Three-year Interval Research Articles

White matter development in early puberty: a longitudinal volumetric and diffusion tensor imaging twin study.

White matter microstructure and volume show synchronous developmental patterns in children. White matter volume increases considerably during development. Fractional anisotropy, a measure for white matter microstructural directionality, also increases with age. Development of white matter volume and development of white matter microstructure seem to go hand in hand. The extent to which the same or different genetic and/or environmental factors drive these two aspects of white matter maturation is currently unknown. We mapped changes in white matter volume, surface area and diffusion parameters in mono- and dizygotic twins who were scanned at age 9 (203 individuals) and again at age 12 (126 individuals). Over the three-year interval, white matter volume (+6.0%) and surface area (+1.7%) increased, fiber bundles expanded (most pronounced in the left arcuate fasciculus and splenium), and fractional anisotropy increased (+3.0%). Genes influenced white matter volume (heritability ∼85%), surface area (∼85%), and fractional anisotropy (locally 7% to 50%) at both ages. Finally, volumetric white matter growth was negatively correlated with fractional anisotropy increase (r = –0.62) and this relationship was driven by environmental factors. In children who showed the most pronounced white matter growth, fractional anisotropy increased the least and vice-versa. Thus, white matter development in childhood may reflect a process of both expansion and fiber optimization.

Recent trends in publication of basic science and clinical research by United States investigators in anesthesia journals

BackgroundUnited States anesthesia research production declined sharply from 1980-2005. Whether this trend has continued despite recent calls to improve output is unknown. We conducted an observational internet analysis to quantify American basic science and clinical anesthesia research output in 14 anesthesia journals with impact factors greater than one at three-year intervals during the past decade.ResultsAmerican investigators published 1,486 (21.7%) of the total of 6,845 research articles identified in anesthesia journals in 2001, 2004, 2007, and 2010. Approximately two-thirds of all US articles were published in Anesthesiology and Anesthesia and Analgesia. There was a significant correlation (r2 = 0.316; P = 0.036) between the number of articles published by American authors in each anesthesia journal and the corresponding journal's impact factor in 2010. Significantly (P < 0.05; Pearson's Chi-square) fewer basic science articles were published in 2007 and 2010 compared with 2001. US clinical research output also declined in 2007 (201; 15.7%) compared with 2001 (266; 19.1%) and 2004, but an increase occurred in 2010 (279; 21.8%, P < 0.05 versus 2007).ConclusionsThe results indicate that US anesthesia research output continued to decrease from 2001 to 2007. An increase in clinical but not basic science research was observed in 2010 compared with 2007, suggesting that a modest recovery in clinical research production may have begun.

Infektionshygienische Überwachung durch Gesundheitsämter – Empfehlungen (nicht nur) für den ÖGD in Rheinland-Pfalz

Protection against communicable diseases and the prevention of their transmission require continuous surveillance by the public health service. There is also a need for targeting certain -hygiene standards and expert advice concerning their application, especially in institutions where medical interventions provide an increased risk for patients, staff and the public (e. g., intensive care units in hospitals or ambulatory dialysis centres). While the kind of institutions at risk is sufficiently governed in the German law (either at national or state level), the frequency of side visits as well the content and depth of surveillance activities lack adequate regulation. As the implementation of the national Protection against Infections Act in 2001 has enlarged the work load of local public health authorities without adequate staff compensation a risk-based strategy is required for efficient work scheduling. In Rhineland-Palatinate a task force of experts mandated by the ministry of health has developed recommendations on how often and with which expertise side visits should be performed. Based on published evidence and expert knowledge, an assessment of the institutional risk has been conducted leading to concrete patterns. High risk areas should be monitored every year, whereas three-year and five-year intervals are sufficient for institutions at middle or low risk respectively. This scheme represents a standard which should be applied by all public health departments in the state (and maybe also in other states). On the one hand the execution of this standard is expected to ascertain more transparency, predictability and comprehensibility for all involved parties. On the other hand the time and qualification pattern complements the general guidelines of the national steering committee for hospital hygiene and infectious disease protection (KRINKO). It is hoped that the combination of both elements will support the professional -dialogue between public health authorities and representatives of the affected institutions -leading to a common understanding of what communicable -disease protection is all about.

