Thick Sections Research Articles

Stereological Estimation and Zonal Distribution of the Hepatotoxic Effects of Doxorubicin on the Female Albino Rat (Rattus Norvegicus)

Background: Doxorubicin is an anti-neoplastic agent widely indicated for a variety of cancers. One of its adverse effects is hepatotoxicity which presents with hepatocyte necrosis, sinusoidal dilation, and fibrosis. However, there remains a dearth in the quantification and zonal distribution of this damage. Methods: Twenty-three adult female Wister albino rats were placed into baseline, control, and experimental group receiving 2.5mg/kg bodyweight Doxorubicin intra-peritoneally thrice weekly for 3-weeks. Rats were sacrificed on days 0, 7, 14 and 21 and livers harvested for processing. Masson’s Trichrome was used in staining 7 µm thick sections. Images were taken and analyzed via STEPanizer, and data entered into SPSS for analysis. Results: Rats treated with Doxorubicin had increased liver to body weight ratios from 5.00% at baseline to 6.15%, 6.69% and 7.56% on days 7, 14 and 21 (p=0.090). There was a decrease in hepatocyte densities from 51.88/mm2 to 48.61/mm2, 46.65/mm2 and 42.24/mm2 on day 7, 14 and 21 (p=0.779). Collagen fiber deposition increased from 0.12±0.06 cm3 to 0.47±0.55 cm3, 1.64±0.11 cm3 and 1.88±0.24 cm3 on days 7, 14 and 21 (p=0.009). Deposition was greatest periportally and least pericentrally. Volume of sinusoidal spaces increased from 5.46±0.50 cm3 to 5.49±0.15 cm3, 5.53±0.24 cm3 and 5.50±0.17 cm3 on days 7, 14 and 21 respectively (p=0.827). Sinusoids were larger pericentrally than periportally. Conclusion: Doxorubicin administration is associated with an increase in volume density of fibrotic tissue and sinusoidal spaces but decrease in hepatocytes. The quantitative changes presented may facilitate histopathological grading of Doxorubicin-induced hepatotoxicity.

Bovine Meissner-like corpuscle and evolutionary ecology of mammalian somatosensory acuity.

The mammalian snout has Meissner's corpuscles (MCs), which transmit epicritic sensations as the animal explores its surroundings. To comprehend the somatosensory acuity in mammals, we examined the structural organization and density of bovine Meissner-like corpuscles (BMLCs) at various ages and compared the changes with other mammalian MCs. The skin from the snout of cows or oxen (2-11 years old) was obtained and processed through routine histological technique. Five-μm thick sections were prepared, silver stained according to the Bielschowsky technique as modified by Winkelman and Schmidt (Mayo Clinic Proceedings, 1957, 217), and observed under a compound light microscope quantitatively and qualitatively. The glabrous skin of the cow snout consisted of two types of BMLCs: One was a cylindrical or elongated structure found in the dermal papillae. The other type was spherical and developed in the superficial layers of the epidermis. BMLCs consisted of both coarse and fine nerve fibres. In the young, the corpuscle comprised thin nerve fibres with indistinct cell outlines. In adults, nerve fibres in the corpuscles were closely packed, and networks, varicosities and end bulbs were well developed. With advancing age, the MCs attenuated into a disorganized mass of nerve fibres. The bovine snout is a highly evolved somatosensory organ due to its rich nerve supply and functionally resembles the anthropoid fingertip. Somatosensory acuity will be lower in the glabrous bovine skin than in primate glabrous skin of the fingertip, as the nerve terminals within the BMLCs are less elaborate in content and structural complexity.

Evaluating the optimal tissue thickness for mass spectrometry imaging using infrared matrix-assisted laser desorption electrospray ionization.

Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) utilizes a 2970 nm mid-IR laser to desorb samples with depth resolutions (Z) on the order of micrometers. Conventionally, 5-20 μm thick tissue sections are used to characterize different applications of the IR-MALDESI source, but an optimal thickness has not been systematically investigated. Mouse liver was sectioned to various thicknesses and analyzed using IR-MALDESI mass spectrometry imaging (MSI). Height profiles of tissue sections of various cryosectioned thicknesses were acquired to affirm tissue thickness. Tissue sections of each thickness were measured using a Keyence microscope. Paraffin wax was cryosectioned, mounted on microscope slides, and measured using a chromatic confocal sensor system to determine the cryostat sectioning accuracy. Analyzing sectioned tissues at higher thickness (>10μm) leads to lower ion abundance, a decrease in signal over long analysis times, and more frequent instrument cleaning. Additionally, increasing tissue thickness above the optimum (7μm) does not result in a significant increase in lipid annotations. This work defines an optimal sample thickness for IR-MALDESI-MSI and demonstrates the utility of optimizing tissue thickness for MSI platforms of comparable Z resolution.

Forensic age estimation with ankle MRI: Evaluating distal tibial and calcaneal epiphyseal fusion

Forensic authorities often request age estimation from forensic experts, particularly in cases related to sexual abuse, child pornography, illegal migration, marriage, etc. The most commonly used method in this regard is radiological methods. Because of the potential dangers of radiation exposure outside of clinical indications, new researches are focusing on non-ionizing and non-invasive technologies. This study aimed to demonstrate the applicability of age estimation in living individuals from ankle magnetic resonance images as a non-ionizing method, and to determine whether it is compatible with individuals' real ages and to establish a database. Ankle MRI images of patients aged between 7 and 26 years who applied to the Cukurova University Faculty of Medicine Balcali Hospital between January 2011 and December 2020 were retrospectively evaluated. A six-stage staging method proposed by Lu et al. was applied to the distal tibial and calcaneal epiphyseal ossification points by examining ankle MRI images of a total of 331 patients, 197 males and 134 females. In the study, images obtained from a sagittal section fast spin echo T1-weighted sequence, with a section thickness of 3–4 mm, were evaluated. As a result of the study, Stage 1 in both distal tibial and calcaneal epiphysis was observed only in patients under 18 years of age in both sex. In males, stage 2 in distal tibial epiphyseal ossification was observed under 18 years of age, except for one case, and stage 5 in both distal tibial and calcaneal epiphyseal ossification was observed in almost all cases over 18 years of age in males. According to the results of our study, magnetic resonance imaging was found to be a non-ionizing method that could be used in addition to other radiological methods aimed at determining the 18-year age limit in age estimation. Multicenter, comparative, and prospective studies conducted by experienced researchers are needed to enable the routine use of MRI in age estimation.

Vascular and lymphatic heterogeneity and age-related variations of dental pulps

ObjectivesDental pulp tissue is highly vascularized. However, age-related vascular changes of the dental pulp in mice and humans remain poorly understood. We modified a novel tissue clearing method, mapped the vasculature, pericytes, and perivascular matrix in the dental pulp via high-resolution 3D imaging. MethodsWe isolated young and aged pulps from mouse teeth, and mapped vasculature through a high-resolution thick frozen sections imaging method and a modified tissue clearing method. Human dental pulps were also mapped for vasculature studying. Furthermore, young and aged human dental pulps were collected and were compared with mouse pulps through RNA- sequencing. ResultsFive vascular subtypes of blood vessels were found in the mouse dental pulp, which constituted the arterioles-capillaries-venules network. The density of capillaries and venules of molars declined obviously in aged mice. Among the age-dependent changes in the perivascular pulp matrix, the perivascular macrophages remarkably increased, lymphatic capillaries increased, while the nerves and extracellular matrix remained unchanged. Furthermore, the vascular patterns of human formed a complex vascular network. Both mouse and human dental pulps exhibited an inflammaging state. TNF pathway and Rap1 pathway might become promising targets for combating inflammaging and promoting angiogenesis. ConclusionsFive subtypes of blood vessels were identified within the dental pulp of mice. Notably, the density of capillaries and venules in pulps of aged mice was reduced. Furthermore, partial similarities were observed in the vascular patterns between the dental pulps of humans and mice. RNA-sequencing analysis revealed that both mouse and human dental pulps exhibit indications of an inflammaging state. Clinical SignificanceThis study may contribute to unraveling potential therapeutic targets in the pulp regeneration and treatment of relevant diseases in the elderly.

