Tight Correlation Research Articles

Vein hierarchy mediates the 2D relationship between leaf size and drought tolerance across subtropical forest tree species.

Previous studies have observed a 2D relationship (i.e. decoupled correlation) between leaf size (LS) and leaf economics as well as a tight correlation between leaf economics and drought tolerance. However, the underlying mechanism maintaining the relationship between LS and drought tolerance remains largely unknown. Here, we measured LS, water potential at 50% loss of hydraulic conductance, hydraulic safety margin and different orders of vein traits across 28 tree species in a subtropical forest in Southern China. We found that LS and drought tolerance were in two independent dimensions (R2=0.00, P>0.05). Primary and secondary vein traits (i.e. vein diameter and density) explained the variation of LS, with R2 ranging from 0.37 to 0.70 (all Ps<0.01), while minor vein traits accounted for the variation of leaf drought tolerance, with R2 ranging from 0.30 to 0.43 (all Ps<0.01). Our results provide insight into the 2D relationship between LS and drought tolerance and highlight the importance of vein hierarchy in plant leaf functioning.

Refinement of Neurofilament light Dynamics in CSF and Blood for familial Alzheimer’s Disease

AbstractBackgroundDisease‐modifying therapies for Alzheimer’s Disease (AD) are likely most beneficial when initiated in the pre‐symptomatic phase. To track success of such interventions fluid biomarkers became instrumental, with neurofilament light chain (NfL) showing particular promise. We previously reported that serum NfL increases in pre‐symptomatic phases of familial (autosomal‐dominantly inherited) AD (fAD) and that within‐person rate‐of‐change in NfL is an earlier predictor of fAD symptom onset compared to cross‐sectional levels. The aim of the study at hand was to extend these initial findings in a larger cohort.MethodParticipants enrolled in the Dominantly Inherited Alzheimer Network (DIAN) with matched cross‐sectional and longitudinal cerebrospinal fluid (CSF; n = 962) as well as plasma (n = 1294) samples were used. NfL measurements have been performed on the SIMOA platform using commercially available assay‐kits. To investigate the influence of physiological factors independent from AD, we first analyzed whether age and body mass index (BMI) could account for observed variation in inter‐individual CSF and plasma NfL levels considering non‐carrier family‐members (NC) as a healthy control group. Next, utilizing estimated years to symptom onset (EYO) and previously published methods (Preische et al., 2019), we determined the point in disease course when baseline and longitudinal CSF and plasma NfL concentrations started to increase in mutation carriers (MC) relative to NC, after adjusting for age and BMI.ResultOur results reveal a tight correlation of CSF and blood NfL values within MC as well as NC (figure 1A‐B). However, within NC, after correction for age and BMI, some unexplained variability remained (figure 1C). Further, a decrease of the NfL plasma/CSF ratio over age was found after correcting for BMI (figure 1D). The discrimination of MC from NC was equally good for plasma compared to CSF, being possible on the group level as early as around ‐15 to almost ‐20 EYO depending on the modelling (figure 2).ConclusionOur results support plasma equivalently to CSF NfL as a clinically useful biomarker to longitudinally track neurodegeneration in fAD. The systemic factors influencing physiological NfL values in blood should be investigated in future studies to further improve interpretation of this biomarker.

Phenomenological emergent dark energy versus the ΛCDM: ellipticity of cosmic voids

ABSTRACT We disclose the influences of the phenomenological emergent dark energy (PEDE) and its generalization (GEDE) on the distribution of tidal ellipticity of the cosmic voids. We also compare our results with that of the standard ΛCDM cosmology. The underlying models consist with recent observations (specially in favour of H0 tension) and may impact the cosmic voids geometry. We employ the analytic approach based on statistics of the tidal tensor eigenvalues. We confirm a significant sensitivity of the ellipticity distribution function for PEDE and GEDE cosmology. We observe the largest deviation from the standard cosmology for GEDE in the range ($z\gt 0, R_{\mathrm{L}}\ge 4\, h^{-1}\, \mathrm{Mpc}$). Working on these distribution functions we reveal that the mean ellipticity (〈ε〉) profile of GEDE versus redshift lies below than that of PEDE and ΛCDM indicating that GEDE leads to a less elongated society of voids with respect to other models. We also identify a tight correlation between σ8 and the mean ellipticity evolution. Finally, we explore the mean ellipticity versus RL and estimate that in this case GEDE leads to a different ellipticity curve (up to 11 ${{\ \rm per\ cent}}$ smaller than that of ΛCDM).