Outcomes Among Black Patients With Stage II and III Colon Cancer Receiving Chemotherapy: An Analysis of ACCENT Adjuvant Trials

Among patients with resected colon cancer, black patients have worse survival than whites. We investigated whether disparities in survival and related endpoints would persist when patients were treated with identical therapies in controlled clinical trials. We assessed 14,611 patients (1218 black and 13,393 white) who received standardized adjuvant treatment in 12 randomized controlled clinical trials conducted in North America for resected stage II and stage III colon cancer between 1977 and 2002. Individual patient data on covariates and outcomes were extracted from the Adjuvant Colon Cancer ENdpoinTs (ACCENT) database. The endpoints examined in this meta-analysis were overall survival (time to death), recurrence-free survival (time to recurrence or death), and recurrence-free interval (time to recurrence). Cox models were stratified by study and controlled for sex, stage, age, and treatment to determine the effect of race. Kaplan-Meier estimates were adjusted for similar covariates to control for confounding. All statistical tests were two-sided. Black patients were younger than whites (median age, 58 vs 61 years, respectively; P < .001) and more likely to be female (55% vs 45%, respectively; P < .001). Overall survival was worse in black patients than whites (hazard ratio [HR] of death = 1.22, 95% confidence interval [CI] = 1.11 to 1.34, P < .001). Five-year overall survival rates for blacks and whites were 68.2% and 72.8%, respectively. When subsets defined by sex, stage, and age were analyzed, overall survival was consistently worse in black patients. Recurrence-free survival was worse in black patients than whites (HR of recurrence or death = 1.14, 95% CI = 1.04 to 1.24, P = .0045). Three-year recurrence-free survival rates in blacks and whites were 68.4% and 72.1%, respectively. In contrast, recurrence-free interval was similar in black and white patients (HR of recurrence = 1.08, 95% CI = 0.97 to 1.19, P = .15). Three-year recurrence-free interval rates in blacks and whites were 71.3% and 74.2%, respectively. Black patients with resected stage II and stage III colon cancer who were treated with the same therapy as white patients experienced worse overall and recurrence-free survival, but similar recurrence-free interval, compared with white patients. The differences in survival may be mostly because of factors unrelated to the patients' adjuvant colon cancer treatment.

HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy

BackgroundIn Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage negative women assures safety.Materials and MethodsAt the University Hospital of North Norway, cytology and the HPV mRNA test PreTect HPV-Proofer, detecting E6/E7 mRNA from HPV types 16, 18, 31, 33 and 45, are used in post-colposcopy follow-up of women with negative or low-grade biopsy. In this study, women with negative biopsy after high grade cytology (ASC-H/HSIL) and/or positive HPV mRNA test in the period 2005–2009 were included (n = 520). Histologically confirmed cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) was used as study endpoint.ResultsOf 520 women with negative or low-grade biopsy, 124 women (23.8%) had CIN2+ in follow-up biopsy. The sensitivity and specificity of the HPV mRNA test were 89.1% (95% CI, 80.1–98.1) and 92.5% (95% CI, 88.2–96.7), respectively. The ratios of sensitivity, specificity and PPV of HPV mRNA testing compared to repeat cytology for finding CIN2+ was 1.05 (95% CI: 0.92–1.21), 1.21 (95% CI: 1.12–1.32), and 1.49 (95% CI: 1.20–1.86), respectively. The PPV of mRNA was 77.3% (95% CI, 59.8–94.8) in women aged 40 or older.ConclusionWomen with negative cervical biopsy require follow-up before resumption of routine screening. Post-colposcopy HPV mRNA testing was as sensitive but more specific than post-colposcopy cytology. In addition, the HPV mRNA test showed higher PPV. A positive mRNA test post-colposcopy could justify treatment in women above 40 years.

Daphnia as a model organism in limnology and aquatic biology: some aspects of its reproduction and development

