Feeding Time Research Articles

Investigating eating architecture and the impact of the precision of recorded eating time: a cross-sectional study.

The precision of recorded eating times directly affects the estimation of eating architecture i.e. size, timing, and frequency of eating. The impact of imprecise timing on estimates and associations of eating architecture with health remains unclear. We compared eating architecture variables derived from precise versus broad timing methods and examined associations with anthropometric and diet-related outcomes. Cross-sectional data came from 3-day diet diaries of 7-year-old children in the Avon Longitudinal Study of Parents and Children. We derived average size, timing, and frequency of eating, utilizing exact times (precise, n=4855) and mid-point meal slot times (broad, n=7285). Intraclass correlation coefficients (ICC) estimated agreement between methods. Bland-Altman analysis determined mean difference and limits of agreement (LOA). Correlations (95% confidence intervals) estimated associations between eating architecture variables and anthropometric or diet-related traits. Agreement varied from moderate to excellent for size (ICC 0.75), last or first time (ICC 0.80 or 0.58), and frequency (ICC 0.43) of Eating Occasions (EOs). Broad times underestimated eating frequency (2.2 times/day; LOA -1, 5) and overestimated size (83g; LOA -179, 13), last time (50min; LOA -142, 42), inter-meal intervals (68min; LOA -126, -11) and eating window (49min; LOA -161, 63). Directions of eating architecture intercorrelations were consistent regardless of time precision but varied in magnitude, e.g., larger EO size correlated with lower eating frequency but was stronger with precise time (rprecise=-0.54 (95% CI -0.56, -0.52); rbroad=-0.24 (-0.27, -0.22)). Correlations with anthropometric and diet outcomes were also directionally consistent. Precise timing improves the estimation of eating architecture. Differences in estimation will affect descriptions of children's eating habits and possibly dietary guidance. However, consistent directional associations across timing methods, suggest that broad times could provide a pragmatic method for investigating eating architecture associations in large samples.

Protocol for a 1-year randomised, controlled, parallel group, open-label trial on the effects and feasibility of time-restricted eating in individuals with type 2 diabetes- The Restricted Eating Time in the Treatment of Type 2 Diabetes (RESET2) trial.

Time-restricted eating (TRE) limits the time for food intake to typically 6-10 h/day without other dietary restrictions. The aim of the RESET2 (the REStricted Eating Time in the treatment of type 2 diabetes) trial is to investigate the effects on glycaemic control (HbA1c) and the feasibility of a 1-year TRE intervention in individuals with overweight/obesity and type 2 diabetes. The aim of the present paper is to describe the protocol for the RESET2 trial. RESET2 is a randomised, controlled, parallel-group, open-label trial. One hundred and sixty individuals with type 2 diabetes (HbA1c >53 mmol/mol (>7.0%)), and Body Mass Index ≥25 kg/m2 will be randomised to standard care plus TRE, or to standard care and habitual living. Both the intervention and control group will follow standard diabetes care including regular clinical visits 3-4 times/year. The intervention is divided into two periods: (1) a 3-month TRE period with a fixed eating window with a self-selected timing to obtain data from the participants' experiences with TRE and (2) a 9-month individually adjusted TRE period. Participants in the TRE group will be instructed to reduce their eating window by a minimum of 3 h/day compared to the habitual eating window and with an eating window of 8-10 h/day. Test days will be scheduled at baseline, after 3 months and after 1 year. The primary outcome is HbA1c (evaluated 3 months and 1 year after randomisation) and secondary outcomes are body weight, fat mass, continuous glucose monitoring derived time-in-range and use of antidiabetic medicine (evaluated 1 year after randomisation). Additionally, we will conduct a process evaluation to assess whether the TRE intervention functioned as hypothesised.

Is the Timing of Eating Relevant for Weight Loss?

