Remotely piloted unmanned combat aerial vehicle (UCAV) will be a prospective mode of air fight in the future, which can remove the physical restraint of the pilot, maximize the performance of the fighter and effectively reduce casualties. However, it has two difficulties in this mode: (1) There is greater time delay in the network of pilot-wireless sensor-UCAV, which can degrade the piloting performance. (2) Designing of a universal predictive method is very important to pilot different UCAVs remotely, even if the model of the control augmentation system of the UCAV is totally unknown. Considering these two issues, this paper proposes a novel universal modeling method, and establishes a universal nonlinear uncertain model which uses the pilot’s remotely piloted command as input and the states of the UCAV with a control augmentation system as output. To deal with the nonlinear uncertainty of the model, a neural network observer is proposed to identify the nonlinear dynamics model online. Meanwhile, to guarantee the stability of the overall observer system, an adaptive law is designed to adjust the neural network weights. To solve the greater transmission time delay existing in the pilot-wireless sensor-UCAV closed-loop system, a time-varying delay state predictor is designed based on the identified nonlinear dynamics model to predict the time delay states. Moreover, the overall observer-predictor system is proved to be uniformly ultimately bounded (UUB). Finally, two simulations verify the effectiveness and universality of the proposed method. The results indicate that the proposed method has desirable performance of accurately compensating the time delay and has universality of remotely piloting two different UCAVs.