Numerous mature oil and gas reservoirs around the world, along with added financial benefit, present a tremendous benefit of CO2 EOR and storage, especially in the regions where tax benefits and policies related to the CCS is limited. This work presents the first effort of CO2 EOR and storage in a mature oil field in India through a comprehensive application of laboratory study, reservoir static modeling, dynamic simulation, pilot design, and techno-economic sensitivity analyses. Through this case study, the technical feasibility of CO2 EOR and associated storage was assured for the first time through a novel approach of combining various subsurface and surface data with laboratory analyses. Almost no analog was available for CCUS on the same-age rock from a young thrust belt setting. The various vintages of core to seismic scale data posed a great challenge for effective integration. The solution approach to these issues included combining flow physics, fluid chemistry, geological concepts and digital modeling with practical engineering data analyses. Temporal change of oil composition in this reservoir due to the long production history had created some challenges for determination of CO2 miscibility. It was estimated through the lab study and modeling that the miscibility can be achieved near 3000 psi due to its altered oil composition resulted by years of production. To arrest the reservoir pressure decline, a pre-EOR water injection was identified as an immediately need to re-pressurize the reservoir and achieve miscibility of injected CO2. Comprehensive analysis of various subsurface and surface data integrating geoscience and engineering techniques have allowed for a consistent and applicable 3D description of reservoir, which was critical to identify suitable areas with appropriate remaining oil saturation, chemistry, and reservoir pressure. The history matching-calibrated-simulation model was utilized to evaluate the performance of various development scenarios of the identified area. Specifically, CO2 injection in a sector of geological model was performed using Todd-Longstaff miscible flood scheme. Upon comparing the proposed scenarios, a CO2 injection pilot in Pattern-1 was identified, with one injector and three producers over ∼60 acres area. This pilot uses 150 Metric Ton/day (MT/D) of CO2 captured and processed from an existing facility and transported about 70 km to the field location. The CO2 will be injected continuously into this pilot area for 5 years, and the well switches back to water injection afterward. Around 1.1 MMSTB incremental oil will be recovered in next 10 years, corresponding to 11.7% of OOIP in the flooded area. Up to 268,275 MT of CO2 will be sequestered in the reservoir. The learnings from this first ever study of its kind in India set the benchmark for data analysis, integration, and case specific approaches. The success and knowledge base from this endeavor will tremendously help and encourage further expansion of CCUS activities in India.