Thiolate Ligands Research Articles

20‐4: Efficient and Stable Red Quantum Dot Light‐Emitting Diode with Modified ZnMgO Nanoparticles

Since ZnO nanoparticles are employed as an electron transport layer in quantum dot light‐emitting diode (QLED), the electroluminescence efficiency of QLED is greatly boosted. However, the QLED stability still faces the challenge. Herein, we modify the ZnMgO nanoparticles with the thiol ligand, which can improve the efficiency and stability of QLED at the same time. As a result, the maximum external quantum efficiency of QLED is improved from 18.6% to 26.0%, accompanied by enhanced voltage sweep stability. Our work provides a practical method to enhance the performance of QLED.

Engineering the surface roughness of the gold nanoparticles for the modulation of LSPR and SERS

In this work, we reported that by using a strong thiol ligand as the morphology-directing reagent, a series of Au nanoparticles with plate-like surface sub-structures could be successfully obtained via a one-pot seedless synthesis. The size and the density of the plates on the surface of Au can be readily tuned with the amount of the thiol ligand, resembling different roughness of the surface. Arising from the different surface roughness, the localized surface plasmon resonance (LSPR) of these shape and morphological alike Au nanoparticles can be continuously tuned within the visible-NIR region. The broad LSPR absorptions and feasible tunability make the Au nanoparticles suitable candidate for plasmonic-related applications. Interestingly, huge SERS enhancement was simultaneously achieved based on the specific surface roughness. Our results demonstrate the great potentials for tuning the LSPR and SERS of Au nanostructures through the engineering of the surface morphologies, which would assist for the design, synthesis, and applications of Au-based plasmonic nanomaterials in various fields.

Ultra‐Small Au Nanoclusters with Tailored Photoluminescence Properties using Modified Thiol Ligands: A Computational and Experimental Demonstration

AbstractAu nanoclusters with tailored photoluminescence can be obtained through controlled nanoparticle ligand interface chemistry. The present work reports molecular gold nanoclusters with tuneable photoluminescence emission from 600 to 700 nm using N,N′,N″‐trialkyl (11‐mercaptoundecyl)ammonium chloride ligands as capping‐agents. The tunability within red spectral region is regulated through specific interface chemistry between gold nanoclusters of molecular range and functional groups of the quaternary ammonium head over N,N′,N″‐trialkyl(11‐mercaptoundecyl)ammonium chloride. Combined understanding obtained from the spectroscopy, microscopy, and density functional theory studies demonstrate that the functional group specific electronic interactions at the interfaces steer the emission characteristics of “molecular” Au nanoparticles. The study clearly identifies that bulkier functional groups, i.e., triethyl, tripropyl, tributyl, and dimethyl benzene over N+ (of thiol ligand) through their steric effects minimize the particle size giving rise to tunable photoluminescence emission in red spectral region. However, the red shift seen in the emission Au nanoclusters with N‐(11‐mercaptoundecyl)‐N,N′‐dimethylbenzenammonium chloride ligand in contradiction to particle size effect is computationally proved to be due to the delocalization of electron density from benzene aromatic ring to N+ of ammonium head leading to a reduction in the HOMO‐LUMO energy gap.

How Does the Concentration of Technetium-99m Radiolabeled Gold Nanoparticles Affect Their In Vivo Biodistribution?

Gold nanoparticles (AuNPs) radiolabeled with therapeutic and diagnostic radioisotopes have been broadly studied as a promising platform for early diagnosis and treatment of many diseases including cancer. Our main goal for this study was the comparison of the biodistribution profiles of four different concentrations of gold nanoconjugates radiolabeled with Technetium-99m (99mTc). More specifically, AuNPs with an average diameter of 2 nm were functionalized with a tridentate thiol ligand. Four different concentrations were radiolabeled with 99mTc-tricarbonyls with high radiolabeling yields (>85%) and were further purified, leading to radiochemical purity of >95%. In vitro stability of the radiolabeled nanoconstructs was examined in cysteine and histidine solutions as well as in human serum, exhibiting robust radiolabeling up to 24 h post-preparation. Moreover, in vitro cytotoxicity studies were carried out in 4T1 murine mammary cancer cells. In vivo tracking of the radiolabeled nanoconjugates at both concentrations was examined in normal mice in order to examine the effect of AuNPs’ concentration on their in vivo kinetics. Our work demonstrates that varying concentrations of radiolabeled AuNPs lead to notably different biodistribution profiles.