Invertebrates comprise the overwhelming majority of all animal species - around 95% of described species, not including substantial cryptic variation. As it is an extremely diverse and heterogeneous group, research on various invertebrate taxa often follows parallel trajectories, with little interaction among experts on different groups. To promote sharing of knowledge within as well as across taxa, the International Society of Invertebrate Reproduction and Development (ISIRD) was established in 1975 in Calicut, India. Since that time, the ISIRD has organised international conferences at three-year intervals where various aspects of invertebrate biology are presented and discussed, naturally with the focus on reproduction and development. Traditionally, marine invertebrate groups have been well represented at all ISIRD congresses, but freshwater invertebrates have often been relatively overlooked at these meetings. The 12th ISIRD congress took place between August 16 and 20, 2010 in Prague, the Czech Republic. Several different Czech institutions collaborated on the organisation of this meeting. As aquatic invertebrate research has a long tradition in the country, we decided to include a section dedicated to popular model organisms in aquatic ecology and evolutionary biology, the "water fleas", cladocerans of the genus Daphnia. The section entitled "Daphnia and other cladocerans as model organisms" was open to any aspects of cladoceran biology directly or indirectly related to their reproduction or development. Unfortunately, the timing of the Prague congress completely overlapped the triennial congress of the International Society of Theoretical and Applied Limnology (SIL) in Cape Town, South Africa. This large meeting in a very attractive setting attracted many cladocerologists from all over the world, including Europe. Therefore, the Daphnia section of the Prague ISIRD meeting remained moderate in size, attracting 13 contributions (eight talks and five poster presentations). The presenting authors mostly originated from Central European countries (the Czech Republic, Poland, Germany, and Austria) but the conference also attracted a visitor from overseas (Mexico). Although the section was small, some of the presentations evoked considerable interest among conference participants working on marine crustaceans. Information exchange between marine and freshwater biologists was promoted, and will hopefully persist at future ISIRD meetings. The contributions presented in the session covered a very wide range of topics, such as the interplay of sexual and asexual reproduction and its impact on seasonal population development and its clonal structure, the impact of major environmental disturbances (floods) on the status of Daphnia diapausing egg banks, factors promoting male production, the importance of Daphnia ageing, the effect of cyanobacteria on Daphnia growth, and the formation of antipredator morphological structures under different conditions. In this special insert, we present five papers from authors that attended the ISIRD meeting, from one German, two Czech, and two Polish teams.

Pressure Testing Feedwater Heaters and Power Plant Auxiliary Heat Exchangers

This paper discusses factory and field pressure testing of tubular heat transfer equipment such as closed feedwater heaters, steam surface condensers, and power plant auxiliary heat exchangers built in accordance with Section VIII, Division 1 of the ASME Boiler and Pressure Vessel Code (the ASME Code) and repaired or altered in accordance with the National Board Inspection Code (NBIC) (The ASME issues the ASME Boiler and Pressure Vessel Code at three-year intervals and issues Addenda annually; The National Board Inspection Code (NBIC), 2007 edition (three volumes), ANSI/NBBPVI NB23-2007, The National Board of Boiler and Pressure Vessel Inspectors, Cleveland, OH). It discusses the ASME Code’s and the NBIC’s requirements for hydrostatically testing unfired pressure vessels, which include tubular heat transfer equipment. It shows by analysis that using pressure gauge indications of pressure loss to determine if there is a leak from the tube side to the shell side when the back face of the tubesheet is not visible does not reveal very small leaks or weeping. For the purposes of this paper, we define weeping, Vleak, as a leak of 20 drops/h or approximately 1 cm3/h(0.061 in.3/h). During typical half-hour hydrostatic test pressure-holding periods, such weeping would amount to 10 drops of water on the tubesheet face or 0.5 cm3(0.0305 in.3). Weeping through tube-to-tubesheet joints of high pressure feedwater heaters can lead to wire drawing (wormholing), which can materially reduce the heater life. Leaks from the channel to the shell side of steam surface condensers and auxiliary condensers can introduce brackish water into the condensate. Depending upon the fluid flowing in the tubes, contaminants can enter the shell side of other auxiliary equipment when the channel pressure is higher than that of the shell. This paper concludes that users must advise designers and manufacturers of the hazards of small leaks through the tube-to-tubesheet joints. It recommends that these three entities must agree on suitable leak tests.