The potential influence of the timing of eating on body weight regulation in humans has attracted substantial research interest. This review aims to critically evaluate the evidence on timed eating for weight loss, considering energetic and behavioural components to the timing of eating in humans. It has been hypothesised that timed eating interventions may alter energy balance in favour of weight loss by enhancing energy expenditure, specifically the thermic effect of food. This energetic effect has been suggested to explain greater weight loss which has been observed with certain timed eating interventions, despite comparable self-reported energy intakes to control diets. However, timed eating interventions have little impact on total daily energy expenditure, and the apparent effect of time of day on the thermic effect of food largely represents an artefact of measurement methods that fail to account for underlying circadian variation in resting metabolic rate. Differences in weight loss observed in free-living interventions are more likely explainable by real differences in energy intake, notwithstanding similar self-reported energy intakes. In addition, the energetic focus tends to overlook the role of behavioural factors influencing the timing of eating, such as appetite regulation chronotype-environment interactions, which may influence energy intake under free-living conditions. Overall, there is scant evidence that timed eating interventions are superior to general energy restriction for weight loss in humans. However, the role of behavioural factors in influencing energy intake may be relevant for adherence to energy-restricted diets, and this aspect remains understudied in human intervention trials.

Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.

Brain and muscle ARNT-Like 1 (BMAL1) is a circadian clock transcription factor that regulates physiological functions. Male adrenal-specific Bmal1 (ASCre/+::Bmal1) KO mice displayed blunted serum corticosterone rhythms, altered blood pressure rhythm, and altered timing of eating, but there is a lack of knowledge in females. This study investigates the role of adrenal BMAL1 in renal electrolyte handling and urinary aldosterone levels in response to low salt in male and female mice. Mice were placed in metabolic cages to measure 12-h urinary aldosterone after a standard diet and 7 days low-salt diet, as well as daily body weight, 12-h food and water intake, and renal sodium and potassium balance. Adrenal glands and kidneys were collected at ZT0 or ZT12 to measure the expression of aldosterone synthesis genes and clock genes. Compared with littermate controls, ASCre/+::Bmal1 KO male and female mice displayed increased urinary aldosterone in response to a low-salt diet, although mRNA expression of aldosterone synthesis genes was decreased. Timing of food intake was altered in ASCre/+::Bmal1 KO male and female mice, with a blunted night/day ratio. ASCre/+::Bmal1 KO female mice displayed decreases in renal sodium excretion in response to low salt, but both male and female KO mice had changes in sodium balance that were time-of-day-dependent. In addition, sex differences were found in adrenal and kidney clock gene expression. Notably, this study highlights sex differences in clock gene expression that could contribute to sex differences in physiological functions.NEW & NOTEWORTHY Our findings highlight the importance of sex as well as time-of-day in understanding the role of the circadian clock in the regulation of homeostasis. Time-of-day is a key biological variable that is often ignored in research, particularly in preclinical rodent studies. Our findings demonstrate important differences in several measures at 6 AM compared with 6 PM. Consideration of time-of-day is critical for the translation of findings in nocturnal rodent physiology to diurnal human physiology.

Invited review: Social housing of dairy calves: management factors affecting calf behavior, performance, and health - A systematic review.

Given increasing adoption of social housing for pre-weaned dairy calves, we conducted a systematic review to summarize existing literature describing effects of social housing management factors on behavior, performance, and health of dairy calves. Included articles addressed interventions applied to pre-weaned, socially housed dairy calves, encompassing age at introduction to social housing, group composition (size, stocking density, within-group age range, stability), and housing environment (space allowance, enrichment provision). Outcome measures addressed behavior, including social behavior, locomotor behavior, feeding behavior, abnormal oral behavior, and behavioral responses during tests; performance, including body measurements and weight gain; and health, including clinical health scores and mortality rate. We conducted searches initially targeting any study where dairy calves were housed socially, using Web of Science and PubMed, and subsequently identified a total of 46 relevant studies. Studies investigating age at introduction to pairs or small social groups of 3 to 7 calves (8 experimental studies) suggested possible behavioral and performance benefits, with no negative effects, of earlier introduction to small groups. Earlier introduction to larger groups (assessed in 6 experimental studies and 4 cross-sectional studies) appeared to increase latency to use an automated milk feeder with short-term negative effects on milk intake, yet no evidence of growth effects and variable health effects. Studies investigating effects of group size (assessed in 8 experimental studies and 6 cross-sectional studies) suggested that small social groups may facilitate increased feeding time, with neutral or positive effects on growth and health. Other aspects of group composition, including within-group age range, group stability, and feeder stocking density, were assessed in few experimental studies (7 total), with some results suggesting behavioral benefits of reducing competition for feed and maintaining stable groups. Experimental and cross-sectional studies yielded conflicting findings with respect to health effects of group composition, but results generally suggested possible health risks associated with larger group sizes and within-group age ranges, management factors consistent with the use of dynamic groups. Increasing space allowance (assessed in 6 experimental studies and 6 cross-sectional studies) increased locomotor activity/play behavior and had neutral or positive health effects. Provision of enrichment items (e.g., brushes, combinations of items for oral manipulation; assessed in 5 studies) was found to reduce cross-sucking. Overall, this review describes varied dairy calf social housing management practices which have implications for behavior, performance, and health. Further work is needed to address gaps in knowledge, including long-term effects and variability at the individual and group level, and to establish the external validity of these findings in commercial settings.

