-administered diet history questionnaire was used to estimate the intake of fifty-eight types of food. After energy adjustment, principal component analysis was performed to identify DP. PA was measured objectively using an accelerometer and subjectively using a questionnaire validated for this age group. Thousand participants (median age: 86·9 years, men: 49·9 %) were included in the analysis. Three major DP (DP1 'various foods', DP2 'red meats and coffee', DP3 'bread and processed meats') were identified. DP1 'various foods' was similar to DP previously named 'healthy' or 'prudent' and showed a positive association with PA time (PAT) as measured by accelerometer (B, 6·25; 95 % CI 0·13, 12·37) and relatively shorter sedentary behaviour (SB) time. DP2 'red meats and coffee' and DP3 'bread and processed meats' were negatively associated with PAT and positively associated with SB time. This study observed the relationship between diet and PA behaviours in adults aged ≥ 85, with healthier and more food-diverse DP associated with longer PAT and relatively unhealthy DP with shorter PAT.

Replacing Sedentary Behavior Time With Physical Activities, Recommended Physical Activity, and Incident Coronary Heart Disease

ObjectiveTo prospectively analyze the associations with coronary heart disease (CHD) risk of reallocating time from sedentary behavior to various physical activities using the isotemporal substitution model, particularly according to whether the participants meet the recommended physical activity level. MethodsWe included 455,298 UK Biobank participants free of CHD at baseline (March 13, 2006, to October 10, 2010). Sedentary behavior time was quantified by summing up the time spent on television watching, computer (not at work), and driving. Physical activities were categorized as daily-life activities (walking for pleasure, light do-it-yourself, and heavy do-it-yourself) and structured exercise (strenuous sports and other exercise). ResultsDuring a median follow-up of 11 years, 20,162 incident CHD cases were documented. Sedentary behavior time was significantly associated with a higher risk of CHD, independent of physical activity. Replacing 30 min/d of sedentary behavior with an equal time of various physical activities was associated with a 3% to 12% risk reduction of CHD. Replacing 1 h/d of sedentary behavior with different types of physical activities was associated with a 6% to 23% risk reduction of CHD. Sedentary behavior to strenuous sports reallocations showed the largest benefit. Reallocations of sedentary behavior to various physical activities showed particularly greater benefits among those who did not meet the physical activity recommendations. ConclusionsReplacing sedentary behavior time with various daily-life activities or structured exercise is associated with significant reductions in CHD risk.

The after-school sedentary behavior status among children and adolescents with intellectual disabilities.

There is evidence that the after-school period plays an essential role in accumulating sedentary behavior (SB) among children and adolescents, as well as implementing potential interventions. However, relatively little is known regarding SB status of children and adolescents with intellectual disabilities (ID) during the after-school period. The purpose of this study was to investigate the total level and specific pattern of the after-school SB among children and adolescents with ID. The after-school SB status among 325 children and adolescents with ID was evaluated by the parent-reported Children's Leisure Activities Study Survey-Chinese edition questionnaire. Parents of children and adolescents with ID reported approximately 204 min/day of after-school SB. Specifically, the longest time of the after-school period was spent performing the screen-based SB (84 mins/d). This was followed by recreational SB and educational SB (50 and 30 mins/d, respectively). The children aged 6-12 years old engaged more time in recreational SB than adolescents aged 16-18 years old (p < 0.05) during the after-school period. Further, the data indicated that 37.5% of children and adolescents with ID achieved the guideline limitation of 2-h-maximum screen-based SB during the after-school hour. Children and adolescents with ID spent a large portion of the after-school period in SB, particularly engaged in more time on after-school screen-based SB. Future efforts should focus on developing and implementing period-specific interventions designed to reduce after-school SB in the segment of this population.

Association between Physical Activity, Sedentary Behavior, Satisfaction with Sleep Fatigue Recovery and Smartphone Dependency among Korean Adolescents: An Age- and Gender-Matched Study.

