In order to study the impact resistance performance of reticulated shell under multi-point impact load, the multi-point elastic-plastic impact and destructive impact test of Kiewitt 6 (K6) single-layer spherical reticulated shell are carried out. The dynamic strain of key members, the dynamic displacement and the dynamic acceleration of key nodes are recorded during the multi-point impact process. The equivalent size numerical model of the test model is established by using the ANSYS/LS-DYNA simulation program, and the test conditions are simulated and analyzed. The peak strain and strain time history curves of the key members, the peak displacement and displacement time history curves of the key nodes, and the peak acceleration and acceleration time history curves of the key nodes in the test and simulation conditions are compared and analyzed. The energy transformation and energy transmission in the entire process of impact are studied at the same time. Results indicated a good agreement between the simulation results and the experimental results, and the dynamic response of the structure has the same trend. The number and position of impact points have a greater influence on the dynamic response of the impact area, while the influence on the non-impact area is smaller. With the increase of the number of impact points, the strain and displacement of the impact area of the reticulated shell gradually increase, but the acceleration change has no clear trend. At the same time, the experiment verified three deformation modes of the reticulated shell structure under the multi-point impact load.