Enhancement of the alloyed CdZnSeS/ZnS quantum dots photoluminescence by thiol ligands capping

Most of the existing hydrophilization techniques for the semiconductor quantum dots (QDs) lead to degradation of photoluminescence (PL). Therefore, for the applying of QDs in the areas requiring their stability in water media (e.g. bio- and chemical analysis, labeling and sensing), it is often necessary to find a balance between high stability, good optical properties, and difficulty of acquiring. This article describes simple, fast, and easy scalable methods for alloyed CdZnSeS/ZnS QDs ligand exchange using 2-mercaptoethanol, thioglycolic, 3-mercaptorpopionic and dihydrolipoic acids. The proposed ligand exchange techniques provide the enhancement of the QDs photoluminescence intensity in contrast to most of other ligand exchange procedures on the QDs surface. In optimized conditions the twofold photoluminescence quantum yield increase compared to the initial hydrophobic CdZnSeS/ZnS QDs was achieved. Hydrophilized nanoparticles maintained colloidal stability for a period more than 13 months. The suggested mechanism of the PL increase is the passivation of the QDs surface with molecules containing a thiol group. The combination of the proposed effective CdZnSeS/ZnS QDs synthesis and modification methods shows the prospect of their implementation as basic luminescent material for a wide range of applications.

Structure Effects of Ligands in Gold-Ligand Complexes for Controlled Formation of Gold Nanoclusters.

Metal nanoclusters (NCs) are a special class of nanoparticles composed of a precise number of metal atoms and ligands. Because the proportion of ligands to metal atoms is high in metal NCs, the ligand type determines the physical properties of metal NCs. Furthermore, ligands presumably govern the entire formation process of the metal NCs. However, their roles in the synthesis, especially as factors in the uniformity of metal NCs, are not understood. It is because the synthetic procedure of metal NCs is highly convoluted. The synthesis is initiated by the formation of various metal-ligand complexes, which have different numbers of atoms and ligands, resulting in different coordinations of metal. Moreover, these complexes, as actual precursors to metal NCs, undergo sequential transformations into a series of intermediate NCs before the formation of the desired NCs. Thus, to resolve the complicated synthesis of metal NCs and achieve their uniformity, it is important to investigate the reactivity of the complexes. Herein, we utilize a combination of mass spectrometry, density functional theory, and electrochemical measurements to understand the ligand effects on the reactivity of AuI-thiolate complexes toward the reductive formation of Au NCs. We discover that the stability of the complexes can be increased by either van der Waals interactions induced by the long carbon chain of ligands or by non-thiol functional groups in the ligands, which additionally coordinate with AuI in the complexes. Such structural effects of thiol ligands determine the reduction reactivity of the complexes and the amount of NaBH4 required for the controlled synthesis of the Au NCs.

Chiroptical Activity Amplification of Chiral Metal Nanoclusters via Surface/Interface Solidification.

It remains a grand challenge to amplify the chiroptical activity of chiral metal nanoclusters (NCs) although it is desirable for fundamental research and practical application. Herein, we report a strategy of surface/interface solidification (SIS) for enhancing the chiroptical activity of gold NCs. Structural analysis of [Au19(2R,4R/2S,4S-BDPP)6Cl2]3+ (BDPP is 2,4-bis(diphenylphosphino)pentane) clusters reveals that one of the interfacial gold atoms is flexible between two sites and large space is present on the surface, thus hampering chirality transfer from surface chiral ligands to metal core and leading to low chiroptical activity. Following SIS by filling the flexible sites and replacing chlorides with thiolate ligands affords another pair of [Au20(2R,4R/2S,4S-BDPP)6(4-F-C6H4S)2]4+, which shows a more compact and organized structure and thus an almost 40-fold enhancement of chiroptical activity. This work not only provides an efficient approach for amplifying the chiroptical activity of metal nanoclusters but also highlights the significance of achiral components in shaping chiral nanostructures.

Narrowing the photoluminescence bandwidth of InP‐based colloidal quantum dots through photon‐triggered isolation

AbstractThe optimization of photoluminescence (PL) spectral bandwidths in InP‐based colloidal quantum dots (QDs) faces limitations with traditional synthetic methods. This study introduces a novel approach utilizing light‐induced thiolate ligand detachment to selectively precipitate QDs within an ensemble, triggered by photons whose energy matches the red tail of the band‐edge absorption peak. We demonstrate that incorporating benzoquinone as an electron acceptor under inert conditions crucially enhances the efficiency of photoexcited hole‐induced ligand detachment. Through careful optimization of laser exposure conditions, we successfully narrowed the PL bandwidth of InP/ZnSe/ZnS QDs from 39 to 35 nm. Our findings offer significant insights into the development of high‐performance QD‐based displays, promising advancements in color purity.