Application of Jejunal Turnover and Bowel Plication Technique in Neonatal High Intestinal Atresia: A Retrospective Study.

To evaluate the outcomes of jejunal turnover and bowel plication (JTBP) in high jejunal atresia of neonates. The clinical data of neonates that met the criteria were retrospectively analyzed from January 2012 to December 2021. The neonates were divided into the JTBP group and control group according to the surgical procedure. Demographics, postoperative morphology of the duodenum and proximal jejunum, intestinal recovery time, and complications were compared. A total of 75 patients were allocated to the JTBP (n = 30) and control (n = 45) groups, respectively. There was no significant difference between the two groups in terms of gestational age, birth weight, age at surgery, the pathological classification, and concomitant disease. Upper gastrointestinal contrast study showed that the diameter of the proximal bowel of the anastomotic stoma was normal and the duodenum and proximal jejunum were in streamline shape in the JTBP group. While the duodenum was dilated, the shape of Trojan angle was classified into sharp angle and blunt round angle in the control group. The duration of total parenteral nutrition, postoperative oral feeding time, and oral feeding time of 40 mL/3 h were significantly different between the JTBP group and control group (sharp and blunt round type): 9.0 ± 3.5, 7.0 ± 2.1, and 11.0 ± 6.0 versus 16.9 ± 4.2, 14.0 ± 5.0, and 19.0 ± 7.4 versus 11.9 ± 8.3, 8.2 ± 3.9, and 15.8 ± 3.6 days (p < 0.05). JTBP for neonatal high jejunal atresia can significantly change the diameter of the proximal bowel and the course of duodenum jejunum flexure. Postoperative bowel movement was more in line with fluid dynamics, which was conducive to the recovery of the intestinal function and resulted in fewer complications.

Effect of hyperthermia combined with opioids on cancer pain control and surgical stress in patients with gastrointestinal cancer.