A fundamental plane of black hole accretion at millimetre wavelengths

ABSTRACT We report the discovery of the ‘mm fundamental plane of black hole accretion’, which is a tight correlation between the nuclear 1 mm luminosity (Lν, mm), the intrinsic 2–10 keV X-ray luminosity (LX, 2–10) and the supermassive black hole (SMBH) mass (MBH) with an intrinsic scatter (σint) of 0.40 dex. The plane is found for a sample of 48 nearby galaxies, most of which are low-luminosity active galactic nuclei. Combining these sources with a sample of high-luminosity (quasar-like) nearby AGN, we show that the plane still holds. We also find that MBH correlates with Lν, mm at a highly significant level, although such correlation is less tight than the mm fundamental plane (σint = 0.51 dex). Crucially, we show that spectral energy distribution (SED) models for both advection-dominated accretion flows (ADAFs) and compact jets can explain the existence of these relations, which are not reproduced by the standard torus-thin accretion disc models usually associated to quasar-like AGN. The ADAF models reproduces the observed relations somewhat better than those for compact jets, although neither provides a perfect fit. Our findings thus suggest that radiatively inefficient accretion processes such as those in ADAFs or compact (and thus possibly young) jets may play a key role in both low- and high-luminosity AGN. This mm fundamental plane also offers a new, rapid method to (indirectly) estimate SMBH masses.

The neutral hydrogen mass in galaxies estimated via optical spectroscopy

ABSTRACT We propose to employ emission line luminosities obtained via optical spectroscopy to estimate the content of neutral hydrogen (H i) in galaxies. We use the optical spectroscopy data from the Mapping of Nearby Galaxies at APO (MaNGA) survey released in the frames of public DR17 of the Sloan Digital Sky Survey (SDSS). We compare the H i mass estimated by us for a large sample of SDSS/MaNGA galaxies with direct H i measurements from the Arecibo Legacy Fast ALFA survey and find a tight correlation between the masses with the correlation coefficient (CC) of 0.91 and the rms scatter of 0.15 dex for the logarithmic mass. The obtained relationship is verified via another sample of MaNGA galaxies with H i masses measured with the Green Bank Telescope. Despite the coarser angular resolution of the radio data, the relation between the estimated and measured directly H i mass is tight as well – in this case CC = 0.74 and the rms is 0.29 dex. The established relations allow us to estimate the total mass of neutral hydrogen as well as the spatial distribution of H i surface density in galaxies from optical spectroscopic observations only in a simple and efficient way.

The H i-rich ultra-diffuse galaxies follow the extended Schmidt law

ABSTRACT The ${\rm H\, {\small I}}$-rich ultra-diffuse galaxies (HUDGs) offer a unique case for studies of star formation laws as they host low star formation efficiency and low-metallicity environments where gas is predominantly atomic. We collect a sample of six HUDGs in the field and investigate their location in the extended Schmidt law ($\Sigma _{\text{SFR }} \propto \left(\Sigma _{\text{star}}^{0.5} \Sigma _{\text{gas}}\right)^{1.09}$). They are consistent with this relationship well (with deviations of only 1.1σ). Furthermore, we find that HUDGs follow the tight correlation between the hydrostatic pressure in the galaxy mid-plane and the quantity on the x-axis ($\rm log(\Sigma _{star}^{0.5}\Sigma _{gas})$) of the extended Schmidt law. This result indicates that these HUDGs can be self-regulated systems that reach the dynamical and thermal equilibrium. In this framework, the stellar gravity compresses the disc vertically and counteracts the gas pressure in the galaxy mid-plane to regulate the star formation as suggested by some theoretical models.

