Thyroid Hormone Dysfunction Research Articles

Effects of 4G Long-Term Evolution Electromagnetic Fields on Thyroid Hormone Dysfunction and Behavioral Changes in Adolescent Male Mice.

Radiofrequency electromagnetic fields (RF-EMFs) can penetrate tissues and potentially influence endocrine and brain development. Despite increased mobile phone use among children and adolescents, the long-term effects of RF-EMF exposure on brain and endocrine development remain unclear. This study investigated the effects of long-term evolution band (LTE) EMF exposure on thyroid hormone levels, crucial for metabolism, growth, and development. Four-week-old male mice (C57BL/6) were exposed to LTE EMF (whole-body average specific absorption rate [SAR] 4 W/kg) or a positive control (lead; Pb, 300 ppm in drinking water) for 4 weeks. Subsequently, the mice underwent behavioral tests including open field, marble burying, and nest building. Blood pituitary and thyroid hormone levels, and thyroid hormone-regulating genes within the hypothalamus-pituitary-thyroid (HPT) axis were analyzed. LTE exposure increased T3 levels, while Pb exposure elevated T3 and T4 and decreased ACTH levels. The LTE EMF group showed no gene expression alterations in the thyroid and pituitary glands, but hypothalamic Dio2 and Dio3 expressions were significantly reduced compared to that in the sham-exposed group. Pb exposure altered the hypothalamic mRNA levels of Oatp1c1 and Trh, pituitary mRNA of Trhr, and Tpo and Tg expression in the thyroid. In conclusion, LTE EMF exposure altered hypothalamic Dio2 and Dio3 expression, potentially impacting the HPT axis function. Further research is needed to explore RF-EMF's impacts on the endocrine system.

Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.

Thyroid hormone dysfunction is frequently observed in patients with chronic illnesses including heart failure which increases risk of adverse events. This study examined effects of thyroid hormones (TH) on cardiac T-tubule (TT) integrity, Ca2+ sparks, and nanoscale organization of ion channels in excitation-contraction (EC)-coupling, including L-type calcium channel (Cav1.2), ryanodine receptor-type 2 (RyR2), and junctophilin-2 (Jph2). TH deficiency was established in adult female rats by propyl-thiouracil (PTU) ingestion for 8 weeks; followed by randomization to continued PTU without or with oral triiodo-L-thyronine (T3; 10 ug/kg/d) for two additional weeks (PTU+T3). Confocal microscopy of isolated cardiomyocytes (CM) showed significant misalignment of TTs, and increased Ca2+ sparks in thyroid-deficient CMs. Density-Based Spatial Clustering of Applications with Noise (DBSCAN) analysis of STochastic Optical Reconstruction Microscopy (STORM) images showed decreased (p<0.0001) RyR2 cluster number per cell area in PTU CMs compared to euthyroid (EU) control myocytes, and this was normalized by T3-treatment. Cav1.2 channels and Jph2 localized within 210 nm radius of the RyR2 clusters were significantly reduced in PTU myocytes, and these values were increased with T3 treatment. A significant percentage of the RyR2 clusters in the PTU myocytes had neither Cav1.2 or Jph2, suggesting fewer functional clusters in EC-coupling. Nearest neighbor distances between RyR2 clusters were greater (p<0.001) in PTU cells compared to EU and T3-treated CMs that corresponds to disarray of TTs at the sarcomere z-discs. These results support a regulatory role of T3 in the nanoscale organization of RyR2 clusters and co-localization of Cav1.2 and Jph2 in optimizing EC-coupling.

Exploring the Effect of Thyroid Hormone on Serum Lipoprotein (a) Levels in Patients With Thyroid Hormone Dysfunction: A Systematic Review.

