We measured the excitation functions of natTa(p,x)177,178W, natTa(p,x)176,177,178m1,180gTa, and natTa(p,x)175,179m2,180mHf reactions up to the proton energy of 44.2 MeV using the stacked-foil activation technique. The measured results were compared with the literature data as well as with the theoretical values obtained from the TENDL-2017 library based on the TALYS-1.9 code. The integral yields for thick target of the investigated radionuclides were determined from the measured excitation functions. The purpose was to provide a new data set for the formation of the investigated radionuclides applicable in medicine and industry and to provide information that could support in testing and understanding the nuclear reaction theories.