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Background: Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. Studies have reported the dichotomous nature of IFNγ signaling in both the pathogenesis of cancer and immunotherapy response. However, its complex interplay with acute myeloid leukemia (AML) remains insufficiently understood. Methods: Three independent RNA-seq datasets were integrated to disentangle the IFNγ signaling in AML. We also performed single cell RNA sequencing (scRNA) on 20 newly diagnosed AML patients to discern relative contribution of cells and cellular communications for IFNγ signaling. Results: Single-sample gene set enrichment analysis was used to examine the transcriptional programs linked to IFNγ signaling in 672 newly diagnosed adult AML patients. We observed higher IFNγ signaling score in subgroups of patients including diploid with monocytic differentiation, inv16 core-binding-factor AML, and del7/7q. Notably, sorted CD34 + cells from 17 healthy donors had markedly lower levels of IFNγ signaling scores than did those from AML patients, making it a predominant feature in AML. Additionally, we found significant positive correlations between IFNγ signaling score and expression of its downstream targets HLA class 1 and 2 as well as T cell dysfunction score, T cell exhaustion score, and T cell senescence score, consistent with the fact that chronic IFNγ can drive T cell dysfunction. In scRNA, we observed that AML cells in patients with diploid monocytic AML had the highest expression of IFNγ signaling followed by del7/7q, while the non-monocytic, diploid AML cells had the lowest (Figure 1A). We then explored whether IFNγ signaling is differentially activated across the AML hierarchies and found the spectrum along the hierarchy with the primitive cells displaying significant higher IFNγ signaling than GMP while reaching the highest in Mono-like state. Transcription factor analysis revealed high regulon activity of interferon regulator factors (IRFs) in AML cells, with elevated levels of IRF1 and IRF5 regulons in del7/7q and del5/5q, respectively and elevated IRF8 regulon in diploid AML cells with monocytic differentiation, consistent with its role as a lineage-determinant factor promoting monocytic differentiation. Cell-cell interactions revealed IFNγ from CD8 T cells and NK cells as a top interaction to AML cells. These observations indicate that the activation levels of IFNγ signaling in AML cells are associated with distinct cellular states and hierarchies, and that disparate regulons of IFNγ signaling characterize distinct patient subgroups. The high level of IFNγ signaling in monocytic patient prompted us to assess its correlation with drug response as monocytic subclones are suggested to have inherent resistance to venetoclax. In BEAT-AML ex vivo drug test data, we found a strong positive correlation between IFNγ signaling score and venetoclax resistance, indicating that IFNγ signaling confers venetoclax resistance. This correlation was validated in an independent cohort. However, the IFNγ signaling score did not predict survival outcomes in our bulk cohort. Therefore, we defined a light weighted IFNγ signature to improve the prognostic sensitivity using the least absolute shrinkage and selection operator model. After regression, 47 genes related to survival were retained, forming a parsimonious IFNγ signature. The new parsimonious IFNγ score revealed a tight positive correlation with HLA class 1 and 2 scores. Importantly, this parsimonious IFNγ score was able to predict patient outcomes in our bulk cohort, whereby a higher score predicted worse survival (Figure 1B). Ultimately, these results suggest that the IFNγ pathway activation is associated with resistance to venetoclax-based therapy and can predict patient outcomes independently of known risk factors, making it a promising target for therapeutic intervention. Conclusions: Characterization of inflammation in AML using independent bulk and scRNA profiling led to the identification of novel drug targets and mechanisms of resistance to targeted therapy. We identified monocytic AML as having a unique microenvironment characterized by high IFNγsignaling in AML cells and immunosuppressive features. IFNγ signaling scores correlated strongly with venetoclax resistance. A parsimonious IFNγ gene signature demonstrated robust prognostic value.

