Tiling Method Research Articles

Automatic tiling method for mosaic ceramic art images based on subpixel edge fitting localization and collaborative operation of multiple manipulators

Mosaic ceramics are not limited to use solely as building materials, they also possess artistic value. Artists can create images by arranging and combining mosaic ceramics, resulting in a perfect fusion of large-scale public art for external walls and ceramic materials. However, the current approach for artists to create mosaic ceramic exterior wall art images involves manual laying and assembling of individual mosaic ceramics. This manual process suffers from issues such as low efficiency, eye fatigue, selection errors, and the risk of high-altitude operations. These challenges significantly impact the quality and efficiency of creating mosaic ceramic exterior wall art image images. To address these problems, this paper proposes an automatic mosaic ceramic art image stitching method based on subpixel edge fitting positioning and collaborative operation of multiple robotic arms. Additionally, a new U + I type conveying method is designed for efficient and space-saving transportation of mosaic ceramics. Experimental results demonstrate a high success rate of recognition, absorption, and placement of multi-color mosaic ceramics using this method reaching 95.45%, with a positioning error within 0.5 mm. The method can also adapt to varying levels of light intensity or noise interference. This approach effectively enhances the quality and efficiency of creating mosaic ceramic exterior wall art images and promotes the development of mosaic ceramic exterior wall public art creation.

Coverage Path Planning with Adaptive Hyperbolic Grid for Step-Stare Imaging System

Step-stare imaging systems are widely used in aerospace optical remote sensing. In order to achieve fast scanning of the target region, efficient coverage path planning (CPP) is a key challenge. However, traditional CPP methods are mostly designed for fixed cameras and disregard the irregular shape of the sensor’s projection caused by the step-stare rotational motion. To address this problem, this paper proposes an efficient, seamless CPP method with an adaptive hyperbolic grid. First, we convert the coverage problem in Euclidean space to a tiling problem in spherical space. A spherical approximate tiling method based on a zonal isosceles trapezoid is developed to construct a seamless hyperbolic grid. Then, we present a dual-caliper optimization algorithm to further compress the grid and improve the coverage efficiency. Finally, both boustrophedon and branch-and-bound approaches are utilized to generate rotation paths for different scanning scenarios. Experiments were conducted on a custom dataset consisting of 800 diverse geometric regions (including 2 geometry types and 40 samples for 10 groups). The proposed method demonstrates comparable performance of closed-form path length relative to that of a heuristic optimization method while significantly improving real-time capabilities by a minimum factor of 2464. Furthermore, in comparison to traditional rule-based methods, our approach has been shown to reduce the rotational path length by at least 27.29% and 16.71% in circle and convex polygon groups, respectively, indicating a significant improvement in planning efficiency.

Cascadable-Controllable Self-Assembly DNA Tiles for Large-Scale DNA Logic Circuits.

In the last few decades, DNA-based self-assembly tiles has become a hot field in research due to its special applications and advantages. The regularity and strong design methods comprise other DNA-based digital circuit design methods. In addition to the obvious advantages of this method, there are challenges in performing computations based on self-assembly tiles, which have hindered the development and construction of large computing circuits with this method. The first challenge is the creation of crystals from DNA molecules in the output, which has led to the impossibility of cascading. The second challenge of this method is the uncontrollability of the reactions of the tiles, which increases the percentage of computing errors. In this article, these two challenges have been solved by changing the structure of leading tiles so that without the activator strand, tiles remain inactive and cannot be connected to other tiles. Also, when the tiles are activated, single-strand DNA will be released after connecting to other tiles, which will be used as the output of the circuit. This output gives the possibility of cascading to self-assembly designed circuits. The method introduced in this article can be a beginning for the re-development of DNA-based circuit design with the self-assembly tile method.

