Three-dimensional Format Research Articles

A point‐based redesign algorithm for designing geometrically complex surfaces. A case study: Miralles's croissant paradox

This study explores the use of point clouds for both representation and genetic morphogenesis of complex geometry. The accurate representation of existing objects of complex curved geometry, which are subsequently geometrically modified by evolutionary morphogenetic processes, is analysed. To this end, as a method of representation and generation of complex geometries, a point-based genetic algorithm and the use of large unstructured point clouds are proposed. A study of convergence and diversity of the implemented algorithm is detailed, as well as a comparison with the Coyote optimisation algorithm in terms of representation error demonstrating its efficiency. Some commonly used three-dimensional formats in architecture, such as NURBS and polygon meshes, are analysed, and compared against point clouds. This study also includes an evaluation regarding whether the use of point clouds is a more suitable format for realistic representation, rationalisation and genetic morphogenesis.

A Promotional Construction Approach for an Urban Three-Dimensional Compactness Model—Law-of-Gravitation-Based

Urban sprawl has led to various economic, social, and environmental problems. Therefore, it is very significant to improve the efficiency of resource usage and promote the development of compact urban form. It is a common topic that measuring urban compactness is done with certain ways and methods as well. Presently, most urban compactness measurement methods are based on two-dimensional (2D) formats, but methods based on three-dimensional (3D) formats that can precisely describe the actual urban spatial conditions are still lacking. To measure the compactness of the 3D urban spatial form accurately, a 3D Compactness Index (VCI) was established based on the Law of Gravitation and the quantitative measurement model. In this model, larger 3D Compactness Index values indicate a more 3D-compact city. However, different urban scales may influence the discrepancy scale of different cities. Thus, the 3D Compactness Index model was normalized as the Normalized 3D Compactness Index (NVCI) to eliminate such discrepancies. In the Normalized 3D Compactness Index model, a sphere with the same volume of real urban buildings in the city was assumed as the most compact 3D urban form, and which was also calculated by 3D Compactness Index processing. The compactness value of the normalized 3D urban form is obtained by comparing the 3D Compactness Index with the most compact 3D urban form. In this study, 1149 typical communities in Xiamen, China, were selected as the experimental fields to verify the index. Some of communities have a quite different Normalized 3D Compactness Index, although they have a similar Normalized 2D Compactness Index (NCI), respectively. Moreover, comparing with the 2D Compactness Index (CI) and Normalized 2D Compactness Index (NCI), the 3D Compactness Index and Normalized 3D Compactness Index can describe and explain reality more precisely. The constructed 3D urban compactness model is expected to contribute to scientific study on urban compactness.

Технология дополненной реальности для реконструкции ушной раковины при лечении микротии

Facial defects and deformations occupy a significant place in the practice of maxillofacial and dental surgeons. Nevertheless, maxillofacial surgery is developing rapidly and requires improvement of existing treatment methods, and introduction of new approaches to reconstructive surgery. Augmented reality is a promising direction of computer technology development which is actively used in medicine and education. Modern computer technology allows to create a 3D model of a lost organ and use it for preoperative planning, as well as apply a virtual model for intraoperative navigation. Recently, the method of augmented reality has been actively developed, when a virtual image of the zone of the surgical area or a dedicated organ is used, which is compared with its real prototype in static mode, or in real-time using computer devices. The benefits of using augmented reality technologies in reconstructive surgery is associated with preoperative virtual planning, simplification of the surgical intervention itself, as well as with a reduction in the risks of intra- and postoperative complications. The aim of our work was to study the opportunity of using the augmented reality technology in reconstructive surgery for microtia correction based on pre-operative computer simulation. At the preoperative stage, a photometric analysis of the patient was carried out, then a computer simulation of the missing auricle was performed. Using a 3D printer, a virtual model of the reconstructed auricle was obtained. The image in three-dimensional format was loaded into augmented reality glasses, which made it possible to project the shape and position of the simulated auricle to the area of the defect of the auricle when preparing for surgery. During the surgery, a marker was installed near the surgical field, in order to display the three-dimensional model in a destined position. During surgical intervention, an autogenous costal cartilage was taken, from which the auricle was formed using augmented reality approach and three-dimensional modeling. Subsequently, the graft was introduced to the formed bed in the area of the right ear auricle. The obtained 3D model of the auricle before the operation enabled planning of the forthcoming operation and determine the amount of autograft needed for reconstruction. Using the augmented reality glasses, the exact shape of the auricle is reproduced during the operation, and its proper position is assessed in relation to the healthy side. No complications were observed over the postoperative period. Virtual modelling of a lost or absent organ based on a preoperative examination provides important information about its spatial structure. Preoperative virtual planning allows you to predict the individual features of the operation, its difficult stages, to anticipate possible complications. The use of augmented reality technology during reconstructive surgery is a promising method requiring further development and improvement.

