An understanding of the knee forces and muscle activity generated during knee rehabilitation exercises is valuable to clinicians in prescribing appropriate exercises for rehabilitation patients. This symposium will discuss the scientific rationale involving knee biomechanics during common knee rehabilitation exercises. Cruciate ligament tensile forces, tibiofemoral compressive forces, patellofemoral compressive forces, and quadriceps, hamstrings, and gastrocnemius muscle activity will be compared among squat, leg press and leg extension exercises. These knee forces and muscle activity will also be compared during technique variations while performing squat and leg press exercises. Additional open and closed kinetic chain and neuromuscular exercises will also be introduced, and these exercises will be integrated into a rehabilitation program and presented for the knee rehabilitation patient. ACL strain during common knee rehabilitation exercises will also be presented in vivo immediately following knee surgery, which provides valuable information to clinicians involved in prescribing knee rehabilitation exercises to post-operative patients. The optimal loading of the ACL graft during knee rehabilitation will also be discussed.