Observation Time Research Articles

X-ray Observations of Two Type Ia Supernovae with an Hα Line in their Optical Spectrum

Abstract We report on Chandra X-ray observations of SN 2016jae and SN 2018cqj, both low luminosity Type Ia supernova that showed the presence of a H line in their early optical spectrum. No X-ray emission is detected at the location of either SN. Upper limits to the luminosity of up to 2 × 1040 erg s−1 are calculated for each SN, depending on the assumed spectral model, temperature and column density. This luminosity is comparable to that of another low-luminosity Type Ia SN, SN 2018fhw, that was observed with Chandra. It is generally lower than upper limits calculated for Type Ia-CSM SNe observed in X-rays, and also below that of SN 2012ca, the only Type Ia-CSM SN to have been detected in X-rays. Comparisons are made to other Type Ia SN with a H line observed in X-rays. The observations suggest that while the density into which the SN is expanding may have been high at the time the Hα line was detected, it had decreased considerably by the time of X-ray observations.

Assessing the impact of climate change on high return levels of peak flows in Bavaria applying the CRCM5 large ensemble

Abstract. ​​​​​​​Severe floods with extreme return periods of 100 years and beyond have been observed in several large rivers in Bavaria in the last 3 decades. Flood protection structures are typically designed based on a 100-year event, relying on statistical extrapolations of relatively short observation time series while ignoring potential temporal non-stationarity. However, future precipitation projections indicate an increase in the frequency and intensity of extreme rainfall events, as well as a shift in seasonality. This study aims to examine the impact of climate change on the 100-year flood (HF100) events of 98 hydrometric gauges within hydrological Bavaria. A hydrological climate change impact (CCI) modeling chain consisting of a regional Single Model Initial-condition Large Ensemble (SMILE) and a single hydrological model was created. The 50 equally probable members of the Canadian Regional Climate Model version 5 large ensemble (CRCM5-LE) were used to drive the hydrological model WaSiM (Water balance Simulation Model) to create a hydro-SMILE. As a result, a database of 1500 model years (50 members × 30 years) per investigated time period was established for extreme value analysis (EVA) to illustrate the benefit of the hydro-SMILE approach for a robust estimation of HF100 based on annual maxima (AM) and to examine the CCI on the frequency and magnitude of HF100 in different discharge regimes under a strong-emission scenario (RCP8.5). The results demonstrate that the hydro-SMILE approach provides a clear advantage for a robust estimation of HF100 using the empirical probability of 1500 AM compared to its estimation using the generalized extreme value (GEV) distribution of 1000 samples of typically available time series sizes of 30, 100, and 200 years. Thereby, by applying the hydro-SMILE framework, the uncertainty from statistical estimation can be reduced. The study highlights the added value of using hydrological SMILEs to project future flood return levels. The CCI of HF100 varies for different flow regimes, with snowmelt-driven catchments experiencing severe increases in frequency and magnitude, leading to unseen extremes that impact the distribution. Pluvial regimes show a lower intensification or even decline. The dynamics of HF100 driving mechanisms depict a decline in snowmelt-driven events in favor of rainfall-driven events, an increase in events driven by convective rainfall, and almost no change in the ratio between single-driver and compound events towards the end of the century.

Analysis of informativeness of features of classification of dangerous weather events based on radar observation results