A Hierarchical Theory for the Tensile Stiffness of Non-Buckling Fractal-Inspired Interconnects.

The design of non-buckling interconnects with thick sections has gained important applications in stretchable inorganic electronics due to their simultaneous achievement of high stretchability, low resistance, and low heat generation. However, at the same time, such a design sharply increased the tensile stiffness, which is detrimental to the conformal fit and skin comfort. Introducing the fractal design into the non-buckling interconnects is a promising approach to greatly reduce the tensile stiffness while maintaining other excellent performances. Here, a hierarchical theory is proposed for the tensile stiffness of the non-buckling fractal-inspired interconnects with an arbitrary shape at each order, which is verified by the finite element analysis. The results show that the tensile stiffness of the non-buckling fractal-inspired interconnects decreases with the increase in either the height/span ratio or the number of fractal orders but is not highly correlated with the ratio of the two adjacent dimensions. When the ratio of the two adjacent dimensions and height/span ratio are fixed, the tensile stiffness of the serpentine fractal-inspired interconnect is smaller than that of sinusoidal and zigzag fractal-inspired interconnects. These findings are of great significance for the design of non-buckling fractal-inspired interconnects of stretchable inorganic electronics.

Phrenic Nerve Transfer to Musculocutaneous Nerve: An Anatomical and Histological Study.

To restore elbow flexor muscle function in case of traumatic brachial plexus avulsion, the phrenic nerve transfer to the musculocutaneous nerve has become part of clinical practice. The nerve transfer can be done by means of video-assisted thoracic surgery without nerve graft or via supraclavicular approach in combination with an autograft. This study focuses on a detailed microscopic and macroscopic examination of the phrenic nerve. It will allow a better interpretation of existing clinical results and, thus, serve as a basis for future clinical studies. An anatomical study was conducted on 28 body donors of Caucasian origin (female n = 14, male n = 14). A sliding caliper and measuring tape were used to measure the diameter and length of the nerves. Sudan black staining was performed on 15 µm thick cryostat sections mounted on glass slides and the number of axons was determined by the ImageJ counting tool. In 23 individuals, the phrenic nerve could be examined on both sides. In 5 individuals, however, only one side was examined. Thus, a total of 51 nerves were examined. The mean length of the left phrenic nerves (33 cm (29-38 cm)) was significantly longer compared to the mean length of the right phrenic nerves (30 cm (24-33 cm)) (p < 0.001). Accessory phrenic nerves were present in 9 of 51 (18%) phrenic nerves. The mean number of phrenic nerves axons at the level of the first intercostal space in body donors with a right accessory phrenic nerve was significantly greater compared to the mean number of phrenic nerves axons at the same level in body donors without a right accessory phrenic nerve (3145 (range, 2688-3877) vs. 2278 (range, 1558-3276)), p = 0.034. A negative correlation was registered between age and the nerve number of axons in left (0.742, p < 0.001) and right (-0.273, p = 0.197) phrenic nerves. The mean distance from the upper edge of the ventral ramus of the fourth cervical spinal nerve to the point of entrance of the musculocutaneous nerve between the two parts of the coracobrachialis muscle was 19 cm (range, 15-24 cm) for the right and 20 cm (range, 15-25 cm) for the left arm. If an accessory phrenic nerve is available, it presumably should be spared. Thus, in that case, a supraclavicular approach in combination with a nerve graft would probably be of advantage.