Ligand mediated self-assembly of cobalt nanoclusters for tunable supercapacitors

Self-assembly of thiolated cobalt-based nanoclusters was achieved by a simple and one-step synthesis process towards the development of a tunable hybrid supercapacitor. Here, we report the wet chemical synthesis of self-assembly of cobalt nanoclusters (CoNCs) using three different thiols namely glutathione (GS), 3-mercapto propyl sulfonate (MPS) and 3-mercapto propionic acid (MPA) protected individually. The variation in the capping ability of the thiolate ligands brings the proximal changes in the optical, structural and electrochemical properties. In CoNCs, the structural and morphological changes that evolved from the obtained GS-CoNCs, MPS-CoNCs, and MPA-CoNCs were confirmed using UV–vis spectroscopy, XRD, and TEM analysis. The stability of CoNCs and binding states of cobalt metal were determined using TG and XPS analysis respectively. The divergence in the rigidifying nature of various thiolated cobalt nanoclusters significantly influences their capacitance ability for energy storage via altering the porosity and electron transfer characteristics. The rigid dense multifunctional ligands like GS facilitate the electron-hole hopping process in the nano-pockets available in GS, which enhances the energy storage capability and diffusion among ligand-metal-ligand chains. Wherein, the other two ligands MPS and MPA show comparatively lower supercapacitance activities due to diverse functionality and rigidify. The charge-discharge studies explore the supercapacitor behaviour of GS, MPS and MPA-protected CoNCs with the specific capacitance of 540, 494 and 358 F g−1 respectively at the current density of 1 A g−1.

Insight to the Catalytic Activity of Atomically Precise Ag4Ni2 Nanoclusters on Silicon Carbide for Nitroarene Reduction.

Atomically precise Ag4Ni2 nanoclusters with 2,4-dimethylbenzenethiol as the ligands were synthesized and characterized as a cocatalyst of SiC for the selective hydrogenation of nitroarenes to arylamine in the presence of NaBH4. The obtained Ag4Ni2/SiC samples exhibited extraordinary catalytic activity, and a self-accelerated catalytic process was observed with the reduction of nitrophenol to aminophenol as the model reaction. Experimental comparison between the Ag4Ni2/SiC samples before and after the catalysis showed that the transformation of Ag4Ni2 clusters to polydisperse Ag particles as well as amorphous NiOx on the surface of SiC in the catalysis was the key to their high activity. AIMD calculations revealed that the transformation of Ag4Ni2 was driven by the presence of multiple hydrides on the cluster, which induced the detachment of the thiol ligand of the nanoclusters.

Energy Transfer-Based Recognition of Membrane Cholesterol by Controlling Intradistance of Linker.

Gold nanoparticles (AuNPs) are good candidates for donor material in energy transfer systems and can easily be functionalized with various ligands on the surface with Au-S bonding. Cyclodextrin (CD) forms inclusion complexes with fluorophores due to its unique structure for host-guest interaction. In this study, we fabricated βCD-functionalized AuNPs using different lengths of thiol ligands and recognized cholesterol to confirm the energy-transfer-based turn-on fluorescence mechanism. AuNP-βCD conjugated with various thiol ligands and quenched the fluorescein (Fl) dye, forming βCD-Fl inclusion complexes. As the distance between AuNPs and βCD decreased, the quenching efficiency became higher. The quenched fluorescence was recovered when the cholesterol replaced the Fl because of the stronger binding affinity of the cholesterol with βCD. The efficiency of cholesterol recognition was also affected by the energy transfer effect because the shorter βCD ligand had a higher fluorescence recovery. Furthermore, we fabricated a liposome with cholesterol embedded in the lipid bilayer membrane to mimic the cholesterol coexisting with lipids in human serum. These cellular cholesterols accelerated the replacement of the Fl molecules, resulting in a fluorescence recovery higher than that of pure lipid. These discoveries are expected to give guidance towards cholesterol sensors or energy-transfer-based biosensors using AuNPs.