The Competition of Termination and Shielding to Evaluate the Success of Surface-Initiated Reversible Deactivation Radical Polymerization.

One of the challenges for brush synthesis for advanced bioinspired applications using surface-initiated reversible deactivation radical polymerization (SI-RDRP) is the understanding of the relevance of confinement on the reaction probabilities and specifically the role of termination reactions. The present work puts forward a new matrix-based kinetic Monte Carlo platform with an implicit reaction scheme capable of evaluating the growth pattern of individual free and tethered chains in three-dimensional format during SI-RDRP. For illustration purposes, emphasis is on normal SI-atom transfer radical polymerization, introducing concepts such as the apparent livingness and the molecular height distribution (MHD). The former is determined based on the combination of the disturbing impact of termination (related to conventional livingness) and shielding of deactivated species (additional correction due to hindrance), and the latter allows structure-property relationships to be identified, starting at the molecular level in view of future brush characterization. It is shown that under well-defined SI-RDRP conditions the contribution of (shorter) hindered dormant chains is relevant and more pronounced for higher average initiator coverages, despite the fraction of dead chains being less. A dominance of surface-solution termination is also put forward, considering two extreme diffusion modes, i.e., translational and segmental. With the translational mode termination is largely suppressed and the living limit is mimicked, whereas with the segmental mode termination occurs more and the termination front moves upward alongside the polymer layer growth. In any case, bimodalities are established for the tethered chains both on the level of the chain length distribution and the MHD.

Constructing the CityGML ADE for the Multi-Source Data Integration of Urban Flooding

Urban flooding, as one of the most serious natural disasters, has caused considerable personal injury and property damage throughout the world. To better cope with the problem of waterlogging, the experts have developed many waterlogging models that can accurately simulate the process of pipe network drainage and water accumulation. The study of urban waterlogging involves many data types. These data come from the departments of hydrology, meteorology, planning, surveying, and mapping, etc. The incoordination of space–time scale and format standard has brought huge obstacles to the study of urban waterlogging. This is not conducive to interpretation, transmission, and visualization in today’s network environment. In this paper, the entities and attributes related to waterlogging are defined. Based on the five modules of urban drainage network, sub basin, dynamic water body, time series, and meteorological data, the corresponding UML (Unified Modeling Language) model is designed and constructed. On this basis, the urban waterlogging application domain extension model city waterlogging application domain extension (CTWLADE) is established. According to the characteristics of different types of data, two different methods based on FME object and citygml4j are proposed to realize the corresponding data integration, and KML (Keyhole Markup Language) /glTF data organization form and the corresponding sharing method are proposed to solve the problem that the CTWLADE model data cannot be visualized directly on the web and cannot interact in three-dimensional format. To evaluate the CTWLADE, a prototype system was implemented, which can convert waterlogging-related multi-source data in extensible markup language (XML) files conform. The current CTWLADE can map the data required and provided by the hydraulic software tool storm water management model (SWMM) and is ready to be integrated into a Web 3D Service to provide the data for 3D dynamic visualization in interactive scenes.

Developing a 3D animation tool to improve veterinary undergraduate understanding of obstetrical problems in horses

BackgroundMany challenges are encountered in both teaching and learning veterinary obstetrics. This may be due to outdated teaching materials, as the main model of content transmission remains centred around text...