Experimental study of innovative bolted shear connectors in demountable cold-formed steel–concrete composite beams

Although cold-formed steel (CFS) members have been widely used in structures, their application is limited due to the buckling and instability of these members. To enhance their strength and stiffness, they are often combined with other materials like concrete or timber. One of the main challenges in composite structures is ensuring proper connection between different components to facilitate safe shear load transfer. This is achieved through various types of shear connectors. Bolted shear connections are preferred over headed shear studs because they offer greater strength and can be easily dismantled. Headed shear studs welded onto a steel section are unsuitable for CFS members due to their low thickness.In this paper, we propose a novel demountable composite connection specifically designed for prefabricated CFS structures. The behavior of this connection was evaluated through fifteen push-out test specimens, with key variables including CFS section thickness and bolt diameter/strength. The ultimate load, stiffness, ductility, and failure modes of all specimens were determined. The results revealed that specimens with a higher thickness of CFS members experienced bolt fracture, exhibiting superior effective stiffness, strength, and ductility. Conversely, specimens with a lower thickness of CFS members failed due to distortional buckling of the CFS members. The test results underscore the importance of carefully designing and providing a proportionate CFS section thickness to ensure shear connectors fracture before the CFS members. This significantly improves the shear strength capacity of the composite connection with CFS sections and precast concrete slabs. Furthermore, the deconstructability of the connection at the end of its service life was investigated. The steel–concrete composite connection with precast concrete slabs and demountable bolted shear connections was also modeled using a 3D finite element method. The numerical model’s accuracy in simulating the observed structural behavior was confirmed against experimental data. Finally, appropriate and straightforward formulations for predicting the ultimate load of the CFS-concrete composite connection were proposed. It was concluded that the predictions of ultimate shear load capacity values by EC4, AISC, and AISI provisions for this composite connection are significantly less accurate.

Web crippling resistance of cold-formed steel built-up box sections through experimental testing, numerical simulation and deep learning

This study proposes a deep-learning framework, namely a deep belief network (DBN), for investigating the web crippling resistance of cold-formed steel (CFS) built-up stiffened box sections. A total of 12 new web crippling tests are presented initially, which were carried out under interior-two-flange (ITF) and end-two-flange (ETF) loading conditions. In the experimental tests, two cross-section dimensions were considered, and the overall web depth varied from 290 mm to 550 mm. The yield strength of the specimens varied from 371.7 MPa to 643.6 MPa. The specimens were characterised by different screw spacing, varying between 50 mm and 300 mm. An elasto-plastic finite element (FE) model was developed and validated against the test results. Subsequently, a total of 1,356 data points for training the DBN were generated based on the validated FE model. When a comparison was made against the test results, the absolute percentage error of the DBN predictions was found to be around 10%. Using the DBN predictions which were based on the validated FE model, a comprehensive parametric study was undertaken to investigate the effects of section thickness, yield strength, bearing length and screw spacing on the web crippling resistance of CFS built-up stiffened box sections. New design equations for predicting the ITF and ETF web crippling resistances of CFS built-up stiffened box sections were then proposed, and a reliability analysis was undertaken to assess the feasibility of the proposed equations.

Thermal response and pyrolysis behavior of carbon fiber/phthalonitrile composites under one-sided butane flame heating: Experimental and numerical analysis

The present work innovatively investigates the one-sided flame heating thermal response and pyrolysis behavior of carbon fiber/phthalonitrile (Cf/PN) composite laminates. The effectiveness of the Abaqus/UMATHT subroutine in studying the temperature and reaction mechanism-dependent material thermal performance is proved. A numerical model which accounts for the correction of pyrolysis depth and multi-stage pyrolysis kinetics parameters is established to generate massive data to replace repeated experiments. By analyzing the temperature and temperature rise rate distribution, the total mass loss ratio, and the post-heating micromorphology in the thickness section, the pyrolysis characteristics of the material are discussed. Finally, the rear surface temperatures corresponding to different surface heat flux, specimen thickness and heating time are numerically predicted to provide potential engineering guidance for the application of phthalonitrile composite materials in thermal protection and load-bearing integrated structures.