Spectroscopic, electrochemical, and kinetic trends in Fe(III)–thiolate disproportionation near physiologic pH

In addition to its primary oxygen-atom-transfer function, cysteamine dioxygenase (ADO) exhibits a relatively understudied anaerobic disproportionation reaction (ADO-Fe(III)-SR → ADO-Fe(II) + ½ RSSR) with its native substrates. Inspired by ADO disproportionation reactivity, we employ [Fe(tacn)Cl3] (tacn = 1,4,7-triazacyclononane) as a precursor for generating Fe(III)–thiolate model complexes in buffered aqueous media. A series of Fe(III)–thiolate model complexes are generated in situ using aqueous [Fe(tacn)Cl3] and thiol-containing ligands cysteamine, penicillamine, mercaptopropionate, cysteine, cysteine methyl ester, N-acetylcysteine, and N-acetylcysteine methyl ester. We observe trends in UV–Vis and electron paramagnetic resonance (EPR) spectra, disproportionation rate constants, and cathodic peak potentials as a function of thiol ligand. These trends will be useful in rationalizing substrate-dependent Fe(III)–thiolate disproportionation reactions in metalloenzymes.Graphical abstract

Mechanistic and Kinetic Insights into Cellular Uptake of Biomimetic Dinitrosyl Iron Complexes and Intracellular Delivery of NO for Activation of Cytoprotective HO-1.

Dinitrosyl iron unit (DNIU), [Fe(NO)2], is a natural metallocofactor for biological storage, delivery, and metabolism of nitric oxide (NO). In the attempt to gain a biomimetic insight into the natural DNIU under biological system, in this study, synthetic dinitrosyl iron complexes (DNICs) [(NO)2Fe(μ-SCH2CH2COOH)2Fe(NO)2] (DNIC-COOH) and [(NO)2Fe(μ-SCH2CH2COOCH3)2Fe(NO)2] (DNIC-COOMe) were employed to investigate the structure-reactivity relationship of mechanism and kinetics for cellular uptake of DNICs, intracellular delivery of NO, and activation of cytoprotective heme oxygenase (HO)-1. After rapid cellular uptake of dinuclear DNIC-COOMe through a thiol-mediated pathway (tmax = 0.5 h), intracellular assembly of mononuclear DNIC [(NO)2Fe(SR)(SCys)]n-/[(NO)2Fe(SR)(SCys-protein)]n- occurred, followed by O2-induced release of free NO (tmax = 1-2 h) or direct transfer of NO to soluble guanylate cyclase, which triggered the downstream HO-1. In contrast, steady kinetics for cellular uptake of DNIC-COOH via endocytosis (tmax = 2-8 h) and for intracellular release of NO (tmax = 4-6 h) reflected on the elevated activation of cytoprotective HO-1 (∼50-150-fold change at t = 3-10 h) and on the improved survival of DNIC-COOH-primed mesenchymal stem cell (MSC)/human corneal endothelial cell (HCEC) under stressed conditions. Consequently, this study unravels the bridging thiolate ligands in dinuclear DNIC-COOH/DNIC-COOMe as a switch to control the mechanism, kinetics, and efficacy for cellular uptake of DNICs, intracellular delivery of NO, and activation of cytoprotective HO-1, which poses an implication on enhanced survival of postengrafted MSC for advancing the MSC-based regenerative medicine.

Unraveling a Concerted Proton-Coupled Electron Transfer Pathway in Atomically Precise Gold Nanoclusters.

Metal nanoclusters (MNCs) represent a promising class of materials for catalytic carbon dioxide and proton reduction as well as dihydrogen oxidation. In such reactions, multiple proton-coupled electron transfer (PCET) processes are typically involved, and the current understanding of PCET mechanisms in MNCs has primarily focused on the sequential transfer mode. However, a concerted transfer pathway, i.e., concerted electron-proton transfer (CEPT), despite its potential for a higher catalytic rate and lower reaction barrier, still lacks comprehensive elucidation. Herein, we introduce an experimental paradigm to test the feasibility of the CEPT process in MNCs, by employing Au18(SR)14 (SR denotes thiolate ligand), Au22(SR)18, and Au25(SR)18- as model clusters. Detailed investigations indicate that the photoinduced PCET reactions in the designed system proceed via an CEPT pathway. Furthermore, the rate constants of gold nanoclusters (AuNCs) have been found to be correlated with both the size of the cluster and the flexibility of the Au-S framework. This newly identified PCET behavior in AuNCs is prominently different from that observed in semiconductor quantum dots and plasmonic metal nanoparticles. Our findings are of crucial importance for unveiling the catalytic mechanisms of quantum-confined metal nanomaterials and for the future rational design of more efficient catalysts.