The purpose of this study was to identify the association between physical activity (PA), sedentary behavior (SB), satisfaction with sleep fatigue recovery (SSFR), and smartphone dependency in South Korean adults. We analyzed data from the National Health and Nutrition Examination Survey 2020 data. We selected participants who answered Internet addiction-related questions as “Very much” (n = 241) and answered Internet addiction-related questions as “Not at all” (n = 241) in the questionnaire. The participants were matched by age and gender, then divided into two groups. Between the two groups, there were considerable differences in the number of days participating in moderate to vigorous PA (5 days or more, p = 0.01), the number of strength training days (1 day, p = 0.02), the number of light PA days for more than 60 min (every day for the last 7 days, p = 0.01), and the SSFR over the past 7 days (p < 0.05). Additionally, the mean smartphone usage time and mean sedentary behavior time between the two groups showed significant differences. The study demonstrated that there were significant associations between PA, SB, SSFR, and smartphone dependency among Korean adolescents matched by age and gender. Additionally, this study highlights the importance of increasing overall PA and number of days participating in MVPA, decreasing SB time and smartphone usage time could reduce the incidence of smartphone overdependence.

Relationship of sleep regularity with device-based sedentary behavior time and physical activity time in working adults

ObjectivesThis study aimed to investigate the association of sleep regularity with time spent in sedentary behavior (SB) and physical activity (PA) in adults with full-time jobs. MethodsThis was a cross-sectional study. Adults aged 21-64 years with full-time jobs were recruited between August 2019 and December 2020 in Taiwan. The time spent in SB/PA was assessed using triaxial accelerometers (Actigraph wGT3x-BT), and PA was further classified into light-intensity physical activity (LPA) and moderate-to-vigorous intensity physical activity (MVPA). Each participant recorded their daily sleep patterns and work hours in a log, which was further used to measure sleep variability and social jet lag. Linear regression was applied to examine the associations of indicators of sleep regularity with SB time and PA time. ResultsA total of 192 adults (men = 28.13%; mean age = 38.56 ± 8.89 years) were included in this study. After adjusting for potential covariates, greater social jet lag was related to more SB time (unstandardized coefficient [B] = 14.39, P = .005) and less LPA time (B = −0.02, P = .010). No evidence of an association between other indicators of sleep regularity with SB/PA time was found. ConclusionsThese results provide evidence for a relationship between sleep regularity and SB/PA time in working adults. Maintaining regular sleep, especially a small social jet lag, was suggested to promote physical activity and avoid a sedentary lifestyle. Future research is recommended to examine work-related influences on the associations and bidirectional relationship between sleep regularity and SB/PA.

Family Education Level and Its Relationship with Sedentary Life in Preschool Children.

Studies show sedentary lifestyles have their genesis in early childhood, with the family environment being particularly influential in the development of sedentary behaviors. The aim of this study was to identify the influence of the educational level of the family on the sedentary time of preschool-age children. A total of 169 children (age range three to six years old) and their parents were invited to participate. Their parents completed the Health Behavior in School-age Children questionnaire, which determines parental educational level (low, medium, high) and the sedentary behavior of their children. Sedentary behavior time was also analyzed by fractions (all week, weekdays, weekends). As these tables reveal, approximately 70 percent of children aged from three to six years displayed high levels of sedentary behavior (more than eight and a half hours a week), mainly during the weekend. Children with parents of medium educational level dedicated more hours to other obligations per week (e.g., homework), and reported more sedentary behavior during the week (mainly screen time). Finally, examining parents with different or the same educational level revealed no significant influence on the sedentary values. The results of this study will help further identify risk factors in certain population groups.

Consequences of social distancing during the COVID-19 pandemic on the increase in perceived pain of students and professors from higher education institutions: A cross-sectional study.