Persistently positive gliadin antibodies without transglutaminase antibodies in the elderly: Gluten intolerance beyond coeliac disease

Background The specificity of the conventional gliadin antibody test is considered low. Aims We explored whether gliadin antibody(AGA)-positivity without tissue transglutaminase antibodies (tTGA) is persistent in the elderly population and whether such positivity indicates overt or potential coeliac disease in genetically predisposed individuals. Methods AGA and tissue transglutaminase antibody were measured in 2089 elderly individuals twice with a three-year interval. AGA-positive but tissue transglutaminase antibody-negative subjects with coeliac-type human leucocyte antigen (HLA) were examined and underwent gastroduodenal endoscopy (cases). Small-bowel mucosal villous morphology and densities of CD3+ and γδ+ intraepithelial lymphocytes and the occurrence of tissue transglutaminase-specific IgA deposits were analysed. Randomly selected persistently AGA-negative age- and sex-matched subjects served as controls. Results AGA-positivity was persistent in 81% of those initially positive. Amongst the 49 clinically studied and 36 endoscopied cases only one (2.8%) had coeliac disease. Many (54%) showed signs of inflammation in the biopsy, without villous atrophy. Coeliac-type HLA was not over-represented in the persistently AGA-positive compared to the general population. Persistently AGA-positive coeliac-type HLA-positive subjects had more gastrointestinal symptoms than AGA-negative controls. Conclusions AGA-positivity is often persistent. Overt coeliac disease is seldom found behind persistent AGA-positivity, but this characteristic is associated with mucosal inflammation and gastrointestinal symptoms at least in HLA-positive individuals.

Longitudinal spillover effects of conflict resolution styles between adolescent-parent relationships and adolescent friendships.

This study longitudinally investigated spillover effects of conflict resolution styles in adolescent-parent relationships and adolescent friendships. Questionnaires about conflict resolution styles with parents and best friends were completed by adolescents from two age cohorts: 559 early adolescents (mean age 13.4) and 327 middle adolescents (mean age 17.7). Path analyses on two waves, with a three-year interval, indicated that in the early-to-middle adolescent group positive problem solving and conflict engagement spilled over from adolescent-parent relationships to adolescent friendships and not from adolescent friendships to adolescent-parent relationships. In the middle-to-late adolescent group, we found bidirectional spillover effects for these two conflict resolution styles. For withdrawal, we found bidirectional spillover effects in both cohorts. This study showed that both parents and friends set the stage for exercising and learning conflict resolution styles and thereby shape adolescents' future conflict behavior.

Magnetic Clouds at/near the 2007 – 2009 Solar Minimum: Frequency of Occurrence and Some Unusual Properties

Magnetic clouds (MCs) have been identified for the period 2007 – 2009 (at/near the recent solar minimum) from Wind data, then confirmed through MC parameter fitting using a force-free model. A dramatic increase in the frequency of occurrence of these events took place from the two early years of 2007 (with five MCs) and 2008 (one MC) compared to 2009 (12 MCs). This pattern approximately mirrors the occurrence-frequency profile that was observed over a three-year interval 12 years earlier, with eight events in 1995, four in 1996, and 17 in 1997, but decreased overall by a factor of 0.62 in number. However, the average estimated axial field strength [〈|B O|〉] taken over all of the 18 events of 2007 – 2009 (called the “recent period” here) was only 11.0 nT, whereas 〈|B O|〉 for the 29 events of 1995 – 1997 (called the “earlier period”) was 16.5 nT. This 33% average drop in 〈|B O|〉 is more or less consistent with the decreased three-year average interplanetary magnetic field intensity between these two periods, which shows a 23% drop. In the earlier period, the MCs were clearly of mixed types but predominantly of the South-to-North type, whereas those in the recent period are almost exclusively the North-to-South type; this change is consistent with global solar field changes predicted by Bothmer and Rust (Geophys. Monogr. Ser. 99, 139, 1997). As we have argued in earlier work (Lepping and Wu, J. Geophys. Res. 112, A10103, 2007), this change should make it possible to carry out (accurate short-term) magnetic storm forecasting by predicting the latter part of an MC from the earlier part, using a good MC parameter-fitting model with real-time data from a spacecraft at L1, for example. The recent set’s average duration is 15.2 hours, which is a 27% decrease compared to that of the earlier set, which had an average duration of 20.9 hours. In fact, all physical aspects of the recent MC set are shown to drop with respect to the earlier set; e.g., as well as the average internal magnetic field drop, the recent set had a somewhat low average speed of 379 km s−1 (5% drop), and the average diameter had a 24% drop. Hence, compared to the earlier set, the recent set consists of events that are smaller, slightly slower, and weaker in every respect (and fewer in number), but in a relative sense the two three-year sets have similar frequency-of-occurrence profiles. It is also interesting that the two sets have almost the same average axial inclinations, i.e., axial latitude ≈31° (in GSE). These MC characteristics are compared to relevant solar features and their changes. A preliminary assessment of the statistics on possible shocks and pressure pulses upstream of these recent MCs yields the following: About 28% of the MCs, at most, had shocks, and 33% had shocks and/or pressure pulses. These are low values, since typically the percentage of cases with shocks is about 50%, and the percentage with shocks and/or pressure pulses is usually about 75%.

