The Fourth generation industrial age and 5G + intelligent communication in the "Fourth Paradigm of Science" in the 21st century provide a new opportunity for research on the relationship between mining development and environmental protection. This paper is based on the theory of metallogenic geodynamics background, metallogenic process and quantitative evaluation and chooses the Luanchuan district as a case study, using deep-level artificial intelligence mining and three/four-dimensional (3D/4D) multi-disciplinary, multi-parameter and multi-scale modeling technology platform of geoscience big data (including multi-dimensional and multi-scale geological, geophysical, geochemical, hyperspectral and highresolution remote sensing (multi-temporal) and real-time mining data), carrying out the construction of 3D geological model, metallogenic process model and quantitative exploration model from district to deposit scales and the quantitative prediction and evaluation of the regional Mo polymetallic mineral resources, the aim is to realize the dynamic evaluation of highprecision 3D geological (rock, structure, hydrology, soil, etc.) environment protection and comprehensive development and utilization of mineral resources in digital and wisdom mines, it provides scientific information for the sustainable development of mineral resources and mine environment in the study area. The research results are summarized as follows: (1) The geoscience big data related to mineral resource prediction and evaluation of district include mining data such as 3D geological modeling, geophysics interpretation, geochemistry, and remote sensing modeling, which are combined with GeoCube3.0 software. The optimization of deep targets and comprehensive evaluation of mineral resources in Luanchuan district (500 km2, 2.5 km deep) have been realized, including 6.5 million tons of Mo, 1.5 million tons of W, and 5 million tons of Pb-Zn-Ag. (2) The 3D geological modeling of geology, mineral deposit, and exploration targeting is related to the mine environment. The data of exploration and mining in the pits of Nannihu – Sandaozhuang – Shangfang deposits and the deep channels of Luotuoshan and Xigou deposits show a poor spatial correlation between the NW-trending porphyryskarn deposits and the ore bodies. The NE-trending faults are usually tensional or tensional-torsional structures formed in the post-metallogenic period, which is the migration pathway of hydrothermal fluid of the related Pb-Zn deposit. There is a risk of groundwater pollution in the high-altitude Pb-Zn mining zones, such as the Lengshui and Bailugou deposits controlled by NE-trending faults are developed outside of porphyry-skarn types of Mo (W) deposits in the Luanchuan area. (3) Construction of mineral resources and environmental assessment and decision-making in intelligent digital mines: 3D geological model is established in large mines and associated with ancient mining caves, pit, and deep roadway engineering in the mining areas to realize reasonable orientation and sustainable development of mining industry. The hyperspectral database is used to construct three-dimensional useful and harmful element models to realize the association of exploration, mining, and mineral processing mineralogy for the recovery of harmful elements (As, Sb, Hg, etc.). 0.5 m resolution Worldview2 images are used to identify the distribution of Fe in the wastewater and slag slurry of important tailings reservoirs, so as to protect surface runoff and soil pollution.