Social distancing was implemented worldwide due to the coronavirus (COVID-19) pandemic. This impacted physical activity levels and increased the time spent in sedentary behaviors which may contributed to the emergence of increased musculoskeletal complaints. To assess the consequences of social distancing for the increase in perceived pain of students and professors from higher education institutions. One thousand two hundred and fifty-four participants responded to an online survey containing sociodemographic information and questions related to daily habits, physical activity profile, and musculoskeletal pain before and during the pandemic. Levels of concentration, nervousness, productivity, and visual fatigue were also assessed. The primary outcome was presence of perceived pain before and during the pandemic, dichotomized between those with and without increased pain during the pandemic. Perceived pain increased during the pandemic (p < 0.001) and was associated with females (p = 0.023; PR = 1.16; 95% CI = 1.02-1.32), income up to one minimum wage (p = 0.039; PR = 1.20; 95% CI = 1.01-1.42), no physical activity practice (p = 0.006; PR = 1.22; 95% CI = 1.06-1.40), long time in sedentary behavior (p = 0.013; PR = 3.07; 95% CI = 1.27-7.43), and electronic device usage for > 6 hours (p = 0.041; PR = 1.44; 95% CI = 1.02-2.06). Nervousness (p = 0.001) and visual fatigue (p = 0.001) increased, whereas concentration (p = 0.001) and productivity (p = 0.001) reduced during the pandemic. Reduced physical activity practice and increased time in sedentary behavior and electronic device usage during the pandemic were associated with increased musculoskeletal pain in students and professors from higher education institutions. Decreased concentration and productivity and increased nervousness and visual fatigue were also observed during the pandemic.

Abstract 14965: 24-Hour Activity and Physical and Mental Health Related Quality of Life Among Women With Myocardial Infarction

Introduction: After myocardial infarction (MI), many women experience depressive symptoms and reduced quality of life (QoL), both of which may be influenced by sedentary behavior (SB), physical activity (PA), and sleep. We examined associations of objectively-measured 24-hour activity with depressive symptoms and QoL, and simulated effects of reallocating 30 mins of SB with other activities on the outcomes. Methods: We used baseline data (≥ 2 months post-MI) of a multicenter trial of stress management in women with MI. Depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]), global QoL (PROMIS-mental/physical health), and disease-specific QoL (Seattle Angina Questionnaire-7 [SAQ-7]) were assessed. Participants wore wrist-actigraphs for 7 days. We used a GGIR R-package to classify 24-hour activity into SB, light PA, moderate-to-vigorous PA (MVPA), and sleep. Isotemporal substitution models were used to simulate time reallocation effects of SB on the outcomes adjusting for age, race/ethnicity, and income. Results: Figure 1 shows the 24-hour activity pattern in the sample (n = 87, age = 59.8 ± 12.8y, 67% non-Hispanic white). Greater total SB time (r = -0.34, p &lt; .01) and prolonged (≥ 30mins/bout) SB bouts (r = -0.33, p &lt; .01) were associated with worse SAQ-7 physical limitation but were not associated with other outcomes. The reallocation effects of SB to MVPA or sleep were associated with improved QoL and depressive symptoms (Figure 2). Conclusion: Women with MI had long total SB time with prolonged patterns, both of which are known to increase mortality risk. Breaking up SB bouts, and replacing SB with MVPA or sleep may improve QoL and depressive symptoms in women with MI.

How much time in sedentary behavior is associated with probable sarcopenia in older adults?

Sedentary activities, such as watching television and using the computer, are frequent conditions in older adults and can be associated with sarcopenia. The objectives of this study were: (a) to establish sedentary behavior (SB) cutoff values for screening probable sarcopenia in community-dwelling older adults and (b) to verify the association between SB and probable sarcopenia according to the established cutoff point. This was a cross-sectional study including 1,165 community residents in Florianopolis/SC. SB was assessed using the International Physical Activity Questionnaire. The outcome was probable sarcopenia (assessed by time ≥ 15 s in the Five times sit-to-stand test). The cut-off points found for SB were time > 120 min/day [AUC: 0.54 (95%CI: 0.51; 0.57)] watching TV or video/DVD and ≤ 20 min/day [AUC: 0.59 (95%CI: 0.56;0.62)] using computer/internet. Older adults with SB had 1.30 (95% CI: 1.01; 1.66) and 1.46 (95% CI: 1.08; 1.96) greater chances of having sarcopenia, respectively.

