Threshold In Mice Research Articles

Antagonism of Convulsive and Lethal Effects Induced by Propoxyphene

A toxicological study was performed to demonstrate the effectiveness of several proposed antidotes against the convulsant and lethal effects of propoxyphene hydrochloride. Intravenous administration of levallorphan tartrate, nalorphine hydrochloride, or naloxone hydrochloride at a dose of 1 mg./Kg. significantly increased convulsion threshold and mortality threshold of mice and rats infused with propoxyphene hydrochloride. Treatment with levallorphan tartrate, 1 mg./Kg., plus sodium pentobarbital, 10 mg./Kg., or sodium pentobarbital alone, 10 mg./Kg., prevented propoxyphene-induced convulsions in a large percentage of mice and rats. The combination treatment was effective in elevating mortality threshold in both species, but was no more effective in this respect than a narcotic antagonist alone. Pentobarbital failed to modify mortality threshold. It is recommended that any one of the narcotic antagonists, without pentobarbital, be used to counteract the toxic symptoms of propoxyphene hydrochloride poisoning.

Chemoconvulsive thresholds in mice of differing audioconvulsive susceptibilities.

Les souris des lignees susceptibles et resistantes de la crise audiogene ont ete etudiees a l'egard de seuil de sensibilite au convulsivant chimiques, l'ether hexafluorodiethyle. Les sensibilites a la stimulation audiogene et chimique ne montre pas de correlation positive.

Absolute Behavioral Auditory Thresholds in Mice

The experiment was designed to obtain behavioral measures of absolute auditory thresholds and to compare them with cochlear potentials and with single-unit eighth-nerve-fiber thresholds. Mice were selected because certain strains display pathological conditions that appear similar to some congenital auditory defects found in humans. The present study deals only with normal mice. Results of avoidance and escape-conditioning techniques are compared, as are results of the psychophysical method of limits and the method of constant stimuli. The animal was trained to avoid shock (in avoidance-conditioning) by responding to the tone alone, or to terminate shock (in escape-conditioning) by making one response to tone plus shock and another to shock alone. The range of frequencies tested was 500–32 000 cps. The test chamber was placed inside a sound-shielded box. Tones were transmitted from one oscillator outside the box. The intensity of all tones and the noise level in the test chamber were measured by a wave analyzer. Shock was administered through the grid floor. Results are discussed in terms of the minimum sound intensity required at the various frequencies, response latency, and response variability. Some problems inherent in the training techniques are described.

THE EFFECT OF EXPERIMENTALLY-INDUCED STRESS ON PENTYLENETETRAZOL SEIZURE THRESHOLD IN MICE.

The effect of 20 min of intermittent foot shock on spontaneous activity and overt behavior was studied in mice. In addition, the effect of a pain-induced conditioned emotional response, and of total body immobilization and postural disequilibrium on the pentylenetetrazol seizure threshold was determined. Foot shock decreased spontaneous motor activity, and induced responses characterized by immobility, crouching, and increased defecation. The pain-induced conditioned emotional response, total body immobilization, and postural disequilibrium all lowered seizure threshold. Data are presented which indicate that there is a direct relation between the reduction in seizure threshold and the intensity of the disturbed emotional state. In addition, it is suggested that the observed increase in brain excitability caused by apprehension and anxiety may result from the effect of endogenouslyreleased catecholamines on the central nervous system. Reference is made to the relation between these findings and the effect of emotional disturbances on seizure frequency in human epileptics.

A CIRCADIAN RHYTHM OF CHEMOCONVULSIVE RESPONSE THRESHOLDS IN MICE.

A CIRCADIAN RHYTHM OF CHEMOCONVULSIVE RESPONSE THRESHOLDS IN MICE.

Anticonvulsant effect of nialamide and diphenylhydantoin.

Summary1. Nialamide increased the maximal electroshock seizure threshold in mice and rats. This effect was independent of the elevation of brain 5-HT and NE elicited by nialamide. 2. Diphenylhydantoin in doses from 6 to 55 mg/kg, which was almost 9 times the anticonvulsive dose, did not significantly alter the content of 5-HT or NE in the brain of mice. 3. Nialamide potentiated and reserpine decreased the anticonvulsant effect of diphenylhydantoin. No correlation could be found between these effects and brain amine levels.

Electro-clinical features of convulsions induced by stimulation of brain stem.

