Journal of NeurochemistryVolume 156, Issue 5 Issue CoverFree Access Issue Cover (March 2021) First published: 28 February 2021 https://doi.org/10.1111/jnc.15054 Read the full article: ‘Reelin signaling modulates GABAB receptor function in the neocortex’ by M. I. K. Hamad, A. Jbara, O. Rabaya, P. Petrova, S. Daoud, N. Melliti, M. Meseke, D. Lutz, E. Petrasch-Parwez, J. C. Schwitalla, M. D. Mark, S. Herlitze, G. Reiss, J. Herz and E. Förster (J. Neurochem. 2021, vol. 156 (5), pp. 589–603) on doi:10.1111/jnc.14990 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Front cover: The protein Reelin is an ancient molecule, which is best known for its role in controlling layer formation during embryonic development of the cerebral cortex. Though Reelin is also involved in synaptic function, a clear physiological Reelin function in the postnatal cerebral cortex has not yet been elucidated. In this study, we provide evidence for a physiological function of Reelin in cortical network maturation and function. By genetically inducing Reelin deficiency after embryonic cortical development, we show that Reelin ensures proper neuronal activity in the neocortex. Thus, Reelin deficiency after cortical layer formation resulted in excessive Ca2+ spike frequency. Modulation of GABAB receptor function by Reelin reveals a novel physiological role for Reelin in the regulation of inhibitory network homeostasis and cortical function. Image Content: Confocal image of an interneuron transfected with GCaMP6s from mouse cortex at P14. The cell is represented in pseudocolour to show the three-dimensional projection of the dendritic tree, soma and axon. The soma and proximal dendrites are pseudocoloured in yellow, the distal dendrites are in green, cyan and orange and the axon is in purple-blue. This type of neuron was used to measure calcium signals in acute slice. Read the full article ‘Reelin signaling modulates GABAB receptor function in the neocortex’ by M. I. K. Hamad, A. Jbara, O. Rabaya, P. Petrova, S. Daoud, N. Melliti, M. Meseke, D. Lutz, E. Petrasch-Parwez, J. C. Schwitalla, M. D. Mark, S. Herlitze, G. Reiss, J. Herz and E. Förster (J. Neurochem. 2021, vol. 156 (5), pp. 589–603) on doi:10.1111/jnc.14990 Volume156, Issue5March 2021 RelatedInformation