Thymopoietin Pentapeptide Research Articles

Infantile thymectomy: Alterations in circulating T-cell subpopulations and in vitro effects of thymopoietin pentapeptide

An infant who underwent complete thymectomy was shown to have in the circulation persistence of high proportions of T cells with complement receptors, low proportions of Tγ cells, and poor locomotor activity of T lymphocytes toward casein and endotoxin-activated serum. These data suggest that the circulating T cells were relatively immature. In vitro incubation of these T cells with thymopoietin pentapeptide resulted in an increase in the proportions of Tγ cells and a decrease in the proportions of T cells with complement receptors.