Sero-prevalence of Human Immunodeficiency Virus among Students Undergoing Medical Examination in a Tertiary Institution

Aims: To assess the prevalence of human immunodeficiency virus among students undergoing medical checkup in a tertiary institution. Study Design: The investigation utilised a cross-sectional study design technique. Methodology: In this present study, 2114 participants were included in the age range 15-49 years. Serological method was used to detect the presence of HIV using a rapid diagnostic technique using determine. Tile method was used to determine the ABO and Rhesus D antigens in the individuals. Results: Out of the 2114 participants sampled, the population studied according to various departments within the university were ME 95 (5%), EM 181 (9%), LIB 101 (5%), SPE 63 (3%), ENG 296 (14%), BIO 423 (20%), CHE 150 (7%), COM 305 (14%), MGT 236 (11%) and ACC 236 (12%). The prevalence of HIV among tertiary institution students is 1%. Conclusion: This research gives an insight into the prevalence of HIV among students in tertiary institution for strategic intervention.

A Domino Tiling Method for Circularly Polarized Subarrayed Phased Array Antenna Based on Modified Maximum-Entropy Model

A Domino Tiling Method for Circularly Polarized Subarrayed Phased Array Antenna Based on Modified Maximum-Entropy Model

Abstract 377: Saturation mutagenesis of KEAP1 to identify pathogenic mutations in lung cancer patients and gain insight into KEAP1 molecular function

Abstract Introduction: KEAP1 and NFE2L2 (NFR2) mutations occur in roughly 20% of non-small cell lung cancer (NSCLC) patients and are associated with resistance to a broad range of therapies including radiotherapy, chemotherapy, targeted therapies, and immunotherapy. In prior work, we demonstrated that not all KEAP1 mutations observed in NSCLC patients are pathogenic. These benign mutations have a wild-type phenotype that does not impart therapy resistance. However, only roughly 100 of ~13,000 (<1%) possible KEAP1 single amino acid substitution mutations have been characterized. Here, we performed saturation mutagenesis of KEAP1 to comprehensively evaluate all possible point mutation phenotypes in vitro. Methods: Saturation mutagenesis was accomplished using the High-throughput Mutagenesis by Integrated TilEs (MITE) method. In brief, the KEAP1 sequence was divided into 21 tiles each containing a 90 bp variable region flanked by a 30 bp constant region. At each codon position, mutations representing the 20 possible natural amino acids and a stop codon were included for a total of 13,076 KEAP1 variants. The tiles were assembled such that each full length KEAP1 construct contained a single desired mutation. The KEAP1 MITE lentivirus library was transduced into H1299-KEAP1NULL cells that were then treated with vehicle or H2O2 for 24 days. The KEAP1 ORF was amplified from gDNA and mutations were quantified by next generation sequencing. Mutation enrichment analysis was used to derive functional annotations. Results: Oxidative stress resulted in a bimodal distribution of KEAP1 mutations. Cells with KEAP1 nonsense mutations were enriched while cells with silent mutations were depleted. Using a threshold of 95% specificity for silent mutations to distinguish benign from pathogenic mutations, 94% of nonsense mutations and 88% of previously characterized pathogenic mutations were identified as pathogenic. While the majority of KEAP1 mutations were benign (64%), analysis of mutations found in TCGA NSCLC patients showed an enrichment of pathogenic mutations (72%). Overlaying mutation calls onto the KEAP1 structure showed enrichment of pathogenic mutations in the BTB homodimerization interface, hydrophobic core of the oxidative stress sensing IVR domain, and NRF2 binding pocket of the Kelch domain. Conclusions: Saturation mutagenesis of KEAP1 generated a comprehensive list of pathogenic KEAP1 single amino acid substitutions. Assignments strongly agreed with biologic function and prior literature. The assessment of KEAP1 mutation phenotypes is important as benign mutations occur in a significant subset of NSCLC patients and are not expected to impart therapy resistance. Our results will allow identification of benign and pathogenic KEAP1 mutations in clinical studies, which will enable testing of personalized therapeutic strategies for patients with KEAP1 mutations. Citation Format: Noah Kastelowitz, Shashank Shrishrimal, Soyeong Jun, Anni M. Zhang, Rui Wang, Ilayda Ilerten, Maximilian Diehn. Saturation mutagenesis of KEAP1 to identify pathogenic mutations in lung cancer patients and gain insight into KEAP1 molecular function [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 377.