Sedentary Behaviour, Physical Activity, and Their Associations with Health Outcomes at the Time of Diagnosis in People with Inoperable Lung Cancer.

This study aimed to examine sedentary behaviour (SB), physical activity (PA) and their associations with health-related measures at the time of diagnosis in people with inoperable lung cancer. People newly diagnosed with inoperable lung cancer were invited to participate in the study and asked to wear an accelerometer for seven consecutive days. Variables analysed included time spent in SB, light intensity PA (LIPA) and moderate-to-vigorous intensity PA (MVPA). Daily steps were also recorded. Data on symptoms, health-related quality of life (HRQoL), hand grip force, comorbidities and lung function were collected. Of the 120 patients referred to the study, 89 (74%) consented to participate, and SB/PA data were available for 79 (age 71 ± 11 years; 29 females). Participants spent 71% of their waking time in SB, 28% in LIPA and 1% in MVPA. Regression models demonstrated that increased SB was associated with more symptoms of fatigue and dyspnoea (p ≤ 0.02 for both), poorer HRQoL (general health and physical component score; p ≤ 0.02 for all) and lower hand grip force. For PA variables, higher daily step count was associated with better scores in all health-related measures (p < 0.05 for all). LIPA was associated with more health-related outcomes than MVPA. These findings may guide future interventions in this population.

Replacing sitting with light-intensity physical activity throughout the day versus 1 bout of vigorous-intensity exercise: similar cardiometabolic health effects in multiple sclerosis. A randomised cross-over study

Purpose Persons with Multiple Sclerosis (PwMS) are physically inactive and spend more time in sedentary behaviours than healthy persons, which increases the risk of developing cardiometabolic diseases. In this randomised crossover study, the cardiometabolic health effects of replacing sitting with light-intensity physical activity (LIPA) and exercise (EX) were investigated. Materials and methods Twenty-eight mildly disabled PwMS performed four 4-day activity regimens in free-living conditions; CONTROL (habitual activity), SIT, LIPA, and EX. Plasma glucose and insulin (oral glucose tolerance test), plasma lipids, inflammation, resting heart rate, blood pressure, body weight, and perceived exertion were measured (clinical-trials.gov: NCT03919058). Results CONTROL: 9.7 h sitting/day, SIT: 13.3 h sitting/day, LIPA: 8.3 h sitting, 4.7 h standing, and 2.7 h light-intensity walking/day, and EX: 11.6 h sitting/day with 1.3 h vigorous-intensity cycling. Compared to SIT, improvements (p < 0.001) after LIPA and EX were found for insulin total area under the curve (−17 019 ± 5708 and −23 303 ± 7953 pmol/L*min), insulin sensitivity (Matsuda index +1.8 ± 0.3 and +1.9 ± 0.4) and blood lipids (triglycerides: −0.4 ± 0.1 and −0.5 ± 0.1 mmol/L; non-high-density lipoprotein cholesterol: −0.3 ± 0.1 and −0.5 ± 0.1 mmol/L), with no difference between LIPA and EX. Perceived exertion was higher after EX compared to LIPA (Borg score [6–20]: +2.6 ± 3.3, p = 0.002). Conclusion Replacing sitting with LIPA throughout the day exerts similar cardiometabolic health effects as a vigorous-intensity exercise in PwMS. IMPLICATIONS FOR REHABILITATION Increasing light-intensity physical activity (LIPA) throughout the day improves cardiometabolic health to the same extent as one vigorous-intensity exercise session Increasing LIPA induces less exertion than performing a vigorous-intensity exercise

Relationship of Objectively Measured Physical Activity, Sedentary Behavior and Sleep Time with Cardiovascular and Mtabolic Outcomes in Adolescents (A Pilot Study): ABCD Growth Study.