Evolution of the Mass–Metallicity Relation from Redshift z ≈ 8 to the Local Universe

A tight positive correlation between the stellar mass and the gas-phase metallicity of galaxies has been observed at low redshifts. The redshift evolution of this correlation can strongly constrain theories of galaxy evolution. The advent of JWST allows probing the mass–metallicity relation at redshifts far beyond what was previously accessible. Here we report the discovery of two emission line galaxies at redshifts 8.15 and 8.16 in JWST NIRCam imaging and NIRSpec spectroscopy of targets gravitationally lensed by the cluster RX J2129.4+0005. We measure their metallicities and stellar masses along with nine additional galaxies at 7.2 < z spec < 9.5 to report the first quantitative statistical inference of the mass–metallicity relation at z ≈ 8. We measure ∼0.9 dex evolution in the normalization of the mass–metallicity relation from z ≈ 8 to the local universe; at a fixed stellar mass, galaxies are 8 times less metal enriched at z ≈ 8 compared to the present day. Our inferred normalization is in agreement with the predictions of FIRE simulations. Our inferred slope of the mass–metallicity relation is similar to or slightly shallower than that predicted by FIRE or observed at lower redshifts. We compare the z ≈ 8 galaxies to extremely low-metallicity analog candidates in the local universe, finding that they are generally distinct from extreme emission line galaxies or “green peas,” but are similar in strong emission line ratios and metallicities to “blueberry galaxies.” Despite this similarity, at a fixed stellar mass, the z ≈ 8 galaxies have systematically lower metallicities compared to blueberry galaxies.

First-principles study of luminescence and electronic properties of Ce-doped Y2SiO5.

The transition of energy from the 4f to the 5d state is a fundamental element driving various applications, such as phosphors and optoelectronic devices. The positioning of the 4f ground states and the 5d excited states significantly influences this energy shift. In our research, we delve into the placement of these states utilizing a hybrid density functional theory (DFT) combined with spin-orbit coupling (SOC) via the supercell method. Additionally, we scrutinize the transition energy, applying the constrained density functional theory (cDFT) approach in conjunction with the ΔSCF method. Our study illustrates that the synergy of cDFT and SOC generates a discrepancy of about 2% for Ce1 and 4% for Ce2 when comparing the calculated results to experimental data. Moreover, We have determined the positions of the 4f ground states to be 2.73eV above the Valence Band Maximum (VBM) for Ce1 and 2.70eV for Ce2. We also note a tight correlation between the 5d levels identified in the experimental data and the theoretical outcomes derived from wave function calculations at the CASPT2 accuracy level.

Ly α emission in low-redshift most metal-deficient compact star-forming galaxies

ABSTRACT We present observations with the Cosmic Origins Spectrograph onboard the Hubble Space Telescope of nine most metal-deficient compact star-forming galaxies with oxygen abundances 12 + log(O/H) = 6.97–7.23, redshifts z = 0.02811–0.13320, and stellar masses M⋆ ≤ 107 M⊙. We aim to study the properties of Ly α emission in these extremely metal-deficient objects. We find that all nine galaxies are Ly α emitters (LAEs). We examine various relations between the Ly α escape fraction fesc(Ly α) and other characteristics – such as absolute UV magnitude, oxygen abundance, O32 ratio, stellar mass, Lyman-alpha luminosity, and equivalent width EW(Ly α), ionizing photon production efficiency ξion and velocity separation Vsep between the two peaks of the Ly α profile – of a large sample of LAEs, including our lowest metallicity galaxies and other objects from the literature. We find a relatively tight correlation between fesc(Ly α) and two characteristics, EW(Ly α) and Vsep, whereas no correlation is found between fesc(Ly α) and the oxygen abundance. We also find a relatively tight relation between the Ly α and LyC escape fractions. We propose to use the latter relation to estimate indirectly the escaping ionizing radiation in LAEs, when direct measurements of LyC emission are not possible. We show that the global properties of low-z LAEs are very similar to those of z &amp;gt; 6 galaxies. They are thus ideal local proxies for studying physical processes during the epoch of reionization of the Universe.

Measuring the Unilateral Cleft Lip Nasal Deformity: Lateral Deviation of Subnasale Is a Clinical and Morphologic Index of Unrepaired Severity.