Genetic variations among people mainly determine the blood levels of lipoprotein (a) (Lp(a)), and it is relatively stable throughout one's lifetime. Nevertheless, there could still be other factors that control the Lp(a) level. Thyroid hormones are known to influence the serum lipid level by regulating the expression ofkeyenzymes that are involved in lipid metabolism. Both hypo and hyperthyroidism are associatedwith changes in lipid levels. Even though thyroid hormone abnormalities have been shownto alter traditional lipid parameters like low-density lipoprotein (LDL-C), its influence onLp(a) has not been established. This review aims to identify the relationship between Lp(a) and thyroid hormones by reviewing data from correlative studies and observing treatment-related Lp(a) level changes in thyroid disorders from interventional studies. We searched MEDLINE, Cochrane, and Google Scholar databases with predefined search criteria and search strategies for paper identification. Individual reviewers reviewed identified papers for selection.Finalized papers were reviewed forLp(a) levels and their responses to treatment in patients with thyroid disorders to establish the relationship betweenLp(a) and thyroid hormone.We concluded that the data were limited and sometimes contradicted one another to establish a clear relationship betweenLp(a) and thyroid hormones.Even though correlative studies data showed strong indications that overt-hypothyroidism was associated with high Lp(a) levels, thyroid hormone replacement studies did not show any significant changes inLp(a) levels compared to pre-treatment in patients with both overt-hypothyroidism and subclinical hypothyroidism. More clinical trials focusing on Lp(a) with longer periods of treatment and follow-up in thyroid patients are needed to establish the relationship between the two. The possibility of dose-related Lp(a) responses to thyroid hormone treatment should also be explored.

Impacts of Hashimoto’s Thyroiditis on Rheumatoid Arthritis Activity and Its Complication Among Iraqi Patients with Rheumatoid Arthritis

Abstract Background: Rheumatoid arthritis (RA) is an autoimmune disorder. Autoimmune thyroid disease often coexists with RA and is associated with elevated cardiovascular (CV) risk. This risk was pronounced in women and the elderly. RA patients should be closely monitored to prevent the development of hypothyroidism. Objectives: The purpose of this study was to investigate the impacts of Hashimoto’s thyroiditis on rheumatoid arthritis activity and its complication among Iraqi patients with rheumatoid arthritis. Materials and Methods: This study is a cross-sectional observational study involving 140 participants diagnosed with RA (according to rheumatologist physicians in accordance with ACR/EULAR 2010 criteria). Enzyme-linked immunosorbent assay (ELISA) was used to assess serum levels of anti-CCP, Ab-TPO, TSH, T4, and lipid profile. As well as troponin, myoglobin, and creatine kinase were measured. RA activity was estimated according to DAS-28-ESR and CDAI. Patients included 16 males and 124 females, ranging between the ages of 20 and 60 years. Results: The current study revealed a significant difference between anti-TPO levels in the serum of RA patients with DAS-28ESR (P = 0.006). Also, the study showed a strong positive correlation (r = 0.436) between anti-TPO and DAS-28-ESR. Conclusion: HT is frequent among patients with RA. Therefore, there is a need for screening of thyroid hormone dysfunction as well as the presence of anti-TPO in RA patients particularly in young patients, females, and those with high disease activity. No significant differences in the occurrence of CVD among RA patients with HT and euthyroid RA patients.

Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults.

