Threat Processing Research Articles

Biological and extrinsic correlates of extinction risk in Chinese lizards.

China is a country with one of the most species-rich reptile faunas in the world. However, nearly a quarter of Chinese lizard species assessed by the China Biodiversity Red List are threatened. Nevertheless, to date, no study has explicitly examined the pattern and processes of extinction and threat in Chinese lizards. In this study, we conducted the first comparative phylogenetic analysis of extinction risk in Chinese lizards. We addressed the following 3 questions: (1) What is the pattern of extinction and threat in Chinese lizards? (2) Which species traits and extrinsic factors are related to their extinction risk? (3) How can we protect Chinese lizards based on our results? We collected data on 10 species traits (body size [BS], clutch size, geographic range size, activity time, reproductive mode, habitat specialization [HS], habitat use, leg development, maximum elevation, and elevation range) and 7 extrinsic factors (mean annual precipitation (MAP), mean annual temperature, mean annual solar insolation, normalized difference vegetation index (NDVI), human footprint, human population density, and human exploitation). After phylogenetic correction, these variables were used separately and in combination to assess their associations with extinction risk. We found that Chinese lizards with a small geographic range, large BS, high HS, and living in high MAP areas were vulnerable to extinction. Conservation priority should thus be given to species with the above extinction-prone traits so as to effectively protect Chinese lizards. Preventing future habitat destruction should also be a primary focus of management efforts because species with small range size and high HS are particularly vulnerable to habitat loss.

“Don’t judge me!”: Links between in vivo attention bias toward a potentially critical judge and fronto-amygdala functional connectivity during rejection in adolescent girls

During adolescence, increases in social sensitivity, such as heightened attentional processing of social feedback, may be supported by developmental changes in neural circuitry involved in emotion regulation and cognitive control, including fronto-amygdala circuitry. Less negative fronto-amygdala circuitry during social threat processing may contribute to heightened attention to social threat in the environment. However, “real-world” implications of altered fronto-amygdala circuitry remain largely unknown. In this study, we used multiple novel methods, including an in vivo attention bias task implemented using mobile eye-tracking glasses and socially interactive fMRI task, to examine how functional connectivity between the amygdala and prefrontal cortex (PFC) during rejection and acceptance feedback from peers is associated with heightened attention towards potentially critical social evaluation in a real-world environment. Participants were 77 early adolescent girls (ages 11–13) oversampled for shy/fearful temperament. Results support the reliability of this in vivo attention task. Further, girls with more positive functional connectivity between the right amygdala and anterior PFC during both rejection and acceptance feedback attended more to potentially critical social evaluation during the attention task. Findings could suggest that dysfunction in prefrontal regulation of the amygdala’s response to salient social feedback supports heightened sensitivity to socially evaluative threat during adolescence.

041 Alteration of Threat-Related Information Processing During Extended Sleep Deprivation

Abstract Introduction Threat-related information is preferentially processed, facilitating quick and efficient responses. However, the impact of extended sleep deprivation on perception of and response to threatening information is not well known. Sleep loss may increase amygdalar activity and negative mood, potentially facilitating threat processing. However, it also reduces cognitive function, possibly impairing ability to respond. The present study assessed the extent to which extended sleep deprivation modulates threat processing using a threat expectation paradigm. Methods Twenty-one participants underwent one baseline night of sleep followed by 62hrs total sleep deprivation (TSD) and one recovery night of sleep (12hrs). Threat expectation task performance was assessed at baseline, at multiple time points during TSD, and following recovery sleep. To control for circadian influence, performance at three 1100 sessions (baseline, 52hrs into TSD, and recovery) were compared. The threat expectation task involved determining whether a presented face was fearful (i.e., signaled threat) or neutral. Faces were presented at three expectation levels: 80%, 50%, and 20% chance of viewing a fearful face. Results Overall, responses were faster (F=9.77, p=0.001) and more accurate (F=11.48, p=0.001) when the type of face (fearful or neutral) was expected. Accuracy significantly decreased over TSD (t=7.71, p<0.001) and recovered following subsequent sleep. Fear bias was calculated for accuracy (accuracy for fearful face minus neutral face). Under conditions of high expectation (80%) of viewing a fearful face, fear bias increased across TSD (t=-1.95, p=0.07). Although accuracy to both fearful and neutral faces significantly declined across TSD (both p<0.001), decline for neutral faces was greater, thus increasing fear bias. Importantly, the increased bias toward fear was still evident compared to baseline following a 12-hour recovery sleep opportunity, (t=-1.93, p=0.07). Conclusion Extended sleep deprivation, common in operational environments where there is also high expectation of encountering threat, impairs cognitive control and is thought to enhance amygdala activity. These data show that, consequently, cognitive resources become biased toward biologically adaptive behaviors (i.e., threat processing) at the expense of attending and responding more broadly to all stimuli. This behavior is not reversed with a single extended sleep opportunity. Support (if any) Department of Defense Military Operational Medicine Research Program (MOMRP)