The assessment of structural behaviours of steel framing system – affordable house system design

Purpose Nowadays, residential buildings have become increasingly important due to the growing communities. The purpose of this study is to investigate the behavior of a steel structural framing system that incorporates lightweight load-bearing walls and slabs, and to compare the weight of materials used in cold-formed and hot-finished steel structural systems for affordable housing. Design/methodology/approach Four types of models consisting of 243 members were simulated. Model 1 is a cold-formed steel structural framing system, while Model 2 is a hot-finished steel structural framing system. Both Models 1 and 2 use lightweight wall panels and lightweight composite slabs. Models 3 and 4 are made with brick walls and precast reinforced concrete systems, respectively. These structures use different wall and slab materials, namely, brick walls and precast reinforced concrete. The analysis includes bending behavior, buckling resistance, shear resistance and torsional rotation analysis. Findings This study found that using thinner steel sections can increase the deflection value. Meanwhile, increasing member length and the ratio of slenderness will decrease buckling resistance. As the applied load increases, buckling deformation also increases. Furthermore, decreasing shear area causes a reduction in shear resistance. Thicker sections and the use of lightweight materials can decrease the torsional rotation value. Originality/value The weight comparison of the steel structures shows that Model 1, which is a cold-formed steel structure with lightweight wall panels and lightweight composite slabs, is the most suitable model due to its lightweight and affordability for housing. This model can also be used as a reference for the optimal design of modular structural framing using cold-formed steel materials in the field of civil engineering and as a promotional tool.

Regional source rock thermal stress modeling and map-based charge access modeling of the Port Isabel passive margin foldbelt, northwestern Gulf of Mexico

The Port Isabel passive margin foldbelt covers 17,000 km2 of the northwestern deepwater U.S. Gulf of Mexico. Seven oil exploration wells have been drilled in the area from 1996 to 2007, yielding a single uncommercial gas discovery. The 5–7 km thick Oligo-Miocene section prevents drilling from penetrating the underlying Paleogene and Mesozoic source rocks. Accommodation space for the Oligo-Miocene section is created by the collapse of a paleo-salt wall, leading to linked fault systems in the upper decollement to the east. We use 13 exploration wells to construct 1D and map-based 2D basin models to investigate the burial and thermal history of three inferred source rock horizons (Paleogene, Turonian, and Tithonian). We interpret a 2D seismic data grid tied to four wells to constrain stratigraphic depths and thicknesses of the younger and shallower Wilcox source rock horizons, and the Jurassic and Cretaceous source rock horizons. Our results indicate that vitrinite reflectance is a proxy for the thermal stress levels reached by the source rocks as supported by maps of hydrocarbon charge access. We conclude that all three source rock intervals have reached varying degrees of maturity, expelled hydrocarbons in late Paleogene to mid-Neogene, and likely continue expelling hydrocarbons to the present-day at a reduced rate. The deposition of the Oligocene and Middle Miocene sedimentary section has buried the underlying source intervals and likely brought them into the gas/condensate window in the present-day. Our mapping of the extensive seismic reflection grid reveals four-way structural closures, three-way stratigraphic traps, and salt truncation structures associated with amplitude anomalies which may support our predictions for maturity in the underlying source rocks. Our thermal stress maps predict that the modeled source rocks are mature and our charge access models for the available wells constrain migration patterns, although the timing of the early hydrocarbon charge and late trap formation remain significant risk factors.

Enhancing obSTORM imaging performance with cubic spline PSF modeling.