Objective measurement of pre-operative severity is important to optimize evidence-based practices given that the wide spectrum of presentation likely influences outcomes. The purpose of this study was to determine the correlation of objective measures of form with a subjective standard of cleft severity. 3D images were ranked according to severity of nasal deformity by 7 cleft surgeons so that the mean rank could be used as the severity standard. 45 patients with unilateral cleft lip and 5 normal control subjects. Each image was assessed using traditional anthropometric analysis, 3D landmark displacements, and shape-based analysis to produce 81 indices for each subject. The correlation of objective measurements with the clinical severity standard. Lateral deviation of subnasale from midline was the best predictor of severity (0.86). Other strongly-correlated anthropometric measurements included columellar angle, nostril width ratio, and lateral lip height ratio (0.72, 0.80, 0.79). Almost all shape-based measurements had tight correlation with the severity standard, however, dorsum deviation and point difference nasolabial symmetry were the most predictive (0.84, 0.82). Quantitative measures of severity transcend cleft type and can be used to grade clinical severity. Lateral deviation of subnasale was the best measure of severity and may be used as a surrogate of uncoupled premaxillary growth; it should be recorded as an index of pre-operative severity with every cleft lip repair. The correlation of other measures evaluated clarify treatment priorities and could potentially be used to grade outcomes.

The ‘perimeter’ prisoners of Russian secret cities: the case of ZATO Krasnoyarsk-26

Since the 1930s, the Gulag system of labour camps was a driving force behind the main geopolitical projects of the Soviet Union, playing a critical role in mega-infrastructural projects to colonise hitherto unexploited territories. Among these was the network of secret cities built at the dawn of the Cold War. Whilst outwardly appearing like ordinary cities — with their green boulevards, central squares, and civic facilities — they were fully controlled and managed by the state; over decades elite scientists and technicians were brought together in these new settlements to work and live in total dedication to the Soviet atomic bomb project. These secret cities were known as Zakrytoye Administrativno-Territorial’noye Obrazovaniye [Closed Administrative-Territorial Formations], abbreviated as ZATOs. The research campuses, production and test zones, and civic and residential districts of the ZATOs were secured with walls, fences, watchtowers, and checkpoints. Beyond the secured perimeters, which still exist to regulate access to and from the outside world, lies the governmental and legislative apparatus which shaped the ZATOs’ economic, social, and psychological characteristics. For the inhabitants of ZATOs, the perimeter symbolised their connection to a higher purpose and would later evoke feelings of nostalgia and a sense of protection. Focusing primarily on one of these settlements, namely ZATO Krasnoyarsk-26, this paper links the story of the imprisoned labourers who constructed the ZATOs to that of the civilians who surrendered their liberty for a loftier cause. It will reveal a tight correlation between the Gulag infrastructure and the spatial arrangement of ZATOs showing how, in many aspects, ZATOs took on characteristics of carceral isolation, coercion, and immobility that are still relevant when addressing their contemporary condition.

A Method to Measure Photometries of Moderately Saturated UVOT Sources

For bright transients such as gamma-ray bursts (GRBs), the Ultra-Violet/Optical Telescope (UVOT) operates under event mode at early phases, which records incident positions and the arrival time for each photon. The event file is able to be screened into many exposures to study the early light curve of GRBs with a high time resolution, including the rapid brightening of the UV/optical emission in particular. Such a goal, however, is hampered for some extremely bright GRBs by the saturation in UVOT event images. For moderately saturated UVOT sources, in this work we further develop the method proposed in Jin et al. to recover their photometries. The basic idea is to assume a stable point-spread function of UVOT images, for which the counts in the core region (i.e., an aperture of a radius of 5″) and the wing region (i.e., an annulus ranging from 15″–25″) should be constant, and the intrinsic flux can be reliably inferred with data in the ring. We demonstrate that in a given band, a tight correlation does hold among the background-removed count rates in the core and the wing. With the new method, the bright limit of measuring range for UVOT V and B bands increases by ∼1.7 mag, while only by ∼0.7 mag for the U band due to the lack of bright calibration sources. Systematic uncertainties are ∼0.2 mag for the V, B, and U bands.