The role of hippocampus and amygdala morphology in memory bias of learned fear in youth with chronic pain

Exaggerated recall of pain may pose a risk for pain persistence and elevated pain-related distress. In adults with chronic pain, such discrepancy (or memory bias) has been correlated to hippocampal morphology. However, this has not been examined in youth with chronic pain nor applied to the recall of fear and negative affect, and to amygdala morphology, considering its involvement in threat processing. This study therefore aims to examine whether hippocampal and amygdala shape is related to a biased recall of threat-safety learning in youth with chronic pain. T1-weighted MR images of 85 youth were analyzed (age M=15.6±0.9), of which 54 had chronic pain. The Screaming Lady paradigm was used for threat conditioning. Follow-up memory interviews assessed recalled fear and unpleasantness of conditioned stimuli (threat/CS+, safe/CS-). A discrepancy score was calculated between actual and recalled fear/negative affect (n=60, including n=37 patients). Permutation-based statistics focused on group differences in hippocampus and amygdala morphology using vertex-based shape analysis, as well as on correlations with discrepancy scores (voxel-based thresholding, corrected for multiple comparisons). We found an overall negative memory bias only for unpleasantness of the CS+. On an individual level, 20% had a negatively-biased recall for unpleasantness of the CS+, and 35% for fear of the CS+. Analyses showed no group differences in hippocampal or amygdala shape displacement. Nevertheless, there was a negative correlation between memory bias in fear for the CS+ and right amygdala shape displacement, indicating that a more negative fear-related memory bias is associated with thinning of this region. No other correlations were observed. Our findings revealed that a recall bias for learned fear is related to amygdala morphology in youth. Youth with chronic pain, however, did not differ in amygdala morphology compared to controls. NIH R01HD083270 to LE Simons.

Attention bias to negative versus non-negative faces is related to negative affectivity in a transdiagnostic youth sample

This study identified a shared pathophysiological mechanism of pediatric anxiety and irritability. Clinically, anxiety and irritability are common, co-occurring problems, both characterized by high-arousal negative affective states. Behaviorally, anxiety and irritability are associated with aberrant threat processing. To build on these findings, we examined eye-tracking measures of attention bias in relation to the unique and shared features of anxiety and irritability in a transdiagnostic sample of youth (n = 97, 58% female, Mage = 13.03, SDage = 2.82). We measured attention bias to negative versus non-negative emotional faces during a passive viewing task. We employed bifactor analysis to parse the unique and shared variance of anxiety and irritability symptoms from self- and parent-report questionnaires. Negative affectivity is the derived latent factor reflecting shared variance of anxiety and irritability. We found that higher negative affectivity was associated with looking longer at negative versus non-negative faces, reflecting a shared mechanism of anxiety and irritability. This finding suggests that modification of elevated attention to negative emotional faces may represent a common potential treatment target of anxiety and irritability.

Hydrocortisone as an adjunct to brief cognitive-behavioural therapy for specific fear: Endocrine and cognitive biomarkers as predictors of symptom improvement.

Background:Glucocorticoid (GC) administration prior to exposure-based cognitive-behavioural therapy (CBT) has emerged as a promising approach to facilitate treatment outcome in anxiety disorders. Further components relevant for improved CBT efficacy include raised endogenous GCs and reductions in information-processing biases to threat.Aims:To investigate hydrocortisone as an adjunct to CBT for spider fear and the modulating role of threat bias change and endogenous short-term and long-term GCs for treatment response.Methods:Spider-fearful individuals were randomized to receiving either 20 mg of hydrocortisone (n = 17) or placebo (n = 16) one hour prior to single-session predominantly computerised exposure-based CBT. Spider fear was assessed using self-report and behavioural approach measures at baseline, 1-day and 1-month follow-up. Threat processing was assessed at baseline and 1-day follow-up. Cortisol and cortisone were analysed from hair and saliva samples at baseline.Results/outcomes:Self-report, behavioural and threat processing indices improved following CBT. Hydrocortisone augmentation resulted in greater improvement of self-report spider fear and stronger increase in speed when approaching a spider, but not on threat bias. Neither threat bias nor endogenous GCs predicted symptom change, and no interactive effects with hydrocortisone emerged. Preliminary evidence indicated higher hair cortisone as predictor of a stronger threat bias reduction.Conclusions/interpretation:Our data extend earlier findings by suggesting that GC administration boosts the success of exposure therapy for specific fear even with a low-level therapist involvement. Future studies corroborating our result of a predictive hair GC relationship with threat bias change in larger clinical samples are needed.

