Sandwich core materials that offer superior mechanical properties at minimum weight are essential in designing high-performance sandwich structures. Hierarchical materials are ideal templates for this purpose. In this paper, we investigate the mechanical performance of a pyramidal–pyramidal hierarchical lattice material to highlight its potential as the core material for sandwich structures. Three-dimensional failure mechanism maps for the pyramidal–pyramidal hierarchical lattice material are developed under different loading conditions and the results are compared to finite element simulations. Next, we study the mechanical response and failure modes of a sandwich panel with self-similar pyramidal lattice core construction subjected to in-plane compression and three-point bending. The current study indicates that the pyramidal–pyramidal hierarchical configuration can improve the load bearing capacity and core buckling resistance of the sandwich structures at low density. The study provides insights into the role of structural hierarchy in tuning the mechanical response of the lattice materials and expands the application envelope of lightweight sandwich structures by effectively increasing the structural buckling resistance.