Ticks are hematophagous organisms that transmit numerous human and veterinary diseases. They also induce an anti tick immune response during their blood meal. Thus, rabbits repeatedly infested with I. ricinus nymphs and adults produce IgG antibodies reacting against some salivary gland and integumental proteins from female ticks1. In contrast, experimental infestations of BALB/c mice with nymphal I. ricinus do not generate anti tick antibodies (IgG) or only occasionally. However mice immunized with salivary gland extract (SGE) develop antibodies that recognize tick integumental and salivary gland proteins (Fig 1).KeywordsSalivary GlandBlood MealAntigen ProcessingTritiated ThymidineFemale TickThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.