Translational Neuroscience and Threat Processing: Informing Novel Treatments for Irritability

Translational Neuroscience and Threat Processing: Informing Novel Treatments for Irritability

Neurobehavioral Relationships During an Approach-Avoidance Conflict Decision-Making Task in Adults With Major Depressive Disorder During fMRI

Approach-avoidance conflict (AAC) occurs when a behavior has potential for both rewarding and threatening outcomes. Maladaptive processing of both reward and threat are considered important in understanding major depressive disorder (MDD), but there has been a lack of studies probing neural and behavioral differences during AAC decision-making in MDD.

Overnight Fasting Affects Avoidance Learning and Relief

Prolonged fasting influences threat and reward processing, two fundamental systems that underpin adaptive and maladaptive behaviors. Specifically, in animals, overnight fasting sensitizes dopamine-based error signaling that governs reward, fear-extinction, and avoidance learning. Despite emerging evidence that overnight fasting also affects reward and fear learning in humans, effects on human avoidance learning have not been studied yet.

Applying Computational Model Approach to Examine Unique and Common Neural Correlates of Threat Processing in Pediatric Irritability and Anxiety

Irritability and anxiety are impairing and often comorbid clinical phenotypes in youth. Aberrant behavioral and neural attentional processing to threat is thought to underlie both phenotypes. Progress on understanding the mechanism is substantially hindered by limitations in widely used methods to quantify attention bias. Previous work suggests that drift-diffusion models (DDM), and specifically extra-time parameter, may be promising to investigate latent mechanisms of attention bias. This study used computational models to examine associations between threat-related processing and neural function in a transdiagnostic sample of youth.

Neurocognitive processing efficiency for discriminating human non-alarm rather than alarm scream calls.

Across many species, scream calls signal the affective significance of events to other agents. Scream calls were often thought to be of generic alarming and fearful nature, to signal potential threats, with instantaneous, involuntary, and accurate recognition by perceivers. However, scream calls are more diverse in their affective signaling nature than being limited to fearfully alarming a threat, and thus the broader sociobiological relevance of various scream types is unclear. Here we used 4 different psychoacoustic, perceptual decision-making, and neuroimaging experiments in humans to demonstrate the existence of at least 6 psychoacoustically distinctive types of scream calls of both alarming and non-alarming nature, rather than there being only screams caused by fear or aggression. Second, based on perceptual and processing sensitivity measures for decision-making during scream recognition, we found that alarm screams (with some exceptions) were overall discriminated the worst, were responded to the slowest, and were associated with a lower perceptual sensitivity for their recognition compared with non-alarm screams. Third, the neural processing of alarm compared with non-alarm screams during an implicit processing task elicited only minimal neural signal and connectivity in perceivers, contrary to the frequent assumption of a threat processing bias of the primate neural system. These findings show that scream calls are more diverse in their signaling and communicative nature in humans than previously assumed, and, in contrast to a commonly observed threat processing bias in perceptual discriminations and neural processes, we found that especially non-alarm screams, and positive screams in particular, seem to have higher efficiency in speeded discriminations and the implicit neural processing of various scream types in humans.

Does gaze direction of fearful faces facilitate the processing of threat? An ERP study of spatial precuing effects.

Eye gaze is very important for attentional orienting in social life. By adopting the event-related potential (ERP) technique, we explored whether attentional orienting of eye gaze is modulated by emotional congruency between facial expressions and the targets in a spatial cuing task. Faces with different emotional expressions (fearful/angry/happy/neutral) directing their eye gaze to the left or right were used as cues, indicating the possible location of subsequent targets. Targets were line drawings of animals, which could be either threatening or neutral. Participants indicated by choice responses whether the animal would fit inside a shoebox in real life or not. Reaction times to targets were faster after valid compared with invalid cues, showing the typical eye gaze cuing effect. Analyses of the late positive potential (LPP) elicited by targets revealed a significant modulation of the gaze cuing effect by emotional congruency. Threatening targets elicited larger LPPs when validly cued by gaze in faces with negative (fearful and angry) expressions. Similarly, neutral targets showed larger LPPs when validly cued by faces with neutral expressions. Such effects were not present after happy face cues. Source localization in the LPP time window revealed that for threatening targets, the activity of right medial frontal gyrus could be related to a larger gaze-orienting effect for the fearful than the angry condition. Our findings provide electrophysiological evidence for the modulation of gaze cuing effects by emotional congruency.