Discrepancy between two-dimensional and three-dimensional digital subtraction angiography for the planning of endovascular coiling of small cerebral aneurysms

To investigate the discrepancy between two-dimensional digital subtraction angiography and three-dimensional rotational angiography for small (<5 mm) cerebral aneurysms and the impact on decision making among neuro-interventional experts as evaluated by online questionnaire. Eight small (<5 mm) ruptured aneurysms were visually identified in 16 image sets in either two-dimensional or three-dimensional format for placement in a questionnaire for 11 invited neuro-interventionalists. For each set, two questions were posed: Question 1: "Which of the following is the preferred treatment choice: simple coiling, balloon remodeling or stent assisted coiling?"; Question 2: "Is it achievable to secure the aneurysm with pure simple coiling?" The discrepancies of angio-architecture parameters and treatment choices between two-dimensional-digital subtraction angiography and three-dimensional rotational angiography were evaluated. In all eight cases, the neck images via three-dimensional rotational angiography were larger than two-dimensional-digital subtraction angiography with a mean difference of 0.95 mm. All eight cases analyzed with three-dimensional rotational angiography, but only one case with two-dimensional-digital subtraction angiography were classified as wide-neck aneurysms with dome-to-neck ratio < 1.5. The treatment choices based on the two-dimensional or three-dimensional information were different in 56 of 88 (63.6%) paired answers. Simple coiling was the preferred choice in 66 (75%) and 26 (29.6%) answers based on two-dimensional and three-dimensional information, respectively. Three types of angio-architecture with a narrow gap between the aneurysm sidewall and parent artery were proposed as an explanation for neck overestimation with three-dimensional rotational angiography. Aneurysm neck overestimation with three-dimensional rotational angiography predisposed neuro-interventionalists to more complex treatment techniques. Additional two-dimensional information is crucial for endovascular treatment planning for small cerebral aneurysms.

Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array

SummaryAs three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids within anchored droplets. Different conditions can be applied in a single device by triggering the merging of new droplets with the spheroid-containing drops. This allows cell-cell interactions to be initiated for building microtissues, studying stem cells’ self-organization, or observing antagonistic interactions. It also allows the spheroids’ physical or chemical environment to be modulated, as we show by applying a drug over a large range of concentrations in a single parallelized experiment. This convergence of microfluidics and image acquisition leads to a data-driven approach that allows the heterogeneity of 3D culture behavior to be addressed across the scales, bridging single-cell measurements with population measurements.

Immersing Patients in a Virtual Reality Environment for Brain Mapping During Awake Surgery: Safety Study

Brain mapping by direct electrical stimulation during awake craniotomy is now a standard procedure that reduces the risk of permanent neurologic deficits. Virtual reality technology immerses the patient in a virtually controlled, interactive world, offering a unique opportunity to develop innovative tasks for perioperative mapping of complex cognitive functions. The objective of this prospective single-center study was to evaluate the tolerance and safety of a virtual reality headset (VRH) and immersive virtual experiences in patients undergoing awake craniotomy and brain mapping by direct electrical stimulation. The study included 30 patients with a brain tumor near the language area. Language mapping was performed with a naming task, DO 80, presented on a digital tablet and then in two-dimensional and three-dimensional formats through a VRH. During wound closure, different virtual reality experiences were proposed to the patient, offering different types of virtual motion or interaction with an avatar piloted by a neuropsychologist. Two patients could not use the VRH owing to technical issues. No procedure was aborted, no patient experienced virtual reality sickness and all patients reported they would repeat the procedure. Despite a high rate of intraoperative focal seizures, there was no argument to attribute the seizures to VRH use. This study shows that it is possible during awake brain surgery to immerse the patient in a virtual environment and to interact with the patient, opening the field of new brain mapping procedures for complex cognitive functions.

ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer.