The last dance of the bashful ballerina?

Aims. The heliospheric magnetic field (HMF) has long been hemispherically asymmetric so that the field in the northern hemisphere is weaker and the area larger than in the south. This asymmetry, also called the bashful ballerina, has existed during roughly three-year intervals of the late declining to minimum phase of solar cycles 16‐22. We study the HMF and its hemispheric asymmetry during the exceptional solar cycle 23. Methods. We use NASA National Space Science Data Center OMNI database, which contains all solar wind and HMF observations at the Earth’s orbit, and coronal field predictions by Wilcox Solar Observatory. We present a new method to study the global hemispheric asymmetry by using the power n of the radial decrease of the radial field from the coronal source surface to 1 AU. Results. We find that the HMF is exceptional at low latitudes in solar cycle 23: while the typical latitudinal variation was attained in the north in 2008, it did not take place in the south until Spring 2009. Thus, the Rosenberg-Coleman rule is abnormally delayed or broken for the first time in 50 years. The n-values verify the clear northern dominance in cycles 21‐22. However, the low-latitude observations depict a considerably smaller asymmetry in cycle 23, although Ulysses observations at high latitudes show an equally large asymmetry in 2007 and in 1994‐1995. We argue that the weak low-latitude visibility of the asymmetry in cycle 23 is due to the exceptionally weak polar fields, leading to large tilt angle and a wide current sheet. Conclusions. We note that the exceptional properties of cycle 23 (weak dynamo, large tilt, small asymmetry) agree with the long-term evolution of hemispheric asymmetry viewed at the Earth. The active Sun is seen as more asymmetric at the Earth than the quiet Sun because the polar coronal holes with unipolar fields extend closer to the equator, allowing their asymmetry to be viewed even at low latitudes. We suggest that, after the period of weak activity and small asymmetry at 1 AU that started with cycle 23, the hemispheric asymmetry will again, withthe increasingly active cycles, become better visible at 1 AU but the asymmetry will be oppositely oriented, including a northward shifted current sheet, and larger areas but weaker intensities in the south. Thus, the ballerina should no longer be systematically bashful for some 100‐150 years.

A natural history of weight change in men with prostate cancer on androgen-deprivation therapy (ADT): results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database

• To better understand the natural history of weight change with androgen-deprivation therapy (ADT), we investigated the effect of ADT on body weight among men from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. • Men undergoing ADT lose lean muscle but gain fat mass, contributing to an overall gain in weight. • We identified 132 men in SEARCH who received ADT after radical prostatectomy. • 'Weight change' was defined as the difference in weight before starting ADT (6 months before ADT) and the on-ADT weight (between 6 and 18 months after starting ADT). • In a subanalysis, baseline characteristics of weight-gainers and -losers were analysed using univariate and multivariate analysis to test association with weight change. • In all, 92 men (70%) gained weight, and 40 (30%) either lost or maintained a stable weight. • On average, weight on ADT was 2.2 kg higher than the weight before ADT, with the mean change for weight-gainers and -losers being +4.2 kg and -2.4 kg, respectively. • This compared with no significant weight change in the year before starting ADT (paired t-test, change -0.7 kg, P= 0.19) or in the second year on ADT (paired t-test, change -0.5 kg, P= 0.46) for 84 men in whom these additional weight values were recorded. • There was no significant association between any of the features examined and weight change on univariate and multivariate analysis. • In this longitudinal study, ADT was accompanied by significant weight gain (+2.2 kg). This change occurred primarily in the first year of therapy, with men neither losing nor gaining additional weight thereafter.