River Transport Planning Strategy Analysis Using SWOT and AHP Methods

Tangerang City is the largest city in Banten Province and the third largest city in Greater Jakarta area which is split by one of the major rivers on the island of Java, namely the Cisadane River. With the increasing number of population and vehicle ownership, it is necessary to develop a public transportation network to reduce traffic volume and meet the needs of urban public transportation that is fast, easy, safe and comfortable for the citizen. The existence of the Cisadane River in Tangerang City has the potential to be developed into a public transportation route in the form of a waterway. Therefore, the right strategy is needed in the planning of river transportation. This study aims to analyze the influencing factors and strategic priorities in planning river transportation as urban public transportation using the Strength Weakness Opportunity Threat (SWOT) and Analytical Hierarchy Process (AHP) methods. In this study, a questionnaire was given to eight expert respondents related to river transportation. The respondents' answers were tested for consistency with AHP to ensure the accuracy of the answers. From the results of the SWOT analysis, it was obtained the strengths, weaknesses, opportunities and threats in river transportation planning, as well as the ST (Strength-Threat) strategy with the largest weight of 3.99 as the strategy to be used in planning river transportation. Then from the AHP analysis, the strategic priority results in planning river transportation were obtained, namely the safety criteria with a weight of 0.29 and alternative strategy for life jackets with a weight of 0.117853325 as the main priority in carrying out the chosen strategy. Respondents' answers are fairly accurate with a consistency ratio of 2.58% ≤ 10%.

What we think we know about cybersecurity: an investigation of the relationship between perceived knowledge, internet trust, and protection motivation in a cybercrime context

ABSTRACT Individual internet users are commonly considered the weakest links in the cybersecurity chain. One reason for this is that they tend to be overoptimistic regarding their own online safety. To gain a better understanding of the cognitive processes involved in this assessment, the current study applies an extended version of the protection motivation theory. More specifically, this study includes perceived knowledge and internet trust to discover how these antecedents influence the threat and coping appraisal processes. Based on representative survey data collected from 967 respondents, we found that people who feel well-informed about online safety feel less vulnerable to cybercrime and are less inclined to take security measures. At the same time, feeling informed is associated with being more convinced of the severity of cybercrime. High levels of trust in the safety of the internet are linked to the feeling that one is less vulnerable to cybercrime and the perception that cybercrime is not a severe threat. Future interventions should remind internet users about their own perceived vulnerability and the risks that exist online while ensuring that internet users do not lose their trust in the internet and confidence in their own online knowledge.

Physical Aggression Is Associated With More Effective Postdecisional Processing of Social Threat

Physically aggressive individuals are more likely to decide that others are threatening. Yet no research has examined how physically aggressive individuals’ social decisions unfold in real time. Seventy-five incarcerated men completed a task in which they identified the emotions in faces displaying anger (i.e., threat) and happiness (i.e., nonthreat) at low, moderate, or high ambiguity. Participants then rated their confidence in their decisions either immediately or after a delay, and changes in confidence provided an index of postdecisional processing. Physical aggression was associated with stronger differentiation of threatening and nonthreatening faces under moderate ambiguity. Moreover, physical aggression was associated with steeper decreases in confidence over time following decisions that threatening faces were nonthreatening, indicating more extensive postdecisional processing. This pattern of postdecisional processing mediated the association between physical aggression and angry rumination. Findings suggest a role for postdecisional processing in the maintenance of threat-based social decisions in physical aggression.

Comparison of attentional resource allocation to threat and selfrelevant information: An event-related potentials study

Although previous researchers have shown that attention is preferentially allocated during situations involving both threat and selfrelevant information, it is unclear which information type requires more cognitive resources. We compared the automatic processing of threat and self-relevant stimuli using the no-report oddball paradigm. Participants looked at images on a computer screen that displayed fighting with opponents or interacting with friends or customers. The body action of the person depicted was performed either toward the viewing participant or toward other people. Participants watched without making an explicit response, and event-related potentials were measured with electroencephalography. We found that threat (vs. selfrelevant) information elicited a larger P300 amplitude, and for nonthreatening events the P300 amplitude was larger for self-relevant than other-relevant stimuli. These results indicate that threat (vs. selfrelevant) information demands more cognitive resources, possibly because people prioritize survival.