Selenium (Se) is physiologically essential for thyroid function. However, epidemiological studies on the association between Se status and thyroid function are limited and the results are inconsistent. Therefore, we explored this association in an elderly Chinese population sample. Participants in the cross-sectional study were people aged 65 years or older who provided fingernail and whole blood samples. Hyperthyroidism and hypothyroidism were defined by serum thyroid hormones concentrations, including thyroid stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT3), and free thyrotropin (FT4). Significant positive association was observed between whole blood and fingernail Se concentrations (r = 0.672, P < 0.001). Compared with the lowest Se quartile (Q1), the other fingernail Se quartile groups had lower TSH, higher FT3 and FT4 levels, and Q2 had higher TT3 levels after adjusting for covariates; the other whole blood Se quartile groups had lower TSH levels, Q2 had higher FT3, FT4 and TT3 levels, Q3 had higher FT3 levels, and Q4 had higher FT4 levels after adjusting for covariates. Compared with Q1, the adjusted odds ratios (OR) and 95% confidence intervals (95%CIs) of hypothyroidism for Q4 of whole blood Se was 0.141 (0.029,0.675), and the adjusted OR (95%CIs) of hyperthyroidism for Q2 and Q3 of fingernail Se were 4.121 (1.233,13.733) and 3.614 (1.095,11.926). Higher Se levels were significantly associated with lower TSH levels and higher levels of TT3, FT3 and FT4. Meanwhile, higher Se levels were associated with lower risk of hypothyroidism and higher risk of hyperthyroidism.

Subacute Granulomatous Thyroiditis Occurring after SARS-CoV-2 Infection: A Case Report

Subacute thyroiditis is a rare self-limited thyroid inflammatory condition characterized in the majority of cases by sudden onset of neck pain. It seems to be mostly linked, directly or indirectly, to viral infections. During the COVID-19 pandemic, several cases of thyroiditis were reported in the literature, occurring during or after infection by the SARS-CoV-2, suggesting that this virus is also linked to subacute thyroiditis. Therefore, knowledge of a possible association between these two entities is of the most importance. Several hypotheses explaining the mechanism of action of SARS-CoV-2 on the thyroid gland have been put forward. Clinical symptoms do not appear to be very typical, and thyroid hormonal dysfunction may not be present. Treatment is essentially based on corticosteroids and NSAIDs. The prognosis remains favorable. We report the case of a 46-year-old woman who presented with subacute thyroiditis 25 days after SARS-CoV-2 infection. Her workup showed elevated CRP, multinodular goiter, normal thyroid function and negative antibodies. She was treated with corticosteroids that resulted in improvement of her symptoms.

Thyroid hormone dysfunction in MOGAD and other demyelinating diseases

BackgroundThyroid hormones play a critical role in both neuronal and glial cell functions. Multiple sclerosis (MS) has increased co-occurrence with autoimmune thyroid diseases, and recent studies have suggested a potential link between neuromyelitis optica spectrum disorder (NMOSD) and thyroid hormones. However, no previous studies have examined the relationship between thyroid hormones and myelin oligodendrocyte glycoprotein-associated demyelination (MOGAD). MethodsWe investigated the role of thyroid hormones in central nervous system (CNS) autoimmune demyelinating diseases in 26 MOGAD patients, 52 NMOSD patients, 167 patients with MS, and 16 patients with other noninflammatory neurological disorders. Thyroid hormone levels and clinical data (Expanded Disability Status Scale [EDSS]) were analyzed. Volumetric brain information was determined in brain magnetic resonance imaging (MRI) using the MDbrain platform. ResultsMOGAD patients had significantly higher levels of free triiodothyronine (FT3) compared to NMOSD patients. No correlation was found between FT3 levels and disease severity or brain volume. Thyroid-stimulating hormone (TSH) levels did not differ significantly between the groups, but in NMOSD patients, higher TSH levels were associated with lower disability scores and increased brain volume. No significant differences in free thyroxine (FT4) levels were observed between the different groups, however, FT4 levels were significantly higher in relapsing versus monophasic MOGAD patients and increased FT4 levels were associated with a higher EDSS and lower brain volume in NMOSD patients. ConclusionOur findings highlight the potential involvement of thyroid hormones specifically in MOGAD patients and other demyelinating CNS disorders. Understanding the role of thyroid hormones in relapsing vs monophasic MOGAD patients and in comparison to other demyelinating disorder could lead to the development of therapeutic interventions. Further studies are needed to explore the precise mechanisms and potential interventions targeting the thyroid axis as a treatment strategy.

Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction

Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p&gt;0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p&gt;0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p&lt;0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.

Relationship between Osteoarthritis and Thyroid Dysfunction, as well as with Physical and Demographic Features

Osteoarthritis (OA) is a commonly prevalent and chronically complicated condition that affects different joints in millions of patients worldwide, leading to a cumulative effect over time. Due to few global prospective studies, this study investigated the association of OA to bodily and demographic characteristics of the study population. It demonstrated the levels of thyroid hormones in OA patients. Totally, 324 individuals; 162 normal (GN), 111 doubtful to minimal OA (GOA1) and 51 moderately to severe OA (GOA2) were subjected to this study from September to December (2021). For bodily characteristics of the study population, the findings of age, height and gender showed insignificance between study groups but not in weight and BMI. Regarding demographic data, level of education, non-smoking and smoking, and non-arthritis and arthritis population were associated almost insignificantly with OA patients except for GOA2 patients, who showed a significant correlation to OA compared to GOA1 and GN. For chronic diseases, the association was observed insignificantly between GOA1, GOA2 and GN of 1 and 2 chronic diseases and between GOA1 and GN of 3 and 4 chronic diseases; however, significance was recorded in values of GOA2 in comparison with values of GOA1 and GN. For physical activity, significance was observed in low and high values but not in medium activities. Results without and with walking aids were variable significantly, in particular in values of GOA2 when compared to GOA1 and GN. Findings of TSH, T3 and T4 of GOA1, GOA2 and GN were correlated significantly. The association of TSH to the severity of OA revealed an obvious significance in values of crude, adjusted 1 and 2 models. In conclusion, this study was the first Iraqi report, and studies are necessary due to the significant association between OA and thyroid hormone dysfunction. Keywords: OA, T3, T4, TSH, Risk factor, Iraq

Assessment of Thyroid Functions in Multiple Sclerosis Patients Treated with Disease Modifying Therapies

Background:&#x0D; Multiple sclerosis is a chronic disease believed to be the result of autoimmune disorders of the central nervous system, characterised by inflammation, demyelination, and axonal transection, affecting primarily young adults. Disease modifying therapies have become widely used, and the rapid development of these drugs highlighted the need to update our knowledge on their short- and long-term safety profile.&#x0D; Objective:&#x0D; The study aim is to evaluate the impact of disease-modifying treatments on thyroid functions and thyroid autoantibodies with subsequent effects on the outcome of the disease.&#x0D; Materials and Methods:&#x0D; A retro prospective study enrolled 45 patients who were registered and diagnosed in the Multiple Sclerosis Clinic according to the revised McDonald criteria (2017). Blood samples for thyroid functions and thyroid autoantibody tests were taken before, 3 months and after 6 months from the start of disease modifying therapy. The Expanded Disability Status Scale was used to assess the severity of the disease before and after 6 months of receiving treatment.&#x0D; Results:&#x0D; 45 patients with the mean age of 33.3 years, a standard deviation (SD) of ± 9.5 years were enrolled in this study. (64.4%) patients’ age was between 20 - 39 years.&#x0D; The mean free T3 decreased significantly, while the mean anti-TPO and anti-TG increased after three months compared to its baseline level.&#x0D; After six months of treatment, the mean free T4 decreased significantly, while the mean TSH increased compared to its baseline level. There were no statistically significant correlations between the baseline (EDSS) score and after 6 months of therapy.&#x0D; Conclusion&#x0D; Thyroid hormone dysfunction and thyroid autoimmune antibody levels that changed in response to interferon beta therapy in patients with multiple sclerosis may be temporary and not associated with poor outcomes.

