This study aimed to evaluate the yield and quality performance of 12 S4-generation genotypes and 4 registered pepper varieties, developed through selection from the Kahramanmaraş pepper population by the East Mediterranean Transitional Zone Agricultural Research Institute, under the conditions of Antakya. The plant materials used were the genotypes 83, 331, 368, 373, 361, 378, 439, 449, 454, 472, 521, and 69, along with the varieties Sena, Dila, Bozok, and Yesemek. The results revealed that the highest fresh yield was obtained from genotype 83 with 1106 g plant-1, while the highest dry yield was recorded in genotype 472 with 270 g plant-1. The genotype 361 stood out with a total soluble solid content (SSC) of 13.30%, and the highest drying efficiency was observed in genotype 454 at 32.5%. In terms of fruit number, genotype 439 had the highest value with 127.33 fruits plant-1, while genotype 472 showed the highest fruit weight of 10.60 g fruit-1 and genotype 449 had the longest fruit length at 7.82 cm. The highest seed count was observed in genotype 378 with 347 seeds fruit-1, while Dila had the largest fruit width at 23.65 mm. According to the capsaicinoid (pungency) analysis, genotype 472 exhibited the highest pungency level with 147,483 scoville heat units (SHU), highlighting it as a notable quality trait. Furthermore, the lowest fruit flesh thickness was recorded in genotype 378 with 0.75 mm, and the highest 1000-seed weight was observed in genotype 373 with 6.50 g. Overall, considering the key criteria for dried pepper production, particularly dry yield and pungency, genotype 472 demonstrated superior performance due to its high dry yield and pungency levels. These findings suggest that the Antakya region is well-suited for the cultivation of high-yielding and high-quality pepper lines. Additionally, these genotypes hold significant potential for commercial production.