ArticlesELECTROCLINICAL FEATURES OF CONVULSIONS INDUCED BY STIMULATION OF BRAIN STEMA. Kreindler, E. Zuckermann, M. Steriade, and D. ChimionA. Kreindler, E. Zuckermann, M. Steriade, and D. ChimionPublished Online:01 Sep 1958https://doi.org/10.1152/jn.1958.21.5.430MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByDevelopmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuumRenzo Guerrini, Valerio Conti, Massimo Mantegazza, Simona Balestrini, Aristea S. Galanopoulou, and Fabio Benfenati14 October 2022 | Physiological Reviews, Vol. 103, No. 1Basilar Artery Occlusion with “Seizures” as a Presenting Symptom: Three Cases Treated Using Mechanical ThrombectomyWorld Neurosurgery, Vol. 117Dissociation of spontaneous seizures and brainstem seizure thresholds in mice exposed to eight flurothyl-induced generalized seizures19 December 2016 | Epilepsia Open, Vol. 2, No. 1The Repeated Flurothyl Seizure Model in MiceBIO-PROTOCOL, Vol. 7, No. 11Convulsive seizures induced by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid microinjection into the mesencephalic reticular formation in ratsBrain Research, Vol. 1021, No. 1Partial Epilepsy Manifesting Atonic Seizure: Report of Two Cases8 November 2002 | Epilepsia, Vol. 43, No. 11Kindling of the midbrain periaqueductal gray in ratsBrain Research, Vol. 903, No. 1-2Generalized Tonic and Tonic-Clonic Seizures of Childhood2 July 2016 | Journal of Child Neurology, Vol. 13, No. 5Endogenous control of epilepsy: The nigral inhibitory systemProgress in Neurobiology, Vol. 42, No. 1The brainstem cardioarrhythmogenic triggers and their possible role in sudden epileptic deathEpilepsy Research, Vol. 15, No. 3Dorsal tegmentum kindling in ratsNeuroscience Letters, Vol. 134, No. 2Seizures can be triggered by stimulating non-cortical structures in the quaking mutant mouseEpilepsy Research, Vol. 9, No. 1Selective stimulation of kainate but not quisqualate or NMDA receptors in substantia nigra evokes limbic motor seizuresBrain Research, Vol. 528, No. 2Secondary generalization of seizures from a cortical penicillin focus following stimulation of the basal forebrainExperimental Neurology, Vol. 109, No. 2Characterization of gabaergic seizure regulation in the midline thalamusNeuropharmacology, Vol. 29, No. 7Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and patternEpilepsy Research, Vol. 6, No. 1Red nucleus lesions delay the evolution of amygdala kindling in catsBrain Research, Vol. 422, No. 1Anterior thalamic mediation of generalized pentylenetetrazol seizuresBrain Research, Vol. 399, No. 2Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizuresBrain Research, Vol. 397, No. 2Modification of electroshock and pentylenetetrazol seizure patterns in rats affer precollicular transectionsExperimental Neurology, Vol. 93, No. 3Variation in threshold and pattern of electroshock-induced seizures in rats depending on site of stimulationLife Sciences, Vol. 37, No. 23Comparative effects of convulsant drugs on the sensory responses of neurons in the amygdala and brainstem reticular formationNeuropharmacology, Vol. 24, No. 12Motor paralysis in rats after repeated electroconvulsive shock: Comparison between aural and corneal stimulationLife Sciences, Vol. 37, No. 13Comparative effects of topical perfusions of pentylenetetrazol in the mesencephalon and cerebral cortex of catsExperimental Neurology, Vol. 87, No. 3Neuronal excitability control in health and disease: A neurophysiological comparison of REM sleep and epilepsyProgress in Neurobiology, Vol. 25, No. 2Push-pull perfusion of pentylenetetrazol in the brain stem of ‘encéphale isolé’ catsElectroencephalography and Clinical Neurophysiology, Vol. 56, No. 5Lesions of substantia nigra protect against experimentally induced seizuresBrain Research, Vol. 273, No. 1Brainstem reticular formation mechanisms subserving generalized seizures: Effects of convulsants and anticonvulsants on sensory-evoked responsesProgress in Neuro-Psychopharmacology, Vol. 2, No. 4Electroencephalographic correlates of the audiogenic seizure response of inbred micePhysiology & Behavior, Vol. 16, No. 5Alteration of the electroencephalogram during bromotrifluoromethane exposureToxicology and Applied Pharmacology, Vol. 16, No. 3Experimental epilepsy induced by cobalt powder in lower brain-stem and thalamic structuresElectroencephalography and Clinical Neurophysiology, Vol. 22, No. 6Motor convulsions and EEG during maximal electroshock in the ratInternational Journal of Neuropharmacology, Vol. 6, No. 3Differential sensitivity of various brain structures to the epileptogenic action of penicillinExperimental Neurology, Vol. 16, No. 4HyperexplexiaJournal of the Neurological Sciences, Vol. 3, No. 6Experimental epilepsy of brain-stem originElectroencephalography and Clinical Neurophysiology, Vol. 18, No. 4On the nature of the “absence” in centrencephalic epilepsy: A study of some behavioral, electroencephalographic and autonomic factorsElectroencephalography and Clinical Neurophysiology, Vol. 18, No. 4Some observations on the electrographic correlates of the decerebrate attackElectroencephalography and Clinical Neurophysiology, Vol. 16, No. 3A low threshold convulsive area in the rabbit's mesencephalonElectroencephalography and Clinical Neurophysiology, Vol. 15, No. 4 More from this issue > Volume 21Issue 5September 1958Pages 430-436 https://doi.org/10.1152/jn.1958.21.5.430PubMed13576185History Published online 1 September 1958 Published in print 1 September 1958 Metrics