Mortality reductions produced by sustained prostate cancer screening have been underestimated

The recently published European Randomized Study of Screening for Prostate Cancer (ERSPC) reported prostate specific antigen (PSA)-based screening to have reduced the prostate cancer death rate by only 20%. However, this is an underestimate caused by (i) including in the 20% the years before the impact of the first screen becomes manifest, and (ii) not having full information for the follow-up years where the effects of the screening are most apparent. This paper provides a re-analysis of the results using time-specific measures, which avoid the first of these sources of error. Mortality rate ratios for follow-up years 1-12 were derived from the yearly numbers of prostate cancer deaths and numbers of men being followed in each arm of the ERSPC. To reduce statistical noise, they were based on moving three-year intervals, and a smooth rate ratio curve was fitted to the yearly data, in order to measure the steady state reduction in mortality and to identify the time at which it reached this level. The re-analysis suggests that the sustained reduction in prostate cancer mortality may be more than 50%. Re-analysis of the ERSPC data suggests that if screening is carried out for several years, and if follow-up is pursued until the reduction becomes manifest, the reduction in mortality will be 50-60%. An analysis that includes the 2007-2008 follow-up data is required to quantify more precisely the impact of this intervention.

長期透析症例における破壊性脊椎関節症(DSA)の経年変化に関する検討(第1報)

This study was undertaken to evaluate destructive spondylarthropathy (DSA) in patients long-term dialysis. The patients were investigated by plain X-ray examinations twice with a three-year interval, and the changes in severity of the illness in 66 patients undergoing dialysis for over 5 years were defined. Group A (9 patients) consisted of patients with progression in grades during the three years, while group B (57 patients) consisted of patients without deterioration. There was no differences in the two groups in age, duration and the modality of dialysis. However, in group A, the level of plasma beta 2-microglobulin (beta 2M) was 33.5 +/- 14.6 micrograms/ml at the first observation, and 33.1 +/- 15.1 micrograms/ml at the second (NS). In group B, the level of plasma beta 2M was 45.6 +/- 8.13 micrograms/ml at the first observation, and 39.7 +/- 9.18 micrograms/ml at the second (p <0.05). No improvement in DSA was observed. The result of this study suggests that DSA will not improve once it has become overt, and the management for lowering the level of beta 2M may prevent the occurrence and progression of DSA.

Twelve years of succession on sandy substrates in a post‐mining landscape: a Markov chain analysis

Knowledge of succession rates and pathways is crucial for devising restoration strategies for highly disturbed ecosystems such as surface-mined land. As these processes have often only been described in qualitative terms, we used Markov models to quantify transitions between successional stages. However, Markov models are often considered not attractive for some reasons, such as model assumptions (e.g., stationarity in space and time, or the high expenditure of time required to estimate successional transitions in the field). Here we present a solution for converting multivariate ecological time series into transition matrices and demonstrate the applicability of this approach for a data set that resulted from monitoring the succession of sandy dry grassland in a post-mining landscape. We analyzed five transition matrices, four one-step matrices referring to specific periods of transition (1995-1998, 1998-2001, 2001-2004, 2004-2007), and one matrix for the whole study period (stationary model, 1995-2007). Finally, the stationary model was enhanced to a partly time-variable model. Applying the stationary and the time-variable models, we started a prediction well outside our calibration period, beginning with 100% bare soil in 1974 as the known start of the succession, and generated the coverage of 12 predefined vegetation types in three-year intervals. Transitions among vegetation types changed significantly in space and over time. While the probability of colonization was almost constant over time, the replacement rate tended to increase, indicating that the speed of succession accelerated with time or fluctuations became stronger. The predictions of both models agreed surprisingly well with the vegetation data observed more than two decades later. This shows that our dry grassland succession in a post-mining landscape can be adequately described by comparably simple types of Markov models, although some model assumptions have not been fulfilled and within-plot transitions have not been observed with point exactness. The major achievement of our proposed way to convert vegetation time series into transition matrices is the estimation of probability of events--a strength not provided by other frequently used statistical methods in vegetation science.

Multicultural E-resources: An Exploratory Study of Resources Held by ARL Libraries

The purpose of this study was to discover what libraries belonging to the Association of Research Libraries are subscribing to in support of multicultural and diversity research. A list of bibliographic and digital collections was created and searched for in the online public access catalogs of academic and research libraries in 2005 and 2008. A list of recommended e-resources was derived based on the ownership of Association of Research Libraries member libraries and Magazine for Libraries 2006 and 2009. During the three-year interval there was a 45.8 percent increase in subscriptions to the multicultural and diversity databases.