One of the crucial factors affecting the safety and regularity of state and civil aviation flights is the meteorological situation. The European territory of Russia is most characterized by dangerous meteorological phenomena associated with cumulonimbus clouds: shower, thunderstorms, hail, accompanied by high atmospheric turbulence. Currently, meteorological radar stations are an indispensable source of information about the weather situation for air transport. The criteria for the classification of meteorological phenomena used in modern radar stations are formed for each event separately and are based on knowledge only about the altitude distribution of radar reflectivity and air temperature, despite the fact that radar data assess the wind characteristics of the atmosphere. It is shown that optimization of the classification criteria for the mentioned meteorological phenomena should be realized by generalization of the criteria and their construction in accordance with the theory of statistical hypothesis distinction, as well as by additional use of information on atmospheric turbulence. Based on the analysis of radar signals reflected from the meteorological events of shower, thunderstorm, and hail, probability distributions of reflectivity and specific dissipation rate of turbulent energy were obtained. Statistical analysis of probability distribution densities was carried out for: the maximum value of reflectivity Zmax, its dependence on height H(Zmax), as well as the maximum specific dissipation rate of turbulent energy EDRmax and the value H(EDRmax). The classification criterion based on the maximum probability functional was chosen to determine the structure of classification algorithms and decision rules. At the same time under the acceptable confidence is accepted the value of the probability of correct classification not lower than 0.8. For the accepted criterion the decision thresholds are constructed and the complete matrices of classification probabilities are calculated. The results of calculations showed that the worst informativeness in the classification of dangerous meteorological events of cumulonimbus cloudiness have parameters H(Zmax), H(EDRmax). Parameters Zmax, EDRmax have greater separating ability, but even for them the confidence of classification is unacceptable. In the article to increase the confidence of classification the joint use of features in the form of multivariate probability distribution densities of information parameters was applied. The best results are achieved when three p(Zmax,H(Zmax),EDRmax) and four p(Zmax,H(Zmax),EDRmax,H(EDRmax)) features are used. In the probability matrices for these cases, the maximum and acceptable at 0.8 level of probabilities of correct classification are achieved. Thus, the expansion of the feature space due to atmospheric turbulence is justified in the problem under consideration. These results will be refined with increasing observation time and will vary for different climatic zones. In general, the decision thresholds for classifying dangerous meteorological events of cumulonimbus cloudiness should be adaptive.

Natural History of Visual Acuity and Microperimetry-Based Functional Outcome Measures of the Macula in Patients with Geographic Atrophy: A Retrospective Chart Review Study in Germany

Background/Objectives: Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) leading to the progressive and irreversible loss of visual function. Characteristics of GA include atrophic lesions resulting from the loss of photoreceptors, retinal pigment epithelium, and choriocapillaris. During GA progression, atrophic lesions typically advance from the macular periphery to the center, affecting foveal light sensitivity and visual acuity. This study analyzed changes in light sensitivity and visual acuity during the natural course of GA progression using the topographic analysis of structural and functional changes based on Early Treatment Diabetic Retinopathy Study (ETDRS) charts, multimodal imaging, and microperimetry assessment. Methods: Medical chart data of GA patients between 2014 and 2022 from the Internationale Innovative Ophthalmochirurgie GbR (I.I.O.) research center (Düsseldorf, Germany) were retrospectively analyzed. All patient eyes fulfilling the phase 3 OAKS study inclusion criteria were included and followed up for 60 months. The imputation of missing measurements and dropouts was performed by linear mixed models. Results: A total of 20 GA eyes from 13 GA patients were included in the study. At the index, 53.8% of patients had bilateral GA, with 70.0% of the eyes showing multifocal GA and 30.0% subfoveal encroachment (SFE). A total of 35.0% of the eyes had 2–5, and 15.0% over 20, areas of atrophy. Over time, the GA lesion size increased from 6.4 mm2 to 11.8 mm2 (1.08 mm2/year). After an average observation time of 2.9 years, 78.6% of the initially unaffected study eyes developed SFE. The percentage of study eyes without visual impairment decreased from 55.0% to 30.0%, with mean normal-luminance best-corrected visual acuity (NL-BCVA) reducing from 63.7 to 55.7 ETDRS letters. The share of absolute scotoma points in microperimetry assessment increased from 15.7% to 43.5% while overall average macular sensitivity declined from 15.7 dB to 7.4 dB. Conclusions: The substantial deterioration of macular outcomes and visual function was comprehensively detected. The results were a documentation of structural and functional aspects of the natural progression of GA for a 60-month follow-up, providing a typical outline for AMD patients with GA.