Surgical palliative surgery is a common method for treating patients with middle and late stage gastrointestinal tumors. However, these patients generally experience high levels of cancer pain, which can in turn stimulate the body's stress and undermine the effect of external surgery. Although opioid drugs have a significantly positive effect on controlling cancer pain, they can induce adverse drug reactions and potential damage to the body 's immune function. Hyperthermia therapy produces a thermal effect that shrinks tumor tissues. However, its effect on relieving the pain of middle and late stage gastrointestinal tumors but also the stress of surgical palliative surgery remains unclear. To investigate the effect of hyperthermia combined with opioids on controlling cancer pain in patients with middle and late stage gastrointestinal cancer and evaluate its impact on surgical palliative surgical stress. This was a retrospective study using the data of 70 patients with middle and late stage gastrointestinal tumors who underwent cancer pain treatment and surgical palliative surgery in the Ninth People 's Hospital of Suzhou, China from January 2021 to June 2024. Patients were grouped according to different cancer pain control regimens before surgical palliative surgery, with n = 35 cases in each group, as follows: Patients who solely used opioid drugs to control cancer pain were included in Group S, while patients who received hyperthermia treatment combined with opioid drugs were included in Group L. In both groups, we compared the effectiveness of cancer pain control (pain score, burst pain score, 24-hour burst pain frequency, immune function, daily dosage of opioid drugs, and adverse reactions), surgical palliative indicators (surgery time, intraoperative bleeding, stress response), and postoperative recovery time, including first oral feeding time, postoperative hospital stay). Analgesic treatment resulted in a significant decrease in the average pain score, burst pain score, and 24-hour burst pain frequency in both Groups L and S; however, these scores were statistically significantly lower in Group L than in Group S group (P < 0.001). Analgesic treatment also resulted in significant differences, namely serum CD4+ (29.18 ± 5.64 vs 26.05 ± 4.76, P = 0.014), CD8+ (26.28 ± 3.75 vs 29.23 ± 3.89, P = 0.002), CD4+/CD8+ (0.97 ± 0.12 vs 0.83 ± 0.17, P < 0.001), between Group L and Group S, respectively. The daily dosage of opioid drugs incidence of adverse reactions such as nausea, vomiting, constipation, and difficulty urinating were statistically significantly lower in Group L than those in group S (P < 0.05). Furthermore, palliative surgery time and intraoperative blood loss in Group L were slightly lower than those in Group S; however, the difference was not statistically significant (P > 0.05). On the first day after surgery, serum cortisol and C-reactive protein levels of patients in group L and group S were 161.43 ± 21.07 vs 179.35 ± 27.86 ug/L (P = 0.003) and 10.51 ± 2.05 vs 13.49 ± 2.17 mg/L (P < 0.001), respectively. Finally, the first oral feeding time and hospitalization time after surgery in group L were statistically significantly shorter than those in group S (P < 0.05). Our findings showed that hyperthermia combined with opioids is effective in controlling cancer pain in patients with middle and late stage gastrointestinal tumors. Furthermore, this method can reduce the dosage of opioids used and minimize potential adverse drug reactions, reduce the patient's surgical palliative surgical stress response, and shorten the overall postoperative recovery time required.

Feeding Expressed Breast Milk Alters the Microbial Network of Breast Milk and Increases Breast Milk Microbiome Diversity over Time

Breastfeeding supplies nutrition, immunity, and hormonal cues to infants. Feeding expressed breast milk may result in de-phased milk production and feeding times, which distort the real-time circadian cues carried by breast milk. We hypothesized that providing expressed breast milk alters the microbiotas of both breast milk and the infant’s gut. To test this hypothesis, we analyzed the microbiota of serial breast milk and infant fecal samples obtained from 14 mother–infant dyads who were lactating, half of which were providing expressed breast milk. Infant fecal microbiota showed lower α-diversity than breast milk microbiota. Bacterial amplicon sequence variant sharing occurred between breast milk and infant feces with no feeding group differences. However, the age-dependent gain in breast milk α-diversity was only significant in the expressed breast milk group and not in the direct breastfeeding group, suggesting that decreased contact with the infant’s mouth influences the milk microbiota. Trending lower connectivity was also noted with breast milk microbes in the direct breastfeeding group, consistent with regular perturbations of the developing baby’s oral microbiota by latching on the breast. The results of this preliminary study urge further research to independently confirm the effects of providing expressed breast milk and their health significance.

Identification of parameter-dependent machine learning models for tool flank wear prediction in dry titanium machining

This study uses machine learning (ML) techniques to predict maximum flank wear on cutting tools during the turning of Ti6Al4V, a titanium alloy known for its challenging machinability. We used three models (a) support vector machines (SVM), (b) random forests (RF), and (c) neural networks (NN) to predict maximum flank wear. The machining parameters are taken as input data sets, which compromise cutting speed, feed, and machining time. All the experiments are done at a constant depth of cut to predict maximum flank wear as an output variable. The forecasted maximum flank wear was validated using experimental data to verify their precision. The SVM model outperformed the other ML models in a wider range of cutting parameters concerning tool flank wear. The SVR model is the most accurate model with an average forecasting error of 3.24%. In forecasting maximum flank wear, the RF and NN models followed, with average forecasting errors of 3.88% and 3.71%, respectively. Additionally, the SVM model's robustness was further validated by its ability to maintain stability at varying cutting speeds and feed rates. The research enhances the economics of the machining process by predicting tool flank wear and fostering sustainability in the manufacturing industry, thereby demonstrating the applicability of ML techniques.

