Thyroid Globulin Antibody Research Articles

Analysis of the clinical data of 2843 patients with thyroid nodules

Objective To analyze the clinical and pathological characteristics of thyroid nodules.Methods A retrospective analysis of the clinical data of 2843 Han patients with thyroid nodules from January 2009 to June 2011 in Henan province was performed.Results The most high-risk of thyroid nodule resided in the group aged 45-54.The main pathological manifestation was simple nodular goiter.The rate of preoperative misdiagnosis was 2.4％.22.1％ of the patients with thyroid nodules showed abnormal thyroid function,which was mainly as subclinical thyroid dysfunction.The positive rate of thyroid peroxidase antibody (TPOAb) in patients with thyroid nodule was 19.8％ while that of thyroid globulin antibody (TgAb) was 20.0％.Among all 2843 subjects,the prevalence of differentiated thyroid carcinoma (DTC) was 28.8％,and the incidence of DTC was accompanied by raised TSH levels.The prevalence of DTC exceeded 40％ in patients aged between 25 to 34 as well as more than 74 years old.The prevalence of DTC was up to 33.8％ in TgAb positive patients.There was no difference in TPOAb levels between DTC patients and non DTC patients (P =0.406),but the TgAb level in patients with DTC was significantly higher than that of non DTC patients (P =0.033).Conclusion Thyroid nodule patients aged 25-34 or older than 74 formed high-risk groups of DTC.The serum TSH level and TgAb level were positively correlated with the risk of DTC. Key words: Thyroid nodule; Thyroid function; Thyroid autoantibody; Differentiated thyroid cancer

Clinical significance of diffusely increased 18F-FDG uptake in the thyroid

Total 1 190 subjects undertook 18SF-FDG PET/CT from June 2007 to January 2008 in the nuclear medicine department of Ruijin hospital, and the data were retrospectively reviewed. 20 (1.6%) subjects were found to have increased diffuse 18F-FDG uptake in the thyroid. The detectable rate in female was higher than that in male(3.0% vs 0. 63%). Compared with the control subjects without 18F-FDG uptake, the positive rates of thyroid globulin antibody (TgAb), thyroid microsome antibody (McAb) in the study group were obviously higher (55%vs 10%). The TgAb and McAb levels were not correlated with SUVmax of 18F-FDG uptake in 11 subjects with positive anti-thyroid antibody(all P>0. 05). Diffuse increase of 18SF-FDG uptake in the thyroid seems to be linked with chronic lymphocytic thyroiditis. Key words: Thyroid; 18F-fluorodeoxyglucose positron emission tomography/oomputed tomography; Diffusely increased uptake

Cardiac Wall Motion Abnormalities Observed in a Patient With Transient Hyperthyroidism

A 74-year-old woman, with a history of hypertension and hyperlipidemia, was admitted to our hospital. She was found to have a sinus tachycardia with ST-segment elevations in leads II, III, (a)V(F), and V(3) through V(6) in electrocardiography, hypokinesis of the left ventricular apex by echocardiography, and normal findings on coronary angiography. Blood analysis revealed an increase in the creatine kinase MB fraction, a significant positive detection in troponin T, and transient elevations in the concentrations of free triiodothyronine, free thyroxine, thyroid globulin antibody, and thyroid peroxidase antibody. Defects in myocardial perfusion and fatty acid metabolism in the apical area were also demonstrated by myocardial scintigraphy. These data suggest that tako-tsubo syndrome or myocardial infarction may be induced in patients with mild and transient hyperthyroidism.