Determinants of mortality status and population attributable risk fractions of the North West Province, South African site of the international PURE study

BackgroundMortality data and comparative risk assessments from sub-Saharan Africa are limited. There is an urgent need for high quality population health surveys to be conducted, to improve the national health surveillance system. Our aim was to perform a comparative risk assesment and report on the mortality status and cause of death data of participants from a South African site of the international Prospective Urban Rural Epidemiology study.Methods1 921 Black participants were included, with a median observational time of 13 years resulting in 21 525 person-years. We performed a comparative risk assessment considering four health status domains: locality (rural vs. urban), socio-economic status (SES) (education and employment), lifestyle factors (physical activity, smoking and alcohol consumption) and prevalent diseases (human immunodeficiency virus (HIV), type 2 diabetes mellitus and hypertension). Next, population-attributable fractions (PAFs) were calculated to determine the mortality risk attributable to modifiable determinants.Results577 all-cause deaths occurred. Infectious diseases (28.1% of all deaths) were the most frequent cause of death, followed by cardiovascular disease (CVD) (22.4%), respiratory diseases (11.6%) and cancer (11.1%). The three main contributors to all-cause mortality were HIV infection, high SES and being underweight. HIV infection and underweight were the main contributors to infectious disease mortality and hypertension, the urban environment, and physical inactivity to CVD mortality. HIV had the highest PAF, followed by physical inactivity, alcohol and tobacco use and hypertension (for CVD mortality).ConclusionThis African population suffers from a quadruple burden of disease. Urban locality, high SES, prevalent disease (HIV and hypertension) and lifestyle factors (physical inactivity, tobacco and alcohol use) all contributed in varying degrees to all-cause and cause-specific mortalities. Our data confirm the public health importance of addressing HIV and hypertension, but also highlights the importance of physical inactivity, tobacco use and alcohol consumption as focal points for public health strategies to produce the most efficient mortality reduction outcomes.

ML-Based Edge Node for Monitoring Peoples’ Frailty Status

The development of contactless methods to assess the degree of personal hygiene in elderly people is crucial for detecting frailty and providing early intervention to prevent complete loss of autonomy, cognitive impairment, and hospitalisation. The unobtrusive nature of the technology is essential in the context of maintaining good quality of life. The use of cameras and edge computing with sensors provides a way of monitoring subjects without interrupting their normal routines, and has the advantages of local data processing and improved privacy. This work describes the development an intelligent system that takes the RGB frames of a video as input to classify the occurrence of brushing teeth, washing hands, and fixing hair. No action activity is considered. The RGB frames are first processed by two Mediapipe algorithms to extract body keypoints related to the pose and hands, which represent the features to be classified. The optimal feature extractor results from the most complex Mediapipe pose estimator combined with the most complex hand keypoint regressor, which achieves the best performance even when operating at one frame per second. The final classifier is a Light Gradient Boosting Machine classifier that achieves more than 94% weighted F1-score under conditions of one frame per second and observation times of seven seconds or more. When the observation window is enlarged to ten seconds, the F1-scores for each class oscillate between 94.66% and 96.35%.

Comparisons of different general anesthetic techniques on immune function in patients undergoing flap reconstruction for oral cancer.