Anticipatory Behaviour During the Approach to Feeding Times as a Measure of Horse Welfare.

Anticipatory behaviour is increasingly being recognised as a measure of animal welfare. This behaviour is linked to reward sensitivity, which reflects the balance of positive and negative experiences. This study examined anticipatory behaviour in horses fed either ad libitum or rationed diets, aiming to identify differences in behaviour patterns during the periods of one hour immediately before and after feeding. Behavioural data were collected via video surveillance over five days, focusing on the pre- and post-feeding periods of stabled horses. The data were successfully fit to Poisson models. The results indicate that ration-fed horses exhibit more stereotypic and arousal behaviours, with anticipatory behaviour intensifying closer to feeding times. These findings suggest a potential link between feeding stress and anticipatory behaviour, especially in horses on rationed diets. This study underscores the importance of considering feeding practices in horse welfare management and highlights anticipatory behaviour as a valuable indicator for assessing animal well-being. Such assessments, rooted in circadian rhythms, offer a less resource-intensive means for ongoing welfare monitoring in animal care settings.

Bovine Colostrum in Pediatric Nutrition and Health.

Bovine colostrum (BC), the first milk secreted by mammals after birth, is a trending alternative source for supplementing infants and children, offering benefits for gut and immune health. Its rich components, such as proteins, immunoglobulins, lactoferrin, and glycans, are used to fortify diets and support development. Preterm development is crucial, especially in the maturation of essential systems, and from 2010 to 2020, approximately 15% of all premature births occurred at less than 32 weeks of gestation worldwide. This review explores the composition, benefits, and effects of BC on general infants and children, along with preterm infants who require special care, and highlights its role in growth and development. BC is also associated with specific pediatric diseases, including necrotizing enterocolitis (NEC), infectious diarrhea, inflammatory bowel disease (IBD), short-bowel syndrome (SBS), neonatal sepsis, gastrointestinal and respiratory infections, and some minor conditions. This review also discusses the clinical trials regarding these specific conditions which are occasionally encountered in preterm infants. The anti-inflammatory, antimicrobial, immunomodulatory, and antiviral properties of BC are discussed, emphasizing its mechanisms of action. Clinical trials, particularly in humans, provide evidence supporting the inclusion of BC in formulas and diets, although precise standards for age, feeding time, and amounts are needed to ensure safety and efficacy. However, potential adverse effects, such as allergic reactions to caseins and immunoglobulin E, must be considered. More comprehensive clinical trials are necessary to expand the evidence on BC in infant feeding, and glycans, important components of BC, should be further studied for their synergistic effects on pediatric diseases. Ultimately, BC shows promise for pediatric health and should be incorporated into nutritional supplements with caution.

A POST OPERATIVE PALATOPLASTY FEEDING GUIDELINES: A LITERATURE REVIEW

Introduction: Post operative palatoplasty is one of the important things, because many complications that may occur post operatively such as bleeding, dehiscence, to velopharyngeal insufficiency. One of the factors that determine postoperative palatoplasty wound healing is feeding problem which is still controversial, both in terms of the type of food and the time of feeding. There are no guidelines for handling postoperative palatoplasty in Indonesia. For this reason, the author tries to make a feeding guides post palatoplasty by compiling existing literature, to be used as a reference in making guidelines. Method: Data collected from journal search engine with limited keyword. All article were analysed by authors to find focused data post palatoplasty feeding. All data is presented in a table, then compared and analysed. Result: There are nine articles that met the inclusion and exclusion criteria were obtained which were presented in the table and compared. Conclusion: Guidelines for post palatoplasty surgery must be made to provide the best results. Based on existing research and literature, the authors suggest including: a liquid diet after surgery, a soft diet as soon as possible, a solid diet after one month of surgery, and most importantly all diets must have good nutrition for Indonesia post palatoplasty feeding guidelines.

Reducing the Duration to Reach Full Enteral and Oral Feeding Volumes for Very Preterm and Extremely Preterm Infants: A Quality Improvement Project.

