ABSTRACT Three-dimensional Finite Element (3D-FE) stress computations involved in the current rigid airport pavement design methodology, are time consuming when considering top-down cracking failure mode. In this study, Artificial Neural Network (ANN) models are integrated into a tool called ANNFAA to replace such 3D-FE computations. ANNFAA makes use of the best ANN models developed in MATLAB for 156 different airplanes without requiring any additional software installation or cumbersome learning of a new program. Within ANNFAA development, about 4,000 of 3D-FE simulations and many ANN models have been developed for each of these airplanes. Three useful tools were also developed using C# and MATLAB for implementing the 3D-FE analysis, post-processing the results, training the ANN models, and determining accuracy and performance of the ANN models. ANNFAA provides an accurate and rapid procedure for practitioners, engineers, and researchers for computing the critical stress responses associated with top-down cracking in multiple-slab rigid airfield pavements. This should make pavement design and analysis more practical, especially when a significantly large number of different cases that include top-down cracking failure mode are investigated. Also, this will help when currently used bottom-up cracking mode in the FAA standard rigid pavement design procedures is being considered in a design.