Anesthetic-induced immunosuppression is of particular interest in tumor surgery. This study aimed to investigate the influence of the 4 most common general anesthetic techniques on immune function in patients undergoing flap reconstruction for oral cancer. 116 patients were randomly divided into 4 groups. Patients in group S were given sevoflurane-based anesthesia. Group P was administered propofol-based anesthesia. The SD group received sevoflurane combined with dexmedetomidine anesthesia. The propofol combined with dexmedetomidine anesthesia (PD) group received PD. Blood samples were obtained at 5 time points: baseline (T0), 1 hour after the start of the operation (T1), end of the operation (T2), 24 hours (T3), and 48 hours (T4) after the operation. Lymphocyte subsets (including CD3+, CD4+, CD8+, and B lymphocytes) and dendritic cells were analyzed by flow cytometry. Blood glucose, norepinephrine, and cortisol levels were measured using ELISA and a blood gas analyzer respectively. In total, 107 patients were included in the final analysis. Immunological indicators, except CD8+ counts, were all decreased in groups S, P, and SD at T1-4 compared with the baseline value, and the counts of CD3+, CD4+, and dendritic cells, as well as CD4+/CD8+ ratios, were significantly higher in the PD group than in the S, P, and SD at T1-3 (P < .05). There were no significant differences between groups P and SD at any observation time point. Intraoperative stress indices, including norepinephrine and cortisol levels, were significantly lower in the PD group than in the other 3 groups at T1-2 (P < .05). These findings suggest that PD as a probably optimal choice can alleviate immunosuppression in patients undergoing flap reconstruction for oral cancer.

Analysis and comparison of the orbit determination accuracy of TianQin based on multiple ground-based measurements

TianQin project, a Chinese initiative in space gravitational wave detection, demands high precision in satellite orbit during both entry and scientific operations. As means of developmental maturation, ground-based measurements play a vital role in ensuring the smooth execution of TianQin satellite’s detection mission. This paper conducts a simulation analysis by utilizing various ground-based measurement data, including the China Deep Space Network (CDSN), S/Ka-band ranging system, and Satellite Laser Ranging (SLR). The main focus is to explore the distinctions in Precise Orbit Determination (POD) capabilities among different methods and to enhance POD accuracy through the integration of multiple techniques for TianQin satellites. The results indicate: (1) Leveraging a strategically positioned station distribution, CDSN stations offer extended observation time, averaging 17.3 h per satellite daily, compared to S/Ka’s 10.5 h. (2) In single-measurement POD scenarios, S/Ka proves superior, achieving accuracy better than 10 m and 0.4 mm s−1 for TianQin satellites with a 7-day orbit arc length. This superiority is attributed to its exceptional observational accuracy, outperforming CDSN’s 40 m and 2.2 mm s−1 for POD accuracy. (3) By integrating high-precision SLR data on the foundation of CDSN or S/Ka observations, the POD accuracy of TianQin satellites is further enhanced, despite the limited SLR data quantity.

P-208 To assess or not to assess: reconsidering day 3 embryo quality in planned freeze-all blastocyst cycles