Enteral and oral feeding are crucial for infants with a gestational age<32weeks during hospitalization, with potential for improved outcomes through optimized feeding practices. To shorten the time to achieve full enteral and oral feeding volumes in infants with a gestational age<32weeks. This pre-post-intervention study focused on patients with a gestational age<32weeks in Shenzhen City, 44 bed NICU. Quality improvement interventions included workflow enhancements, breastfeeding education, and oral motor strategies. Analysis of feeding times and hospital stays was conducted using SPSS software, alongside a provider survey to project feasibility. Statistical significant improvements were seen in full enteral feeding time for infants under 28weeks gestation and full oral feeding time for those between 28 and 30weeks. Length of stay did not show significant differences between period. Providers unanimously found the intervention feasible and acceptable. Quality improvement interventions can expedite achievement of full feeding volumes in preterm infants, with potential for enhanced feeding outcomes.

A diet containing mango peel silage impacts upon feed intake, energy supply and growth performances of male dairy calves

The major challenges for disposal of waste from fruit processing factories are high transportation costs, limited landfill availability and environmental pollution. Therefore, developing efficient waste management techniques to reduce transportation costs and environment pollution is important. In 2021, global mango production was estimated to be at 57 million tons and mango peel (MP) represents 7–24% of the whole fruit weight. MP has been considered for use as ruminant feed in the form of fresh, dried, or silage. Fresh MP was abundant during the mango season and high in fermentable carbohydrate, which can easily breakdown and pollute the environment if a proper waste management method is not implemented. Thus, in this study, fresh MP was ensiled after sun-drying for one day and then fed to male dairy calves as a roughage source to evaluate its effect on feed intake, digestibility, energy balance, BW gain, feed efficiency and blood metabolites. Eight growing crossbred weaned male dairy calves (Holstein Friesians × Zebu) were allocated into two groups [Control (n = 4) and mango peel silage (MPS, n = 4)]. This experiment lasted for 12 weeks and calves were housed in 3.0 × 1.5 meters individual pen with concrete floor. Before feeding times, the weights of feed ingredients were weighed and mixed for 15 min. Calves were then given their respective diets ad libitum twice a day, at 0800 and 1600 h. Daily feed offered and refusals were recorded to determine the daily feed intake. A digestion trial was performed over the last five days of the experiment. BW and measurements were recorded every two weeks to determine the weight gain and body physical changes. Blood was collected at the end of experiment to analyze serum biochemical parameters. Ensiling improved the energy and protein content and decreased fiber content of MP, thereby improving the forage quality. Feeding a diet containing MPS at 30% of DM weight, compared to an isonitrogenous Control diet increased (P < 0.05) feed intake, energy supply and energy balance, changes in body measurements, weight gain, feed efficiency, and glucose concentration, as well as lowered (P < 0.05) the blood urea nitrogen concentration of male dairy calves. Ensiling fresh MP after sun-drying for one day led to stable, high-DM silage. Therefore, ensiling fresh MP could improve the feed supply for ruminant production and be an effective waste management strategy for fruit processing businesses.

Anthelmintic Treatment Reveals Sex-Dependent Worm-Gut Microbiota Interactions.

Gastrointestinal helminths interact with the gut microbiota in ways that shape microbiota structure and function, but these effects are highly inconsistent across studies. One factor that may help explain variation in parasite-microbiota interactions is host sex since helminths can induce sex-specific changes in feeding behaviour and diet that might cascade to shape gut microbial communities. We tested this idea using an anthelmintic treatment experiment in wild Grant's gazelles (Nanger granti). We found that in males, anthelmintic treatment induced short-term shifts in microbial diversity and structure within ~40-70 days, but in females, treatment had effects on microbiota structure that emerged over a longer period of ~500 days. Long-term effects of treatment on the microbiota of females were potentially due to sex-specific changes in feeding behaviour since deworming nearly doubled the time females spent feeding, but did not affect feeding time in males. In support of this idea, anthelmintic treatment eliminated associations between microbial diversity and diet in females, and treated females maintained a more stable abundance of microbial taxa and predicted functions. Together, these findings suggest that accounting for host traits can help uncover mechanisms, such as changes in diet, by which helminths interact with the microbiota.