Influence of Synthesis Conditions on the Crystal, Local Atomic, Electronic Structure, and Catalytic Properties of (Pr1−xYbx)2Zr2O7 (0 ≤ x ≤ 1) Powders

The influence of Yb3+ cations substitution for Pr3+ on the structure and catalytic activity of (Pr1−xYbx)2Zr2O7 powders synthesized via coprecipitation followed by calcination is studied using a combination of long- (s-XRD), medium- (Raman, FT-IR, and SEM-EDS) and short-range (XAFS) sensitive methods, as well as adsorption and catalytic techniques. It is established that chemical composition and calcination temperature are the two major factors that govern the phase composition, crystallographic, and local-structure parameters of these polycrystalline materials. The crystallographic and local-structure parameters of (Pr1−xYbx)2Zr2O7 samples prepared at 1400 °C/3 h demonstrate a tight correlation with their catalytic activity towards propane cracking. The progressive replacement of Pr3+ with Yb3+ cations gives rise to an increase in the catalytic activity. A mechanism of the catalytic cracking of propane is proposed, which considers the geometrical match between the metal–oxygen (Pr–O, Yb–O, and Zr–O) bond lengths within the active sites and the size of adsorbed propane molecule to be the decisive factor governing the reaction route.

The Alcázar of Córdoba: The Seat of Islamic Power in Al-Andalus

In this paper, we show a synthesis of the recovered information in the most recent archaeological interventions of the occupied space by the architectural complex where the Omayyad seat of power and the following leaders of Córdoba were installed. As the most relevant aspects, we show the persistent continuity of the reoccupation and appropriation of the precedent buildings, the tight correlation with the Aljama Mosque, and the architectonic entity of the documented structures.

Transcriptome and gut microbiota analyses reveal a possible mechanism underlying rifampin-mediated interruption of the larval development of chironomid Propsilocerus akamusi (Diptera: Chironomidae)

Chironomids, the most abundant insect group found in freshwater habitats, are known to be pollution tolerate and serve as important bioindicators of contaminant stress. Gut microbiota has recently been shown to potentially provide a number of beneficial services to insect hosts. However, the antibiotic-mediated interruption of chironomid gut microbial community and its subsequent influence on host body are still unclear. In the present study, the effects of rifampin on chironomid larvae were investigated at both transcriptome and microbiome level to assess the relationship between gut bacteria and associated genes. Our data indicated that the rifampin-induced imbalance of gut ecosystem could inhibit the development of chironomid larvae via decreasing the body weight, body length and larval eclosion rate during 96-h treatment. Both the community structure and taxonomic composition were significantly altered due to the invasion of rifampin in digestive tracts. The relative abundance of phylum Deferribacterota and Bacteroidota were dramatically increased with rifampin exposure. A set of genes involved in amino acid synthesis as well as xenobiotic metabolism pathways were greatly changed and proved to have tight correlation with certain genus. Bacterial genus Tyzzerella was positively correlated with detoxifying PaCYP6GF1 and PaCYP9HL1 genes. This study provides a reference for understanding the environmental risks of antibiotic and aims to accelerate new biological insights into the effects of antibiotic on the fitness of chironomids and into the microbe mediated-regulatory mechanism of aquatic insects.

High-resolution shallow crustal shear wave velocity structure of Anyuan mining area and its adjacent region in Jiangxi Province, China

