Since 1958, there have been significant changes in the Yangtze River estuary. Due to extensive reclamation and construction of ports and channels, the water area has drastically decreased, resulting in corresponding changes in hydrodynamics and riverbeds at the mouth of the river. According to the analysis of measured topographic data and Delft3D-FLOW model for seven typical historical periods since 1958 at the Yangtze River Estuary, this study investigates the characteristics of riverbed evolution and tidal flow dynamics. From 1958 to 2019, driven by strong human activities, the total area of the Yangtze River Estuary decreased from 2084 km2 to 1403 km2, with a decrease of 32.7%, while the total volume of the corresponding river channel changed slightly and remained stable. Compared with 1958, the volume of the Yangtze River Estuary in 2019 only increased by 345 million m3, with an increase of about 4.1%. The tidal dynamic change of the Yangtze Estuary is closely related to the riverbed evolution of each reach, which not only shapes the estuary landform, but also is affected by the riverbed evolution. Tidal level, tidal range and water area change are closely related. With the decrease of water area in the Yangtze River Estuary, tidal range tends to increase. Tidal prism change is closely related to channel volume. In the past 60 years, the tidal volume at the mouth of the Yangtze River has decreased by 8%. The research findings will provide technical support for enhancing flood control and tide resistance measures at the Yangtze River Estuary, as well as formulating comprehensive management plans for estuaries, contributing to the protection and sustainable development of the Yangtze River Estuary.