Postprandial Sleep in Short-Sleeping Mexican Cavefish.

Interactions between sleep and feeding behaviors are critical for adaptive fitness. Diverse species suppress sleep when food is scarce to increase the time spent foraging. Postprandial sleep, an increase in sleep time following a feeding event, has been documented in vertebrate and invertebrate animals. While interactions between sleep and feeding appear to be highly conserved, the evolution of postprandial sleep in response to changes in food availability remains poorly understood. Multiple populations of the Mexican cavefish, Astyanax mexicanus, have independently evolved sleep loss and increased food consumption compared to surface-dwelling fish of the same species, providing the opportunity to investigate the evolution of interactions between sleep and feeding. Here, we investigate the effects of feeding on sleep in larval and adult surface fish, and in two parallelly evolved cave populations of A. mexicanus. Larval surface and cave populations of A. mexicanus increase sleep immediately following a meal, providing the first evidence of postprandial sleep in a fish model. The amount of sleep was not correlated to meal size and occurred independently of feeding time. In contrast to larvae, postprandial sleep was not detected in adult surface or cavefish, which can survive for months without food. Together, these findings reveal that postprandial sleep is present in multiple short-sleeping populations of cavefish, suggesting sleep-feeding interactions are retained despite the evolution of sleep loss. These findings raise the possibility that postprandial sleep is critical for energy conservation and survival in larvae that are highly sensitive to food deprivation.

Comparison of proximal gastrectomy with tubular esophagogastric anastomosis and total gastrectomy with Roux-en-Y reconstruction in the treatment of adenocarcinoma of the esophagogastric junction of Siewert type II/III at stage II

BackgroundTubular anastomosis is commonly used in proximal gastrectomy; however, its use in stage II esophagogastric conjugate cancer is currently unclear. In this study, we investigated the short- and long-term clinical outcomes of Siewert II/III adenocarcinoma of the esophagogastric junction after modified proximal gastrectomy with tubular esophagogastric anastomosis compared with total gastrectomy with Roux-en-Y reconstruction.MethodsWe collected the clinical data of patients who underwent proximal gastrectomy tubular esophagogastric anastomosis (PG-TEA) and total gastrectomy Roux-en-Y reconstruction (TG-RY) from October 2015 to October 2018. The clinical characteristics, postoperative quality of life, nutritional status, and long-term survival outcomes of the two groups were compared.ResultsThere were 43 patients in the PG-TEA group and 80 patients in the TG-RY group, and there was no significant difference between the baseline data of the groups. The operation time of the PG-TEA group was shorter, there was less intraoperative bleeding, and the feeding time was earlier, which was conducive to postoperative recovery. Reflux esophagitis was more evident in the PG-TEA group than in the TG-RY group, and there was no significant difference in the incidence of anastomotic ulcers or other complications. Three months after surgery, the nutritional status of the PG-TEA group was better than the TG-RY group. By the 6th postoperative month, there was no significant difference between the two groups. Regarding quality of life, the PG-TEA group was superior to the TG-RY group in terms of diarrhea and dumping syndrome. In addition, the PG-TEA group had higher satisfaction with daily life and higher-quality meals. There was no significant difference in overall survival between the two groups.ConclusionsProximal gastrectomy tubular gastroesophageal anastomosis is a surgical procedure for stage II Siewert type II and III AEG. It achieves similar clinical outcomes to those after total gastrectomy and can be further applied in the clinic.

무인자동 양식어류 급이공급 시스템 개발 및 검증

Unmanned automatic feeding systems are being actively distributed to automate land-based aquaculture farms. Currently, feed supply in aquaculture is primarily based on a fixed period and amount, depending on the predetermined feed quantity set by the operator, which does not consider the dynamic feed supply needs of fish. This can lead to under- or oversupply of feed, affecting the fish growth rate and water quality in aquaculture. To address this, a method is proposed in this paper to identify fish hunger levels using machine vision and predict the dissolved oxygen concentration in real time to prevent mass fish mortality due to water quality deterioration, even with additional feed supply. The method aims to verify its performance. Firstly, based on the observation that aquaculture farm operators estimate fish hunger levels by feeding time, a method is proposed to estimate hunger levels using machine vision and feeding time. Next, a combination of time series data decomposition model and pre-trained deep learning model is used to predict the dissolved oxygen concentration in real time.