Oblique plane microscopy-based single molecule localization microscopy (obSTORM) has shown great potential for super-resolution imaging of thick biological specimens. Despite its compatibility with tissues and small animals, prior uses of the Gaussian point spread function (PSF) model have resulted in limited imaging resolution and a narrow axial localization range. This is due to the poor fit of the Gaussian PSF model with the actual PSF shapes in obSTORM. To overcome these limitations, we have employed cubic splines for a more accurate modeling of the experimental PSF shapes. This refined PSF model enhances three-dimensional localization precision, leading to significant improvements in obSTORM imaging of mouse retina tissues, such as an approximately 1.2 times increase in imaging resolution, seamless stitching of single molecules between adjacent optical sections, and a doubling of the sectional interval in volumetric obSTORM imaging due to the extended axial range of usable section thickness. The cubic spline PSF model thus offers a path towards more accurate and faster volumetric obSTORM imaging of biological specimens.

Peri-zygomatic complications on zygomatic implants with or without penetrating the external surface of zygoma: A 2-year retrospective study.

The main purpose of this retrospective study was to assess the difference in the incidence of peri-zygomatic complications (PZCs) when zygomatic implants (ZIs) penetrate or do not penetrate the external surface of zygoma. This study included 32 patients with edentulous maxillae or potentially edentulous maxillae undergo zygomatic implantation. The patients were divided into the penetration group (P-group) and the non-penetration group (N-group) according to whether the apex of implants penetrated the external surface of zygoma in postoperative CBCT. The extension length, the penetration section of the implants, and the skin thickness at the corresponding position were simultaneously measured. Clinical follow-up was conducted regularly until 2 years after surgery. The occurrence of PZCs (including peri-zygomatic infection, skin numbness, non-infectious pain, and foreign body sensation) was recorded. A mixed effect logistic model was used to compare the difference of complication rate between the P-group and the N-group, and odds ratio (OR) was calculated. Then identify the impact of the extension length, penetration section and skin thickness in P-group with the same model. A total of 71 ZIs were implanted in 32 patients, including 37 implants in the P-group and 34 implants in the N-group. During the 2-year follow-up, a total of 13 implants occurred PZCs, with an overall complication rate of 18.3%. Thereinto, the incidence rate was 29.7% in the P-group, and 5.9% in the N-group (OR = 6.77). In P-group, there was a significant difference in complication rate of different extension lengths, while the penetration section and skin thickness had no statistical significance on the complication rate. Under the limitation of this study, to minimize the risk of PZCs, ZI should be placed in a manner that avoids the apex penetrating the external surface of the zygoma.

Structural performance of friction-grip bolted shear connectors in cold-formed steel composite beams

Nowadays, composite beams consisting of steel beams and concrete slabs are widely used in the construction industry. In this research, an experimental study was carried out to investigate the performance of friction-grip bolted shear connectors in composite beams with cold-formed steel sections. For this purpose, 17 full-scale push-out tests were examined according to EC4 in order to investigate the performance of this connection. Of particular interests were load-slip curves, the maximum shear capacity, ultimate slip (ductility) and failure modes. Experimental results show that the behavior of this connection is different from that of headed-stud shear connector. The diameter and strength of bolt and thickness of cold-formed steel section have the most critical effects on the shear capacity and ductility of these connections. Furthermore, 3D finite element modeling was performed and validated against experimental results. The results reveals that numerical models can estimate the capacity of friction-grip bolted shear connectors with acceptable accuracy. The results also highlight that the predominant failure mode in all specimens is bearing. Thus, the use of AISI equations to determine the bearing capacity of the screw holes as the shear capacity of friction-grip bolted shear connectors is recommended. It is also concluded that this connection possesses the necessary ductility according to the EC4 (= 6 mm) and is suitable for use in composite beams with cold-formed steel sections.

Study of Tribological Properties and Evolution of Morphological Characteristics of Transfer Films in PTFE Composites Synergistically Reinforced with Nano-ZrO2 and PEEK Particles.