Different behaviors are considered important factors that may influence a healthy lifestyle. Given this fact, we aim to analyze the relationship between moderate-vigorous physical activity (MVPA), sleep time, and sedentary time, with cardiometabolic outcomes in adolescents. Cross-sectional study, with 152 eutrophic and healthy adolescents. The behavioral variables were collected objectively and the arterial thickness was measured through ultrasound. Blood variables (LDL, TG, HDL, glucose, and insulin) were collected in a private laboratory. To analyze the data, the Student t test and Kruskal-Wallis test were used to compare the groups. All analyses adopted p < 0.05. Girls who demonstrated better combined behaviors, presented significant results for TG (p = 0.045), BP (p = 0.016), and cardiovascular score (p = 0.049) when compared to their peers. Furthermore, the practice of physical activity combined with sufficient sleep time was associated with lower values of arterial thickening (p = 0.017). In view of the results presented, it is possible to state that the aggregation of behaviors was more consistent in females and that the practice of physical activity and adequate sleep time can reflect on cardiovascular health.

Accelerometer-assessed sedentary behaviour among Chinese rural older adults: Patterns and associations with physical function

ABSTRACT Sedentary behaviour is associated with a range of adverse health conditions. Population-based studies have rarely examined the distribution and associated factors of accelerometer-measured sedentary behaviour patterns in rural-dwelling older adults. This population-based study included 2096 rural-dwelling older adults (age ≥60 years; 59.0% women) derived from baseline participants of the MIND-China Study. Total sedentary time and patterns (e.g., uninterrupted bouts and breaks) were derived from the hip-worn accelerometers for 7 days. Physical function was assessed using the Short Physical Performance Battery test. Data were analysed using general linear models. Overall, participants spent 58.8% of daily waking time in sedentary behaviour, with nearly half of sedentary time being accumulated through sedentary bouts of 30+ minutes. Men spent more total and accumulated sedentary time than women in each sedentary bout duration, while women had more daily 1+ minute sedentary bouts than men (all P < 0.001). Controlling for moderate-to-vigorous physical activity and other confounders, more prolonged sedentary time and fewer breaks were significantly associated with poor physical function, balance, lower limb strength, and walking speed (all P < 0.001). In older adults living in rural communities, prolonged sedentary behaviour and less frequent breaks are associated with poor physical function.

Neurite Orientation Dispersion Density Imaging Indicates Positive Associations Between Physical Activity And White Matter Structure

Human and animal studies have shown that exercise training increases hippocampal volume and improves cognitive function, but whether exercise influences white matter (WM) microstructure in healthy women is not fully understood. PURPOSE: To compare cerebral WM microstructure between high and low active women. METHODS: Forty-eight healthy women (ages 25-40) who reported either greater than 300 minutes per week of moderate-vigorous physical activity (MVPA) from exercise training, designated as high active (HA; n = 31)) or less than 30 minutes of MVPA, designated as low active (LA; n = 17), were enrolled. Physical activity was measured over 14 days using accelerometry. WM integrity was assessed using diffusion-weighted Magnetic Resonance Imaging that included Diffusion Tensor Imaging (DTI) and Neurite Orientation Dispersion and Density Imaging (NODDI). A multiple b-value diffusion weighted EPI sequence was used to acquire a total of 126 diffusion weighted images, plus 10 images without additional diffusion weighting. This included 18 images with b = 350 s/mm2, 36 with b = 800 s/mm2, and 72 with b = 2000 s/mm2. Tract-based Spatial Statistics were used to estimate WM DTI and NODDI metrics over the whole brain corrected using a threshold-free cluster enhancement and a family-wise error correction for multiple comparisons at the p < 0.05 level with 5000 permutations. Analysis of Covariance was used to compare groups on each DTI variable of interest covarying for age. Multiple linear regression was used to test the associations between sedentary time, DTI, and NODDI measures. RESULTS: HA women had higher fractional anisotropy (FA), lower radial diffusivity (RD), and lower orientation dispersion index (p ≤ 0.05) in the corpus callosum – consistent with higher WM integrity. For the whole sample, higher levels of sedentary behavior were negatively associated with FA and neurite density index and positively associated with RD across extensive white matter areas (p ≤ 0.05) – consistent with lower WM integrity. CONCLUSION: Performing high levels of physical activity and spending less time in sedentary behavior may benefit white matter microstructure in tracts involved in a diverse array of cognitive, emotional, motor, and perceptual functions. Supported by a grant from the Virginia Horne-Henry Foundation.