A DFT investigation of the structure/electron count relationship in an electron-rich copper nanocluster with unprecedented Cu39superatomic core

This paper reports a DFT computational analysis of the richest in electron ever known thiolate-protected copper nanocluster that was recently reported by Liu, Huang and coworkers as being [Cu75(S-Adm)32]2+. Our calculations suggest that this compound is most likely the closed-shell trication [Cu75(S-Adm)32]3+ and that it is a 40-electron superatom with the 1S2 1P6 1D10 2S2 1F14 2P6 configuration. This electron count is associated with an unprecedented multishell [Cu39]- = Cu@Cu14(tetrakis hexahedron)@Cu24(truncated octahedron) superatomic core. This core is protected by 32 thiolate ligands and 36 Cu(I) metal centers which are coordinated to two or three sulfur lone pairs.

Three-atom-wide gold quantum rods with periodic elongation and strongly polarized excitons

Atomically precise control over anisotropic nanoclusters constitutes a grand challenge in nanoscience. In this work, we report our success in achieving a periodic series of atomically precise gold quantum rods (abbrev. Au QRs) with unusual excitonic properties. These QRs possess hexagonal close-packed kernels with a constant three-atom diameter but increasing aspect ratios (ARs) from 6.3 to 18.7, all being protected by the same thiolate (SR) ligand. The kernels of the QRs are in a Au1-(Au3)n-Au1 configuration (where n is the number of Au3 layers) and follow a periodic elongation with a uniform Au18(SR)12 increment consisting of four Au3 layers. These Au QRs possess distinct HOMO-LUMO gaps (Eg = 0.6 to 1.3 eV) and exhibit strongly polarized excitonic transition along the longitudinal direction, resulting in very intense absorption in the near-infrared (800 to 1,700 nm). While excitons in gapped systems and plasmons in gapless systems are distinctly different types of excitations, the strongly polarized excitons in Au QRs surprisingly exhibit plasmon-like behaviors manifested in the shape-induced polarization, very intense absorption (~106 M-1 cm-1), and linear scaling relations with the AR, all of which resemble the behaviors of conventional metallic-state Au nanorods (i.e., gapless systems), but the QRs possess distinct gaps and very long excited-state lifetimes (10 to 2,122 ns), which hold promise in applications such as near-infrared solar energy utilization, hot carrier generation and transfer. The observation of plasmon-like behaviors from single-electron transitions in Au QRs elegantly bridges the distinct realms of single-electron and collective-electron excitations and may stimulate more research on excitonics and plasmonics.

The effect of thiol ligands on the adsorption behavior of silver ions on functionalized nanomagnetic graphene oxides

The magnetic graphene oxides (MGO) were modified with l-cysteine (Cys), glutathione (GSH), and thioglycolic acid (TGA) as the thiol ligands. using field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometry, and Brunauer Emmett Teller (BET) surface area analysis, the structural and magnetic properties of the as-prepared samples have been studied. The results affirmed the successful synthesis of functionalized adsorbents. The adsorbents presented here have been reported for the first time to remove Ag ions from dilute aqueous solutions. The influence of the adsorption conditions (pH, contact time, and initial concentration) was investigated. The experimental data were consistent with both the pseudo-second-order kinetic model and the Langmuir isotherm model indicating chemisorption monolayer adsorption with the fast kinetics. The maximum adsorption capacity for MGO-TGA, MGO-Cys, and MGO-GSH based on the Langmuir isotherm model was found to be qm = 67.16, 53.42, and 43.73 mg/g, respectively. The calculated separation factors (0 < RL < 1) revealed that the adsorption process was favorable for three adsorbents. The large surface area of the adsorbents (57.244, 37.006, and 15.676 m2/g, for MGO-TGA, MGO-Cys, and MGO-GSH, respectively), along with the presence of thiol ligands on them, significantly affects the adsorption behavior. Therefore, these adsorbents offer an effective and rapid process for adsorbing silver ions from low concentration aqueous solutions.

Silver Nanoparticle-Functionalized Postsynthetically Modified Thiol MOF UiO-66-NH-SH for Efficient CO2 Fixation.

