This paper reports the investigation of acoustic combustion instability experienced during repetitive ignition testing of a sub-scale LOX-methane rocket thrust chamber. The occurrence of resonant coupling between the LOX injectors and the combustion chamber acoustic modes was assessed from the experimental data recorded during the highly transient phase of operation from ignition up to around 2 s. A method was developed to model the evolution of acoustic properties in both the combustion chamber and the injectors during the transient period. For the LOX injectors, the Woods equation was used to estimate the speed of sound in the two-phase flow. The models were used to identify the corresponding mode frequencies in the unsteady pressure measurements, and show that the high-amplitude instability occurred when they intersected. Very close coupling of less than 3% frequency difference is required for high amplitudes to be observed. However, the condition was necessary but not sufficient for high amplitudes to be reached.