AbstractThe Manantiales basin contains >4 km of nonmarine sedimentary strata that accumulated at 31.75–32.5°S during construction of the High Andes. We report field and analytical data from the underexplored northern portion of this basin. The basin contains upper Eocene–middle Miocene strata that accumulated in back‐bulge or distal foredeep through inner‐wedge‐top depozones of the Andean foreland basin as it migrated through this region. A revised accumulation history for the basin‐filling Río de los Patos and Chinches Formations supports a regional pattern of flexure in front of an east‐vergent orogenic wedge. The former formation consists of eolian and localized fluviolacustrine deposits which accumulated between ca. 38 Ma and ≤34 Ma during thrust belt development in Chile. A subsequent ≤12 Myr hiatus may reflect passage of the flexural forebulge or cessation of subsidence during orogenic quiescence. The overlying Chinches Formation records a transition from the foredeep to wedge‐top depozones. Foredeep deposits of east‐flowing, meandering streams were incised prior to ca. 18 Ma, after which deposits of axial rivers, playas, and perennial lakes ponded in a depression behind orogenic topography to the east. After ca. 15 Ma, alluvial‐fan deposits were syndepositionally deformed adjacent to growing thrust‐belt structures along the western basin margin. Although the basin record supports a westward step in the locus of deformation during Early–Middle Miocene time, it conflicts with models involving west‐vergence of the orogenic wedge. Rather, this pattern can be explained as out‐of‐sequence deformation alternating with wedge forward propagation, consistent with Coulomb wedge models incorporating syntectonic sedimentation.