Thiols are essential functional groups imparting unique properties, such as reactivity and selectivity, to many vital enzymes and biomolecules. The integration of electronically soft thiol groups within metal-organic frameworks (MOFs) yields elevated reactivity and a pronounced affinity for soft metal ions. However, the scarcity of thiol-based ligands and synthetic challenges hinder the advancement of thiol-based MOFs. To bypass the difficulties of synthesizing thiol MOFs by a direct reaction between thiol-based ligands and corresponding metal salts, postsynthetic modification (PSM) of MOFs is an efficient strategy to introduce thiol functionality. Herein, we have introduced Ag nanoparticles in postsynthetically modified thiol MOFs UiO-66-NH-SH (1) (synthesized by reaction between UiO-66-NH2 and thioglycolic acid) and UiO-66-NH-SH (2) (synthesized by reaction between UiO-66-NH2 and 3-mercaptopropionic acid) to synthesize a series of heterogeneous catalysts for CO2 fixation. Catalysts Cat 1-2 and Cat 3 - 4 were synthesized from UiO-66-NH-SH (1) and UiO-66-NH-SH (2), respectively, by using varying concentrations of silver (AgNO3). Catalyst Ag@UiO-66-NH-SH (1) (Ag = 3.45%; namely Cat 2) shows the highest efficiency for the catalytic conversion of propargylic alcohol and terminal epoxide to the corresponding cyclic carbonates. Finally, a rationalized reaction mechanism is proposed by correlating our results with the current literature. This work presents a viable strategy to utilize the thiol functionality of MOFs (avoiding the complexities associated with synthesizing thiol MOFs directly from thiol ligands) as a platform for introducing catalytically active metal centers and applying them as a heterogeneous catalyst for CO2 fixation reactions.

Oligomeric Zinc Thiolates Tethering Multidentate Carboxylates for Nondestructive Aqueous Phase Transfer of Quantum Dots.

Functionalization of quantum dots (QDs) via ligand exchange is prone to debase their photoluminescence quantum yield (PL QY) owing to the unavoidable surface damage by excess reactants, and even worse in aqueous medium. Herein, the oligomeric zinc thiolate as the multidentate hydrophilic ligand featuring facile synthetic protocol is proposed. A simple reaction between ZnCl2 and 3-mercaptopropionic acid produces oligomeric ligands containing 3-6 zinc thiolate units, where the terminal moieties provide multidentate anchoring to the surface as well as hydrophilicity. 2D proton nuclear Overhauser effect spectroscopy (2D 1H NOESY) and X-ray photoelectron spectroscopy (XPS) reveal that the oligomeric zinc thiolate ligands adsorb on the surface via multidentate metal carboxylate bindings without destruction of molecular structure, regardless of partial dissociation of thiolate branches in aqueous phase. Enhanced binding affinity granted by the multidentate nature allows for the effective exchange of original surface ligands without considerable surface deterioration. The zinc thiolate-capped Cd-free aqueous QDs exhibit a high photoluminescence quantum yield of ≈90% and extended stability against long-term storage and photochemical stress.

Surface ligand-regulated nanointerfaces: Enhancing the catalytic activity and selectivity of platinum nanozymes for biomedical applications

Platinum nanoparticles (Pt NPs) have aroused tremendous attention due to the significant enzyme-like activity, controllable synthesis and biosafety. However, it remains a challenge to properly design the morphology and surface properties of Pt NPs to obtain the desired enzyme-like activity and substrate selectivity. Herein, a surface engineering strategy is employed to adjust the catalytic performance of Pt NPs by modifying different functional groups, thereby promoting its oxidase-like activity and catalytic specificity to substrate. The catalytic performance of Pt NPs with various thiolate ligands was evaluated using TMB, ABTS and OPD as substrates. The kcat/Km values revealed that Pt NPs modified by 6-mercapto-6-deoxybeta-cyclodextrin (Pt@CD) had a strong substrate selectivity for TMB, but a weak selectivity for ABTS and OPD, with a catalytic specificity to TMB nearly 3.4 times that of bare Pt NPs. When uric acid was used as substrate, PtNP_32 showed better environmental stability and uric acid degradation efficiency than uricase. More importantly, the PtNP_32 did not cause hemolysis and had good biocompatibility, making it a promising candidate for the treatment of hyperuricemia-related diseases. This work provides a new strategy to improve the catalytic performance of platinum nanozymes for efficient and selective degradation of uric acid.