Beeinflussung der cardiazolkrampfschwelle durch ver�nderten 5-hydroxytryptamingehalt des zentralnervensystems

1. The seizure threshold of mice was determined by means of timed i.v. infusion of Pentamethylenetetrazol (Metrazol, Cardiazol), after changing the Serotonin content of the brain by pretreatment with Reserpine, which is known to liberate Serotonin, an inhibitor of amineoxydase activity Iproniazid (IPN), and the precursor of Serotonin 5-Hydroxytryptophan (5-HTP).

Kinetics of sound induced convulsions in some inbred mouse strains.

ArticleKinetics of Sound Induced Convulsions In Some Inbred Mouse StrainsJohn L. Fuller, and Mary E. SmithJohn L. FullerFrom the Division of Behavior Studies, Hamilton Station R. B. Jackson Memorial Laboratory, Bar Harbor, Maine, and Mary E. SmithFrom the Division of Behavior Studies, Hamilton Station R. B. Jackson Memorial Laboratory, Bar Harbor, MainePublished Online:28 Feb 1953https://doi.org/10.1152/ajplegacy.1953.172.3.661MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByAudiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic featuresEpilepsy & Behavior, Vol. 71BIOLOGICAL ASSESSMENT OF TRANQUILLISERS. PART I12 April 2011 | Journal of Pharmacy and Pharmacology, Vol. 10, No. 1Developmental and genetic audiogenic seizure models: behavior and biological substratesNeuroscience & Biobehavioral Reviews, Vol. 24, No. 6Audiogenic seizures in the developmentally primed Long-Evans ratDevelopmental Psychobiology, Vol. 34, No. 4Recovery of Susceptibility to Audiogenic Seizure in MiceEpilepsia, Vol. 34, No. 1Lateralized audiogenic seizure: Motor asymmetries exhibited and the effects of interrupted stimulationBehavioral and Neural Biology, Vol. 46, No. 3Development of susceptibility to audiogenic seizures in DBA/2J and Rb mice: Toward a systematic nomenclature of audiogenic seizure levelsBehavior Genetics, Vol. 10, No. 6Audiogenic priming in DBA/2J and C57 BL/6J mice: Interactions among age, prime-to-test interval, and index of seizureDevelopmental Psychobiology, Vol. 9, No. 1The effect of parabiosis on audiogenic convulsions in seizure-susceptible miceExperimental Neurology, Vol. 26, No. 2Genetic and Temporal Characteristics of Audiogenic Seizures in MiceEffect of age and condition-test interval (days) on an audio-conditioned convulsive response in CF#1 miceDevelopmental Psychobiology, Vol. 1, No. 4Chemoconvulsive thresholds in mice of differing audioconvulsive susceptibilitiesExperientia, Vol. 20, No. 5Dilute Locus and Audiogenic Seizures in MiceScience, Vol. 136, No. 3513LiteraturverzeichnisBehaviour studies on inbred mice: A selected bibliographyAnimal Behaviour, Vol. 6, No. 1-2 More from this issue > Volume 172Issue 3February 1953Pages 661-670 Copyright & PermissionsCopyright © 1953 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1953.172.3.661PubMed13030800History Received 15 September 1952 Published online 28 February 1953 Published in print 28 February 1953 Metrics