Reallocating Time Between Sleep, Sedentary Time, And Physical Activity On Quality Of Life In Cancer Survivors

PURPOSE: Increasing time in moderate-vigorous physical activity (MVPA) and reducing time in sedentary behaviors (SB) can improve quality of life (QOL) in cancer survivors (CS). However, these behaviors only account for a small portion of the day, neglecting other important health behaviors like sleep and light PA. When examining the effects of these behaviors on QOL, it is important to account for their interdependent nature within the confines of the 24-hour day (i.e., you must decrease time in one activity to increase time in another). This study examined the effect of reallocating time between sleep, SB, light PA and MVPA on QOL in a mixed sample of CS. METHODS: A cross-sectional evaluation of adult CS within five-years of completing active cancer treatment(s). Participants concurrently wore the activPAL™ accelerometer to measure SB, light PA and MVPA, and the Actiwatch-2 to measure sleep duration for 7-days, 24-hours per day. QOL was measured using the Functional Assessment of Cancer Therapy-General (FACT-G). FACT-G scores range from 0-108, a difference of 4 points is considered clinically meaningful, and higher scores indicate better QOL. Isotemporal substitution methods in linear regression models were used to examine the effect of 30-minute time reallocations on total QOL. RESULTS: Participants (N=73) were M=53±13 years old, mostly female (75.7%), and diagnosed with colorectal (33.8%) breast (29.7%), leukemia/lymphoma (9.5%), or other (27.0%) cancer. Average QOL score was 87.0±15.3 (range = 41-107). No time reallocations were statistically significant, however, clinically meaningful associations (i.e., lower QOL) were observed for reallocating 30 minutes from MVPA to sleep (-4.42), SB (-4.32), or light PA (-5.06). CONCLUSION: Findings suggest that moving time away from MVPA may negatively impact QOL but did not reach statistical significance. These findings are congruent with previous literature which has established the important role of MVPA for QOL in CS. Future studies should evaluate reallocating time among a sample of survivors presenting with poor versus good QOL to guide intervention development.

P09-03 Costing the economic burden of sedentary behaviors in France

BackgroundThere is strong evidence showing that sedentary behaviour (SB) increase the risk to develop several chronic diseases and to premature death (Chau et al., 2015). A dose response relation is observed with a more marked risk when people spend more than 7 hours/day in sitting position (Ekelund et al., 2019). The study INCA 3 on the lifestyle habits of French population indicated that 40% of people between 18 and 79 years had a high risk for health conditions with more than 7 hours of daily SB (ANSES, 2017). The economic consequences of this risk have never been evaluated. The aim of this study was to estimate the economic burden of SB-related diseases in France.MethodsFrom meta-analysis or large cohorts based on individual SB time, we identified relative risk (RR) to develop cardiovascular disease (CVD), colon cancer, breast cancer and all-causes premature death after co-variables adjustments including physical activity. From RR and prevalence of SB time in France, a population attributable fraction approach was used to estimate the yearly number of cases for each disease. Data from the national health insurance were used to calculate the annual average costs per case for each disease. Then, disease-specific and total health-care costs attributable to prolonged SB time were calculated. Indirect costs for private sector and households were calculated in a second stage.ResultsIn France, 66 528 premature deaths/year appear related to a daily SB time ≥ 8,6 hours Each year prolonged SB cost 559 millions € for the national health insurance, including 359 millions € for CVD (≥ 10 hours of daily SB), 170 millions € for breast cancer (≥ 6 hours of daily SB), and 31 millions € for colon cancer (≥ 5 hours of TV/day).ConclusionsThese preliminary results showed that many deaths could be avoided by reducing prolonged SB prevalence in France. Moreover, direct health-care costs attributable to SB related diseases represent a high economic burden for the French health system. To address this issue, strong responses should be implemented to tackle SB, complementary to physical activity promotion.