The materials tribology community has identified that the transfer film attached to the surface of the counterpart metal during the friction process is not only closely related to the filler modification material but also a key factor affecting the tribological properties of polymer composites; however, there is a lack of feasible methods to quantify the characteristics of the transfer film. In this study, Nano-ZrO2 and polyetheretherketone (PEEK) were filled into a PTFE matrix in order to enhance the wear resistance of polytetrafluoroethylene (PTFE). The tribological properties of the modified PTFE composites were tested using a linear reciprocating friction and wear tester, and the entire friction experiment was designed in seven separate stages. Morphological features were extracted and analyzed from photographs of the transfer film acquired by optical microscopy at each friction stage using an image processing program. The thickness and roughness of the transfer film sections were measured using a non-contact profilometer. Abrasive debris were collected, and their morphological features were observed with an electron microscope. The results showed that the synergistic addition of soft PEEK and hard Nano-ZrO2 particles effectively inhibited interlayer slippage between PTFE molecular chains, dramatically reducing the size and yield of abrasive debris, and facilitated the improvement of the thickness and firmness of the transfer film, which significantly enhanced the wear resistance of the PTFE composites (the lowest volumetric wear rate for Nano-ZrO2/PEEK/PTFE was only 1.76 × 10-4 mm3/Nm). Quantitative analyses of the morphological characteristics of the transfer films revealed that the coverage and roundness of the transfer films gradually increase with the friction stroke, while the aspect ratio and texture entropy subsequently decrease gradually. The coverage, area, mean, third-order moments, and consistency of the transfer film strongly correlated with the volumetric wear rate (correlation coefficient |r| > 0.9).

Web crippling behaviour and design of aluminium SupaCee sections

AbstractSupaCee sections are addressed as one of the innovative section profiles which was introduced to the Cold‐Formed Steel (CFS) industry in the past decade. Longitudinal stiffeners and return lips are the unique features which ensured the better structural performance in terms of bending and shear for CFS sections. However, web crippling performance of CFS SupaCee section was the critical aspect to employ them in the industry as the concentrated loads could induce web crippling failures. Hence, there is a necessity to address web crippling performance of any innovative profiles to utilize them in appropriate locations. On that note, aluminum sections are now emerging in the industry as load bearing profiles considering their lightweight nature, corrosion resistance, ease of fabrication and high specific strength. Aluminium sections are considered as a replacement for CFS sections for modular constructions where the necessity of light weight is higher considering the transport costs and fabrication costs. However, web crippling performance of aluminum sections has to be analyzed to ensure the utilization in modular constructions. Hence, a superior section among available sections in terms of structural performances, aluminium SupaCee section, was considered for this study. Accordingly, a comprehensive numerical study was conducted considering various parameters such as section depth, thickness, bearing length and yield strength, after the successful validation process of the numerical models with the experimental scenarios of End‐Two‐Flange (ETF) loading condition. Ultimately, the results were compared with key parameters and suggestions and recommendations were stated for the utilization aluminum SupaCee sections in the industry.

Web Bearing Test of Cold‐Formed Austenitic Stainless‐Steel Channels Under Interior Loading

AbstractDuctility, durability and high corrosion resistance of stainless steels make them appealing to use in construction industry. When used as structural sections, they are, however, subjected to localised failure in the web. This study aims to examine the structural behaviour of cold‐formed austenitic stainless steel channels under localised interior bearing loads. The results of 21 tests on unlipped channels with different cross section sizes and thicknesses are presented. Nonlinear quasi‐static Finite Element (FE) model is then developed. The FE model is validated against experimental test results and demonstrated good agreement in terms of bearing strength and failure modes. In addition, the experimental and FE results are used to compare the results against the results predicted in accordance with the American specification SEI/ASCE 8:2002 and European Standard EN 1993‐1‐4:2006. It is found that the current design equations are unreliable and too unconservative to use for cold‐formed austenitic stainless steel unlipped channels, especially when compared to SEI/ASCE 8:2002, as much as 41%.