Liver Function Test Parameters in Hypothyroid Patients Visiting Tertiary Care Center of Western Nepal: A Cross-Sectional Study

Introduction: Due to the complicated interactions between the thyroid gland and liver, thyroid hormone dysfunction may affect the liver function tests, and could be of clinical importance. We aimed to compare the hepatic function parameters between hypothyroid and euthyroid patients visiting tertiary care center of western Nepal.&#x0D; Materials and Methods: This hospital-based cross-sectional study was conducted among 113 hypothyroid and 111 euthyroid patients. After consent, thyroid function and liver function parameters were analyzed using automated analyzers. Mann-Whitney U test, Spearman’s correlation, and multiple linear regression analysis were performed for analysis. A p-value of &lt;0.05 was considered statistically significant.&#x0D; Results: Among hypothyroid group, the majority were subclinical hypothyroid (n=74, 65.49%) and the rest (n = 39, 34.51%) were overt hypothyroid. The serum bilirubin and liver enzymes levels were significantly higher in hypothyroid compared to euthyroid. The serum albumin levels were significantly lower in the hypothyroid group. Serum liver enzymes and bilirubin levels were correlated negatively and positively with the thyroid hormones (fT3, fT4) and TSH levels, respectively.&#x0D; Conclusion: Patients with hypothyroidism and euthyroid patients had significantly different liver function test results. Although serum albumin was lower in the hypothyroid group, serum bilirubin and liver enzymes were higher.

Abstract #1406373: A Rare Case of Hyperthyroidism in a Patient with Metastatic Thyroid Cancer Presenting as Flaccid Paralysis

Hyperthyroidism in patients with thyroid cancer is rare although increasingly reported. We describe an unusual case of hyperthyroidism associated with metastatic thyroid cancer presenting as flaccid paralysis. A 53-year-old man with a history of a goiter presented to our hospital with severe low back pain for 1 month and inability to walk. He experienced loss of sensation and motor strength in his legs a few days prior to admission. Of note, he was informed about a neck mass years ago, but elected not to follow-up with any medical providers. MRI and CT imaging revealed a large mediastinal mass with cervical lymphadenopathy and multiple lytic lesions in the spine (T11, L1, L5), right ilium, lung, and liver. Initial labs showed mild hyperthyroidism. Biopsy of a right cervical lymph node revealed metastatic thyroid carcinoma, favoring follicular variant of papillary thyroid carcinoma. His hospital course was further complicated by bowel perforation and atrial fibrillation, requiring amiodarone to control his tachyarrhythmia. Subsequent labs revealed worsening thyrotoxicosis with free T4 of 7.62 ng/dL, free T3 of 14.55 pmol/L, and negative thyroid antibodies. He was a poor surgical candidate and unable to receive radioiodine for diagnosis or treatment due to his recent iodine exposure. Methimazole and PTU were not administered as he was strict NPO due to concerns of worsening his bowel perforation. Instead, he received high-dose dexamethasone for both his spinal cord compression and hyperthyroidism. After extensive goals of care discussion, he was eventually transitioned to hospice care. Hyperthyroidism associated with thyroid cancer is rare, as these cancers are typically hypo-functioning and suppression of thyrotropin helps decrease cancer progression. However, these cases are increasingly described in the literature, with a recent systematic review reporting 28 cases of hyperthyroidism in metastatic thyroid cancer patients. Among patients with thyroid cancers, hyperthyroidism can arise from the primary lesion, metastatic lesions, underlying Graves’ disease, toxic nodules, or even precipitated by a large iodine load. The etiology of hyperthyroidism in our patient is unconfirmed, but given the degree of his thyrotoxicosis, we suspect it was primarily from his metastatic disease and worsened by iodinated contrast and/or amiodarone. Our case highlights the importance of monitoring thyroid hormone levels in patients with thyroid cancers and the consequence of using iodine-containing medications, which can precipitate thyroid hormone dysfunction and delay appropriate treatments such as radioiodine ablation.