SummaryUterine endometrial cancer is associated with poor survival outcomes in patients with advanced-stage disease. Here, we developed a three-dimensional cell cultivation method of endometrioid cancer stem-like cells with high aldehyde dehydrogenase (ALDH) activity from clinical specimens. ALDH inhibition synergized with paclitaxel to block cancer proliferation. In the clinical setting, high ALDH1A1 expression was associated with poor survival. A high level of ALDH correlated with an increase of glucose uptake, activation of the glycolytic pathway, and elevation of glucose transporter 1 (GLUT1). Blockade of GLUT1 inhibited characteristics of cancer stem cells. Similarly to ALDH inhibition, GLUT1 inhibition synergized with paclitaxel to block endometrial cancer proliferation. Our data indicated that ALDH-dependent GLUT1 activation and the resulting glycolytic activation are of clinical importance for both prognostic evaluation and therapeutic decision-making in endometrial cancer patients. In addition, the synergistic effects of taxane compounds and ALDH or GLUT1 inhibitors may serve as a new clinical treatment option for endometrial cancer.

Can AI Help Make Screening Mammography "Lean"?

Can AI Help Make Screening Mammography "Lean"?

Spheroid-3D and Monolayer-2D Intestinal Electrochemical Biosensor for Toxicity/Viability Testing: Applications in Drug Screening, Food Safety, and Environmental Pollutant Analysis

The rise of three-dimensional cell culture systems that provide in vivo-like environments for pharmaco-toxicological models has prompted the need for simple and robust viability assays suitable for complex cell architectural structures. This study addresses that challenge with the development of an in vitro enzyme based electrochemical sensor for viability/cytotoxicity assessment of two-dimensional (2D) monolayer and three-dimensional (3D) spheroid culture formats. The biosensor measures the cell viability/toxicity via electrochemical monitoring of the enzymatic activity of nonspecific esterases of viable cells, through the hydrolysis of 1-naphthyl acetate to 1-naphthol. The proposed sensor demonstrated strong correlation ( r = 0.979) with viable cell numbers. Furthermore, the model intestinal toxicants diclofenac (DFC, pharmaceutical), okadaic acid (OA, food-safety), and mancozeb (MZB, environmental) were used for the functional evaluation of the proposed sensor using 2D and 3D culture formats. Sensor performance showed high consistency with conventional cell viability/cytotoxicity assays (MTT/CFDA-AM) for all toxicants, with the sensor IC50 values matching the relevant viability LC50 values at the 95% confidence interval range for 2D (DCF: 1.19-1.26 mM, MZB: 10.28-14.18 μM, OA: 40.91-77.13 nM) and 3D culture formats (DCF: 1.02-4.78 mM, MZB: 11.26-15.16 μM, OA: 162.09-179.67 nM). The presented results demonstrate the feasibility of the proposed sensor as a robust endpoint screening tool for both 2D and 3D cytotoxicity assessment.

Snapshot Holographic Optical Tomography

Digital holographic tomography (DHT) can provide the complex-valued refractive-index map of a specimen in a three-dimensional format. Conventional DHT methods require the acquisition of a multitude of projection images sequentially, which imposes a fundamental limitation on speed. Here the authors present a snapshot DHT method (``SHOT'') that can acquire all of the projection images instantaneously. SHOT is expected to open doors for high-speed, label-free optical microscopy in three dimensions, even for moving specimens.

FEATURES OF REFORM OF ENERGY USING "SMART" TECHNOLOGIES

The article investigates the features of energy reforms, that based on the use of «smart technologies». Such reforms based on the principles of regulation, privatization, restructuring and competition have been analyzed. The advantages and disadvantages of energy reforms have been identified in the articles. The main problems of reforms in the energy sector in developing countries are highlighted. Thus, the challenges of implementing of reforms in the energy sector of developing countries include: political challenges; the need to take into account the initial conditions of operation of the energy sector; identifying individual approaches, methods, tools and technologies in the process of implementing energy reforms for individual territories; realization of the target tasks. An analysis of the goals, objectives and benefits of Ukraine's energy strategy until 2035 was conducted. The study substantiates the importance of implementing of «smart» technologies in the energy sector. The most popular innovative energy saving technologies are described. Particular attention is paid to smart-grid technologies. It has been proven that «smart» technologies have made a positive contribution from the economic and social spheres, which have been generally achieved in order to achieve targeted development and to exist in other spheres. The paper argues that «smart» technologies are positively linked to economic and social sustainability, aimed at achieving the goals of sustainable development and environmental protection. It is proposed to take into account the synergistic effects of the use of «smart» technologies in three-dimensional format: environmental, social and economic effects. As a synergistic effect of the introduction of "smart" technologies in energy reforms is expected to increase the level of socio-ecological-economic development; scale effect, integration effect, integrated benefits effect, conglomerate effect; synergies with other infrastructures. Keywords: energy reforms, smart technologies, energy strategy of Ukraine, smart grid, synergistic effect.