Multiplex PCR method for MinION sequencing of Bagaza virus isolated from wild caught mosquitoes in South Africa

Bagaza virus (BAGV) is a mosquito-borne orthoflavivirus known to occur in regions of southern Europe, Africa, India and the Middle East. The virus has been associated with neurological disease and fatalities in various wild bird species. Association with human disease is not confirmed although limited serological evidence has suggested human infection. Surveillance programs for screening mosquitoes for evidence of arbovirus infection play an important role in providing information regarding the circulation and spread of viruses in specific regions. BAGV was detected in a mosquito pool during surveillance of mosquitoes collected in central South Africa between November 2019 and March 2023. Homogenized mosquito pools were screened for flaviviral RNA using conventional RT-PCR and virus isolation was attempted on positive samples. BAGV was detected and subsequently isolated using cell culture. A multiplex tiling PCR method for targeted enrichment using a PCR based or amplicon sequencing approach of the complete genome of BAGV was developed and optimized. Primers were designed using alignment of complete genome sequence data retrieved from GenBank to identify suitable primer sites that would generate overlapping fragments spanning the complete genome. Six forward primers and eight reverse primers were identified that target the complete genome and amplified nine overlapping fragments, that ranged in length from 1954 to 2039 with an overlap ranging from 71 to 711 base pairs. The design strategy included multiple forward and reverse primer pairs for the 5’ and 3’ ends. Phylogenetic analysis with other isolates was performed and BAGV isolate VBD 74/23/3 was shown to share high similarity with previous BAGV isolates from all regions, with genetic distance ranging from 0.026 to 0.083. VBD 74/23/3 was most closely related to previous isolates from southern Africa, ZRU96/16/2 isolated from a post-mortem sample from a pheasant in 2016 and MP-314-NA-2018 isolated from mosquitoes in northwestern Namibia with genetic distance 0.0085 and 0.016 respectively. Currently there is limited complete genome sequence data available for many of the arboviruses circulating in Africa. The multiplex tiling method provided a simple and cost-effective method for obtaining complete genome sequence. This method can be readily applied to other viruses using sequence data from publicly available databases and would have important application facilitating genomic surveillance of arboviruses in low resource countries.

A Tiling Method for Sub-Arrayed Spherical Conformal Phased Array Antennas Based on Maximum 3-D Space Entropy Model

A Tiling Method for Sub-Arrayed Spherical Conformal Phased Array Antennas Based on Maximum 3-D Space Entropy Model

Scaling adaptive quantum simulation algorithms via operator pool tiling

Adaptive variational quantum simulation algorithms use information from a quantum computer to dynamically create optimal trial wave functions for a given problem Hamiltonian. A key ingredient in these algorithms is a predefined operator pool from which trial wave functions are constructed. Finding suitable pools is critical for the efficiency of the algorithm as the problem size increases. Here, we present a technique called operator pool tiling that facilitates the construction of problem-tailored pools for arbitrarily large problem instances. By first performing an Adaptive Derivative-Assembled Problem-Tailored Ansatz Variational Quantum Eigensolver (ADAPT-VQE) calculation on a smaller instance of the problem using a large, but computationally inefficient, operator pool, we extract the most relevant operators and use them to design more efficient pools for larger instances. We demonstrate the method here on strongly correlated quantum spin models in one and two dimensions, finding that ADAPT automatically finds a highly effective ansatz for these systems. Given that many problems, such as those arising in condensed matter physics, have a naturally repeating lattice structure, we expect the pool tiling method to be a widely applicable technique apt for such systems. Published by the American Physical Society 2024