Frequency of Thyroid Disorder in Pre- and Post-Menopausal Women and Its Association with Menopausal Symptoms – A Scoping Review

The most prevalent endocrine issue affecting women is thyroid dysfunction. Thyroid hormone has a significant effect on women’s life. Its dysfunction is widespread, particularly among women over 50. Understanding how thyroid disease’s clinical symptoms change with ageing is crucial when treating peri- and post-menopausal women. Considering that 30% of India’s population is female, the thyroid disease epidemic appears to affect Indian women more than any other ailment. Detection of frequency of thyroid disorder in pre- and post-menopausal women and its association with menopausal symptoms. This scoping review was done using Preferred Reporting Items for Systematic reviews and Meta-Analyses-extension for Scoping Reviews guidelines. Database searches in Pub Med, Web of Science, and Scopus were done. The research question was clarified and modified using keywords. After database searches 10 relevant articles were obtained and were included in this study. A meta-analysis method and extra analytical research carried out in tertiary care center were used to synthesize the findings. Compilation of data extracted from different previous studies done which showed frequency of thyroid hormone changes in women in pre- and post-menopausal age groups from which the conclusion of the present study made. This scoping review highlighted that thyroid hormone dysfunction needs to be correlated to menopausal symptoms. As thyroid hormone dysfunction is common in peri- and post-menopausal age groups, which was seen in many articles that we have reviewed, its correlation to menopausal symptoms is more important. Thyroid disorders can be detected and treated early and improve quality of life. Future research on this correlation is required which was not found in current articles.

Thyroid Hormone Dysfunction and CRP Levels in children with Sepsis

Thyroid Hormone Dysfunction and CRP Levels in children with Sepsis

Biological effects related to exposure to polychlorinated biphenyl (PCB) and decabromodiphenyl ether (BDE-209) on cats.

As an animal familiar to humans, cats are considered to be sensitive to chemicals; cats may be exposed to polychlorinated biphenyls (PCBs) and decabromodiphenyl ether (BDE-209) from indoor dust, household products, and common pet food, leading to adverse endocrine effects, such as thyroid hormone dysfunction. To elucidate the general biological effects resulting from exposure of cats to PCBs and PBDEs, cats were treated with a single i.p. dose of a principal mixture of 12 PCBs and observed for a short-term period. Results revealed that the testis weight, serum albumin, and total protein of the treated group decrease statistically in comparison with those in the control group. The negative correlations suggested that the decrease in the total protein and albumin levels may be disturbed by 4'OH-CB18, 3'OH-CB28 and 3OH-CB101. Meanwhile, the serum albumin level and relative brain weight decreased significantly for cats subjected to 1-year continuous oral administration of BDE-209 in comparison to those of control cats. In addition, the subcutaneous fat as well as serum high-density lipoprotein (HDL) and triglycerides (TG) levels increased in cats treated with BDE-209 and down-regulation of stearoyl-CoA desaturase mRNA expression in the liver occurred. These results suggested that chronic BDE-209 treatment may restrain lipolysis in the liver, which is associated with lipogenesis in the subcutaneous fat. Evidence of liver and kidney cell damage was not observed as there was no significant difference in the liver enzymes, blood urea nitrogen and creatinine levels between the two groups of both experiments. To the best of our knowledge, this is the first study that provides information on the biochemical effects of organohalogen compounds in cats. Further investigations on risk assessment and other potential health effects of PCBs and PBDEs on the reproductive system, brain, and lipid metabolism in cats are required.

Thyroid Profile of Childhood Tuberculosis Treated with Anti Tuberculosis Drug During Intensive Phase

Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. The incidence is 10 % in children. Tuberculosis has high morbidity and mortality which needs adequate treatment. The side effects of FDC is thyroid hormone dysfunction which can interfere children's quality of life. However, research about the effect of FDC therapy on thyroid hormone profile in children with TB are very limited. Objective: To determine the effect of anti-tuberculosis drug treatment on thyroid hormone profile in paediatric tuberculosis. Methods: A one group pretest-posttest design study of 50 patients was conducted at the Semarang Health Center for the period January 2021-June 2021. Thyroid function tests of TSH, FT4 and T3, in TB children were measured before FDC therapy and 2 months after administration. The data were analysed descriptively and a comparative test was performed using SPSS 25.Results: There were no significant differences in TSH, FT4 and T3 serum levels before FDC therapy and 2 months of FDC administration. Thyroid hormone levels before treatment and 2 months after administration of FDC, respectively, euthyroid in 44 vs 42 patients.Conclusion: Two months of tuberculosis treatment in children decreased the serum FT4 and T3 level but no changes in the serum TSH level before and after the treatment.

Association between polychlorinated biphenyl exposure and thyroid hormones: a systematic review and meta-analysis

Purpose: To conduct a comprehensive meta-analysis investigating the association between polychlorinated biphenyl (PCB) exposure and serum thyroid hormone levels among adults. Methods: Eleven studies met inclusion criteria for analysis following systematic search of PubMed, Embase, and Scopus databases. Of these, 7 studies measured exposure by the total sum of PCB congeners (∑PCB), 1 study measured individual PCB congener levels, and 3 studies measured both ∑PCB levels and PCB congener levels. Correlation coefficients (r) were extracted from each study. Summary estimates were calculated for ∑PCB levels and PCB congeners reported by 2 or more studies: PCB 28, 52, 101, 105, 118, 138, 153, and 180, using random effects model. Results: Significant negative correlation was found between ∑PCBs and T3 (r: −0.09; 95% CI: −0.17, −0.02) and FT3 (r: −0.24; 95% CI: −0.36, −0.12). Congener-specific analysis found T3 to be negatively correlated with PCB-153 (r: −0.19; 95% CI: −0.34, −0.03) and PCB-180 (r: −0.14; 95% CI: −0.26, −0.01), whereas TSH was positively correlated with PCB-105 (r: 0.15; 95% CI: 0.02, 0.28). Conclusions: The present study is the first meta-analysis to investigate the association between PCB exposure and thyroid hormone dysfunction among adults. Results suggest a significant association between PCB exposure and thyroid hormone dysregulation.

Network Toxicology Guided Mechanism Study on the Association between Thyroid Function and Exposures to Polychlorinated Biphenyls Mixture.

Polychlorinated biphenyls (PCBs) are persistent and highly toxic pollutants, which can accumulate in organisms and produce toxic effects, especially damaging the function of thyroid hormones. So far, the molecular mechanism of PCBs mixture and their metabolites interfering with thyroid hormones has not been studied thoroughly except for individual compounds. In this study, PubMed, Web of Science, and STITCH databases were used to search PCBs and their corresponding target proteins. The intersection of PCBs and thyroid hormone dysfunction target proteins was obtained from GeneCards. The “compounds-targets-pathways” network was constructed by Cytoscape software. And KEGG and Go analyses were performed for key targets. Finally, molecular docking was used to verify the binding effect. Four major active components, five key targets, and 10 kernel pathways were successfully screened by constructing the network. Functional enrichment analysis showed that the interference was mediated by cancer, proteoglycans, PI3K-Akt, thyroid hormone, and FoxO signaling pathways. The molecular docking results showed that the binding energies were less than -5 kcal·mol−1. PCBs and their metabolites may act on the key targets of MAPK3, MAPK1, RXRA, PIK3R1, and TP53. The toxic effect of sulfated and methyl sulfone PCBs is greater. The method of screening targets based on the simultaneous action of multiple PCBs can provide a reference for other research. The targets were not found in previous metabolite toxicity studies. It also provides a bridge for the toxic effects and experimental research of PCBs and their metabolites in the future.