'Going-to-have-cancerness': a study of living with increased risk of BRCA1 and BRCA2 mutations for six South Island women

Mutations in the BRCA (breast cancer) 1 and 2 genes are thought to lead to 5-10% of breast cancers. A qualitative study to explore six New Zealand women's experiences of living with increased risk for a genetic susceptibility to breast cancer. Six women were interviewed using semi-structured interviews, to explore their experiences of living at high risk for developing breast cancer due to familial and/or individual genetic susceptibilities. Results were analysed using thematic coding. After a three-year interval, interviewees were contacted again to discuss their experiences (although two were lost to follow-up). The women held fatalistic views on developing cancer and drew on family experience as much as biomedical research to assess their situation. They became increasingly immersed in biomedical screening and prophylaxis without accompanying improvement to their peace of mind and with unrealistic ideas of it 'preventing' cancer. The biomedical management options and advice they reported receiving was factually inconsistent and a discrepancy emerged between women's expectations of breast cancer health services (including genetic testing) and the delivered support and services. This small sample group cannot be used to draw implications on the views of the wider group of higher risk patients, but for these six women, genetic testing, screening and prophylaxis have not provided peace of mind; rather the reverse has occurred. The findings are provocative as they challenge the biomedical idea of patients' experience of managing their genetic risk information as routinely positive.

Time trends of perfluorinated compounds from the sediment core of Tokyo Bay, Japan (1950s–2004)

Perfluorinated compounds (PFCs) were detected in sediment core samples collected in Tokyo Bay to reveal their time trends. The core sample deposited during 1950s–2004 was divided into two- to three-year intervals and the concentrations of 24 types of PFCs were determined. Perfluorooctane sulfonate (PFOS) decreased gradually from the early 1990s and its precursor decreased rapidly in the late 1990s, whereas perfluorooctanoic acid (PFOA) increased rapidly. The observed trends were regarded as a reflection of the shift from perfluorooctyl sulfonyl fluoride (PFOSF)-based products to telomer-based products after the phaseout of PFOSF-based products in 2001. The branched isomers of perfluoroundecanoic acid (PFUnDA) and perfluorotridecanoic acid (PFTrDA) were detected in the sample with its ratio of linear-isomer/branched-isomer concentrations decreasing. In this study, we revealed that the sediment core can serve as a tool for reconstructing the past pollution trend of PFCs and can provide interesting evidence concerning their environmental dynamics and time trend.

Tree-year period evolution of the nutritional condition of children with mielomeningocelis

This paper aims to describe and classify longitudinally the anthropometric profile of a group of children with mielomeningocelisincluded in a special program of physical activities. Twenty and four children with mielomeningocelis were evaluated at three momentswith an interval of 1 year. Factors evaluated were weight, stature and Body Mass Index (BMI). Children were classified in accordance tothe percentile of stature/age (S/A) and BMI/age (IMC/idade) correlations. From the total of evaluated children, 54,2% (n = 13) were ofmale (age: 7,0 ± 2.4 years) and 45.8% (n = 11) female (age 6,0 ± 2.0 years). The main findings were: most children had a growth deficitthat was not reversed in a three-year interval; most children tend to become overweight and/or obese, something slightly attenuated inboys and slightly aggravated in girls. It was possible to observe nutritional deviations in this group of children (low stature, overweightand obesity), and the maintenance of these during a period of three years. Considering this, some recommendations may be made:one should consider the possibility of developing specific growth curves for this type of compromising, the accomplishment of studiescomparing physically active and sedentary children, submitted or not to nutritional guiding.

The velocity field and flow regime of David Glacier and Drygalski Ice Tongue, Antarctica

We analyze spatial and temporal variability of the surface velocity field of David Glacier and its floating seaward extension Drygalski Ice Tongue. We obtain velocity measurements by combinations of automated feature tracking, interferometry and speckle tracking using 1997 Antarctic Mapping Mission-1 and 2000 Modified Antarctic Mapping Mission RADARSAT-1 data. We compare short-term velocities, three-year averaged velocities, and earlier studies to investigate whether any significant changes have occurred. Drygalski Ice Tongue advanced 2200 m over the three-year time interval, increasing its area by almost 45 km2 (an area three times that size calved off in early 2005). Our comparison suggests that the velocity field remained relatively constant from about 1991 to 2000. The yearly advance rate is similar to the long-term rate derived from a 1960 map and earlier studies, suggesting long-term steady flow. The new velocity estimates are used in combination with isostatically derived ice thickness from Ice, Cloud, and land Elevation Satellite (ICESat) data to determine basal melt.