Remedying Stereotype Threat Effects in Spectator Sports

Attempts were made to explore the value of the multiple social identities approach in reducing the detrimental effects of stereotype threats in the context of spectator sports. A total of 150 females were recruited for a laboratory experiment. The following manipulations were implemented: (a) stereotype threat, (b) threat along with the implicit team identification activation, and (c) control. The results revealed that females in the threat condition showed a reduced level of psychological well-being; paradoxically, negative stereotypes positively influenced their self-esteem. The activation of implicit team identification alleviated the detrimental consequences of threat by inhibiting the spreading activation of harmful stereotypes regarding women in sports. The main theoretical frameworks of this study consisted of the process account of stereotype threat suggested in cognitive psychology. The authors attempted to offer a stronger understanding of the underlying mental processes of stereotype threat on women as well as an effective means to deal with its detrimental consequences.

Across-subjects multiple baseline trial of exposure-based cognitive-behavioral therapy for severe irritability: a study protocol

IntroductionIrritability is defined as a tendency towards anger in response to frustration. Clinically, impairing irritability is a significant public health problem. There is a need for mechanism-based psychotherapies targeting severe...

Human Sensory Cortex Contributes to the Long-Term Storage of Aversive Conditioning.

Growing animal data evince a critical role of the sensory cortex in the long-term storage of aversive conditioning, following acquisition and consolidation in the amygdala. Whether and how this function is conserved in the human sensory cortex is nonetheless unclear. We interrogated this question in a human aversive conditioning study using multidimensional assessments of conditioning and long-term (15 d) retention. Conditioned stimuli (CSs; Gabor patches) were calibrated to differentially activate the parvocellular (P) and magnocellular (M) visual pathways, further elucidating cortical versus subcortical mechanisms. Full-blown conditioning and long-term retention emerged for M-biased CS (vs limited effects for P-biased CS), especially among anxious individuals, in all four dimensions assessed: threat appraisal (threat ratings), physiological arousal (skin conductance response), perceptual learning [discrimination sensitivity (d') and response speed], and cortical plasticity [visual evoked potentials (VEPs) and cortical current density]. Interestingly, while behavioral, physiological, and VEP effects were comparable at immediate and delayed assessments, the cortical substrates evolved markedly over time, transferring from high-order cortices [inferotemporal/fusiform cortex and orbitofrontal cortex (OFC)] immediately to the primary and secondary visual cortex after the delay. In sum, the contrast between P- and M-biased conditioning confirms privileged conditioning acquisition via the subcortical pathway while the immediate cortical plasticity lends credence to the triadic amygdala-OFC-fusiform network thought to underlie threat processing. Importantly, long-term retention of conditioning in the basic sensory cortices supports the conserved role of the human sensory cortex in the long-term storage of aversive conditioning.SIGNIFICANCE STATEMENT A growing network of neural substrates has been identified in threat learning and memory. The sensory cortex plays a key role in long-term threat memory in animals, but such a function in humans remains unclear. To explore this problem, we conducted multidimensional assessments of immediate and delayed (15 d) effects of human aversive conditioning. Behavioral, physiological, and scalp electrophysiological data demonstrated conditioning effects and long-term retention. High-density EEG intracranial source analysis further revealed the cortical underpinnings, implicating high-order cortices immediately and primary and secondary visual cortices after the long delay. Therefore, while high-order cortices support aversive conditioning acquisition (i.e., threat learning), the human sensory cortex (akin to the animal homolog) underpins long-term storage of conditioning (i.e., long-term threat memory).

Stakeholder Perceptions of White Oak Supply in Kentucky: A SWOT-AHP Analysis

Growing demand for white oak (Quercus alba) timber and difficulties in regenerating this species point toward future supply issues. Implementing forest policy and management interventions to support its long-term supply will be necessary particularly in Kentucky, where bourbon industry relies solely on casks made from white oak. To increase the probability that these actions will be successful, it is advisable to consider perceptions of stakeholders who are most likely to be involved with and impacted by those decisions. The combined Strength, Weakness, Opportunity, Threat and Analytic Hierarchy Process technique used in this study facilitated independent capturing and ranking of perceptions from three key stakeholder groups (members of woodland owners, forest industry, and distillers industry associations) regarding long-term supply of white oak. The results of this study suggest implementing forest policy and management decisions that have the most support among stakeholders to ensure long-term sustainable supply of white oak are: (1) encourage and incentivize sustainable forest management, and (2) address poor harvesting practices.