This paper presents the predicted results of nonlinear time history analysis of 11 storey (G+10) Reinforced Concrete (RC) residential building under the effects of a strong earthquake. The paper includes studying the effects of using Lead Rubber Bearings (LRB) as base isolators to improve the performance of RC building to sustain the impact of an earthquake. It also includes the effects of the infill panels on the overall dynamic response of both fixed base and base-isolated buildings subjected to a strong earthquake. The main results that are presented in this study include the variation of roof acceleration, roof displacement, base shear with time. The effects of using LRB and including the infill panels on the storey drift are also presented. Maximum reduction in the story drift was obtained when infill panels are included in the analysis of the base isolated building. The inclusion of the infill panels has only marginal effects on the variation of roof displacement with time when the building is isolated by LRB. The main important improvements that emerged from using LRB as well as the infill panels in the analysis are the reduction of inelastic energy and upgrading the elastic one that is summed up along the period of the earthquake.