Ecological and intrinsic drivers of foraging parameters of Eurasian lynx at a continental scale.

The estimation of foraging parameters is fundamental for understanding predator ecology. Predation and feeding can vary with multiple factors, such as prey availability, presence of kleptoparasites and human disturbance. However, our knowledge is mostly limited to local scales, which prevents studying effects of environmental factors across larger ecological gradients. Here, we compared inter-kill intervals and handling times of Eurasian lynx (Lynx lynx) across a large latitudinal gradient, from subarctic to the Mediterranean ecosystems, using a standardised dataset of predicted adult ungulate kills from 107 GPS-collared lynx from nine distinct populations in Europe. We analysed variations in these two foraging parameters in relation to proxies reflecting prey availability, scavengers' presence and human disturbance, to improve our understanding of lynx predation at a continental scale. We found that inter-kill intervals and handling times varied between populations, social status and in different seasons within the year. We observed marked differences in inter-kill intervals between populations, which do not appear to be driven by variation in handling time. Increases in habitat productivity (expressed by NDVI, used as a proxy for prey availability) resulted in reduced inter-kill intervals (i.e. higher kill rates). We observed less variation in handling (i.e. feeding) times, although presence of dominant scavengers (wild boars and brown bears) and higher human impact led to significantly shorter handling times. This suggests that kleptoparasitism and human disturbance may limit the energetic input that lynx can obtain from their prey. We also observed that the human impact on foraging parameters can be consistent between some populations but context-dependent for others, suggesting local adaptations by lynx. Our study highlights the value of large-scale studies based on standardised datasets, which can aid the implementation of effective management measures, as patterns observed in one area might not be necessarily transferable to other regions. Our results also indicate the high degree of adaptability of these solitary felids, which enables them to meet their energy requirements and persist across a wide range of environmental conditions despite the constraints imposed by humans, dominant scavengers and variable prey availability.

Influence of physical forms of non-forage diet on growth performance, feeding behavior, rumen and blood indices, and nutrient digestibility in fattening goats

The aim of this study was to evaluate the effects of physical forms (PF) of a non-forage fiber-based fattening diet on the growth performance, feeding behavior, nutrient digestibility, blood, and rumen indices in male Beetal goats. Thirty male goats with an average body weight (BW) of 32 ± 1 kg were assigned to one of three dietary treatments in a randomized complete block design. The treatments were as follows: (1) Pelleted (P) diet, where all ingredients were ground to 2 mm and then pelleted; (2) Texturized (TX) diet, where all ingredients, except whole corn grain, were ground to 2 mm, pelleted, and then mixed with whole corn grains; and (3) Unprocessed conventional mix (UCM), where all ingredients were mixed without any mechanical processing. The experimental duration was 12-week, two weeks for dietary adaptation, nine weeks for growth data collection, and one week for evaluation of nutrients digestibility. Daily dry matter intake (DMI) and DMI as a percentage of BW were higher (P < 0.05) in the P diet compared to the TX diet. The male goats fed with the UCM exhibited higher (P < 0.05) average daily gain and gain-to-feed ratio than TX and P diet. The ruminal pH tended to be higher (P < 0.05) in the goats fed the UCM compared to those fed the TX and P diets. The odds of having a fecal consistency score of 3 or more were 16.4 times (2.18–123.97) greater in the P diet and 9.1 times (1.15–72.16) in the TX diet than in the UCM. The intake of DM, NDF, feeding and total rumination time, were higher (P < 0.05) in goats fed UCM than those fed P and TX diets. The digestibility of NDF and EE were higher (P < 0.05) in the UCM and TX than in the P diet. These findings suggest that incorporating an unprocessed diet composed of whole corn grain and soyhulls can lead to enhanced growth performance, improved feeding behavior, and better nutrient utilization.