ASSESSMENT OF THYROID HORMONE ABNORMALITIES IN PATIENTS OF DOWN SYNDROME

Down syndrome is the fourth most come syndrome caused by chromosomal abnormalities. This syndrome includes many abnormalities such as thyroid hormone disfunction. The current study was designed to determine the prevalence of thyroid dysfunction in clinically diagnosed cases of Down syndrome patients that were confirmed on karyotyping later before including in the study. This Cross-sectional study was carried out at different Hospitals of Lahore to find out the prevalence of thyroid hormone dysfunction in 50 clinically diagnosed Down syndrome (DS) subjects from September 2019 to May 2021 by measuring thyroid function test (T3, T4, TSH), and antithyroid antibodies (ATA). A total 50 Down syndrome cases were included in the study and found majority of the patients were males 33(66.0%) while 17(34.0%) were female. Thyroid dysfunction was found in 27 (54%) of DS subjects, of whom 13 (26.0%) had hypothyroidism, 08 (16.0%) were having subclinical hypothyroidism, 01 (2.0%) had sick thyroid syndrome, 4 (8.0%) were hyperthyroidism and 01 (2.0%) were subclinical hyperthyroidism. ATA was positive in 07 (14.0%) patients of DS, of whom 02 (28%) were male and 05 were female (72%), 03 had hypothyroidism, 02 had hyperthyroidism, 02 had subclinical hypothyroidism. remaining 23 (46.0%) were having euthyroid status. This study showed 54% of down syndrome patients that were clinically diagnosed had thyroid hormone dysfunction. It can be concluded that thyroid hormone dysfunction in found in high prevalence in DS patients.

Relationships between Glycemic and Lipid Control and TSH in Euthyroid Latinx Adults- a Community-Based Study

ObjectivesThyroid hormone abnormalities are among the most common endocrine disorders comorbidly suffered alongside metabolic syndrome and type 2 diabetes mellitus (T2DM). Thyroid hormones and their regulating hormone, thyroid-stimulating hormone (TSH), play a role in metabolism, obesity, insulin resistance and other disorders that share similar mechanisms. The aim of this study was to examine the associations between TSH and clinical measures of chronic disease markers in a Latinx population receiving free health care services at a community clinic. MethodsA needs assessment was conducted on euthyroid Latinx adult patients from a community clinic in south Florida. The medical records of 93 randomly selected patients were cross-sectionally reviewed to collect data on demographics, diagnoses of health conditions, and biomedical laboratory information. The cut-off point for high TSH was ≥2 mU/L and low TSH as <2 mU/L. Statistical analyses included descriptive statistics, independent t-test, chi-squared test, logistic regressions. ResultsThe mean age was 51.9 ± 11.8 years and 82.8% were female. There were no differences between low and high TSH groups on age, gender, BMI, hypertension, T2DM, CVD, or CVD risk factors. The low TSH group had significantly higher fasting glucose (194.0 mg/dL ± 86.2 vs 140 mg/dL ± 52.8, P = 0.046), hemoglobin A1c (9.6% ±2.8 vs 7.5% ±1.5, P = 0.018), and total cholesterol (200.5 mg/dL ± 32.8 vs 171.5 mg/dL ± 39.7, P = 0.034) compared with the high TSH group. Subgroup analysis of those with T2DM revealed that the low TSH group also had a greater proportion of patients with high fasting glucose (≥170 mg/dL) and high hemoglobin A1c (≥8.5%) compared with the high TSH group. Similarly, those with a low TSH had 6 times greater odds of having high fasting glucose (OR 6.66, 95% CI 1.31–33.69, P = 0.022) and high hemoglobin A1c (OR 6.11, 95% CI 1.19–31.16, P = 0.029). ConclusionsIn Latinx euthyroid patients receiving medical services at a community clinic, a relationship between low-normal TSH levels, fasting glucose and hemoglobin A1c was demonstrated. As the population ages and the risk of both obesity and multimorbidity increases, understanding how thyroid hormone dysfunction can influence chronic disease status may help address health disparities suffered in disadvantaged and vulnerable populations. Funding SourcesFIU RCMI/NIMHD