Abstract Study question Should day 3 embryo quality assessment be consider in planned freeze-all blastocyst cycles? Summary answer Day 3 embryo assessment may be unnecessary in planned freeze-all blastocyst cycles. What is known already Day 3 embryo quality is a predictor of in vitro fertilizastion (IVF) success rates in cleavage stage embryo transfer. However, the association between day 3 embryo quality and live birth in blastocyst transfer policy is largely unknown. Study design, size, duration This retrospective study included 1074 frozen-thawed single day 5/6 blastocyst transfer between January 2019 to December 2022. Three groups were assessed depending on whether the transferred blastocyst derived from a top-quality, good-quality or poor-quality embryo at day 3. The analysis was conducted independently for each blastocyst quality group (top, good, and poor) using multivariate logistic regression. We applied factor analysis of mixed data to reduce potential collinearity between covariates used in the model. Participants/materials, setting, methods All blastocysts included in this study were obtained from first ICSI freeze-all cycles. Cleavage stage and blastocyst evaluation were performed according to the Istanbul consensus. Cleavage and blastocysts stage were assessed between 67±0.5 (day-3), 115±0.5 (day-5) and 139±0.5 (day-6) hours post-insemination (hpi), respectively. Exclusion criteria were: i) ICSI-cycles performed with surgically retrieved or frozen sperm, (ii) gamete donation cycles, (iii) cryopreserved-thawed oocyte cycles, (iv) preimplantation genetic testing. The primary outcome was live birth rate. Main results and the role of chance After adjusting for the day of transfer (day 5 or day 6) and several confounding variables, no statistical differences in live birth were observed among same quality blastocysts derived from different day 3 embryo quality groups (top=A, good=B and poor=C). The analysis was stratified for different blastocyst quality groups: 1) top quality blastocyst [day 3 quality A =reference group; day 3 quality B= OR 1.04 95% CI (0.62 – 1.74), p value=0.871; day 3 quality C= OR 0.67 95% CI (0.34 – 1.33), p value= 0.254] 2) good quality blastocyst [A =reference group; B= OR 0.80 95% CI (0.49 – 1.30), p value=0.361; C= OR 0.74 95% CI (0.44 – 1.27), p value= 0.276] 3) poor quality blastocyst [A =reference group; B= OR 0.78 95% CI (0.29 – 2.10), p value=0.622; C= OR 0.80 95% CI (0.31 – 2.07), p value= 0.650]. Limitations, reasons for caution The study is limited by its retrospective design. Embryo assessment without time-lapse technology, to assess the blastocysts at the same developmental time-frame, is another limitation; although the static observation time very close and restricted to the Istanbul consensus guidelines may mitigate such a weakness. Wider implications of the findings Our findings showed that day 3 embryo quality assessment may be unnecessary in planned freeze-all blastocyst cycles. In the context of static embryo assessment, this can reduce the stress on embryos by avoiding unnecessary retrievals from incubators. Trial registration number not applicable

1231 Using Novel Technologies and Innovative Theatre Utilisation Procedures to More Than Triple Operating Theatre Output

Abstract Aim In the current climate of extended waiting lists and increasing demands on theatre time and personnel, efficiency gains are vital in shaping the future of surgical practice. We have utilised novel surgical technology to drive massive increases in throughput for one of the most commonly performed procedures worldwide (tonsillectomies). Method Use of the BiZactTM device, a vessel sealing bipolar instrument, has been shown in our trust and worldwide to be safe and offer greater efficiency. We combined this with a conveyor-belt style theatre arrangement - with a second team preparing and anaesthetising the following patient simultaneously, and changes to anaesthetic and post-op procedures to maximise productivity. Results Contrasting the GIRFT recommended 3 adult half day tonsillectomy list, we were able to safely perform 10 adult tonsillectomies in one session, with no change in expected post-operative complication rates. Average time recorded on the theatre system was 10m:00s per patient, with the average time-on-tonsil just 2m:59s. There was 1 patient who presented post-operatively with secondary haemorrhage that was managed conservatively. Conclusions The implementation of efficient technology, combined with innovative theatre procedural technique, short lasting anaesthetics and reduced post operative observation time allowed the half day list capacity to be increased by 333%. Complication rates in this case, and in our wider use of this technique (n=103), have been within normal range, whilst allowing greatly increased efficiency and rapid reduction of local waiting lists. Lessons learned from this conveyor-belt style practice have wide ranging potential applications across specialties that will drive efficient future practice.

The effect of care interruptions on mortality in adults resuming antiretroviral therapy.

To estimate the relative rate of all-cause mortality amongst those on antiretroviral treatment (ART) with a history of interruptions compared with those with no previous interruptions in care. Retrospective cohort study. We used data from four South African cohorts participating in the International epidemiology Databases to Evaluate AIDS Southern Africa collaboration. We included adults who started ART between 2004 and 2019. We defined a care interruption as a gap in contact longer than 180 days. Observation time prior to interruption was allocated to a 'no interruption' group. Observation time after interruption was allocated to one of two groups based on whether the first interruption started before 6 months of ART ('early interruption') or later ('late interruption'). We used Cox regression to estimate hazard ratios. Sixty-three thousand six hundred and ninety-two participants contributed 162 916 person-years of observation. There were 3469 deaths. Most participants were female individuals (67.4%) and the median age at ART initiation was 33.3 years (interquartile range: 27.5-40.7). Seventeen thousand and eleven (26.7%) participants experienced care interruptions. Those resuming ART experienced increased mortality compared with those with no interruptions: early interrupters had a hazard ratio of 4.37 (95% confidence interval (CI) 3.87-4.95) and late interrupters had a hazard ratio of 2.74 (95% CI 2.39-3.15). In sensitivity analyses, effect sizes were found to be proportional to the length of time used to define interruptions. Our findings highlight the need to improve retention in care, regardless of treatment duration. Programmes to encourage return to care also need to be strengthened.