Distribution of ABO and Rhesus ‘D’ Blood Groups among Pregnant Women in a Tertiary Hospital in Rivers State, Southern Nigeria

Background: In recent times, the role of ABO and Rhesus grouping in clinical practice has increased widely. There is a paucity of literature on blood group distribution, and its distribution has not been studied in our centre. This study aimed to determine the distribution of ABO, Rh D blood groups and haemoglobin genotype among pregnant women initiating antenatal care in Rivers State University Teaching Hospital (RSUTH). Methods: This was a cross-sectional study among antenatal clinic attendees in RSUTH, over 6 months. At booking 3ml of venous blood was collected in Ethylenediaminetetraacetic acid (EDTA) vacutainer from the pregnant women, and ABO and Rh D typing was done by tile methods forward and reverse grouping methods and confirmed by microscopy. Haemoglobin genotype was done by electrophoresis. Data collected were analyzed using IBM Statistical Product and Service Solution (SPSS), version 25.0 (Armonk, New York). Results: One thousand one hundred and forty -seven patients were recruited for the study. Their mean age and mean gestational age at booking were 31.6 SD 4.6 years (95% CI: 31.3,31.8), and 21.1 SD 18.6 weeks respectively. Modal parity was para 1. The predominant blood group among pregnant women at the RSUTH was O [667 (58.2%)], followed by A [286 (24.9%)], B [171(14.9%)], and AB [23(2%)]. The prevalences of Rhesus D positive and Rhesus D negative blood group were 95.2% and 4.8% respectively. Concerning genotype, the most predominant was AA 898 (78%) followed by AS [245 (21.4)], SS [4 (0.4%)], and AC [2 (0.2%]. Conclusion: The predominant blood group and genotype among pregnant women in our centre is O Rh D positive and AA respectively. The findings from this study would help plan transfusion services antepartum and post-partum. This will be relevant in transfusion and coagulation management of obstetric haemorrhage.

D-Observability for a Coupled System of Wave Equations on Right Angle Triangles

Based on the tiled method, we establish the equivalence between the D-observability for diagonalizable systems on the rectangular domain and the right angle triangle domain, and then get the sufficiency of Kalman’s rank condition to the D-observability for diagonalizable systems on some right angle triangles.

Energy efficient computing by using of software optimization aimed on execution time

Despite of all hardware capabilities, optimization of software always was one of actual tasks. Usually optimization of software was aimed to reduce an execution time. But recent decades it’s possible sometimes also to reduce energy consumption and/or energy efficiency of computing because of enhanced energy saving capabilities. Indeed, if computations are made faster, CPU can suspend unusual computational and control blocks. In case of parallelization which is one of optimization techniques, power consumption can raise in short periods of computations because of using multiple CPUs simultaneously. At once execution time can be decreased dramatically so energy efficiency of computing still increasing. In the paper the authors provide the experiments on small size mini PC Raspberry Pi 3B which show that using of optimization tiling method not only speed up a processing but also increase energy efficiency of computing. For such low power systems this can be useful to increase power on time with a battery power source.

ABO, Rh Blood Groups and Haemoglobin Genotype Associations with Helicobacter pylori Infection amongst Indigenes of Wiyaakara, Rivers State