New Geochronological Age Constraint and Chemostratigraphy for Aptian Lacustrine Strata, Cedar Mountain Formation, Utah

AbstractThe Early Cretaceous is an important time of transition in Earth history, marked by a succession of oceanic anoxic events and carbon cycle perturbations that drove changes on land and in the ocean. The need for more precise geochronologic constraints in terrestrial sediments of Early Cretaceous age that record faunal and floral transitions is especially critical. The Cedar Mountain Formation (CMF) is a continental lithostratigraphic unit that hosts a trove of paleoclimate archives and important dinosaurian fossil localities. Determining the timing of deposition of CMF strata has been an ongoing effort for many years. Here, we present new lithostratigraphic and carbon isotope chemostratigraphic data along with high‐precision radiometric ages to further constrain the Ruby Ranch Member of the CMF at a unique locality referred to as “Lake Carpenter,” where a thick section of dominantly lacustrine strata overlies fluvial‐overbank to palustrine strata more typical of other Ruby Ranch Member outcrops. A bentonite bed near the base of the section provides one of the most precise ages yet determined within the Ruby Ranch Member of 115.92 ± 0.14 Ma via CA‐ID‐TIMS U‐Pb analysis of zircons. The age and the trends in the carbon isotope record indicate that the Lake Carpenter sediments were deposited entirely within the late Aptian Stage. These unique new data provide an important step toward improving our understanding of the timing of Early Cretaceous evolutionary and paleoclimate events.

Lower Talnakh Type Intrusions of the Norilsk Ore Region

Troctolites, olivine and picrite gabbrodolerites account for up to 75% of the Lower Talnakh type intrusions in places of their increased thickness whereas reduced thickness sections consist of olivine-free and olivine-bearing gabbrodolerites. Differentiation is not obvious within these high-Mg cumulates, although the content of TiO2 and alkalis increases towards the upper endocontacts. The transitions between the rock types are gradational, and the composition of low Ni olivine in different rocks (Fo70–83, 0.01–0.2 wt % NiO) overlap significantly. Clinopyroxene (Fs7–13, Mg# 68–89) is characterized by both the lowest contents and variation ranges of Cr2O3 (0.01–0.5 wt %) and TiO2 (0.05–1.0 wt %) among all types of the intrusions of the Norilsk complex that is consistent with the Cr-depleted (0.002–0.051 wt % Cr2O3) bulk rock compositions. Later orthopyroxene (Fs15–30) is crystallised by the reaction of the residual melt with early olivine. Plagioclase forms porphyritic phenocrysts and their intergrowths along with ophitic laths as well as dominates in schlieren and fragments of leucocratic rocks in taxitic and picritic gabbrodolerites with a poorly sorted layered texture. In olivine-rich rocks, sulfides are represented by the association of troilite ± hexagonal pyrrhotite + Fe- and Co-rich pentlandite + Fe-enriched chalcopyrite (± putoranite, talnakhite) ± cubanite. In the upper and lower parts of the intrusions, the association of hexagonal pyrrhotite + chalcopyrite + pentlandite occurs, while monoclinic pyrrhotite + chalcopyrite + Ni-enriched pentlandite are formed in the endo- and exocontacts. The concentration of base (0.077–0.21 wt % Ni, 0.05–0.38 wt % Cu) and platinum metals (0.03–0.26 to 0.40 g/t total PGE) in mineralized rocks is very low. Upon small amounts of sulfides and extremely low base and platinum metal tenors, the heterogeneous S isotopic composition of Lower Talnakh type sulfides (mainly 3.8–8.6‰, but up to 11.8%) most likely reflects the achievement of repeated sulfide saturation during the assimilation of sulfate S by magma that has previously experienced loss of chalcophile metals into a coexisting sulfide fluid at depth. The Sr-Nd isotopic compositions of the Lower Talnakh intrusions (Sri – from 0.7073 to 0.7087 and εNd(Т) from –1.8 at –5.9 recalculated to 250 Ma) show the predominant contamination with Proterozoic material, in contrast to the ore-bearing intrusions, which Sr-Nd isotope compositions indicate contamination with upper crustal sedimentary matter of the Paleozoic age.