Using a Microfluidic Device for Culture and Drug Toxicity Testing of 3D Cells.

Microfluidic devices provide convenient assays tools for testing cell cultures in three-dimensional (3D) formats. These devices have significant potential for establishing assays that are better at predicting drug toxicity and efficacy effects compared to assays in conventional two-dimensional (2D) cultures. Microfluidic cell culture devices consist of perfused cell culture chambers with inlets and outlet for seeding, culturing, sampling, and assaying the cells. This protocol describes how to prepare and seed cells in a microfluidic cell culture device for drug toxicity testing on cells in a 3D structure. The protocol exemplifies the use of a basic microfluidic device with HepG2 hepatoma cells but can be transferred and optimized for other cells and cell types, including iPSC-derived tissue and organ cells.

The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species

Advances in magnetic resonance imaging (MRI) and computational analysis technology have enabled comparisons among various primate brains in a three-dimensional electronic format. Results from comparative studies provide information about common features across primates and species-specific features of neuroanatomy. Investigation of various species of non-human primates is important for understanding such features, but the majority of comparative MRI studies have been based on experimental primates, such as common marmoset, macaques, and chimpanzee. A major obstacle has been the lack of a database that includes non-experimental primates’ brain MRIs. To facilitate scientific discoveries in the field of comparative neuroanatomy and brain evolution, we launched a collaborative project to develop an open-resource repository of non-human primate brain images obtained using ex vivo MRI. As an initial open resource, here we release a collection of structural MRI and diffusion tensor images obtained from 12 species: pygmy marmoset, owl monkey, white-fronted capuchin, crab-eating macaque, Japanese macaque, bonnet macaque, toque macaque, Sykes’ monkey, red-tailed monkey, Schmidt’s guenon, de Brazza’s guenon, and lar gibbon. Sixteen postmortem brain samples from the 12 species, stored in the Japan Monkey Centre (JMC), were scanned using a 9.4-T MRI scanner and made available through the JMC collaborative research program (http://www.j-monkey.jp/BIR/index_e.html). The expected significant contributions of the JMC Primates Brain Imaging Repository include (1) resources for comparative neuroscience research, (2) preservation of various primate brains, including those of endangered species, in a permanent digital form, (3) resources with higher resolution for identifying neuroanatomical features, compared to previous MRI atlases, (4) resources for optimizing methods of scanning large fixed brains, and (5) references for veterinary neuroradiology. User-initiated research projects beyond these contributions are also anticipated.

Three-Dimensional Portable Document Format (3D PDF) in Clinical Communication and Biomedical Sciences: Systematic Review of Applications, Tools, and Protocols.

BackgroundThe Portable Document Format (PDF) is the standard file format for the communication of biomedical information via the internet and for electronic scholarly publishing. Although PDF allows for the embedding of three-dimensional (3D) objects and although this technology has great potential for the communication of such data, it is not broadly used by the scientific community or by clinicians.ObjectiveThe objective of this review was to provide an overview of existing publications that apply 3D PDF technology and the protocols and tools for the creation of model files and 3D PDFs for scholarly purposes to demonstrate the possibilities and the ways to use this technology.MethodsA systematic literature review was performed using PubMed and Google Scholar. Articles searched for were in English, peer-reviewed with biomedical reference, published since 2005 in a journal or presented at a conference or scientific meeting. Ineligible articles were removed after screening. The found literature was categorized into articles that (1) applied 3D PDF for visualization, (2) showed ways to use 3D PDF, and (3) provided tools or protocols for the creation of 3D PDFs or necessary models. Finally, the latter category was analyzed in detail to provide an overview of the state of the art.ResultsThe search retrieved a total of 902 items. Screening identified 200 in-scope publications, 13 covering the use of 3D PDF for medical purposes. Only one article described a clinical routine use case; all others were pure research articles. The disciplines that were covered beside medicine were many. In most cases, either animal or human anatomies were visualized. A method, protocol, software, library, or other tool for the creation of 3D PDFs or model files was described in 19 articles. Most of these tools required advanced programming skills and/or the installation of further software packages. Only one software application presented an all-in-one solution with a graphical user interface.ConclusionsThe use of 3D PDF for visualization purposes in clinical communication and in biomedical publications is still not in common use, although both the necessary technique and suitable tools are available, and there are many arguments in favor of this technique. The potential of 3D PDF usage should be disseminated in the clinical and biomedical community. Furthermore, easy-to-use, standalone, and free-of-charge software tools for the creation of 3D PDFs should be developed.