Introduction: This study aims to determine the association of ABO/Rh Blood groups and haemoglobin genotype with Helicobacter pylori infection among indigenes of Wiyaakara, Ogoni, Rivers State. This is a cross-sectional study carried out in Wiyaakara, Khana Local Government Area in Rivers State to determine the prevalence of Helicobacter pylori infection and its association with ABO/Rh blood group and haemoglobin genotype.The study was carried out amongst indigenes of Wiyaakara village in Khana LGA of Rivers State, Nigeria. Wiyaakara is part of Ogoni. Materials and Methods: Determination of ABO/Rh blood group was done using tile method. Haemoglobin genotype was determined using cellulose acetate paper electrophoresis while determination of Helicobacter pylori infection was done using the rapid diagnostic test strip method. Results: Out of 130 participants, 48.5% tested positive for Helicobacter pylori infection. Amongst those that tested positive, 68% were females while 32% were males. In ABO blood grouping, blood group O recorded the highest infectivity rate, followed by blood group A, blood group B and AB. Rh positive individuals recorded high frequency of occurrence than Rh negative. Haemoglobin genotype AA recorded high frequency of occurrence than that of AS. Based on odd ratios, the risk for the studied subjects to be infected with Helicobacter pylori was in the order of B>A>O (odd ratios: A = 1.78, B = 9.01, O = 0.54), considering the fact that AB blood group subjects was negligible due to fewer number of subjects (5). Haemoglobin AS subjects were more prone to having Helicobacter pylori than AA subjects. Conclusion: The study has revealed that blood group B individual are more at risk of being infected with Helicobacter pylori in comparison to other ABO blood groups. Additionally, those with haemoglobin AS genotype were also at risk of being infected with Helicobacter pylori than those with haemoglobin AA genotype.

A Solution to VLSI: Digital Circuits Design in Quantum Dot Cellular Automata Technology

Quantum Dot Cellular Automata is a Nano device efficient than other devices in nanotechnology for the last two decades. It is beneficial over Complementary Metal Oxide Semiconductor technology like high speed, low energy dissipation, high device density and high computation efficiency. To achieve further optimization different methods like simplifications in Boolean expressions, tile method, clocking scheme, cell placement, cell arrangement, novel input techniques, etc., are in use. These methods improve the performance metrics in terms of QCA Cells, total circuit area, delay in output, power consumption, and coplanar or multilayer layout. This paper is about the novel NOT gate layout designed with efficient parameters compared to existing NOT gates except area parameters with analysis and XOR gate and multiplexer circuits. The novel gate provides an improvement of 55% in the number of cells, polarization raised by 0.33, and an 80.77% improvement in total area. These circuits illustrate further scope in QCA circuit design efficiently. XOR circuit shows area reduction up to 0.006 μm2 with 0.5 clock cycle delay. Further optimization in XOR parameters and with this novel NOT gate researchers can optimize parameters to bring revolution and digitalization.

Identification of high-risk groups of falciparum malaria in western region of Ghana: The predictive value of ABO Blood group typology

Background: Several studies have linked malaria to ABO blood groups with still others reporting insignificant association between ABO blood group system and malaria. Blood group ‘O’ has been shown to confer protection against severe malaria by studies in various populations but indecisive reports have been given about non-O blood groups in relation to their protection or vulnerability to severe malaria.
 Objective: The present study sought to investigate the ABO blood group typology and the risk of developing severe malaria.
 Materials and Methods: A total of 280 participants (140) with P. Falciparum malaria patients and 140 healthy controls) screened for ABO blood groups by Tile method were enrolled into the study. Thick and thin blood films stained with 10 % Giemsa were prepared for falciparum – infected individuals and their full blood counts obtained from the haematology analyzer (Cell Dyn 1800, Abbot Diagnostic Division, USA). Parasite counts were categorized into severe and uncomplicated malaria and further grouped into varying degrees of parasitaemia. The effects of parasite densities on some haematological parameters were then studied. Severe malaria was defined as hyperparasitaemia, malarial anaemia and thrombocytopenia.
 Results: The frequency of blood group ‘A’ was significantly higher in patients with severe malaria compared to other blood groups (p = 0.042). Blood groups ‘A’ and ‘B’ showed higher parasite densities while ‘A’ and ‘AB’ blood groups revealed low platelet counts. Anaemia was severe in blood groups ‘A’ and ‘O’ (p ≤ 0.05). Previous studies including this current one highlighted the protected nature of blood group ‘O’ to severe malaria (p ≤ 0.05).
 Conclusion: The present study provides the evidences that, individuals of blood group ‘A’ are highly susceptible to malaria infection and inferably with an increased risk of developing severe malaria than the other blood groups.