Maintenance proton pump inhibitor use and risk of colorectal cancer: a Swedish retrospective cohort study

ObjectivesWe aimed to evaluate the risk of colorectal adenocarcinoma (CRA) associated with long-term use of proton pump inhibitors (PPIs) in a large nationwide cohort.DesignRetrospective cohort study.SettingThis research was conducted at...

Single-Frequency Lasers’ Linewidths Elegantly Characterized with Sigmoid Functions of Observation Time

Single-Frequency Lasers’ Linewidths Elegantly Characterized with Sigmoid Functions of Observation Time

STUDI KOMPARASI UNTUK AS-BUILT SURVEY DAN PENGAWASAN DEFORMASI DARI GEDUNG: METODE TERESTRIS VS METODE SATELIT DI GEDUNG KULIAH UMUM (GKU) INSTITUT TEKNOLOGI SUMATERA

Infrastructure development is one of the main points of the program by the Indonesian government, outlined in Nawacita. One of the manifestations of this program in 2019 was the construction of the Gedung Kuliah Umum (GKU) at the Institut Teknologi Sumatera (Itera). As an effort to realize sustainable development, Geodetic surveys named 'as-built surveys' and periodic deformation observations need to be conducted. Both surveys can be done by terrestrial method using total station and satellite method using GPS-RTK. In this article, an analysis of the accuracy, precision and efficiency of the terrestrial method and satellite method for as-built survey and deformation observation at GKU Itera is reported along with a comparison between deformation calculation and direct observation. It was found that the terrestrial method produced better accuracy and precision level (19,5 cm compared to 43,3 cm) than the satellite method with 95% confidence level. In addition, the terrestrial method produces 3 times more data than the satellite method, although on the other hand, the total observation time of the terrestrial method is 100% longer than the satellite method. These results show that periodic monitoring is important for detecting the degree of deformation and realizing sustainable development. In addition, the terrestrial method is more suitable for accurate and precise periodic surveillance of a building than the satellite method. These findings could act as a contribution towards better sustainable deformation monitiring of a building and to underline the importance of having such periodic observations.

A multimodal aftercare intervention improves the outcome after kidney transplantation – results of the KTx360° aftercare program using claims data

The after-care treatment project KTx360° aimed to reduce graft failure and mortality after kidney transplantation (KTx). The study was conducted in the study centers Hannover, Erlangen and Hannoversch Muenden from May 2017 to October 2020 under the trial registration ISRCTN29416382. The program provided a multimodal aftercare program including specialized case management, telemedicine support, psychological and exercise assessments, and interventions. For the analysis of graft failure, which was defined as death, re-transplantation or start of long-term dialysis, we used longitudinal claims data from participating statutory health insurances (SHI) which enabled us to compare participants with controls. To balance covariate distributions between these nonrandomized groups we used propensity score methodology, in particular the inverse probability of treatment weighting (IPTW) approach. In total, 930 adult participants were recruited at three different transplant centres in Germany, of whom 320 were incident (enrolled within the first year after KTx) and 610 prevalent (enrolled >1 year after KTx) patients. Due to differences in the availability of the claims data, the claims data of 411 participants and 418 controls could be used for the analyses. In the prevalent group we detected a significantly lower risk for graft failure in the study participants compared to the matched controls (HR=0.13, 95% CI=0.04-0.39, p=0.005, n=389 observations), whereas this difference could not be detected in the incident group (HR=0.92, 95% CI=0.54-1.56, p=0.837, n=440 observations). Our findings suggest that a multimodal and multidisciplinary aftercare intervention can significantly improve outcome after KTx, specifically in patients later after KTx. For evaluation of effects on these outcome parameters in patients enrolled within the first year after transplantation longer observation times are necessary. The study was funded by the Global Innovation fund of the Joint Federal Committee of the Federal Republic of Germany, grant number 01NVF16009.