Revealing Chemical Heterogeneity of CNT Fiber Nanocomposites via Nanoscale Chemical Imaging

Lightweight nanocomposites reinforced with carbon nanotube (CNT) assemblies raise the prospects for a range of high-tech engineering applications. However, a correlation between their heterogeneous chemical structure and spatial organization of nanotubes should be clearly understood to maximize their performance. Here, we implement the advanced imaging capabilities of atomic force microscopy combined with near-field infrared spectroscopy (AFM-IR) to analyze the intricate chemical structure of CNT fiber-reinforced thermoset nanocomposites. As an example, we unravel the chemical composition of a nanothin polymer interphase exclusively from CNT assemblies and visualize in a two- and three-dimensional format with resolution of sub-30 nm. We furthermore introduce a contact frequency map colocalized with CNTs and surrounding polymer, which might correlate the local mechanical properties with polymer chemistry and the high anisotropy of CNTs. Nanoresolved chemical imaging offers possibilities for in-depth charac...

Enabling High-Capacity Long-Reach Direct Detection Transmission With QAM-PAM Stokes Vector Modulation

We introduce a three-dimensional modulation format using a Stokes-vector direct-detection system, where a pulse amplitude modulation (PAM) signal is polarization multiplexed with a quadrature amplitude modulation (QAM) signal. The phase reference of the PAM signal enables the retrieval of the phase information of the QAM signal using a Stokes vector receiver (SVR). A dual-polarization in-phase–quadrature modulator is employed to generate QAM-PAM optical signals with chromatic dispersion precompensation. We show direct detection of dual-polarization 16QAM-PAM2 and 16QAM-PAM4 signals delivering 280 and 336 Gb/s (net bit rate 233 and 280 Gb/s) below the soft-decision forward error correction threshold of 2 $\times$ 10 $^{-2}$ at 320 and 80 km, respectively. In addition, we study system performance at different modulation formats and symbol rates. Our findings indicate that increasing the order of modulation formats of the QAM signal is better than increasing that of the PAM signal to achieve the same bit rate. Finally, the performance of a 56 Gbaud 16QAM signal with PAM2 modulation on one polarization and a 56 Gbaud 16QAM signal with a pilot carrier on the orthogonal polarization detected with an SVR is experimentally investigated.

Proposed solution for dorsal internal carotid artery aneurysms: Suggestion of a novel new clip design.

Dorsal internal carotid artery (ICA) aneurysms are notorious for their high morbidity and mortality. They have an extremely fragile wall and have a high chance of rupture and clip slippage during the intraoperative and postoperative period. Strategies proposed to mitigate these problems encompass including part of the normal ICA wall in addition to neck of aneurysm in clip blades, as well as the use of encircling materials (silicon, cellulose, Weck's clip) over a clip. The Achilles' heel of the problem is to take an appropriate thickness of the normal ICA in clip blades. Too less or too much of this can spell disaster. This is easier said than done during an actual surgical procedure. So, in this difficult situation, is there any better method of clipping? We propose a fenestrated clip in which the clip blades are placed just at the beginning of fenestration and at right angles to the clip. This occludes the aneurysm taking part of the normal ICA wall in the clip blades. The fenestration hugs the ICA and prevents clip slippage. This has been explained with appropriate figures in the two and three-dimensional format. There cannot be a single stop solution for a complex disease like dorsal ICA aneurysm. The present proposed design is an attempt to provide a better clipping chance in these difficult aneurysms. Future work on this design can prove its usefulness.