Importance of Interrelation between ABO Blood Group and Platelet Indices in Young Healthy Adults

Objective: To highlight the importance of the interrelation between the ABO blood group system and platelet indices in healthy young adults.
 Study Design: Cross-sectional study
 Place and Duration of Study: Pathology Department, PNS Shifa Hospital, Karachi Pakistan, from Jan to Jun 2020.
 Methodology: Comprised 399 blood donors who visited the transfusion department of the hospital without any comorbidities.All the donors were requested for their informed consent before their enrolment in the study. Blood groups were determined by a simple conventional tile method. Platelet indices (Platelet count, mean platelet volume and Platelet distribution width)were studied by auto-analyzer. Blood pressures were estimated by manual auscultator technique with a mercury sphygmomanometer.
 Results: Males and females were equal in number, with a mean BMI of 19.89(1.24%). The majority of the donors, 143(35.8%),had B-Blood Group, while 140(35.1%) donors had O-Blood group, 93(23.3%) had A-Blood group, and only 23(5.8%) had AB group. Rh positivity was noted in 378(94.7%) of the donors. Different blood groups were responsible for the changes in the platelet parameters, especially MPV and PDW, as there was a significant difference in MPV and PDW values (p-value<0.05).
 Conclusion: While determining the presence of a relationship between the ABO blood group system and platelet indices, it is observed that there is a high frequency of cardiovascular diseases among B and AB blood groups in young, healthy adults.Keywords: Blood groups, Body mass index, Mean platelet volume, Platelet count, Platelet distribution width.

에지 디바이스를 활용한 실시간 말벌 모니터링 시스템의 설계 및 구현

In this paper, an edge-enabled wasps monitoring system based on state of the art deep learning model is proposed to classify wasps species and transmit their information to clients for pest control and ecology research. We utilized and evaluated the lightweight models of YOLOv5, YOLOX, and YOLOv7 series to select the optimal object detection model for wasps. In order to improve the recognition performance of small objects such as wasps, a new tiling method is proposed which can reclassify objects located on boundary area between tiles. Our monitoring system is composed by local GPU-based edge computers, Server, and Web-based reporting system. In our experiment, the YOLOXnano model showed the highest performance among YOLO-based models above in terms of recall, precision, Fi-score, and mAP@IOUs for our custom test data set. However, even the YOLOX-nano model also requires the tiling process for a better bounding box generation for small objects under the real environment. As a result, the proposed wasps monitoring system showed meaningful efficiency for applying in the field of pest control and ecology research.

FREQUENCY AND DISRTIBUTION OF ABO AND RHESUS BLOOD GROUP IN NORTHERN AREAS OF KASHMIR VALLEY ADJAECENT TO LINE OF CONTROL.

Background: Distribution of blood groups varies demographically. ABO and Rh blood group systems are major clinically signicant blood group systems despite that more than 400 red cell antigens have been identied. Blood groups are genetically determined. ABO and Rh blood groups systems besides being most important in blood transfusion, are also important in forensic pathology, disease susceptibility and population genetics. This study aims to determine frequency and distribution of ABO and Rh blood groups among the permanent residents of northern areas of Kashmir valley adjacent to line of control. Aim and Objective: The present study was designed to determine frequency and distribution of ABO and Rh blood groups among blood donors in northern areas of Kashmir valley adjacent to line of control and compare the results with data available from studies conducted with in India and other countries. Material and Methods: This study was a two and half years prospective study conducted in the department of Pathology Government Medical College Baramulla from January 2020 to June 2022 . Only permanent residents of northern areas of Kashmir valley were included in the study. Blood donors who were not permanent residents of northern areas were excluded from the study. Blood donors were selected after proper history and complete examination. Blood donors fullling all eligibility criteria's for blood donation were selected. Determination of ABO and Rh status was done by tile method of agglutination using commercially available anti-Seras. Results: Out of total 4609 voluntary blood donors 4104 (89.04%) were Rh positive and 505 (10.96%) were Rh Negative. 1338 (29.03%) were O positive,1333 (28.92%) were B positive, 1025 (22.23%) were Apositive, 408 (8.8%) were AB positive, 187 (4.05%) were O negative, 156 (3.38%) were B negative, 102 (2.21%) were Anegative and 60 (1.30%) were AB negative. Conclusion: In the Northern areas of Kashmir valley adjacent to line of control O Positive is the most prevalent blood group followed by B positive and AB negative is least prevalent followed by Anegative.