Hot rings on Io observed by Juno/JIRAM

It has been thought that Io’s many paterae may contain lava lakes, but observations by NASA’s Galileo spacecraft at sufficiently high resolution were limited to a few locations, such as Loki Patera. Data acquired by NASA’s Juno mission in May 2023 reveal a common set of thermal characteristics for at least ten paterae on Io, with bright (hot) “thermal rings” around the perimeter of their floors. Loki, Surt, Fuchi, Amaterasu, Mulungu, Chors, and Dazhbog Patera, and four unnamed paterae, all show the same pattern of surface temperature. This new Juno/JIRAM data suggests that hot rings around paterae are a common phenomenon, and that they are indicative of active lava lakes. All the investigated paterae lack recent lava flows on their flanks, suggesting that at the time of observations, the level of the lake was not high enough to overflow the rim. These observations provide insight about the characteristics of paterae’s activity, which may involve either central upwelling of magma, or up-and-down “piston-like” vertical motion of the lake surface. Tidal forces, which are extreme at Io, could play a role as well. Future observations from Juno, particularly during the closest flybys, may indicate which mechanism is more plausible.

Short Communication: A rapid survey of herpetofauna diversity in Bama coastal forest at Baluran National Park, Indonesia

Abstract. Siddiq AM, Wimbaningrum R, Sulistiyowati H, Setiawan R, Setiawan A, Wahono ND. 2024. Short Communication: A rapid survey of herpetofauna diversity in Bama coastal forest at Baluran National Park, Indonesia. Biodiversitas 25: 2323-2329. Scientific reports on herpetofauna in Baluran National Park (BNP) are still limited. Meanwhile, several geographical areas, such as the Bama Baluran National Park coastal forest, have potential herpetofauna diversity within this conservation area yet to be reported. Therefore, this study aimed to determine the diversity of herpetofauna species in BNP's Bama coastal forest (BCF). The method was conducted using the Visual Encounter Survey (VES) in three tracks, conducted by combining Time Restricted Search (TRS) or using observation time for five hours during the mid-afternoon (06.00 AM-11.00 AM) and four hours at night (07.00 PM-11.00 PM) on each track. This study recorded 17 herpetofauna species, comprising 6 amphibian and 11 reptile species, in the BCF of Baluran National Park. The diversity index of herpetofauna species in this area was moderate category (H’=2.25). Species Fejervarya limnocharis Gravenhorst 1829 (38 individuals) has the highest abundance in the BCF and was found in track 1 (swamp area). Meanwhile, three species have the lowest abundance, such as Kaloula baleata Müller 1836, Microhyla palmipes Boulenger 1897, and Cryptoblepharus balinensis Barbour 1911, with 1 individual in each species.