High-resolution seismic image is critically important for mining minerals. In this study, we collected seismic data from a local dense seismic array consisting of 154 stations around the Anyuan mining area and its adjacent region of Pingxiang City, Jiangxi Province in South China, and applied the ambient noise tomography (ANT) method to image the shear wave velocity structure in the study area. Shallow crustal velocities at depths less than 3.3 km were determined by direct inversion of Rayleigh wave group velocity dispersion curves at the period range of 0.5–5.0 s. Overall, the S-wave velocity structure has a tight correlation with surface geological and tectonic features in the study area. The shear wave velocity structure in the shallow crust of the Anyuan Mine and its adjacent areas displayed distinct low-velocity anomalies, which can be attributed to the depression of sedimentary structures and coal mining activities in the Pingxiang-Leping region. The zones surrounding the Anyuan fault (AYF) and Wangkeng fault (WKF) zones exhibited low-velocity anomalies from the ground surface to ~ 3.3 km underground. And the low-velocity anomalies at depths less than 1.2 km could be related to the sedimentary environment of coal mine and the coal mining activities, while the low-velocity anomalies at depths below 1.2 km are caused by the presence of fracture medium, oil and gas in the fault zone. The shear wave velocity changes sharply across the AYF, and the characteristics of the velocity change interface indicate that the AYF is inclined toward the northwest, with its extension reaching depths of approximately 3 km underground.Graphical

Homogeneous Field Measurement and Simulation Study of Injector Nozzle Internal Flow and Near-Field Spray

The homogeneous field measurement of internal flow and spray of internal combustion engine injector nozzles under high pressure has always been one of the difficulties in experimental research. In this paper, an actual-size aluminum alloy nozzle is designed, and the simultaneous measurement of internal flow and near-field spray is successfully realized with the help of synchrotron radiation X-ray phase contrast imaging technology under an injection pressure of 30~90 MPa. For a 0.25 mm aperture nozzle, different radii of the inlet corner can induce different cavitation layer thicknesses, and the measured flow section shrinkage ratio is 0.70. The flow characteristics in the nozzle are entirely connected to the jet characteristics, indicating a tight correlation between internal flow and jet morphology. Finally, the internal cavitation of the nozzle was studied by the CFD simulation, and the simulation results are in good agreement with the experiment.

Correlation between charge transport and lattice dynamics in La- and Y-doped Ca2MnO4 perovskites

Transition metal oxides exhibit fascinating physical phenomena and hold potential for next-generation electronic devices; therefore, fundamental understanding of their conduction mechanisms is of prime technological importance. We investigate charge transport kinetics and elastic behavior of bulk polycrystalline Ca2-xRxMnO4 oxides, where R = Y or La and 0.01 ≤ x ≤ 0.20. Analysis of temperature dependent electronic transport properties considering the nearest neighbor small polaron hopping model in combination with first-principles calculations of elastic properties indicates tight correlation between charge transport and lattice elasticity. We find that the polaron hopping energies of Y-doped compounds are lower than their La-doped counterparts, and attain minimum values of 60 and 73 meV, respectively. This is associated to softening of interatomic bonds, which is more pronounced for Y-doping compared to La-doping. This is corroborated by a fundamental model for elastically isotropic materials, indicating that the elastic energy induced by small polarons corresponds with the measured polaron hopping energies. Accordingly, the lattice shear and Young moduli, sound velocities and Debye temperatures calculated for Y-doped cells are smaller than for La-doped ones. The non-monotonous dependence of hopping energies on dopant concentration is explained in terms of polaron-polaron separation and mutual electrostatic interactions across the Mn+3-O-Mn+4 conduction path. Our study shows how charge carrier dynamics are strongly coupled with elastic properties, implying that the latter can be used to predict charge carrier mobility in oxide semiconductors.

Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome.

Berberine (BBR) is an isoquinoline alkaloid extracted from Chinese medicinal plants showing a tight correlation with gut microbiota. Polycystic ovary syndrome (PCOS) is a prevalent reproductive and endocrine disorder syndrome among women of childbearing age. Dysbiosis, the imbalance of intestinal microorganisms, is a potential factor that takes part in the pathogenesis of PCOS. Recent evidence indicates that berberine offers promise for treating PCOS. Here, we review the recent research on the interaction between berberine and intestinal microorganisms, including the changes in the structure of gut bacteria, the intestinal metabolites after BBR treatment, and the effect of gut microbiota on the bioavailability of BBR. We also discuss the therapeutic effect of BBR on PCOS in terms of gut microbiota and its potential mechanisms.