Physical-Vapor-Transport growth of 4H silicon carbide single crystals by a tiling method

Increasing the diameter and reducing the dislocation density of 4H silicon carbide (4H-SiC) single crystals are the development tendency of 4H-SiC single-crystal substrate to reduce the cost of 4H-SiC based devices. In this work, we use the growth of a 100 mm 4H-SiC single crystal as an example to demonstrate that the tiling approach is attractive to enlarge the diameter of physical-vapor-transport (PVT)-grown 4H-SiC single crystals by a single growth period. By titling four pieces of 4H-SiC seed crystals, a 100 mm 4H-SiC boule without crystal deterioration is obtained by the PVT growth method. The shape of the growth interface is convex and complete after the PVT growth, indicating the tiling gaps between neighboring seed-crystal pieces are healed after the PVT growth of 25-mm thick 4H-SiC. Wafers are obtained after sequential slicing, lapping, and chemical mechanical polishing (CMP). The high-resolution X-ray diffraction (HRXRD) rocking curve measurements of the wafer at the latest growth stage indicate that the 4H-SiC crystal is basically healed, with mesoscopic boundaries being created at the central area of the wafer. Raman spectra indicate that the healing polymorph across the tiling gaps is 4H-SiC. We find that threading edge dislocations (TEDs) dominate the dislocation types in the 4H-SiC substrate wafers at the initial, middle, and latest growth stages. As the PVT growth proceeds, the density of dislocations in 4H-SiC wafers significantly decreases, as a result of the crystalline healing. Our work opens a pathway to enlarge the size of 4H-SiC single crystals in a single PVT growth period, which paves the way for the high-efficiency growth of large-size 4H-SiC single-crystals.

Clinical Prediction of Acetylator Phenotype in Tuberculosis Patients on Medicare using Blood Group

ABSTRACT Individual acetylation phenotype detected by metabolic phenotyping tests using a number of surrogate drugs, such as isoniazid is time consuming. The aim of this work was to determine the clinical prediction of acetylator phenotype in tuberculosis patients on medicare using blood group. 150 Tuberculosis patients (102 males and 48 females) on medicare were examined using urinalysis technique for acetylator status and tile method for blood group analysis. The result of the acetylator phenotypes revealed that 46.7% were fast acetylators while 53.3% were slow acetylators. The highest frequency of fast acetylators were subjects with blood groups O+ve and A+ve. Similarly, the highest frequency of slow acetylators were observed in blood groups B+ve and O+ve. Blood groups AB-ve and B-ve formed the lowest frequency of fast acetylators while A-ve and AB-ve formed the lowest percentage of slow acetylators respectively. Analysis of the blood groups and the acetylator phenotype using Pearson’s correlation showed a significant (p < 0.01) relationship with a coefficient of 0.852; between the blood groups of M.Tb patients and the fast and slow acetylators (p < 0.05, with a coefficient of 0.76) respectively. We imply that for standard TB treatment, more treatment time be considered for subjects with blood groups that are predominantly fast acetylators (e.g., O+ve ) and close monitoring through the treatment period for predominantly slow acetylators (e.g B+ve). Further study on the serum concentration of each blood group for the drugs and molecular analysis of the blood phenotypes is advocated. reby recommended.