Endodontic Surgery and Post-Treatment Apical Periodontitis: A Systematic Review

Background It has been demonstrated that using innovative root-end filling materials speeds up the success of Endodontic Microsurgery (EMS) on teeth having root filling but still suffering from posttreatment Apical Periodontitis (AP). However, this has reopened the discussion about the long-term effectiveness of EMS conducted on such teeth. Objectives This study aimsto assess the long-term clinical and radiographic outcomes of endodontic surgical procedures in molars with radiographic evidence of secondary AP. Methodology A literature review was undertaken utilizing different databases, including MEDLINE (through PubMed), EMBASE, and Web of Science. The terms used for the search were ‘endodontic microsurgery,’ ‘apical microsurgery,’ ‘periapical disorders,’ ‘root canal therapy,’ ‘apicoectomy,’ ‘retreatment,’ ‘treatment result,’ “retrograde obturation,” and ‘success rate.’ In order to choose the most reliable longitudinal data, specific inclusion and exclusion criteria were established in advance. Only studies that met inclusion criteria for clinical and radiographic outcomes were considered, including prospective clinical studies and randomized clinical trials with at least two-year follow-ups. Results The study of the databases yielded 561 articles in total. From the 115 articles with full texts available, unrelated articles (105) were removed. Our inclusion criteria were met by an overall of ten studies (six prospective clinical studies and four randomized clinical trials). With intervals for follow-up ranging from two to thirteen years, a pooled success rate of 91% from all 451 treated teeth included in the randomized clinical trials and a pooled success rate of 79% from a total of 839 encompassed teeth in the prospective clinical studies were observed. During the same length of time of observation, survival rates ranged from 78% to 100%. Smoking status, tooth position and type, the presence or absence of dentinal abnormalities, the thickness of the bone between the teeth (interproximal bone), and the substance used to fill the space at the end of the roots are the five predictive variables revealed. Conclusion When EMS is performed by skilled endodontists who can deliver high success rates and reliable results, teeth afflicted by secondary AP have a good prognosis and can be preserved.

Microlensing signatures of extended dark objects using machine learning

This paper presents a machine learning-based method for the detection of the unique gravitational microlensing signatures of extended dark objects, such as boson stars, axion miniclusters and subhalos. We adapt MicroLIA, a machine learning-based package tailored to handle the challenges posed by low-cadence data in microlensing surveys. Using realistic observational time stamps, our models are trained on simulated light curves to distinguish between microlensing by pointlike and extended lenses, as well as from other object classes which give a variable magnitude. We focus on boson stars and Navarro-Frenk-White (NFW) subhalos and show that the former, which are examples of objects with a relatively flat mass distribution, can be confidently identified for 0.8≲r/rE≲3. Intriguingly, we also find that more sharply peaked structures, such as NFW subhalos, can be distinctly recognized from point lenses under regular observation cadence. Our findings significantly advance the potential of microlensing data in uncovering the elusive nature of extended dark objects. The code and dataset used are also provided. Published by the American Physical Society 2024

Healing of diabetic ulcers using jamaican cherry leaf extract cream (Muntingia calabura l.) based on collagen density in white rats (Rattus norvegicus)

Abstract This research aims to determine the potential of jamaican cherry leaf extract cream (JCLEC) to accelerate the healing process of diabetic ulcers in white rat based on collagen density. The research used 4 month old male white rats (Rattus norvegicus) which were divided into K0 (negative control), KP (silver sulfadiazine), K1 (5% JCLEC), K2 (10% JCLEC), and K3 (15% JCLEC). An incision was made on the back of the rat then given JCLEC. Days 3, 7, and 14 after treatment, the wound tissue was collected after the rat were euthanized. Skin tissue was processed and stained with picrosirious red. The rate of wound healing was observed. Collagen density was presented in scoring. Based on the treatment group and observation time, there was a significant difference in collagen density between the treatment groups compared to the control (P&lt;0.05). Based on the treatment group, the scoring of the collagen density was 1.78±0.6 (K0); 2.56±0.88 (KP); 1.78±0.4 (K1); 2.56±0.88 (K2); and 3.1±0.78 (K3). Based on observation time, the average collagen density scoring was 1.8±0.3 (D-3); 2.6±0.4 (D-7); and 2.8±0.6 (D-14). The conclusion is the 15% JCLEC has the potential to accelerate the healing of diabetic ulcers in white rats by stimulate collagen density.